Guilhem Bousquet
YOU?
Author Swipe
View article: Photodynamic Therapy Using Pulsed-Laser Irradiation of Gold Nanoparticles for the Treatment of Cancers with High Basal Oxidative Stress
Photodynamic Therapy Using Pulsed-Laser Irradiation of Gold Nanoparticles for the Treatment of Cancers with High Basal Oxidative Stress Open
For over 20 years, considerable research has been carried out on the use of nanotechnologies in cancer treatment. Beyond the photothermal effect of irradiating gold nanoparticles, the photodynamic effect with reactive oxygen species (ROS) …
View article: SeqOIA platform, an integrative and interactive approach to optimize personalized cancer treatment
SeqOIA platform, an integrative and interactive approach to optimize personalized cancer treatment Open
Here, we report the importance of integrative genomic analysis and combined therapies in precision medicine to achieve durable responses in patients with limited treatment options. We report here data from 27 patients with cancers in a sit…
View article: Characteristics and predictive model for diffuse large B-cell lymphoma with early chemoimmunotherapy failure
Characteristics and predictive model for diffuse large B-cell lymphoma with early chemoimmunotherapy failure Open
Introduction The outcomes of refractory or relapsed diffuse large B-cell lymphoma are generally poor, especially those relapsed or progressed within 12 months from diagnosis named as early chemoimmunotherapy failure (ECF), with a 2-year OS…
View article: Anti-angiogenic tyrosine kinase inhibitors and the pathophysiology of their toxic effects: revisiting the treatment of anemia in metastatic cancers
Anti-angiogenic tyrosine kinase inhibitors and the pathophysiology of their toxic effects: revisiting the treatment of anemia in metastatic cancers Open
Background Anti-angiogenic tyrosine kinase inhibitors (TKIs) have become major drugs for the treatment of various cancer types, but with an overall high incidence of severe toxicities, particularly haematological toxicities including sever…
View article: 3D vascularized microtumors unveil aberrant ccRCC vasculature and differential sensitivity to targeted treatments
3D vascularized microtumors unveil aberrant ccRCC vasculature and differential sensitivity to targeted treatments Open
Clear cell renal cell carcinoma (ccRCC) is largely driven by Von Hippel Lindau (VHL) protein deficiency, promoting epithelial-mesenchymal transition, invasion, and hypervascularization, mediated by vascular endothelial growth factor (VEGF)…
View article: PROM2 overexpression induces metastatic potential through epithelial‐to‐mesenchymal transition and ferroptosis resistance in human cancers
PROM2 overexpression induces metastatic potential through epithelial‐to‐mesenchymal transition and ferroptosis resistance in human cancers Open
Introduction Despite considerable therapeutic advances in the last 20 years, metastatic cancers remain a major cause of death. We previously identified prominin‐2 (PROM2) as a biomarker predictive of distant metastases and decreased surviv…
View article: A Sub-Group of Kidney-Transplant Recipients with Highly Aggressive Squamous Cell Carcinoma Expressing Phosphorylated Serine392p53
A Sub-Group of Kidney-Transplant Recipients with Highly Aggressive Squamous Cell Carcinoma Expressing Phosphorylated Serine392p53 Open
Cutaneous squamous cell carcinomas in kidney-transplant recipients are frequent, with an increasing incidence linked to long immunosuppression durations and exposure to ultraviolet radiation. p53 is at the cornerstone of ultraviolet-induce…
View article: The germline genetics of mild-to-moderate penetrance: An intriguing role of PRAME in multiple carcinogenesis
The germline genetics of mild-to-moderate penetrance: An intriguing role of PRAME in multiple carcinogenesis Open
International audience
View article: OP0014 SHARED MOLECULAR TARGETS OF APOPTOSIS IN CHRONIC INFLAMMATION AND AUTOIMMUNITY: HOW TO BLOCK AUTOIMMUNE ARTHRITIS
OP0014 SHARED MOLECULAR TARGETS OF APOPTOSIS IN CHRONIC INFLAMMATION AND AUTOIMMUNITY: HOW TO BLOCK AUTOIMMUNE ARTHRITIS Open
Background Aging is associated with an increased incidence of cancers and autoimmune diseases, which share pathophysiological mechanisms. Understanding these common pathways would make it possible to better define a certain risk linked to …
View article: A Boom in Nanotechnologies for a High Level of Precision Medicine
A Boom in Nanotechnologies for a High Level of Precision Medicine Open
The number of publications on nanomedicine in oncology has been exponential over the last ten years, going from 640 publications in 2012 to 2487 publications in 2022, reflecting the growing interest and potential of these new technologies …
View article: Supplementary Table 1 from Stem Cells Increase in Numbers in Perinecrotic Areas in Human Renal Cancer
Supplementary Table 1 from Stem Cells Increase in Numbers in Perinecrotic Areas in Human Renal Cancer Open
Supplementary Table 1. Tumorigenic potential of cells sorted from normoxic and hypoxic spheres of the six xenograft models (take rate in percentage)
