Guillaume Gaud
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View article: Early events in TCR signaling – the evolving role of ITAMs
Early events in TCR signaling – the evolving role of ITAMs Open
The T cell antigen receptor (TCR), a multiprotein complex essential for adaptive immunity, is composed of variable TCRα and TCRβ subunits responsible for antigen recognition and six invariant signal transducing CD3 and ζ subunits. Peptide-…
View article: THEMIS increases TCR signaling in CD4 <sup>+</sup> CD8 <sup>+</sup> thymocytes by inhibiting the activity of the tyrosine phosphatase SHP1
THEMIS increases TCR signaling in CD4 <sup>+</sup> CD8 <sup>+</sup> thymocytes by inhibiting the activity of the tyrosine phosphatase SHP1 Open
The T cell lineage–restricted protein THEMIS plays a critical role in T cell development at the positive selection stage. In the SHP1 activation model, THEMIS is proposed to enhance the activity of the tyrosine phosphatase SHP1 (encoded by…
View article: TCR/Chimeric Antigen Receptor (CAR) Cross-Antagonism to Fine-Tune CAR-T cell Immunotherapy
TCR/Chimeric Antigen Receptor (CAR) Cross-Antagonism to Fine-Tune CAR-T cell Immunotherapy Open
Chimeric antigen receptor (CAR) T cells, are created by extracting T cells from a cancer patient, engineering them to express a CAR targeting a tumor specific molecule, then reintroducing them back into the patient. A patient’s T cells con…
View article: GRB2 promotes thymocyte positive selection by facilitating THEMIS-mediated inactivation of SHP1
GRB2 promotes thymocyte positive selection by facilitating THEMIS-mediated inactivation of SHP1 Open
The T-lineage restricted protein THEMIS has been shown to play a critical role in T cell development. THEMIS, via its distinctive CABIT domains, inhibits the catalytic activity of the tyrosine phosphatase SHP1 (PTPN6). SHP1 and THEMIS bind…