Gui-hao Chen
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View article: Network Pharmacology-Based Prediction of Active Ingredients and Mechanisms of Tongxinluo Against Acute Myocardial Infarction
Network Pharmacology-Based Prediction of Active Ingredients and Mechanisms of Tongxinluo Against Acute Myocardial Infarction Open
Purpose : The aim of this network pharmacology was to explore the potential active ingredients and mechanisms of Tongxinluo (TXL) against acute myocardial infarction (AMI). Methods: We selected active ingredients and targets of TXL accordi…
View article: Inhibition of miR-128-3p by Tongxinluo Protects Human Cardiomyocytes from Ischemia/reperfusion Injury via Upregulation of p70s6k1/p-p70s6k1
Inhibition of miR-128-3p by Tongxinluo Protects Human Cardiomyocytes from Ischemia/reperfusion Injury via Upregulation of p70s6k1/p-p70s6k1 Open
Background and Aims: Tongxinluo (TXL) is a multifunctional traditional Chinese medicine that has been widely used to treat cardiovascular and cerebrovascular diseases. However, no studies have explored whether TXL can protect human cardiom…
View article: Exosomes: A Rising Star in Failing Hearts
Exosomes: A Rising Star in Failing Hearts Open
Although exosomes were previously recognized as a mechanism for discharging useless cellular components, growing evidence has elucidated their roles in conveying information between cells. They contribute to cell-cell communication by carr…
View article: Tongxinluo exerts protective effects via anti‐apoptotic and pro‐autophagic mechanisms by activating AMPK pathway in infarcted rat hearts
Tongxinluo exerts protective effects via anti‐apoptotic and pro‐autophagic mechanisms by activating AMPK pathway in infarcted rat hearts Open
New Findings What is the central question of this study? In a rat model of acute myocardial infarction (AMI), we investigated the effect of Tongxinluo (TXL) treatment. Does TXL activate autophagy and attenuate apoptosis of cardiomyocytes t…