View article: Table S2 from A Constitutional Activating <i>MET</i> Mutation Makes the Genetic Link between Malignancies and Chronic Inflammatory Diseases
Table S2 from A Constitutional Activating <i>MET</i> Mutation Makes the Genetic Link between Malignancies and Chronic Inflammatory Diseases Open
Supplementary Table S2
View article: Supplementary methods from Stem Cells Increase in Numbers in Perinecrotic Areas in Human Renal Cancer
Supplementary methods from Stem Cells Increase in Numbers in Perinecrotic Areas in Human Renal Cancer Open
supplementary methods
View article: Table S2 from A Constitutional Activating <i>MET</i> Mutation Makes the Genetic Link between Malignancies and Chronic Inflammatory Diseases
Table S2 from A Constitutional Activating <i>MET</i> Mutation Makes the Genetic Link between Malignancies and Chronic Inflammatory Diseases Open
Supplementary Table S2
View article: Figure S2 from A Constitutional Activating <i>MET</i> Mutation Makes the Genetic Link between Malignancies and Chronic Inflammatory Diseases
Figure S2 from A Constitutional Activating <i>MET</i> Mutation Makes the Genetic Link between Malignancies and Chronic Inflammatory Diseases Open
Supplementary Figure S2
View article: Figure S4 from A Constitutional Activating <i>MET</i> Mutation Makes the Genetic Link between Malignancies and Chronic Inflammatory Diseases
Figure S4 from A Constitutional Activating <i>MET</i> Mutation Makes the Genetic Link between Malignancies and Chronic Inflammatory Diseases Open
Supplementary Figure S4
View article: Figure S6 from A Constitutional Activating <i>MET</i> Mutation Makes the Genetic Link between Malignancies and Chronic Inflammatory Diseases
Figure S6 from A Constitutional Activating <i>MET</i> Mutation Makes the Genetic Link between Malignancies and Chronic Inflammatory Diseases Open
Supplementary Figure S6
View article: Data from A Constitutional Activating <i>MET</i> Mutation Makes the Genetic Link between Malignancies and Chronic Inflammatory Diseases
Data from A Constitutional Activating <i>MET</i> Mutation Makes the Genetic Link between Malignancies and Chronic Inflammatory Diseases Open
Purpose:The genesis of all cancers results from an accumulation of mutations, constitutional and/or acquired when induced by external mutagenic factors. High-speed technologies for genome sequencing have completely changed the study of dis…
View article: Data from A Constitutional Activating <i>MET</i> Mutation Makes the Genetic Link between Malignancies and Chronic Inflammatory Diseases
Data from A Constitutional Activating <i>MET</i> Mutation Makes the Genetic Link between Malignancies and Chronic Inflammatory Diseases Open
Purpose:The genesis of all cancers results from an accumulation of mutations, constitutional and/or acquired when induced by external mutagenic factors. High-speed technologies for genome sequencing have completely changed the study of dis…
View article: Figure S3 from Stem Cells Increase in Numbers in Perinecrotic Areas in Human Renal Cancer
Figure S3 from Stem Cells Increase in Numbers in Perinecrotic Areas in Human Renal Cancer Open
Figure S3. Distribution of pimonidazole-stained hypoxic cells in xenografted human RCC
View article: Figure S2 from Stem Cells Increase in Numbers in Perinecrotic Areas in Human Renal Cancer
Figure S2 from Stem Cells Increase in Numbers in Perinecrotic Areas in Human Renal Cancer Open
Figure S2. On xenograft RCC models non-responder to sunitinib, we assessed the distribution of CD133 positive cells
View article: Data from Stem Cells Increase in Numbers in Perinecrotic Areas in Human Renal Cancer
Data from Stem Cells Increase in Numbers in Perinecrotic Areas in Human Renal Cancer Open
Purpose: Developing strategies to overcome resistance to sunitinib is a major challenge in human renal cell carcinoma (RCC). We hypothesized that sunitinib-induced tumor necrosis–associated hypoxia could interact with renal cancer stem cel…
View article: Figure S4 from A Constitutional Activating <i>MET</i> Mutation Makes the Genetic Link between Malignancies and Chronic Inflammatory Diseases
Figure S4 from A Constitutional Activating <i>MET</i> Mutation Makes the Genetic Link between Malignancies and Chronic Inflammatory Diseases Open
Supplementary Figure S4
View article: Figure S2 from Stem Cells Increase in Numbers in Perinecrotic Areas in Human Renal Cancer
Figure S2 from Stem Cells Increase in Numbers in Perinecrotic Areas in Human Renal Cancer Open
Figure S2. On xenograft RCC models non-responder to sunitinib, we assessed the distribution of CD133 positive cells
View article: Figure S1 from A Constitutional Activating <i>MET</i> Mutation Makes the Genetic Link between Malignancies and Chronic Inflammatory Diseases
Figure S1 from A Constitutional Activating <i>MET</i> Mutation Makes the Genetic Link between Malignancies and Chronic Inflammatory Diseases Open
Supplementary Figure S1
View article: Figure S3 from Stem Cells Increase in Numbers in Perinecrotic Areas in Human Renal Cancer
Figure S3 from Stem Cells Increase in Numbers in Perinecrotic Areas in Human Renal Cancer Open
Figure S3. Distribution of pimonidazole-stained hypoxic cells in xenografted human RCC