Explanipedia

Management of patients with type 2 diabetes and MASLD: An overview and joint statement Open

Yasmina Chouik, Clémence M. Canivet, Jean‐Baptiste Julla, Thomas Mouillot, Lucia Parlati , et al. · 2025

Type 2 diabetes (T2D) and metabolic dysfunction-associated steatotic liver disease (MASLD) are two highly prevalent diseases with rapidly growing incidences worldwide. They are frequently associated due to their shared pathophysiology and …

Recurrence of Hepatocellular Carcinoma After Liver Transplantation: The Blind Spot of HCC Management Open

Massih Ningarhari, Guillaume Lassailly, Sébastien Dharancy, Christophe Moreno, Eric Trépo · 2025

Recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) significantly impacts transplant outcomes, responsible for half of all deaths in the first 5 years after LT for HCC, with a 12–15‐month median overall survival a…

Underdiagnosis of Alpha‐1 Antitrypsin Deficiency in Cirrhotic Liver Transplant Candidates: Findings From a Multicenter Retrospective Study Open

Manon Evain, Isaac Ruiz, Térésa Antonini, Guillaume Lassailly, Alessandra Mazzola , et al. · 2025

Background and Aims Alpha‐1 antitrypsin deficiency (AATD) is a prevalent genetic disorder in Europe causing hepatic fibrosis and often remains undiagnosed, even in severe cases requiring liver transplantation (LT). This study aimed to dete…

Intrahepatic levels of microbiome-derived hippurate associates with improved metabolic dysfunction-associated steatotic liver disease Open

Maxime Deslande, Francesc Puig‐Castellví, Inés Castro-Dionicio, Romina Pacheco‐Tapia, Violeta Raverdy , et al. · 2024

Data-driven cluster analysis identifies distinct types of metabolic dysfunction-associated steatotic liver disease Open

Violeta Raverdy, Federica Tavaglione, Estelle Chatelain, Guillaume Lassailly, Antonio De Vincentis , et al. · 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) exhibits considerable variability in clinical outcomes. Identifying specific phenotypic profiles within MASLD is essential for developing targeted therapeutic strategies. Her…

Early prediction of the impact of public health policies on obesity and lifetime risk of type 2 diabetes: A modelling approach Open

Pierre Bauvin, Claire Delacôte, Line Carolle Ntandja Wandji, Guillaume Lassailly, Violeta Raverdy , et al. · 2024

Objective Help public health decision-making requires a better understanding of the dynamics of obesity and type 2 diabetes and an assessement of different strategies to decrease their burdens. Methods Based on 97,848 individual data, coll…

Issue Information Open

Hannes Hagström, Hannes Hegmar, Christophe Moreno, Manman Xu, Yuping Chen , et al. · 2024

No abstract is available for this article.

Conventional cytotoxic chemotherapy for gastrointestinal cancer in patients with cirrhosis: A multicentre case–control study Open

Massih Ningarhari, Marlène Bertez, Anne Ploquin, Nicolas Bertrand, Christophe Desauw , et al. · 2023

Background & Aims Progresses in management make a higher proportion of cirrhotic patients with gastrointestinal (GI) cancer candidates to chemotherapy. Data are needed on the safety and liver‐related events associated with the use of chemo…

The ubiquitin-like modifier FAT10 is induced in MASLD and impairs the lipid-regulatory activity of PPARα Open

Ludivine Clavreul, Lucie Bernard, Alexia K. Cotte, Nathalie Hennuyer, Cyril Bourouh , et al. · 2023

Time-of-day-dependent variation of the human liver transcriptome and metabolome is disrupted in MASLD Open

Manuel Johanns, Joel T. Haas, Violeta Raverdy, Jimmy Vandel, Julie Dubois‐Chevalier , et al. · 2023

This work characterizes the rhythmic patterns of the transcriptome and metabolome in the human liver. Using a cohort of well-phenotyped patients (n = 290) for whom the time-of-day at biopsy collection was known, we show that time-of-day va…

