Guillaume Turc
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View article: Divided attention and manual visuomotor control in stroke: a combined dual-task and eye movement study
Divided attention and manual visuomotor control in stroke: a combined dual-task and eye movement study Open
View article: Prévention secondaire de l’AVC et prise en charge des facteurs de risque vasculaire
Prévention secondaire de l’AVC et prise en charge des facteurs de risque vasculaire Open
View article: Automated DWI-FLAIR mismatch assessment in stroke using DWI only
Automated DWI-FLAIR mismatch assessment in stroke using DWI only Open
Introduction: In Acute Ischemic Stroke (AIS), mismatch between Diffusion-Weighted Imaging (DWI) and Fluid-Attenuated Inversion-Recovery (FLAIR) helps identify patients who can benefit from thrombolysis when stroke onset time is unknown (15…
View article: The Added Benefit of Intra‐Arterial Thrombolysis After Successful Recanalization by Endovascular Treatment: A Systematic Review and Meta‐Analysis of Randomized‐Controlled Clinical Trials
The Added Benefit of Intra‐Arterial Thrombolysis After Successful Recanalization by Endovascular Treatment: A Systematic Review and Meta‐Analysis of Randomized‐Controlled Clinical Trials Open
Background Despite successful recanalization following endovascular thrombectomy (EVT) for acute ischemic stroke (AIS) with large‐vessel occlusion (LVO), many patients fail to achieve excellent functional outcomes. Post‐EVT intra‐arterial …
View article: Fibrinogen time course in acute ischemic stroke patients treated with intravenous thrombolysis with alteplase or tenecteplase
Fibrinogen time course in acute ischemic stroke patients treated with intravenous thrombolysis with alteplase or tenecteplase Open
Introduction: Limited data exist on intravenous thrombolysis (IVT) effect on fibrinogen depletion, and on possible associations between low fibrinogen levels and hemorrhagic complications, among acute ischemic stroke (AIS) patients. Patien…
View article: Generative T2*-weighted images as a substitute for true T2*-weighted images on brain MRI in patients with acute stroke
Generative T2*-weighted images as a substitute for true T2*-weighted images on brain MRI in patients with acute stroke Open
View article: Longitudinal brain ageing after stroke: a marker for neurodegeneration and its relevance for upper limb motor outcome
Longitudinal brain ageing after stroke: a marker for neurodegeneration and its relevance for upper limb motor outcome Open
Brain age, as distinct from chronological age, may reveal post-stroke recovery mechanisms, but longitudinal studies tracking brain age are lacking. We explored longitudinal change of brain age post-stroke and its relation to upper limb sen…
View article: Intravenous thrombolysis or antiplatelet therapy for acute nondisabling ischemic stroke: A systematic review and network meta-analysis
Intravenous thrombolysis or antiplatelet therapy for acute nondisabling ischemic stroke: A systematic review and network meta-analysis Open
Purpose: Uncertainties remain on the optimal treatment for acute minor stroke with nondisabling symptoms. The two most common therapeutic approaches are intravenous thrombolysis (IVT) and antiplatelet therapy, notably dual antiplatelet the…
View article: Multicenter validation of synthetic FLAIR as a substitute for FLAIR sequence in acute ischemic stroke
Multicenter validation of synthetic FLAIR as a substitute for FLAIR sequence in acute ischemic stroke Open
Purpose: To evaluate performance of synthetic and real FLAIR for identifying early stroke in a multicenter cohort. Methods: This retrospective study was conducted using DWI and FLAIR extracted from the Endovascular Treatment in Ischemic St…
View article: Letter to the editor in response to Prof. Audebert and Nolte
Letter to the editor in response to Prof. Audebert and Nolte Open
View article: European Stroke Organisation (ESO) and European Society for Minimally Invasive Neurological Therapy (ESMINT) guideline on acute management of basilar artery occlusion
European Stroke Organisation (ESO) and European Society for Minimally Invasive Neurological Therapy (ESMINT) guideline on acute management of basilar artery occlusion Open
The aim of the present European Stroke Organisation (ESO) guideline is to provide evidence-based recommendations on the acute management of patients with basilar artery occlusion (BAO). These guidelines were prepared following the Standard…
View article: Alterations of tactile and anatomical spatial representations of the hand after stroke
Alterations of tactile and anatomical spatial representations of the hand after stroke Open
Stroke often causes long-term motor and somatosensory impairments. Motor planning and tactile perception rely on spatial body representations. However, the link between altered spatial body representations, motor deficit and tactile spatia…
