Guiji Zhang
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View article: Targeted screening and single-cell analysis of genetic variants in melanoma using Mendelian randomization
Targeted screening and single-cell analysis of genetic variants in melanoma using Mendelian randomization Open
View article: Prognostic value of creatine kinase (CK)-MB to total-CK ratio in colorectal cancer patients after curative resection
Prognostic value of creatine kinase (CK)-MB to total-CK ratio in colorectal cancer patients after curative resection Open
View article: Prognostic value of Creatine Kinase (CK)-MB to total-CK ratio in colorectal cancer patients after curative resection
Prognostic value of Creatine Kinase (CK)-MB to total-CK ratio in colorectal cancer patients after curative resection Open
Objectives: This study aimed to evaluate the prognostic significance of postoperative Creatine Kinase (CK)-MB to total-CK ratio (CK-MB/CK) in colorectal cancer (CRC) patients after radical resection. Methods: This was a single-center retro…
View article: PCK1 attenuates tumor stemness via activating the Hippo signaling pathway in hepatocellular carcinoma
PCK1 attenuates tumor stemness via activating the Hippo signaling pathway in hepatocellular carcinoma Open
Liver cancer stem cells were found to rely on glycolysis as the preferred metabolic program. Phosphoenolpyruvate carboxylase 1 (PCK1), a gluconeogenic metabolic enzyme, is down-regulated in hepatocellular carcinoma and is closely related t…
View article: Prognostic impact of Creatine Kinase (CK)-MB to total-CK ratio following curative resection of stage I-III colorectal cancer
Prognostic impact of Creatine Kinase (CK)-MB to total-CK ratio following curative resection of stage I-III colorectal cancer Open
Objectives: The purpose of this study was to evaluate the prognostic significance of Creatine Kinase (CK)-MB to total-CK ratio (CK-MB/CK) in patients with stage I-III colorectal cancer (CRC) after radical resection. Methods: This study was…
View article: A Novel Prognostic Model based on a Coagulation-related Gene Signature for Colorectal Cancer
A Novel Prognostic Model based on a Coagulation-related Gene Signature for Colorectal Cancer Open
Background Colorectal cancer (CRC) is a relatively common malignancy worldwide. The diagnosis of CRC at an early stage is difficult due to the lack of effective molecular biomarkers. Consequently, CRC is associated with a high mortality ra…
View article: Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male mice
Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male mice Open
Metabolic associated fatty liver disease (MAFLD) encompasses a broad spectrum of hepatic disorders, including steatosis, nonalcoholic steatohepatitis (NASH) and fibrosis. We demonstrated that phosphoenolpyruvate carboxykinase 1 (PCK1) play…
View article: Obatoclax inhibits SARS-CoV-2 entry by altered endosomal acidification and impaired cathepsin and furin activity in vitro
Obatoclax inhibits SARS-CoV-2 entry by altered endosomal acidification and impaired cathepsin and furin activity in vitro Open
Coronavirus disease 2019 (COVID-19) caused by the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has set off a global pandemic. There is an urgent unmet need for safe, affordable, and effective therapeu…
View article: Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants
Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants Open
Accumulating mutations in the SARS-CoV-2 Spike (S) protein can increase the possibility of immune escape, challenging the present COVID-19 prophylaxis and clinical interventions. Here, 3 receptor binding domain (RBD) specific monoclonal an…
View article: Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants
Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants Open
Accumulating mutations in the SARS-CoV-2 Spike (S) protein can increase the possibility of immune escape, challenging the present COVID-19 prophylaxis and clinical interventions. Here, 3 receptor binding domain (RBD) specific monoclonal an…
View article: Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products
Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products Open
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major public health issue.The spike (S) protein mutation D614G became dominant in SARS-CoV-2 during a global pandemic, which di…
View article: A Rapid and Efficient Screening System for Neutralizing Antibodies and Its Application for SARS-CoV-2
A Rapid and Efficient Screening System for Neutralizing Antibodies and Its Application for SARS-CoV-2 Open
