Guiling Xiang
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View article: STAT6 deficiency mitigates the severity of pulmonary arterial hypertension caused by chronic intermittent hypoxia by suppressing Th2-inducing cytokines
STAT6 deficiency mitigates the severity of pulmonary arterial hypertension caused by chronic intermittent hypoxia by suppressing Th2-inducing cytokines Open
These findings exhibit the critical role of STAT6 in the pathogenesis of CIH induced PH by regulating Th2 immune response.STAT6 could be a significant therapeutic target for OSA-related PH.
View article: Autocrine TGF-alpha is associated with Benzo(a)pyrene-induced mucus production and MUC5AC expression during allergic asthma
Autocrine TGF-alpha is associated with Benzo(a)pyrene-induced mucus production and MUC5AC expression during allergic asthma Open
Autocrine TGF-α was associated with BaP-induced MUC5AC expression in vitro and in vivo. BaP induced TGF-α secretion by activating AhR and producing ROS, which led to activation of the EGFR-ERK pathway.
View article: Growth differentiation factor 11 induces skeletal muscle atrophy via a STAT3-dependent mechanism in pulmonary arterial hypertension
Growth differentiation factor 11 induces skeletal muscle atrophy via a STAT3-dependent mechanism in pulmonary arterial hypertension Open
Skeletal muscle wasting is a clinically remarkable phenotypic feature of pulmonary arterial hypertension (PAH) that increases the risk of mortality. Growth differentiation factor 11 (GDF11), centrally involved in PAH pathogenesis, has an i…
View article: Respiratory physicians’ awareness and referral of pulmonary rehabilitation in China: a cross-sectional study
Respiratory physicians’ awareness and referral of pulmonary rehabilitation in China: a cross-sectional study Open
Chinese respiratory physicians' awareness of PR and referral to PR remain insufficient to support the delivery of PR to patients with chronic respiratory diseases. PR training for respiratory physicians and building PR centers are necessar…
View article: Serum cartilage oligomeric matrix protein is decreased in patients with pulmonary hypertension: a potential protective factor
Serum cartilage oligomeric matrix protein is decreased in patients with pulmonary hypertension: a potential protective factor Open
Cartilage oligomeric matrix protein (COMP) was a protective factor in the cardiovascular system. Previous studies showed that hypoxia led to decreased COMP in rat models of pulmonary hypertension. However, the expression pattern of COMP in…
View article: Predictors of mortality for hospitalized young adults aged less than 60 years old with severe COVID-19: a retrospective study
Predictors of mortality for hospitalized young adults aged less than 60 years old with severe COVID-19: a retrospective study Open
Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection in young deceased patients appears to cause exuberant inflammatory responses, leading to compromised oxygen exchange, coagulation and multi-organ dysfunction. In additi…
View article: Essential Genes and MiRNA–mRNA Network Contributing to the Pathogenesis of Idiopathic Pulmonary Arterial Hypertension
Essential Genes and MiRNA–mRNA Network Contributing to the Pathogenesis of Idiopathic Pulmonary Arterial Hypertension Open
Background: Idiopathic pulmonary arterial hypertension (IPAH) is a life-threatening disease. Owing to its high fatality rate and narrow therapeutic options, identification of the pathogenic mechanisms of IPAH is becoming increasingly impor…
View article: Left atrial dysfunction in patients with obstructive sleep apnea: a combined assessment by speckle tracking and real-time three-dimensional echocardiography
Left atrial dysfunction in patients with obstructive sleep apnea: a combined assessment by speckle tracking and real-time three-dimensional echocardiography Open
OSA is associated with LA remodeling and dysfunction that occurs in the subclinical stage before the development of LVH and left ventricular diastolic dysfunction, and it will be further aggravated along with the development of LVH and OSA…
View article: The effect of coagulation factors in 2019 novel coronavirus patients
The effect of coagulation factors in 2019 novel coronavirus patients Open
Background: The role of coagulation dysfunction in Severe Coronavirus Disease 2019 (COVID-19) is inconsistent. We aimed to explore the impact of coagulation dysfunction amongst patients with COVID-19. Methods: We searched PubMed, Cochrane …
View article: Clinical risk factors for mortality of hospitalized patients with COVID-19: systematic review and meta-analysis
Clinical risk factors for mortality of hospitalized patients with COVID-19: systematic review and meta-analysis Open
Male, current smoking patients aged 60 years or over might face a greater risk of in-hospital death and the comorbidities such as diabetes, hypertension, CVD, respiratory disease, and CKD could also influence the prognosis of the COVID-19.…
View article: BTB and CNC homology 1 (Bach1) induces lung cancer stem cell phenotypes by inducing CD44 expression
BTB and CNC homology 1 (Bach1) induces lung cancer stem cell phenotypes by inducing CD44 expression Open
Background Growing evidence suggests that CSCs are responsible for cancer initiation in tumors. Bach1 has been identified to contribute to several tumor progression, including lung cancer. The role of Bach1 in CSCs remains poorly known. Th…
View article: Essential genes and miRNA-mRNA network contributing to the pathogenesis of idiopathic pulmonary arterial hypertension
Essential genes and miRNA-mRNA network contributing to the pathogenesis of idiopathic pulmonary arterial hypertension Open