View article: Incidence and predictors of intracranial hemorrhage after intravenous thrombolysis with tenecteplase
Incidence and predictors of intracranial hemorrhage after intravenous thrombolysis with tenecteplase Open
Background: Despite its increasing use, there are limited data on the risk of intracranial hemorrhage (ICH) after intravenous thrombolysis with tenecteplase in the setting of acute ischemic stroke. Our aim was to investigate the incidence …
View article: European Stroke Organisation and European Society for Minimally Invasive Neurological Therapy guideline on acute management of basilar artery occlusion
European Stroke Organisation and European Society for Minimally Invasive Neurological Therapy guideline on acute management of basilar artery occlusion Open
The aim of the present European Stroke Organisation (ESO) guideline is to provide evidence-based recommendations on the acute management of patients with basilar artery occlusion (BAO). These guidelines were prepared following the Standard…
View article: European Stroke Organisation (ESO) Guidelines on the diagnosis and management of patent foramen ovale (PFO) after stroke
European Stroke Organisation (ESO) Guidelines on the diagnosis and management of patent foramen ovale (PFO) after stroke Open
Patent foramen ovale (PFO) is frequently identified in young patients with cryptogenic ischaemic stroke. Potential stroke mechanisms include paradoxical embolism from a venous clot which traverses the PFO, in situ clot formation within the…
View article: Post-Stroke Impairments of Manual Dexterity and Finger Proprioception: Their Contribution to Upper Limb Activity Capacity
Post-Stroke Impairments of Manual Dexterity and Finger Proprioception: Their Contribution to Upper Limb Activity Capacity Open
Background Knowing how impaired manual dexterity and finger proprioception affect upper limb activity capacity is important for delineating targeted post-stroke interventions for upper limb recovery. Objectives To investigate whether impai…
View article: Intravenous alteplase in minor nondisabling ischemic stroke: A systematic review and meta-analysis
Intravenous alteplase in minor nondisabling ischemic stroke: A systematic review and meta-analysis Open
Background: Minor ischemic stroke, defined as National Institute of Health Stroke Scale score of 0–5 on admission, represents half of all acute ischemic strokes. The role of intravenous alteplase (IVA) among patients with minor stroke is i…
View article: Does Atrial Septal Anatomy Still Matter in the Etiological Evaluation of Ischemic Stroke Beyond the Age of 60?
Does Atrial Septal Anatomy Still Matter in the Etiological Evaluation of Ischemic Stroke Beyond the Age of 60? Open
Background Patent foramen ovale (PFO) is causally associated with stroke in some patients younger than 60 years, especially when it is large or associated with an atrial septal aneurysm (ASA). After 60 years of age, this association is les…
View article: Update of Anticoagulation Use in Cardioembolic Stroke With a Special Reference to Endovascular Treatment
Update of Anticoagulation Use in Cardioembolic Stroke With a Special Reference to Endovascular Treatment Open
Cardioembolic stroke is a major cause of morbidity, with a high risk of recurrence, and anticoagulation represents the mainstay of secondary stroke prevention in most patients. The implementation of endovascular treatment in routine clinic…
View article: Tenecteplase for the treatment of acute ischemic stroke in the extended time window: a systematic review and meta-analysis
Tenecteplase for the treatment of acute ischemic stroke in the extended time window: a systematic review and meta-analysis Open
Background: Outcome data regarding the administration of tenecteplase (TNK) to acute ischemic stroke (AIS) patients presenting in the extended time window are limited. Objectives: We aimed to assess the current evidence regarding the effic…
View article: Overview of systematic reviews comparing endovascular to best medical treatment for large-vessel occlusion acute ischaemic stroke: an umbrella review
Overview of systematic reviews comparing endovascular to best medical treatment for large-vessel occlusion acute ischaemic stroke: an umbrella review Open
Background: The literature on endovascular treatment (EVT) for large-vessel occlusion (LVO) acute ischaemic stroke (AIS) has been rapidly increasing after the publication of positive randomized-controlled clinical trials (RCTs) and a pleth…
View article: Incidence, severity and impact on functional outcome of persistent hypoperfusion despite large-vessel recanalization, a potential marker of impaired microvascular reperfusion: Systematic review of the clinical literature
