Guillaume Bonnier
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View article: Blood pressure monitoring during anesthesia induction using PPG morphology features and machine learning
Blood pressure monitoring during anesthesia induction using PPG morphology features and machine learning Open
Blood pressure (BP) is a crucial biomarker giving valuable information regarding cardiovascular diseases but requires accurate continuous monitoring to maximize its value. In the effort of developing non-invasive, non-occlusive and continu…
View article: Accuracy of blood pressure measurement across BMI categories using the OptiBP™ mobile application
Accuracy of blood pressure measurement across BMI categories using the OptiBP™ mobile application Open
This study demonstrated that the OptiBP application is easily applicable to overweight and obese participants. Differences between the reference measure and the OptiBP estimation were within ISO limits (criterion 1). In obese participants,…
View article: Proof-of-Concept Study for Reflectance Pulse Oximetry Using Optical-Fibre-Based Sensors
Proof-of-Concept Study for Reflectance Pulse Oximetry Using Optical-Fibre-Based Sensors Open
Optical fibres enable to design of new textile-based sensors for an unobtrusive, continuous, and long-term acquisition of photoplethysmography (PPG) signals. However, no research has been done about the accuracy of measuring blood oxygen s…
View article: Comparability of a Blood-Pressure-Monitoring Smartphone Application with Conventional Measurements—A Pilot Study
Comparability of a Blood-Pressure-Monitoring Smartphone Application with Conventional Measurements—A Pilot Study Open
(1) Background: New cuffless technologies attempting blood-pressure measurements (BPM) offer possibilities to improve hypertension awareness and control. The aim of this study was to compare a smartphone application (app)-based algorithm w…
View article: Smartphone based blood pressure measurement: accuracy of the OptiBP mobile application according to the AAMI/ESH/ISO universal validation protocol.
Smartphone based blood pressure measurement: accuracy of the OptiBP mobile application according to the AAMI/ESH/ISO universal validation protocol. Open
The smartphone embedded OptiBP cuffless mobile application fulfills the validation requirements of AAMI/ESH/ISO universal standards in a general population for the measurement of SBP and DBP.
View article: Pilot study of comparability of a smartphone blood pressure monitoring algorithm to conventional cuff-based blood pressure measurements
Pilot study of comparability of a smartphone blood pressure monitoring algorithm to conventional cuff-based blood pressure measurements Open
Background/Introduction There is a growing market for smartphone applications (apps), offering medical assessments such as blood pressure measurements (BPM). These apps have the potential to improve blood pressure (BP) control by making BP…
View article: Ultrahigh field in vivo characterization of microstructural abnormalities in the orbitofrontal cortex and amygdala in autism
Ultrahigh field in vivo characterization of microstructural abnormalities in the orbitofrontal cortex and amygdala in autism Open
There are currently no biomarkers for autism spectrum disorder (ASD). This neurodevelopmental condition has previously been associated with histopathological findings, including increased neuronal packing density in the amygdala, abnormal …
View article: Smartphone based blood pressure measurement: accuracy of the OptiBP mobile application according to the AAMI/ESH/ISO universal validation protocol
Smartphone based blood pressure measurement: accuracy of the OptiBP mobile application according to the AAMI/ESH/ISO universal validation protocol Open
Objective The aim of this study was to assess the accuracy of the OptiBP mobile application based on an optical signal recorded by placing the patient’s fingertip on a smartphone’s camera to estimate blood pressure (BP). Measurements were …
View article: Evolution of Cortical and White Matter Lesion Load in Early-Stage Multiple Sclerosis: Correlation With Neuroaxonal Damage and Clinical Changes
Evolution of Cortical and White Matter Lesion Load in Early-Stage Multiple Sclerosis: Correlation With Neuroaxonal Damage and Clinical Changes Open
Introduction: Changes in cortical and white matter lesion (CL, WML) load are pivotal metrics to diagnose and monitor multiple sclerosis patients. Yet, the relationship between (i) changes in CL/WML load and disease progression and between …
View article: Extra‐Axial Inflammatory Signal in Parameninges in Migraine with Visual Aura
Extra‐Axial Inflammatory Signal in Parameninges in Migraine with Visual Aura Open
Objective Cortical spreading depression (CSD) underlies the neurobiology of migraine with aura (MWA). Animal studies reveal networks of microvessels linking brain–meninges–bone marrow. CSD activates the trigeminovascular system, evoking a …
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Issue Information Open
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View article: Quantitative brain relaxation atlases for personalized detection and characterization of brain pathology
Quantitative brain relaxation atlases for personalized detection and characterization of brain pathology Open
Purpose To exploit the improved comparability and hardware independency of quantitative MRI, databases of MR physical parameters in healthy tissue are required, to which tissue properties of patients can be compared. In this work, normativ…
View article: Imaging of neuroinflammation in migraine with aura
Imaging of neuroinflammation in migraine with aura Open
These findings demonstrate that migraine with aura is associated with neuroimmune activation/neuroinflammation, and support a possible link between CSD and glial activation, previously observed in animals.
