Guido Pelletti
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View article: Characterizing post-mortem blood concentrations in methadone-related deaths
Characterizing post-mortem blood concentrations in methadone-related deaths Open
Methadone is a widely used opioid agonist in maintenance therapy for opioid addiction; however, its global diversion is increasing. Determining methadone’s role in drug-related deaths is often challenging due to its pharmacological propert…
View article: Self-contained crash or run-over by a vehicle? Integrating post-mortem CT and kinematic analysis to reconstruct motorcycle accident dynamics
Self-contained crash or run-over by a vehicle? Integrating post-mortem CT and kinematic analysis to reconstruct motorcycle accident dynamics Open
View article: Analysis of Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) on hair after single and repeated short in vivo passive exposures to low- and high-Δ9-THC-cannabis
Analysis of Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) on hair after single and repeated short in vivo passive exposures to low- and high-Δ9-THC-cannabis Open
View article: Cocaine-Induced Sudden Cardiac Death Unravelling a SCN5A-Related Disease
Cocaine-Induced Sudden Cardiac Death Unravelling a SCN5A-Related Disease Open
Cocaine consumption is a significant global problem, with an estimated 20 million users worldwide. Sudden cardiac death is frequently reported in this population, particularly among individuals <40 years of age. The role of underlying inhe…
View article: Morphometric analysis of dog bitemarks. An experimental study
Morphometric analysis of dog bitemarks. An experimental study Open
Dog attacks on humans represent a global issue with significant health and medico-legal implications. A dog attack may cut or puncture a victim's skin resulting in distinctive lesions representing the morphology of the dentition that creat…
View article: The role of myocardial bridge of the left anterior descending artery in a sudden death of a ketamine and cannabis user. Addressing the uncertainties on the cause of death in a forensic pathologist’s casework
The role of myocardial bridge of the left anterior descending artery in a sudden death of a ketamine and cannabis user. Addressing the uncertainties on the cause of death in a forensic pathologist’s casework Open
View article: Correlation between in vivo imaging and post‑mortem autopsy findings for the medico-legal evaluation of a right hepatic artery pseudoaneurysm as a fatal complication of laparoscopic cholecystectomy
Correlation between in vivo imaging and post‑mortem autopsy findings for the medico-legal evaluation of a right hepatic artery pseudoaneurysm as a fatal complication of laparoscopic cholecystectomy Open
View article: The landscape of rare mitochondrial DNA variants in sudden cardiac death: A potential role for ATP synthase
The landscape of rare mitochondrial DNA variants in sudden cardiac death: A potential role for ATP synthase Open
View article: The Application of Molecularly Imprinted Polymers in Forensic Toxicology: Issues and Perspectives
The Application of Molecularly Imprinted Polymers in Forensic Toxicology: Issues and Perspectives Open
Molecularly imprinted polymers (MIPs) are synthetic receptors designed to selectively bind specific molecules, mimicking natural antibody–antigen interactions. Produced through polymerization around a target molecule (template), MIPs creat…
View article: Prevalence of new psychoactive substances and drugs of abuse in the hair of individuals diagnosed with substance use disorder: Polydrug and emerging pattern of consumption
Prevalence of new psychoactive substances and drugs of abuse in the hair of individuals diagnosed with substance use disorder: Polydrug and emerging pattern of consumption Open
People diagnosed with substance use disorder (SUD) might represent a high‐risk subpopulation for New Psychoactive Drugs (NPS) consumption, and hair analysis offers a unique perspective to assess drug prevalence in this population. The pres…
View article: Assessment of Per- and Polyfluoroalkyl Substances (PFAS) in Traditional, Organic and Protein Flours
Assessment of Per- and Polyfluoroalkyl Substances (PFAS) in Traditional, Organic and Protein Flours Open
View article: Motorcycle injuries: a systematic review for forensic evaluation
Motorcycle injuries: a systematic review for forensic evaluation Open
View article: Forensic value of soft tissue detachments from the hyoid bone in death due to strangulation asphyxia
Forensic value of soft tissue detachments from the hyoid bone in death due to strangulation asphyxia Open
Detachment of soft tissues has poor value as a single element to favor the diagnosis of asphyxia due to violent compression of the neck and should be interpreted as an artifactual finding, unrelated to the neck injury or injury vitality.
View article: Bicycle injuries: A systematic review for forensic evaluation
Bicycle injuries: A systematic review for forensic evaluation Open
Bicycles are employed as means of transportation across various age groups, from young students to the elderly, for work, education, health, and leisure trips. Despite not achieving high speeds, bicyclists remain vulnerable to severe and e…
View article: Reliability in distinguishing murder from accidental event with current forensic criteria in traumatic head injury
Reliability in distinguishing murder from accidental event with current forensic criteria in traumatic head injury Open
Discovering a body displaying signs of multiple head trauma requires a thorough examination by the forensic pathologist, and a multidisciplinary approach is recommended. However, determining the manner of death is not always possible. We p…
View article: Optimizing screening cutoffs for drugs of abuse in hair using immunoassay for forensic applications
Optimizing screening cutoffs for drugs of abuse in hair using immunoassay for forensic applications Open
The presented screening method proved to be a useful technique on hair samples for the classes of drugs most commonly found in Italy and Europe and can be applied to forensic analysis.
