Guanrou Wang
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View article: ACT001 inhibits primary central nervous system lymphoma tumor growth by enhancing the anti-tumor effect of T cells
ACT001 inhibits primary central nervous system lymphoma tumor growth by enhancing the anti-tumor effect of T cells Open
Primary central nervous system lymphoma (PCNSL) is a group of malignant brain tumors with a poor prognosis, and new therapeutic approaches for this tumor urgently need to be investigated. Formulated from a long-standing anti-inflammatory d…
View article: The immunologic abnormalities in patients with paroxysmal nocturnal hemoglobinuria are associated with disease progression
The immunologic abnormalities in patients with paroxysmal nocturnal hemoglobinuria are associated with disease progression Open
Our results demonstrated that immune abnormalities are associated with PNH development.
View article: Abnormal expression of <i>CUX1</i> influences autophagy activation in paroxysmal nocturnal hemoglobinuria
Abnormal expression of <i>CUX1</i> influences autophagy activation in paroxysmal nocturnal hemoglobinuria Open
The mechanism underlying autophagy in paroxysmal nocturnal hemoglobinuria (PNH) remains largely unknown. We previously sequenced the entire genome exon of the CD59– cells from 13 patients with PNH and found genes such as CUX1 encoding Cut-…
View article: P758: THE MECHANISM OF ABNORMAL EXPRESSION AND MUTATION OF RBPJ GENE PROMOTING CLONE PROLIFERATION BY REGULATING PAF1 IN PAROXYSMAL NOCTURNAL HEMOGLOBINURIA
P758: THE MECHANISM OF ABNORMAL EXPRESSION AND MUTATION OF RBPJ GENE PROMOTING CLONE PROLIFERATION BY REGULATING PAF1 IN PAROXYSMAL NOCTURNAL HEMOGLOBINURIA Open
Topic: 11. Bone marrow failure syndromes incl. PNH - Biology & Translational Research Background: Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal disease of hematopoietic stem cells caused by somatic mutations. Our Previous…