Guillermo Aldave
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View article: Clinical Correlates of Anxiety and Depression After Diagnosis of a Pediatric Brain Tumor
Clinical Correlates of Anxiety and Depression After Diagnosis of a Pediatric Brain Tumor Open
Background The prevalence and clinical correlates of symptoms of anxiety and depression in pediatric patients with brain tumors are not well described. We aimed to identify clinical characteristics that are correlated with elevated symptom…
View article: CTP-07. Phase I study of intravenous and intracerebroventricular C7R-GD2.CAR T cell therapy for pediatric central nervous system (CNS) tumors
CTP-07. Phase I study of intravenous and intracerebroventricular C7R-GD2.CAR T cell therapy for pediatric central nervous system (CNS) tumors Open
H3K27-altered diffuse midline gliomas (DMGs) and recurrent high-grade CNS tumors have poor prognoses and limited treatment options. GD2-CAR T cells (GD2.CARTs) armored with constitutively active IL7 receptor (C7R) have demonstrated early s…
View article: Cell type transcriptional identities are maintained in cultured<i>ex vivo</i>human brain tissue
Cell type transcriptional identities are maintained in cultured<i>ex vivo</i>human brain tissue Open
It is becoming more broadly accepted that human-based models are needed to better understand the complexities of the human nervous system and its diseases. The recently developed human brain organotypic culture model is one highly promisin…
View article: Common AAV gene therapy vectors show indiscriminate transduction of living human brain cell types
Common AAV gene therapy vectors show indiscriminate transduction of living human brain cell types Open
The development of cell-type-specific gene therapy vectors for treating neurological diseases holds great promise, but has relied on animal models with limited translational utility. We have adapted an ex vivo organotypic model to evaluate…
View article: MDB-103. THE SIGNIFICANCE OF CEREBROSPINAL FLUID CYTOLOGY IN SURVEILLANCE FOR RECURRENT MEDULLOBLASTOMA
MDB-103. THE SIGNIFICANCE OF CEREBROSPINAL FLUID CYTOLOGY IN SURVEILLANCE FOR RECURRENT MEDULLOBLASTOMA Open
BACKGROUND Surveillance of patients with medulloblastoma includes magnetic resonance imaging of the brain and spine and cerebrospinal fluid (CSF) cytology evaluation. Certain protocols require frequent CSF cytology evaluations off-therapy …
View article: OTHR-08. CLINICAL MANAGEMENT OF TWO PEDIATRIC CASES OF INTRACRANIAL MESENCHYMAL TUMORS WITH FET::CREB FUSIONS
OTHR-08. CLINICAL MANAGEMENT OF TWO PEDIATRIC CASES OF INTRACRANIAL MESENCHYMAL TUMORS WITH FET::CREB FUSIONS Open
BACKGROUND Intracranial mesenchymal tumors (IMTs) with FET::CREB fusion are a newly described provisional entity lacking standard management options. This group of neoplasms occur in children and young adults, and is molecularly characteri…
View article: Phase I Trial of GD2.CART Cells Augmented With Constitutive Interleukin-7 Receptor for Treatment of High-Grade Pediatric CNS Tumors
Phase I Trial of GD2.CART Cells Augmented With Constitutive Interleukin-7 Receptor for Treatment of High-Grade Pediatric CNS Tumors Open
PURPOSE T cells modified with chimeric antigen receptors (CARTs) have demonstrated efficacy for hematologic malignancies; however, benefit for patients with CNS tumors has been limited. To enhance T cell activity against GD2+ CNS malignanc…
View article: Adaptive, behavioral, and emotional outcomes following postoperative pediatric cerebellar mutism syndrome in survivors treated for medulloblastoma
Adaptive, behavioral, and emotional outcomes following postoperative pediatric cerebellar mutism syndrome in survivors treated for medulloblastoma Open
OBJECTIVE Patients who experience postoperative pediatric cerebellar mutism syndrome (CMS) during treatment for medulloblastoma have long-term deficits in neurocognitive functioning; however, the consequences on functional or adaptive outc…
View article: IMMU-15. PHASE I TRIAL OF GD2.CART-CELLS AUGMENTED WITH A CONSTITUTIVELY ACTIVE INTERLEUKIN-7 RECEPTOR (C7R) FOR TREATMENT OF HIGH-GRADE PEDIATRIC CNS TUMORS
IMMU-15. PHASE I TRIAL OF GD2.CART-CELLS AUGMENTED WITH A CONSTITUTIVELY ACTIVE INTERLEUKIN-7 RECEPTOR (C7R) FOR TREATMENT OF HIGH-GRADE PEDIATRIC CNS TUMORS Open
