Guilherme G. Schu Peixoto
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View article: Metabolic PET brain networks predict clinical conversion prior to amyloid positivity in cognitively unimpaired individuals
Metabolic PET brain networks predict clinical conversion prior to amyloid positivity in cognitively unimpaired individuals Open
Background The default‐mode network (DMN) consists of brain regions with higher resting activity levels. Amyloid‐ß (Aß) deposition in Alzheimer’s disease (AD) occurs predominantly throughout the DMN, suggesting that activity within the net…
View article: Metabolic PET brain networks predict clinical conversion prior to amyloid positivity in cognitively unimpaired individuals
Metabolic PET brain networks predict clinical conversion prior to amyloid positivity in cognitively unimpaired individuals Open
Background The default‐mode network (DMN) consists of brain regions with higher resting activity levels. Amyloid‐β (Aβ) deposition in Alzheimer’s disease (AD) occurs predominantly throughout the DMN, suggesting that activity within the net…
View article: Metabolic Hyperconnectivity in Underrepresented Individuals with long‐COVID
Metabolic Hyperconnectivity in Underrepresented Individuals with long‐COVID Open
Background Long‐COVID is characterized by persistent symptoms post‐infection with SARS‐CoV‐2. This condition includes neurological manifestations and has been proposed as a potential risk factor for the development of dementia. Individuals…
View article: Metabolic Hyperconnectivity in Underrepresented Individuals with long‐COVID
Metabolic Hyperconnectivity in Underrepresented Individuals with long‐COVID Open
Background Long‐COVID is characterized by persistent symptoms post‐infection with SARS‐CoV‐2. This condition includes neurological manifestations and has been proposed as a potential risk factor for the development of dementia. Individuals…
View article: Activation of the glutamate transport in astrocytes via GLT‐1 reshapes the glutamatergic brain network
Activation of the glutamate transport in astrocytes via GLT‐1 reshapes the glutamatergic brain network Open
Background Glutamate is the main excitatory neurotransmitter in the brain, acting through ionotropic and metabotropic receptors, such as the neuronal metabotropic glutamate receptor 5 (mGluR5). The radiotracer [11C]ABP688 binds allosterica…
View article: Impact of beta‐amyloid oligomers on in vivo brain glucose metabolism
Impact of beta‐amyloid oligomers on in vivo brain glucose metabolism Open
Background The deposition of β‐amyloid (Aβ) plaques is a classical neuropathological feature of Alzheimer’s disease (AD). Currently, it is believed that intermediate products of the Aβ fibrillogenesis process, like the β‐amyloid oligomers …
View article: Activation of the glutamate transport in astrocytes via GLT‐1 reshapes the glutamatergic brain network
Activation of the glutamate transport in astrocytes via GLT‐1 reshapes the glutamatergic brain network Open
Background Glutamate is the main excitatory neurotransmitter in the brain, acting through ionotropic and metabotropic receptors, such as the neuronal metabotropic glutamate receptor 5 (mGluR5). The radiotracer [ 11 C]ABP688 binds allosteri…
View article: Inflammatory and metabolic responses in the aging rat brain
Inflammatory and metabolic responses in the aging rat brain Open
Background The brain is an energetically demanding organ that mostly relies on glucose oxidation to sustain its sophisticated networks. Transcriptomic studies suggest metabolic‐related genes are downregulated in the aging brain but inflamm…
View article: Longitudinal assessment of [<sup>18</sup>F]FDG‐PET in the TgF344‐AD rat
Longitudinal assessment of [<sup>18</sup>F]FDG‐PET in the TgF344‐AD rat Open
Background The development and characterization of biomarkers abnormalities in Alzheimer’s disease (AD) animal models is particularly important for the investigation of pathophysiological mechanisms and drug development. With this is mind,…
View article: Evidence that methylphenidate Treatment Evokes Anxiety-Like Behavior Through Glucose Hypometabolism and Disruption of the Orbitofrontal Cortex Metabolic Networks
Evidence that methylphenidate Treatment Evokes Anxiety-Like Behavior Through Glucose Hypometabolism and Disruption of the Orbitofrontal Cortex Metabolic Networks Open
Methylphenidate (MPH) has been widely misused by children and adolescents who do not meet all diagnostic criteria for attention-deficit/hyperactivity disorder without a consensus about the consequences. Here, we evaluate the effect of MPH …
View article: Ciências humanas: o indivíduo como ponto de partida e chegada
Ciências humanas: o indivíduo como ponto de partida e chegada Open
View article: P2‐099: SEPSIS TRIGGERS ALZHEIMER'S‐LIKE GLUCOSE ABNORMALITIES
P2‐099: SEPSIS TRIGGERS ALZHEIMER'S‐LIKE GLUCOSE ABNORMALITIES Open
Sepsis induces peripheral inflammation, which seems to have strong effects on brain function. Neuroinflammation and long-term brain dysfunction is commonly observed among sepsis-survivors. In this context, brain inflammatory changes have b…
View article: O2‐03‐01: AMYLOIDOSIS INDUCES EARLY METABOLIC REORGANIZATION
O2‐03‐01: AMYLOIDOSIS INDUCES EARLY METABOLIC REORGANIZATION Open
Cerebral glucose hypometabolism – indexed by 18-fluorodeoxyglucose ([18F]FDG) positron emission tomography (PET) imaging – is a metabolic signature of Alzheimer's disease (AD) patients. More than providing regional estimations of glucose m…
View article: P1‐327: AGING REMODELS BRAIN METABOLISM AND ASTROCYTE MARKERS
P1‐327: AGING REMODELS BRAIN METABOLISM AND ASTROCYTE MARKERS Open
Age-related changes in brain metabolism constitute a main risk factor for developing Alzheimer's disease (AD). [18F]Fluorodeoxyglucose ([18F]FDG) positron emission tomography (PET) imaging has been useful for identifying AD since it provid…