Guillaume Rey
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View article: Think-Aloud Testing of a Companion App for Colonoscopy Examinations: Usability Study
Think-Aloud Testing of a Companion App for Colonoscopy Examinations: Usability Study Open
Background Colonoscopies are vital for initial screening, follow-ups, surveillance of neoplasia, and assessing symptoms such as rectal bleeding. Successful colonoscopies require thorough colon preparation, but up to 25% fail due to poor pr…
View article: Multi‐omics correlates of insulin resistance and circadian parameters mapped directly from human serum
Multi‐omics correlates of insulin resistance and circadian parameters mapped directly from human serum Open
While it is generally known that metabolic disorders and circadian dysfunction are intertwined, how the two systems affect each other is not well understood, nor are the genetic factors that might exacerbate this pathological interaction. …
View article: Genetic variation in cis-regulatory domains suggests cell type-specific regulatory mechanisms in immunity
Genetic variation in cis-regulatory domains suggests cell type-specific regulatory mechanisms in immunity Open
View article: Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease
Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease Open
View article: Genetic variation in correlated regulatory regions of immunity
Genetic variation in correlated regulatory regions of immunity Open
Studying the interplay between genetic variation, epigenetic changes and regulation of gene expression in immune cells is important to understand the modification of cellular states in various conditions, including immune diseases. Here, w…
View article: Genetic variation in correlated regulatory region of Immunity
Genetic variation in correlated regulatory region of Immunity Open
Studying the interplay between genetic variation, epigenetic changes and regulation of gene expression in immune cells is important to understand the modification of cellular states in various conditions, including immune diseases. Here, w…
View article: Regulation of HLA class I expression by non-coding gene variations
Regulation of HLA class I expression by non-coding gene variations Open
The Human Leukocyte Antigen (HLA) is a critical genetic system for different outcomes after solid organ and hematopoietic cell transplantation. Its polymorphism is usually determined by molecular technologies at the DNA level. A potential …
View article: Additional file 1 of Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease
Additional file 1 of Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease Open
Additional file 1: Table S1. Sampling scheme and samples used for the study.
View article: Rhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells
Rhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells Open
View article: The transcriptional response of pathogenic Leptospira to peroxide reveals new defenses against infection-related oxidative stress
The transcriptional response of pathogenic Leptospira to peroxide reveals new defenses against infection-related oxidative stress Open
Pathogenic Leptospira spp. are the causative agents of the waterborne zoonotic disease leptospirosis. Leptospira are challenged by numerous adverse conditions, including deadly reactive oxygen species (ROS), when infecting their hosts. Wit…
View article: The adaptive transcriptional response of pathogenic<i>Leptospira</i>to peroxide reveals new defenses against infection-related oxidative stress
The adaptive transcriptional response of pathogenic<i>Leptospira</i>to peroxide reveals new defenses against infection-related oxidative stress Open
Pathogenic Leptospira spp. are the causative agents of the waterborne zoonotic disease leptospirosis. During infection, Leptospira are confronted with dramatic adverse environmental changes such as deadly reactive oxygen species (ROS). Wit…
View article: Les drogues dans tous leurs états
Les drogues dans tous leurs états Open
La question de la réglementation des drogues, en particulier du cannabis, est au cœur de l'actualité, notamment en Suisse. Et pourtant, c'est bien la prohibition qui a été la norme fondatrice des politiques drogues et qui domine encore dan…
View article: Cellular circadian period length inversely correlates with HbA1c levels in individuals with type 2 diabetes
Cellular circadian period length inversely correlates with HbA1c levels in individuals with type 2 diabetes Open
View article: Chromatin three-dimensional interactions mediate genetic effects on gene expression
Chromatin three-dimensional interactions mediate genetic effects on gene expression Open
Noncoding variation and gene expression Natural genetic variation outside of protein coding regions affects multiple molecular phenotypes that can differ across individuals. To examine how genomic variation affects proximal (cis) or distal…
View article: Metabolic oscillations on the circadian time scale in <i>Drosophila</i> cells lacking clock genes
Metabolic oscillations on the circadian time scale in <i>Drosophila</i> cells lacking clock genes Open
View article: Non-canonical circadian oscillations in<i>Drosophila</i>S2 cells drive gene-expression cycles coupled to metabolic oscillations
Non-canonical circadian oscillations in<i>Drosophila</i>S2 cells drive gene-expression cycles coupled to metabolic oscillations Open
Circadian rhythms are cell-autonomous biological oscillations with a period of about 24 hours. Current models propose that transcriptional feedback loops are the principal mechanism for the generation of circadian oscillations. In these mo…
View article: Transcriptional regulatory logic of the diurnal cycle in the mouse liver
Transcriptional regulatory logic of the diurnal cycle in the mouse liver Open
Many organisms exhibit temporal rhythms in gene expression that propel diurnal cycles in physiology. In the liver of mammals, these rhythms are controlled by transcription-translation feedback loops of the core circadian clock and by feedi…
View article: Transcriptional regulatory logic of the diurnal cycle in the mouse liver
Transcriptional regulatory logic of the diurnal cycle in the mouse liver Open
Many organisms exhibit temporal rhythms in gene expression that propel diurnal cycles in physiology. In the liver of mammals, these rhythms are controlled by transcription-translation feedback loops of the core circadian clock and by feedi…
View article: The Pentose Phosphate Pathway Regulates the Circadian Clock
The Pentose Phosphate Pathway Regulates the Circadian Clock Open