Frederico Guilherme Graeff
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View article: EFFECT OF TRAMADOL AS AN ADJUNCTIVE PHARMACOLOGICAL TREATMENT FOR MAJOR DEPRESSIVE DISORDER: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL
EFFECT OF TRAMADOL AS AN ADJUNCTIVE PHARMACOLOGICAL TREATMENT FOR MAJOR DEPRESSIVE DISORDER: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL Open
Background Usual pharmacological treatment of Major Depressive Disorder (MDD) with serotonin/noradrenaline reuptake inhibitors is effective but clinical response may take several weeks to emerge [1], and around 30% of the patients will not…
View article: μ-Opioid and 5-HT1A receptors in the dorsomedial hypothalamus interact for the regulation of panic-related defensive responses
μ-Opioid and 5-HT1A receptors in the dorsomedial hypothalamus interact for the regulation of panic-related defensive responses Open
The dorsomedial hypothalamus (DMH) and the dorsal periaqueductal gray (DPAG) have been implicated in the genesis and regulation of panic-related defensive behaviors, such as escape. Previous results point to an interaction between serotone…
View article: DECREASED REACTIVITY TO ANXIOLYTICS CAUSED BY EARLY PROTEIN MALNUTRITION IN RATS
DECREASED REACTIVITY TO ANXIOLYTICS CAUSED BY EARLY PROTEIN MALNUTRITION IN RATS Open
In order to investigate whether early malnutrition causes lasting changes in the reactivity to anxiolytic drugs, rat dams lactation (21 days) and pops after weaning until the 49th day of life were fed on 8% casein diet (M rats), while thei…