Guillaume Hoeffel
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View article: A secreted Tapasin isoform impairs cytotoxic T lymphocyte recognition by disrupting exogenous MHC class I antigen presentation
A secreted Tapasin isoform impairs cytotoxic T lymphocyte recognition by disrupting exogenous MHC class I antigen presentation Open
Endogenous and exogenous antigen processing and presentation through the MHC class I peptide-loading complex (PLC) are essential for initiating cytotoxic T lymphocyte responses against pathogens and tumors. Tapasin, a key component of the …
View article: Gut microbiota promotes pain chronicity in Myosin1A deficient male mice
Gut microbiota promotes pain chronicity in Myosin1A deficient male mice Open
Chronic pain is a heavily debilitating condition and a huge socio-economic burden, with no efficient treatment. Over the past decade, the gut microbiota has emerged as an important regulator of nervous system's health and disease states. Y…
View article: Gut microbiota promotes pain chronicity in Myosin1A deficient male mice
Gut microbiota promotes pain chronicity in Myosin1A deficient male mice Open
Summary Over the past decade, the gut microbiota has emerged as an important regulator of nervous system’s health and disease states 1 . Yet, its contribution to the pathogenesis of chronic somatic pain remains poorly documented. Chronic p…
View article: Neuroimmune crosstalk in the skin: a delicate balance governing inflammatory processes
Neuroimmune crosstalk in the skin: a delicate balance governing inflammatory processes Open
View article: Sensory neuron-derived TAFA4 promotes macrophage tissue repair functions
Sensory neuron-derived TAFA4 promotes macrophage tissue repair functions Open
View article: Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection
Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection Open
Host protection against cutaneous herpes simplex virus 1 (HSV-1) infection relies on the induction of a robust adaptive immune response. Here, we show that Nav 1.8 + sensory neurons, which are involved in pain perception, control the magni…
View article: Correction: Epidermal γδ T cells originate from yolk sac hematopoiesis and clonally self-renew in the adult
Correction: Epidermal γδ T cells originate from yolk sac hematopoiesis and clonally self-renew in the adult Open
View article: Epidermal γδ T cells originate from yolk sac hematopoiesis and clonally self-renew in the adult
Epidermal γδ T cells originate from yolk sac hematopoiesis and clonally self-renew in the adult Open
The murine epidermis harbors two immune cell lineages, Langerhans cells (LCs) and γδ T cells known as dendritic epidermal T cells (DETCs). LCs develop from both early yolk sac (YS) progenitors and fetal liver monocytes before locally self-…
View article: Hemogenic Endothelial Fate Mapping Reveals Dual Developmental Origin of Mast Cells
Hemogenic Endothelial Fate Mapping Reveals Dual Developmental Origin of Mast Cells Open
View article: Interactions neuro-immunes dans la peau
Interactions neuro-immunes dans la peau Open
Lors d’une infection, notre capacité à éliminer les pathogènes dépend essentiellement de notre système immunitaire. Des études récentes révèlent cependant un rôle du système nerveux dans la régulation des processus infectieux et inflammato…
View article: Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner
Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner Open
View article: Ontogeny of Tissue-Resident Macrophages
Ontogeny of Tissue-Resident Macrophages Open
The origin of tissue-resident macrophages, crucial for homeostasis and immunity, has remained controversial until recently. Originally described as part of the mononuclear phagocyte system, macrophages were long thought to derive solely fr…
View article: Identification of a novel lymphoid population in the murine epidermis
Identification of a novel lymphoid population in the murine epidermis Open
T cell progenitors are known to arise from the foetal liver in embryos and the bone marrow in adults; however different studies have shown that a pool of T cell progenitors may also exist in the periphery. Here, we identified a lymphoid po…
View article: C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages
C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages Open