Guillaume Chapelet
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View article: Resuscitation discussion practices: a survey of European geriatricians
Resuscitation discussion practices: a survey of European geriatricians Open
View article: TORPP - Turtles, One Health Research & Plastic Pollution: A multidisciplinary consortium to evaluate the environmental and health impact of Micro/NanoPlastics (MNPs) pollution
TORPP - Turtles, One Health Research & Plastic Pollution: A multidisciplinary consortium to evaluate the environmental and health impact of Micro/NanoPlastics (MNPs) pollution Open
Although the World Health Organization characterizes a One Health concern as one in which there is the capability to incorporate numerous disciplines to tackle health challenges threatening humans, animals and ecosystems, scientific effort…
View article: Negative effects of institutionalization on the sense of self in Alzheimer's Disease
Negative effects of institutionalization on the sense of self in Alzheimer's Disease Open
View article: Tau dans le tube digestif : expression et phosphorylation dans les neurones entériques et dans les cellules entéroendocrines
Tau dans le tube digestif : expression et phosphorylation dans les neurones entériques et dans les cellules entéroendocrines Open
It is now well established that the gut-brain axis is involved in the development of Parkinson's disease the main type of synucleinopathy. In contrast, existing studies on the possible role of the gut-brain axis in other neurodegenerative …
View article: ChatGPT as a Diagnostic Aid in Alzheimer’s Disease: An Exploratory Study
ChatGPT as a Diagnostic Aid in Alzheimer’s Disease: An Exploratory Study Open
Background: The potential of ChatGPT in medical diagnosis has been explored in various medical conditions. Objective: We assessed whether ChatGPT can contribute to the diagnosis of Alzheimer’s disease (AD). Methods: We provided ChatGPT wit…
View article: Relationship Between Future Thinking and Prospective Memory in Alzheimer’s Disease
Relationship Between Future Thinking and Prospective Memory in Alzheimer’s Disease Open
Background: Future thinking and prospective memory are two cognitive processes oriented toward the future and reliant on the ability to envision oneself in future scenarios. Objective: We explored the connection between future thinking and…
View article: The Pupil Knows: Pupil Dilation Indexes and Their Inhibitory Ability in Normal Aging
The Pupil Knows: Pupil Dilation Indexes and Their Inhibitory Ability in Normal Aging Open
Pupil dilation is considered an index of cognitive effort, as the pupil typically dilates as the cognitive load increases. In this paper, we evaluated whether older adults demonstrate increased pupil size when performing tasks requiring co…
View article: Tau expression and phosphorylation in enteroendocrine cells
Tau expression and phosphorylation in enteroendocrine cells Open
Background and objective There is mounting evidence to suggest that the gut-brain axis is involved in the development of Parkinson’s disease (PD). In this regard, the enteroendocrine cells (EEC), which faces the gut lumen and are connected…
View article: Nocturnal hypoglycemia is underdiagnosed in older people with insulin‐treated type 2 diabetes: The <scp>HYPOAGE</scp> observational study
Nocturnal hypoglycemia is underdiagnosed in older people with insulin‐treated type 2 diabetes: The <span>HYPOAGE</span> observational study Open
Background There is a lack of real‐life data regarding the frequency and predictive factors of hypoglycemia in older patients with type 2 diabetes (T2D). This study aimed to determine the frequency and predictors of hypoglycemia in older p…
View article: How Do Women and Men Look at the Past? Large Scanpath in Women during Autobiographical Retrieval—A Preliminary Study
How Do Women and Men Look at the Past? Large Scanpath in Women during Autobiographical Retrieval—A Preliminary Study Open
While research has consistently demonstrated how autobiographical memory triggers visual exploration, prior studies did not investigate gender differences in this domain. We thus compared eye movement between women and men while performing…
View article: The recombined memory: associative inference in Alzheimer’s disease
The recombined memory: associative inference in Alzheimer’s disease Open
View article: Tau expression and phosphorylation in enteroendocrine cells
Tau expression and phosphorylation in enteroendocrine cells Open
Background and objective There is mounting evidence to suggest that the gut-brain axis is involved in the development of Parkinson’s disease (PD). In this regard, the enteroendocrine cells (EEC), which faces the gut lumen and are connected…
View article: Factors Associated with Dual-Fluency Walk Speed Improvement after Rehabilitation in Older Patients
Factors Associated with Dual-Fluency Walk Speed Improvement after Rehabilitation in Older Patients Open
Walk speed measured under dual-task conditions (neurocognitive tasks) could reflect patient performance in real-life. Rehabilitation programs are effective in increasing walk speed, but few studies have evaluated the associations between g…
View article: The "Sickness" Memory: Can Patients With Alzheimer Disease Remember the Diagnosis Announcement?
The "Sickness" Memory: Can Patients With Alzheimer Disease Remember the Diagnosis Announcement? Open
Retrieval of the diagnosis announcement can activate a strong emotional and personally important experience in patients with AD. When remembering the diagnosis announcement, patients with AD may re-experience some features of that turning …
View article: Executive dysfunction and effectiveness of physical program in older adults: which association?
