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View article: Late-in-life neurodegeneration after chronic sleep loss in young adult mice
Late-in-life neurodegeneration after chronic sleep loss in young adult mice Open
Chronic short sleep (CSS) is prevalent in modern societies and has been proposed as a risk factor for Alzheimer’s disease (AD). In support, short-term sleep loss acutely increases levels of amyloid β (Aβ) and tau in wild type (WT) mice and…
View article: Chronic Sleep Disruption Advances the Temporal Progression of Tauopathy in P301S Mutant Mice
Chronic Sleep Disruption Advances the Temporal Progression of Tauopathy in P301S Mutant Mice Open
Brainstem locus ceruleus neurons (LCn) are among the first neurons across the lifespan to evidence tau pathology, and LCn are implicated in tau propagation throughout the cortices. Yet, events influencing LCn tau are poorly understood. Act…
View article: Intermittent Short Sleep Results in Lasting Sleep Wake Disturbances and Degeneration of Locus Coeruleus and Orexinergic Neurons
Intermittent Short Sleep Results in Lasting Sleep Wake Disturbances and Degeneration of Locus Coeruleus and Orexinergic Neurons Open
Collectively these findings demonstrate for the first time that ISS imparts significant lasting disturbances in sleep/wake activity, degeneration of wake-activated LC and orexinergic neurons, and lasting metabolic changes in remaining neur…
View article: Degeneration in Arousal Neurons in Chronic Sleep Disruption Modeling Sleep Apnea
Degeneration in Arousal Neurons in Chronic Sleep Disruption Modeling Sleep Apnea Open
Chronic sleep disruption (CSD) is a cardinal feature of sleep apnea that predicts impaired wakefulness. Despite effective treatment of apneas and sleep disruption, patients with sleep apnea may have persistent somnolence. Lasting wake dist…