After the pandemic of COVID-19, neutralizing antibodies (NAbs) against SARS-CoV-2 have been developed for the prophylactic and therapeutic purposes. However, few methodologies are described in detail on how to rapidly and efficiently gener…
View article: Ultrapotent SARS-CoV-2 neutralizing antibodies effectively block new-emerging mutational variants
Ultrapotent SARS-CoV-2 neutralizing antibodies effectively block new-emerging mutational variants Open
Accumulating mutations on SARS-CoV-2 Spike (S) protein may increase the possibility of immune escape, challenging the present COVID-19 prophylaxis and clinical interventions. Here, in a panel of receptor binding domain (S-RBD) specific mon…
View article: Deficiency of gluconeogenic enzyme PCK1 promotes non-alcoholic steatohepatitis progression and fibrosis through PI3K/AKT/PDGF axis activation
Deficiency of gluconeogenic enzyme PCK1 promotes non-alcoholic steatohepatitis progression and fibrosis through PI3K/AKT/PDGF axis activation Open
Nonalcoholic steatohepatitis (NASH) is a chronic liver disease characterized by hepatic lipid accumulation, inflammation, and progressive fibrosis. We demonstrated that phosphoenolpyruvate carboxykinase 1 (PCK1) plays a central role in NAS…
View article: Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products in vitro
Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products in vitro Open
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major public health issue. To screen for antiviral drugs for COVID-19 treatment, we constructed a SARS-CoV-2 spike (S) pseudovi…
View article: A rapid and efficient screening system for neutralizing antibodies and its application for SARS-CoV-2
A rapid and efficient screening system for neutralizing antibodies and its application for SARS-CoV-2 Open
After the epidemic of COVID-19, neutralizing antibodies (NAbs) against SARS-CoV-2 has been developed for the preventative and therapeutic purposes. However, few methodologies are reported in detail on how to rapidly and efficiently generat…
View article: A rapid and efficient screening system for neutralizing antibodies and its application for the discovery of potent neutralizing antibodies to SARS-CoV-2 S-RBD
A rapid and efficient screening system for neutralizing antibodies and its application for the discovery of potent neutralizing antibodies to SARS-CoV-2 S-RBD Open
Neutralizing antibodies (Abs) have been considered as promising therapeutics for the prevention and treatment of pathogens. After the outbreak of COVID-19, potent neutralizing Abs to SARS-CoV-2 were promptly developed, and a few of those n…
View article: Longitudinal Dynamics of the Neutralizing Antibody Response to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection
Longitudinal Dynamics of the Neutralizing Antibody Response to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Open
Background Coronavirus disease 2019 (COVID-19) is a global pandemic with no licensed vaccine or specific antiviral agents for therapy. Little is known about the longitudinal dynamics of severe acute respiratory syndrome coronavirus 2 (SARS…
View article: Depletion of VPS35 attenuates metastasis of hepatocellular carcinoma by restraining the Wnt/PCP signaling pathway
Depletion of VPS35 attenuates metastasis of hepatocellular carcinoma by restraining the Wnt/PCP signaling pathway Open
View article: Longitudinal dynamics of the neutralizing antibody response to SARS-CoV-2 infection
Longitudinal dynamics of the neutralizing antibody response to SARS-CoV-2 infection Open
Background Coronavirus disease 2019 (COVID-19) is a global pandemic with no licensed vaccine or specific antiviral agents for therapy. Little is known about the longitudinal dynamics of SARS-CoV-2-specific neutralizing antibodies (NAbs) in…
View article: D614G mutation of SARS-CoV-2 spike protein enhances viral infectivity
D614G mutation of SARS-CoV-2 spike protein enhances viral infectivity Open
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The spike (S) protein that mediates SARS-CoV-2 entry into host cells is a major target for vaccines and therapeutics. Thus, insi…
View article: SLC27A5 deficiency activates NRF2/TXNRD1 pathway by increased lipid peroxidation in HCC
SLC27A5 deficiency activates NRF2/TXNRD1 pathway by increased lipid peroxidation in HCC Open
View article: PCK1 Downregulation Promotes TXNRD1 Expression and Hepatoma Cell Growth via the Nrf2/Keap1 Pathway
PCK1 Downregulation Promotes TXNRD1 Expression and Hepatoma Cell Growth via the Nrf2/Keap1 Pathway Open
Gluconeogenesis, generates glucose from small carbohydrate substrates, and drives the metabolic flux in parallel but opposite to glycolysis. The cytoplasmic isoform of phosphoenolpyruvate carboxykinase (PCK1 or PEPCK-C), a rate-limiting en…