Guido Fadda
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View article: ITAC and Non-ITAC Sinonasal Adenocarcinoma: Classification, Etiopathogenesis, Diagnosis and Therapy Focusing on Interdisciplinarity
ITAC and Non-ITAC Sinonasal Adenocarcinoma: Classification, Etiopathogenesis, Diagnosis and Therapy Focusing on Interdisciplinarity Open
Sinonasal adenocarcinomas are rare malignant tumors arising from the epithelial lining of the sinonasal tract. They are classified into intestinal-type (ITAC) and non-intestinal-type adenocarcinomas (non-ITAC), with different histopatholog…
View article: Histopathologic and ancillary findings of subcentimeter thyroid nodules diagnosed as follicular neoplasms: a retrospective institutional study
Histopathologic and ancillary findings of subcentimeter thyroid nodules diagnosed as follicular neoplasms: a retrospective institutional study Open
Thyroid nodules are frequently encountered, mostly detected during ultrasound evaluation of the head and neck, frequently performed for other reasons. Albeit most nodules arise in the setting of multinodular goiter, hypoechoic subcentimete…
View article: Correction: SCFβ-TRCP suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2
Correction: SCFβ-TRCP suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2 Open
View article: CUPROPTOSIS: A REVIEW ON MECHANISMS, ROLE IN SOLID AND HEMATOLOGICAL TUMORS, AND ASSOCIATION WITH VIRAL INFECTIONS
CUPROPTOSIS: A REVIEW ON MECHANISMS, ROLE IN SOLID AND HEMATOLOGICAL TUMORS, AND ASSOCIATION WITH VIRAL INFECTIONS Open
Cuproptosis is a distinct modality of regulated cell death precipitated by an overload of intracellular copper, critically dependent on mitochondrial respiration. The underlying mechanism involves the direct interaction of copper ions with…
View article: Should indeterminate subcentimeter thyroid nodules be interpreted as follicular neoplasms?
Should indeterminate subcentimeter thyroid nodules be interpreted as follicular neoplasms? Open
Background: Thyroid nodules are frequently encountered, mostly detected during routine ultrasound evaluation. Albeit most nodules arise in the setting of multinodular goiter, hypoechoic subcentimeter nodules can be recognized that show sus…
View article: Evaluation of papillary thryoid carcinoma and its variants: multifocality in thyroid lobectomy and completion thyroidectomy - a single tertiary center retrospective study
Evaluation of papillary thryoid carcinoma and its variants: multifocality in thyroid lobectomy and completion thyroidectomy - a single tertiary center retrospective study Open
Our data could be the basis for performing a longitudinal study in order to establish which risk factors can predict bilateral involvement and to suggest a tailored surgical approach.
View article: Understanding Neovascularization in Glioblastoma: Insights from the Current Literature
Understanding Neovascularization in Glioblastoma: Insights from the Current Literature Open
Glioblastomas (GBMs), among the most aggressive and resilient brain tumors, characteristically exhibit high angiogenic potential, leading to the formation of a dense yet aberrant vasculature, both morphologically and functionally. With the…
View article: PD-L1 expression in prostate cancer and Gleason Grade Group: Is there any relationship? Findings from a multi-institutional cohort.
PD-L1 expression in prostate cancer and Gleason Grade Group: Is there any relationship? Findings from a multi-institutional cohort. Open
Our study highlights a positive correlation between PD-L1 expression and GG in PCa, suggesting that higher PD-L1 expression is linked to more aggressive disease. This finding could have implications for treatment selection and the use of i…
View article: Histologic Evaluation of Thyroid Nodules Treated with Thermal Ablation: An Institutional Experience
Histologic Evaluation of Thyroid Nodules Treated with Thermal Ablation: An Institutional Experience Open
Thyroid nodules are a common, benign condition with a higher prevalence in women, individuals with iodine deficiency, and radiation exposure. Treatment options for benign thyroid nodules include pharmaceutical therapy, thyroidectomy, and t…
View article: Case Report: Plummer's adenoma in Prader–Willi syndrome
Case Report: Plummer's adenoma in Prader–Willi syndrome Open
Thyroid nodules in children are less common than in adults but they are approximately two- to three-fold more likely to be malignant in children. Among thyroid nodular diseases, Plummer's adenoma occurs very rarely in pediatrics, and curre…
View article: Programmed Cell Death Ligand 1 (PD-L1) Immunohistochemical Expression in Advanced Urothelial Bladder Carcinoma: An Updated Review with Clinical and Pathological Implications
Programmed Cell Death Ligand 1 (PD-L1) Immunohistochemical Expression in Advanced Urothelial Bladder Carcinoma: An Updated Review with Clinical and Pathological Implications Open
The management of advanced bladder carcinoma involves a multidisciplinary approach, but the prognosis remains poor for many patients. The immune system plays a crucial role in this disease, influencing both tumor development and response t…
View article: The Morphology of Nasal Polyps in Different Age Groups: Histopathological Features