Time-of-day-dependent variation of the hepatic transcriptome and metabolome is disrupted in non-alcoholic fatty liver disease patients Open

Manuel Johanns, Joel T. Haas, Violeta Raverdy, Jimmy Vandel, Julie Dubois‐Chevalier , et al. · 2023

Liver homeostasis is ensured in part by time-of-day-dependent processes, many of them being paced by the molecular circadian clock. Liver functions are compromised in non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH…

Inevitability of disease recurrence after liver transplantation for NAFLD cirrhosis Open

François Villeret, Sébastien Dharancy, Domitille Erard, Armand Abergel, Louise Barbier , et al. · 2023

Non-alcoholic fatty liver disease (NAFLD) is a growing indication for liver transplantation, but the analysis of disease recurrence, based on graft liver biopsies, has been poorly studied. Cumulative incidences of steatosis, steatohepatiti…

Neo-Adjuvant Use of Sorafenib for Hepatocellular Carcinoma Awaiting Liver Transplantation Open

Kate Minoux, Guillaume Lassailly, Massih Ningarhari, Henri Lubret, Medhi El Amrani , et al. · 2022

Data on efficacy and safety of sorafenib in a neoadjuvant setting for HCC awaiting liver transplantation (LT) are heterogeneous and scarce. We aimed to investigate the trajectory of patients treated with sorafenib while awaiting LT. All pa…

Are Cirrhotic Patients Receiving Invasive Mechanical Ventilation at Risk of Abundant Microaspiration Open

C Lévy, Alexandre Gaudet, Emmanuelle Jaillette, Jean Reignier, Guillaume Lassailly , et al. · 2022

Previous studies have identified cirrhosis as a risk factor for ventilator-associated pneumonia (VAP). The aim of our study was to determine the relationship between cirrhosis and abundant gastric-content microaspiration in intubated criti…

Functional genomics uncovers the transcription factor BNC2 as required for myofibroblastic activation in fibrosis Open

Marie Bobowski, Clémence Boulet, Francesco Paolo Zummo, Julie Dubois‐Chevalier, Céline Gheeraert , et al. · 2022

Tissue injury triggers activation of mesenchymal lineage cells into wound-repairing myofibroblasts, whose unrestrained activity leads to fibrosis. Although this process is largely controlled at the transcriptional level, whether the main t…

Benefits of tailored hepatocellular carcinoma screening in patients with cirrhosis on cancer‐specific and overall mortality: A modeling approach Open

Massih Ningarhari, Abbas Mourad, Claire Delacôte, Line‐Carolle Ntandja Wandji, Guillaume Lassailly , et al. · 2022

To validate cancer screening programs, experts recommend estimating effects on case fatality rates (CFRs) and cancer‐specific mortality. This study evaluates hepatocellular carcinoma (HCC) screening in patients with cirrhosis for those out…

Liver transplantation for <span>NAFLD</span> cirrhosis: Age and recent coronary angioplasty are major determinants of survival Open

François Villeret, Sébastien Dharancy, Domitille Erard, Armand Abergel, Louise Barbier , et al. · 2022

Background and Aims Liver transplantation (LT) is the treatment of end‐stage non‐alcoholic liver disease (NAFLD), that is decompensated cirrhosis and/or complicated by hepatocellular carcinoma (HCC). Few data on long‐term outcome are avail…

Immunosuppression in liver transplanted patients with short bowel syndrome Open

Stéphanie Belaiche, Guillaume Lassailly, Mehdi El Amrani, V. Canva, Emmanuel Boleslawski , et al. · 2022

Short bowel syndrome (SBS) is the consequence of an extensive small intestine resection ranging from 50% to 80% of its length. This results in major hydro electrolyte disorders and severe malabsorption without specific management. The resu…

Liver Transplantation in Alcohol-related Liver Disease and Alcohol-related Hepatitis Open