Executive dysfunction and effectiveness of physical program in older adults: which association? Open
View article: Does Sex Matter? High Semantic Autobiographical Retrieval in Women and Men With Alzheimer’s Disease
Does Sex Matter? High Semantic Autobiographical Retrieval in Women and Men With Alzheimer’s Disease Open
The decline of autobiographical memory in Alzheimer’s disease (AD) is mainly characterized by overgenerality. While there is a large body of research on autobiographical overgenerality in AD, this research has mainly assessed retrieval wit…
View article: Functional Decline in COVID-19 Older Survivors Compared to Other Pneumonia Patients, a Case Control Study
Functional Decline in COVID-19 Older Survivors Compared to Other Pneumonia Patients, a Case Control Study Open
View article: Functional decline, long term symptoms and course of frailty at 3-months follow-up in COVID-19 older survivors, a prospective observational cohort study
Functional decline, long term symptoms and course of frailty at 3-months follow-up in COVID-19 older survivors, a prospective observational cohort study Open
View article: La méthode Snoezelen : une alternative thérapeutique chez les patients ayant des troubles cognitifs ?
La méthode Snoezelen : une alternative thérapeutique chez les patients ayant des troubles cognitifs ? Open
Neuropsychiatric disorders are one of the frequent complications of neurocognitive disease, and have an impact on the quality of life of patients and caregivers. Non-phamacologic interventions are recommended as first-line treatment. The S…
View article: High-dose versus standard-dose vitamin D supplementation in older adults with COVID-19 (COVIT-TRIAL): A multicenter, open-label, randomized controlled superiority trial
High-dose versus standard-dose vitamin D supplementation in older adults with COVID-19 (COVIT-TRIAL): A multicenter, open-label, randomized controlled superiority trial Open
Background Vitamin D supplementation has been proposed as a treatment for Coronavirus Disease 2019 (COVID-19) based on experimental data and data from small and uncontrolled observational studies. The COvid19 and VITamin d TRIAL (COVIT-TRI…
View article: “Who will I be?”: The future of the self as described by Alzheimer's disease (AD) patients
“Who will I be?”: The future of the self as described by Alzheimer's disease (AD) patients Open
View article: On Covid-19 and mental health
On Covid-19 and mental health Open
While visiting and socialization restrictions during lockdowns were instituted to cope with the Covid-19 spread and to prolong the life of residents of retirement homes, these measures could have been expected to decrease the quality of li…
View article: Empathy of individuals with Alzheimer’s disease (AD) toward other AD patients
Empathy of individuals with Alzheimer’s disease (AD) toward other AD patients Open
International audience
View article: The “Sickness” Memory
The “Sickness” Memory Open
Background: Diagnosis of Alzheimer disease (AD) can cause substantial psychological distress in patients. We thus assessed how patients with AD remember the announcement of diagnosis. Methods: We recruited 47 participants with mild AD (26 …
View article: Results from EDIFICE : A French pilot study on COVID-19 and the gut microbiome in a hospital environment
Results from EDIFICE : A French pilot study on COVID-19 and the gut microbiome in a hospital environment Open
BACKGROUND & AIMS Early reports suggest that both fecal shedding and dysbiosis of the gut microbiome are associated to disease severity in COVID-19 patients. We investigated the gut microbiome as well as the prevalence of SARS-CoV-2 in sto…
View article: “My sympathetic clinician”: perception of sympathy by patients with Alzheimer’s disease increases when asked to provide autobiographical memories
“My sympathetic clinician”: perception of sympathy by patients with Alzheimer’s disease increases when asked to provide autobiographical memories Open
View article: Pupil size as an indicator of cognitive activity in mild Alzheimer’s disease
Pupil size as an indicator of cognitive activity in mild Alzheimer’s disease Open
It is well established that pupil activity indexes cognitive processing. For instance, research has consistently demonstrated that the pupil reacts to working memory span task performance. However, little is known about pupil reaction to c…
View article: High Exhaustion in Geriatric Healthcare Professionals During the COVID-19 Second Lockdown
High Exhaustion in Geriatric Healthcare Professionals During the COVID-19 Second Lockdown Open
Background: In a previous study, we assessed burnout in geriatric healthcare workers during the first lockdown that lasted from March to May 2020 in France, in response to the COVID-19 crisis. Objective: We carried out a follow-up study to…
View article: Risk Factors Associated with 30-Day Mortality in Older Patients with Influenza
Risk Factors Associated with 30-Day Mortality in Older Patients with Influenza Open
Background: Influenza is a common viral condition, but factors related to short-term mortality have not been fully studied in older adults. Our objective was to determine whether there is an association between geriatric factors and 30-day…
View article: Tau in the gut, does it really matter?
Tau in the gut, does it really matter? Open
International audience