The Morphology of Nasal Polyps in Different Age Groups: Histopathological Features Open
Background: Nasal polyps (NPs) represent the end-stage manifestation of chronic rhinosinusitis (CRS), a relatively common pathological condition encountered in all ages of life. Methodology: The aim of our study was to evaluate the histolo…
View article: Multifocality in thyroid lobectomy and completion thyroidectomy – a single tertiary center retrospective study
Multifocality in thyroid lobectomy and completion thyroidectomy – a single tertiary center retrospective study Open
Aims The American Thyroid Association (ATA) updated guidelines for the treatment of thyroid cancer, leading to a less aggressive approach depending on clinical-pathological features. As a result, the possibility to perform lobectomy versus…
View article: Multicancer screening test based on the detection of circulating non haematological proliferating atypical cells
Multicancer screening test based on the detection of circulating non haematological proliferating atypical cells Open
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View article: Immunohistochemical Profile of p62/SQSTM1/Sequestosome‐1 in Human Low‐ and High‐Grade Intracranial Meningiomas
Immunohistochemical Profile of p62/SQSTM1/Sequestosome‐1 in Human Low‐ and High‐Grade Intracranial Meningiomas Open
Among autophagic‐related proteins, p62/SQSTM1/Sequestosome‐1 represents a relevant actor in cellular proliferation and neoplastic growth. Although, recently, p62 expression has been analyzed in different neurodegenerative and glial neoplas…
View article: A Rare Case of Osteoma Cutis in the Auricular Pinna: Clinical Presentation and Management Considerations
A Rare Case of Osteoma Cutis in the Auricular Pinna: Clinical Presentation and Management Considerations Open
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View article: Bladder Epicheck Test: A Novel Tool to Support Urothelial Carcinoma Diagnosis in Urine Samples
Bladder Epicheck Test: A Novel Tool to Support Urothelial Carcinoma Diagnosis in Urine Samples Open
Bladder cancer and upper urothelial tract carcinoma are common diseases with a high risk of recurrence, thus necessitating follow-up after initial treatment. The management of non-muscle invasive bladder carcinoma (NMIBC) after transurethr…
View article: Unusual localization and clinical presentation of primary central nervous system extranodal marginal zone B‑cell lymphoma: A case report
Unusual localization and clinical presentation of primary central nervous system extranodal marginal zone B‑cell lymphoma: A case report Open
Primary central nervous system (CNS) extranodal marginal zone B-cell lymphoma (MZBL) is a rare low-grade non-Hodgkin lymphoma, characterised predominantly by small B cells, plasma cells, monocytoid cells and scattered large immunoblasts. P…
View article: Delphi expert consensus for whole slide imaging in thyroid cytopathology
Delphi expert consensus for whole slide imaging in thyroid cytopathology Open
Objective Despite an increase in thyroid fine needle aspiration (FNA) and advances in whole slide imaging (WSI) adoption, digital pathology is still considered inadequate for primary diagnosis of these cases. Herein, we aim to validate the…
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View article: Updates from Our Institutional Experience with Thyroid Nodules Diagnosed as Metastases
Updates from Our Institutional Experience with Thyroid Nodules Diagnosed as Metastases Open
Background: Thyroid metastases (TMs) are a rare entity, ranging between 0 and 24% in the autopsy series. In the assessment of the best management, the discrimination between a primary and a metastatic thyroid lesion is crucial. In this reg…
View article: Digital Examination of LYmph node CYtopathology Using the Sydney system (DELYCYUS): An international, multi‐institutional study
Digital Examination of LYmph node CYtopathology Using the Sydney system (DELYCYUS): An international, multi‐institutional study Open
Background After a series of standardized reporting systems in cytopathology, the Sydney system was recently introduced to address the need for reproducibility and standardization in lymph node cytopathology. Since then, the risk of malign…
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View article: BRAF-AXL-PD-L1 Signaling Axis as a Possible Biological Marker for RAI Treatment in the Thyroid Cancer ATA Intermediate Risk Category
BRAF-AXL-PD-L1 Signaling Axis as a Possible Biological Marker for RAI Treatment in the Thyroid Cancer ATA Intermediate Risk Category Open
The use of radioiodine therapy (RIT) is debated in intermediate-risk differentiated thyroid cancer (DTC) patients. The understanding of the molecular mechanisms involved in the pathogenesis of DTC can be useful to refine patient selection …
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View article: Autophagic-Related Proteins in Brain Gliomas: Role, Mechanisms, and Targeting Agents
Autophagic-Related Proteins in Brain Gliomas: Role, Mechanisms, and Targeting Agents Open
The present review focuses on the phenomenon of autophagy, a catabolic cellular process, which allows for the recycling of damaged organelles, macromolecules, and misfolded proteins. The different steps able to activate autophagy start wit…