View article: Fetal and Infant Effects of Maternal Opioid Use during Pregnancy: A Literature Review including Clinical, Toxicological, Pharmacogenomic, and Epigenetic Aspects for Forensic Evaluation
Fetal and Infant Effects of Maternal Opioid Use during Pregnancy: A Literature Review including Clinical, Toxicological, Pharmacogenomic, and Epigenetic Aspects for Forensic Evaluation Open
The two primary classes of opioid substances are morphine and its synthetic derivative, heroin. Opioids can cross the placental barrier, reaching fetal circulation. Therefore, at any gestational age, the fetus is highly exposed to pharmaco…
View article: Validation and application of a method for the quantification of 137 drugs of abuse and new psychoactive substances in hair
Validation and application of a method for the quantification of 137 drugs of abuse and new psychoactive substances in hair Open
View article: ADB‐HEXINACA—a novel synthetic cannabinoid with a hexyl substituent: phase I metabolism in authentic urine samples, a case report and prevalence on the German market
ADB‐HEXINACA—a novel synthetic cannabinoid with a hexyl substituent: phase I metabolism in authentic urine samples, a case report and prevalence on the German market Open
Synthetic cannabinoid receptor agonists (SCRAs) are one of the largest groups of new psychoactive substances (NPS). Yet, another novel analog started spreading on the NPS market around 2021. Soon after, the substance could be analytically …
View article: Pediatric motor vehicle crashes injuries: A systematic review for forensic evaluation
Pediatric motor vehicle crashes injuries: A systematic review for forensic evaluation Open
View article: On tackling abuse of older people: The forensic challenges in fatal cases investigation
On tackling abuse of older people: The forensic challenges in fatal cases investigation Open
View article: External hair contamination from cannabis and “light cannabis” delivered by smoking and vaping: An in vitro study
External hair contamination from cannabis and “light cannabis” delivered by smoking and vaping: An in vitro study Open
External contamination of hair by cannabis smoking requires a careful evaluation in forensic toxicology. Medical and recreational cannabis are increasingly consumed by e‐cigarettes, which give rise to side‐stream vapor. Moreover, products …
View article: An unusual case of corpse concealment driven by emotional distress
An unusual case of corpse concealment driven by emotional distress Open
View article: Homicide, suicide, or accident? Complex differential diagnosis. A case series
Homicide, suicide, or accident? Complex differential diagnosis. A case series Open
Distinguishing between homicides, suicides, and accidental deaths remains a challenging task. The examination of actual cases, which involve a multitude of variables, significantly contributes to our understanding of these matters. In this…
View article: Homicide or suicide? A probabilistic approach for the evaluation of the manner of death in sharp force fatalities
Homicide or suicide? A probabilistic approach for the evaluation of the manner of death in sharp force fatalities Open
The role of forensic science can be defined as providing relevant opinions to assist investigators and courts of law in answering questions. The Likelihood Ratio (LR) provides a quantitative and logical approach to communicating the streng…
View article: Determination of ethyl glucuronide in hair and self-reported alcohol consumption in university students
Determination of ethyl glucuronide in hair and self-reported alcohol consumption in university students Open
View article: Diagnostic challenges and forensic implications in a case of infantile fatal myocarditis
Diagnostic challenges and forensic implications in a case of infantile fatal myocarditis Open
View article: A Genome-Wide Analysis of a Sudden Cardiac Death Cohort: Identifying Novel Target Variants in the Era of Molecular Autopsy
A Genome-Wide Analysis of a Sudden Cardiac Death Cohort: Identifying Novel Target Variants in the Era of Molecular Autopsy Open
Sudden cardiac death (SCD) is an unexpected natural death due to cardiac causes, usually happening within one hour of symptom manifestation or in individuals in good health up to 24 h before the event. Genomic screening has been increasing…
View article: The Evaluation of CYP2D6, CYP2C9, CYP2C19, and CYP2B6 Phenoconversion in Post-Mortem Casework: The Challenge of Forensic Toxicogenetics
The Evaluation of CYP2D6, CYP2C9, CYP2C19, and CYP2B6 Phenoconversion in Post-Mortem Casework: The Challenge of Forensic Toxicogenetics Open
In toxicogenetics, an integrative approach including the prediction of phenotype based on post-mortem genotyping of drug-metabolising enzymes might help explain the cause of death (CoD) and manner of death (MoD). The use of concomitant dru…
View article: Infection Induced Fetal Inflammatory Response Syndrome (FIRS): State-of- the-Art and Medico-Legal Implications—A Narrative Review
Infection Induced Fetal Inflammatory Response Syndrome (FIRS): State-of- the-Art and Medico-Legal Implications—A Narrative Review Open
Fetal inflammatory response syndrome (FIRS) represents the fetal inflammatory reaction to intrauterine infection or injury, potentially leading to multiorgan impairment, neonatal mortality, and morbidity. Infections induce FIRS after chori…