Background: Idiopathic pulmonary arterial hypertension (IPAH) is a life-threatening disease. Owing to its high fatality rate and narrow therapeutic options, identification of the pathogenic mechanisms of IPAH is becoming increasingly impor…
View article: Association of Different Lactate Indices with 30-Day and 180-Day Mortality in Patients with ST-Segment Elevation Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention: A Retrospective Cohort Study
Association of Different Lactate Indices with 30-Day and 180-Day Mortality in Patients with ST-Segment Elevation Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention: A Retrospective Cohort Study Open
Long Hu,1 Wei Lin,2 Tiancheng Xu,1 Dongjie Liang,1 Guangze Xiang,1 Rujie Zheng,1 Changzuan Zhou,1 Qinxue Dai,3 Danyun Jia3 1Department of Cardiovascular Medicine, The Heart Center, The First Affiliated Hospital of Wenzhou Medical Universit…
View article: A Nomogram for Prediction of Postoperative Pneumonia Risk in Elderly Hip Fracture Patients
A Nomogram for Prediction of Postoperative Pneumonia Risk in Elderly Hip Fracture Patients Open
Guangheng Xiang,1,2,* Xiaoyu Dong,1,* Tao Xu,1 Yongzeng Feng,1 Zili He,1 Chenrong Ke,1 Jian Xiao,1,2 Yi-Min Weng1 1Department of Orthopaedic, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenz…
View article: Pulmonary Function Influences the Performance of Berlin Questionnaire, Modified Berlin Questionnaire, and STOP-Bang Score for Screening Obstructive Sleep Apnea in Subjects with Chronic Obstructive Pulmonary Disease
Pulmonary Function Influences the Performance of Berlin Questionnaire, Modified Berlin Questionnaire, and STOP-Bang Score for Screening Obstructive Sleep Apnea in Subjects with Chronic Obstructive Pulmonary Disease Open
Qinhan Wu,1,2 Liang Xie,1,2 Wenjing Li,1,2 Guiling Xiang,1,2 Weiping Hu,1,2 Hong Jiang,1,2 Xu Wu,1,2 Xiaodan Wu,1,2 Shanqun Li1,2 1Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, People’s Republi…
View article: The Reliability and Validity of the “Activity and Participation” Component in the Brief ICF Core Set for Chronic Obstructive Pulmonary Diseases Based on Rasch Analysis
The Reliability and Validity of the “Activity and Participation” Component in the Brief ICF Core Set for Chronic Obstructive Pulmonary Diseases Based on Rasch Analysis Open
Chengyao Guo,1,* Yingge Liu,1,* Shengyu Hao,2,* Liang Xie,2 Guiling Xiang,2 Yan Wu,1 Shanqun Li2 1Nursing Department, Zhongshan Hospital, Fudan University, Shanghai 200032, People’s Republic of China; 2Department of Pulmonary Medicine, Zho…
View article: <p>The Reliability and Validity of the “Activity and Participation” Component in the Brief ICF Core Set for Chronic Obstructive Pulmonary Diseases Based on Rasch Analysis</p>
The Reliability and Validity of the “Activity and Participation” Component in the Brief ICF Core Set for Chronic Obstructive Pulmonary Diseases Based on Rasch Analysis Open
The "activity and participation" of brief ICF core set for COPD has good reliability and validity, which can be used to test the daily activities of patients with COPD.
View article: <p>Pulmonary Function Influences the Performance of Berlin Questionnaire, Modified Berlin Questionnaire, and STOP-Bang Score for Screening Obstructive Sleep Apnea in Subjects with Chronic Obstructive Pulmonary Disease</p>
Pulmonary Function Influences the Performance of Berlin Questionnaire, Modified Berlin Questionnaire, and STOP-Bang Score for Screening Obstructive Sleep Apnea in Subjects with Chronic Obstructive Pulmonary Disease Open
BQ, MBQ, and STOP-Bang score performed well in COPD subjects for screening OSA. The diagnosis of the three questionnaires was more accurate in subjects with lower FEV1%pred or FVC%pred value. Pulmonary function might exert influence on the…
View article: Effects of neuromuscular electrical stimulation on exercise capacity and quality of life in COPD patients: a systematic review and meta-analysis
Effects of neuromuscular electrical stimulation on exercise capacity and quality of life in COPD patients: a systematic review and meta-analysis Open
Neuromuscular electrical stimulation (NMES) has been shown to produce benefits in the muscle function of chronic obstructive pulmonary disease (COPD) patients. The definite effectiveness of NMES, applied in isolation or concurrently with c…
View article: Effects of non-invasive ventilation in subjects undergoing cardiac surgery on length of hospital stay and cardiac-pulmonary complications: a systematic review and meta-analysis
Effects of non-invasive ventilation in subjects undergoing cardiac surgery on length of hospital stay and cardiac-pulmonary complications: a systematic review and meta-analysis Open
The prophylactic use of NIV immediately in post-cardiac subjects who underwent cardiac surgery might be able to shorten the length of hospital stay and the length of ICU stay, but it has no significant effect on pulmonary complications, ra…
View article: Effects of Tai Chi training on the physical and mental health status in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis
Effects of Tai Chi training on the physical and mental health status in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis Open
Tai Chi may represent an appropriate alternative or complement to standard rehabilitation programs. However, whether Tai Chi is better than pulmonary rehabilitation exercise has not been determined.
View article: Dysfunction of adaptive immunity is related to severity of COVID-19: a retrospective study
Dysfunction of adaptive immunity is related to severity of COVID-19: a retrospective study Open
Background: In December of 2019, coronavirus disease 2019 (Covid-19) was reported in Wuhan, China, and has now rapidly swept around the world. Much research has been carried out since the outbreak, but few studies have focused on the dysfu…