Incidence, severity and impact on functional outcome of persistent hypoperfusion despite large-vessel recanalization, a potential marker of impaired microvascular reperfusion: Systematic review of the clinical literature Open
The reported incidence of persistent hypoperfusion despite complete recanalization as surrogate for impaired microvascular reperfusion (IMR) has varied widely among clinical studies, possibly due to differences in i) definition of complete…
View article: Intravenous thrombolysis with tenecteplase versus alteplase combined with endovascular treatment of anterior circulation tandem occlusions: A pooled analysis of ETIS and TETRIS
Intravenous thrombolysis with tenecteplase versus alteplase combined with endovascular treatment of anterior circulation tandem occlusions: A pooled analysis of ETIS and TETRIS Open
Background: Tandem occlusions are a singular large vessel occlusion entity involving specific endovascular and perioperative antithrombotic management. In this context, data on safety and efficacy of prior intravenous thrombolysis (IVT) wi…
View article: Relevance of National Institutes of Health Stroke Scale subitems for best revascularization therapy in minor stroke patients with large vessel occlusion: An observational multicentric study
Relevance of National Institutes of Health Stroke Scale subitems for best revascularization therapy in minor stroke patients with large vessel occlusion: An observational multicentric study Open
Background and purpose The best management of acute ischemic stroke patients with a minor stroke and large vessel occlusion is still uncertain. Specific clinical and radiological data may help to select patients who would benefit from endo…
View article: Penumbral Rescue by normobaric O = O administration in patients with ischemic stroke and target mismatch proFile (PROOF): Study protocol of a phase IIb trial
Penumbral Rescue by normobaric O = O administration in patients with ischemic stroke and target mismatch proFile (PROOF): Study protocol of a phase IIb trial Open
Rationale: Oxygen is essential for cellular energy metabolism. Neurons are particularly vulnerable to hypoxia. Increasing oxygen supply shortly after stroke onset could preserve the ischemic penumbra until revascularization occurs. Aims: P…
View article: Efficacy of interactive manual dexterity training after stroke: a pilot single-blinded randomized controlled trial
Efficacy of interactive manual dexterity training after stroke: a pilot single-blinded randomized controlled trial Open
Objective To compare the efficacy of Dextrain Manipulandum™ training of dexterity components such as force control and independent finger movements, to dose-matched conventional therapy (CT) post-stroke. Methods A prospective, single-blind…
View article: A tablet-based quantitative assessment of manual dexterity for detection of early psychosis
A tablet-based quantitative assessment of manual dexterity for detection of early psychosis Open
Background We performed a pilot study on whether tablet-based measures of manual dexterity can provide behavioral markers for detection of first-episode psychosis (FEP), and whether cortical excitability/inhibition was altered in FEP. Meth…
View article: Diffusion-Weighted Imaging Lesion Reversal in Older Patients With Stroke Treated With Mechanical Thrombectomy
Diffusion-Weighted Imaging Lesion Reversal in Older Patients With Stroke Treated With Mechanical Thrombectomy Open
BACKGROUND: Diffusion-weighted imaging lesion reversal (DWIR) is frequently observed after mechanical thrombectomy for acute ischemic stroke, but little is known about age-related differences and impact on outcome. We aimed to compare, in …
View article: Early recanalization among patients undergoing bridging therapy with tenecteplase or alteplase
Early recanalization among patients undergoing bridging therapy with tenecteplase or alteplase Open
Background Intravenous thrombolysis (IVT) with alteplase or tenecteplase prior to mechanical thrombectomy (MT) is the recommended treatment for large-vessel occlusion acute ischemic stroke (LVOS). There are divergent data on whether these …
View article: Interaction between intravenous thrombolysis and clinical outcome between slow and fast progressors undergoing mechanical thrombectomy: a post-hoc analysis of the SWIFT-DIRECT trial
Interaction between intravenous thrombolysis and clinical outcome between slow and fast progressors undergoing mechanical thrombectomy: a post-hoc analysis of the SWIFT-DIRECT trial Open
Background In proximal occlusions, the effect of reperfusion therapies may differ between slow or fast progressors. We investigated the effect of intravenous thrombolysis (IVT) (with alteplase) plus mechanical thrombectomy (MT) versus thro…