View article: Rivastigmine decreases brain damage in <scp>HIV</scp> patients with mild cognitive deficits
Rivastigmine decreases brain damage in <span>HIV</span> patients with mild cognitive deficits Open
Rivastigmine has been shown to improve cognition in HIV + patients with minor neurocognitive disorders; however, the mechanisms underlying such beneficial effect are currently unknown. To assess whether rivastigmine therapy is associated w…
View article: The Combined Quantification and Interpretation of Multiple Quantitative Magnetic Resonance Imaging Metrics Enlightens Longitudinal Changes Compatible with Brain Repair in Relapsing-Remitting Multiple Sclerosis Patients
The Combined Quantification and Interpretation of Multiple Quantitative Magnetic Resonance Imaging Metrics Enlightens Longitudinal Changes Compatible with Brain Repair in Relapsing-Remitting Multiple Sclerosis Patients Open
In patients, we measured a significant longitudinal decrease of mean T2 relaxation times in NA white matter (p = 0.005) and a decrease of T1 relaxation times in the pallidum (p < 0.05), which are compatible with edema reabsorption and/or i…
View article: A Longitudinal Study of Neurite Orientation Dispersion and Density Imaging in Relapsing-Remitting Multiple Sclerosis
A Longitudinal Study of Neurite Orientation Dispersion and Density Imaging in Relapsing-Remitting Multiple Sclerosis Open
We explored the sensitivity of a novel diffusion MRI method i.e. “Neurite orientation dispersion and density imaging”, to detect and characterize brain microstructure alterations in relapsing-remitting multiple sclerosis patients that we f…
View article: An Ultra-High Field Study of Cerebellar Pathology in Early Relapsing-Remitting Multiple Sclerosis Using MP2RAGE
An Ultra-High Field Study of Cerebellar Pathology in Early Relapsing-Remitting Multiple Sclerosis Using MP2RAGE Open
Objectives The aim of this study was to study focal cerebellar pathology in early stages of multiple sclerosis (MS) using ultra-high-field magnetization-prepared 2 inversion-contrast rapid gradient-echo (7T MP2RAGE). Materials and Methods …
View article: Prospective head motion correction using FID‐guided on‐demand image navigators
Prospective head motion correction using FID‐guided on‐demand image navigators Open
Purpose We suggest a motion correction concept that employs free‐induction‐decay (FID) navigator signals to continuously monitor motion and to guide the acquisition of image navigators for prospective motion correction following motion det…
View article: A New Approach for Deep Gray Matter Analysis Using Partial-Volume Estimation
A New Approach for Deep Gray Matter Analysis Using Partial-Volume Estimation Open
The presented methodology provides additional information to standard MR signal averaging approaches that holds promise to identify the presence and nature of diffuse pathology in neuro-inflammatory and neurodegenerative diseases.