Line Carolle Ntandja Wandji, Massih Ningarhari, Guillaume Lassailly, Sébastien Dharancy, Emmanuel Boleslawski , et al. · 2022

Morbid obesity increases death and dropout from the liver transplantation waiting list: A prospective cohort study Open

Claire Delacôte, Mathilde Favre, Medhi El Amrani, Massih Ningarhari, Elise Lemaître , et al. · 2022

Liver transplant (LT) candidates with a body mass index (BMI) over 40 kg/m 2 have lower access to a liver graft without clear explanation. Thus, we studied the impact of obesity on the waiting list (WL) and aimed to explore graft proposals…

Covid-19 in liver transplant recipients: the French SOT COVID registry Open

Jérôme Dumortier, Christophe Duvoux, Olivier Roux, Mario Altieri, Hélène Barraud , et al. · 2021

Changes in bone mineral density in liver transplant patients and effects of bisphosphonates Open

Agathe Grandjean, Sébastien Dharancy, Guillaume Lassailly, Bernard Cortet, Isabelle Legroux-Gérot · 2021

Subclinical proximal tubulopathy in hepatitis B: The roles of nucleot(s)ide analogue treatment and the hepatitis B virus Open

Anaïs Brayette, Marie Essig, Paul Carrier, Marilyne Debette‐Gratien, Anaïs Labrunie , et al. · 2020

The prevalence and incidence of SPT was higher in TDF-treated patients compared to naïve patients. SPT in the naïve population suggests that HBV can induce renal tubular toxicity.

Prise en charge chirurgicale de l’obèse et de l’obèse morbide : conséquences sur la stéatopathie métabolique et sur l’accès à la transplantation hépatique Open

Guillaume Lassailly · 2020

Obesity is now considered as a disease by WHO with a Global threat. Responsible for a decrease in life expectancy due to increased cardiovascular and carcinologic mortality, obesity has endocrine metabolic consequences with the onset of ty…

A tool to predict progression of non‐alcoholic fatty liver disease in severely obese patients Open

Pierre Bauvin, Claire Delacôte, Guillaume Lassailly, Line Carolle Ntandja Wandji, Viviane Gnemmi , et al. · 2020

Background & Aims Severely obese patients are a growing population at risk of non‐alcoholic fatty liver disease (NAFLD). Considering the increasing burden, a predictive tool of NAFLD progression would be of interest. Our objective was to p…

Caution With the Use of Lopinavir/Ritonavir in Severely Ill Patients for the Treatment of SARS-CoV-2: A Report of Severe Jaundice Open

C Lévy, Guillaume Lassailly, Erika Parmentier-Decrucq, Thibault Duburcq, Philippe Mathurin , et al. · 2020

INTRODUCTION: We investigated the potential hepatotoxicity of lopinavir/ritonavir recently used in the treatment of Severe Acute Respiratory Syndrome Coronavirus. METHODS: This is a retrospective cohort of critical patients in a teaching h…

Usefulness of phosphatidylethanol and urinary ethyl glucuronide to monitor alcohol abstinence in patients awaiting liver transplantation Open

Olivier Ménard, Hakim Florian, Cecile Guenard, Jean Michel Gaulier, Delphine Allorge , et al. · 2020

Early liver transplantation for severe alcoholic hepatitis not responding to medical treatment: results of the French-Belgian prospective study QuickTrans Open

Alexandre Louvet, Julien Labreuche, Christophe Moreno, Claire Vanlemmens, Romain Moirand , et al. · 2020

Long-term results of the first study of early liver transplantation for alcoholic hepatitis Open

Sébastien Dharancy, Christophe Moreno, Jérôme Dumortier, Claire Francoz, Jean‐Charles Duclos‐Vallée , et al. · 2020

Severe obesity increases death and dropout from liver waiting list: French liver transplant cohort Open

Claire Delacôte, Mathilde Favre, Hélène Montialoux, Eric Nguyen Khac, Alexandre Louvet , et al. · 2020

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