BACKGROUND Treatment of pediatric CNS tumors with T-cells modified with chimeric antigen receptors (CARTs) provides an innovative approach. We employ GD2-directed CART-cells (GD2.CARTs) modified to express a constitutively active interleuk…
View article: METB-06. HIGH FREQUENCY OF CLINICALLY RELEVANT ALTERATIONS DETECTED BY INTEGRATED TUMOR AND GERMLINE GENE PANEL TESTING IN CHILDREN WITH CNS TUMORS – RESULTS FROM THE TEXAS KIDSCANSEQ STUDY
METB-06. HIGH FREQUENCY OF CLINICALLY RELEVANT ALTERATIONS DETECTED BY INTEGRATED TUMOR AND GERMLINE GENE PANEL TESTING IN CHILDREN WITH CNS TUMORS – RESULTS FROM THE TEXAS KIDSCANSEQ STUDY Open
BACKGROUND Tumor and germline alterations detected by sequencing have the potential to inform management of children with CNS tumors. Comparative clinical utility data for available molecular sequencing modalities are needed to optimize te…
View article: Comparison of neurocognitive and quality-of-life outcomes in pediatric craniopharyngioma patients treated with partial resection and radiotherapy versus gross-total resection only
Comparison of neurocognitive and quality-of-life outcomes in pediatric craniopharyngioma patients treated with partial resection and radiotherapy versus gross-total resection only Open
OBJECTIVE The optimal management of pediatric craniopharyngioma patients remains controversial, shifting from radical resection (gross-total resection [GTR]) to a more conservative approach with partial resection/biopsy followed by radioth…
View article: Primary spinal intramedullary anaplastic ganglioglioma in a pediatric patient
Primary spinal intramedullary anaplastic ganglioglioma in a pediatric patient Open
Background: Gangliogliomas (GGs) are rare tumors of the central nervous system composed of neoplastic neural and glial cells and are typically low-grade. Intramedullary spinal anaplastic GGs (AGG) are rare, poorly understood, and often agg…
View article: Interhemispheric transcallosal intervenous approach to a pineal region tumor
Interhemispheric transcallosal intervenous approach to a pineal region tumor Open
Pineal region tumors represent a formidable challenge to the neurosurgeon. Choosing the right approach is key to optimizing the extent of resection and minimizing surgical morbidity. In this video, the authors show an interhemispheric tran…
View article: PATH-29. HIGH FREQUENCY OF CLINICALLY-RELEVANT TUMOR VARIANTS DETECTED BY MOLECULAR TESTING OF HIGH-RISK PEDIATRIC CNS TUMORS – PRELIMINARY FINDINGS FROM THE TEXAS KidsCanSeq STUDY
PATH-29. HIGH FREQUENCY OF CLINICALLY-RELEVANT TUMOR VARIANTS DETECTED BY MOLECULAR TESTING OF HIGH-RISK PEDIATRIC CNS TUMORS – PRELIMINARY FINDINGS FROM THE TEXAS KidsCanSeq STUDY Open
BACKGROUND DNA and RNA-based tumor sequencing tests have the potential to guide the clinical management of children with CNS tumors. However, data describing the utility of these tests are limited. METHODS Children with high-risk or recurr…
View article: IMG-07. GADOLINIUM IS NOT NECESSARY FOR SURVEILLANCE MR IMAGING IN CHILDREN WITH CHIASMATIC-HYPOTHALAMIC LOW GRADE GLIOMA
IMG-07. GADOLINIUM IS NOT NECESSARY FOR SURVEILLANCE MR IMAGING IN CHILDREN WITH CHIASMATIC-HYPOTHALAMIC LOW GRADE GLIOMA Open
BACKGROUND Patients with chiasmatic-hypothalamic low grade glioma (CHLGG) have frequent MRIs with gadolinium based contrast agents (GBCA) for disease monitoring. Cumulative gadolinium deposition in children is a potential concern. The purp…
View article: THER-09. ONCOLYTIC ADENOVIRUS, DNX-2401, FOR NAIVE DIFFUSE INTRINSIC PONTINE GLIOMAS: A PHASE I CLINICAL TRIAL
THER-09. ONCOLYTIC ADENOVIRUS, DNX-2401, FOR NAIVE DIFFUSE INTRINSIC PONTINE GLIOMAS: A PHASE I CLINICAL TRIAL Open
The objective of this trial is to determine the safety, tolerability, and toxicity of DNX-2401 in newly diagnosed DIPG patients (NCT03178032) followed by radiotherapy. Secondary endpoints are overall survival at 12 months, percentage of re…
View article: Enhancing access to the suprasellar region: the transcallosal translamina terminalis approach
Enhancing access to the suprasellar region: the transcallosal translamina terminalis approach Open
Craniopharyngioma represents one of the most challenging brain tumors to treat. Surgery may be the definitive treatment, and multiple surgical approaches have been described, each based on different anatomical considerations. Some approach…
View article: Seizures following surgery for supratentorial extratemporal low-grade tumors in children: a multicenter retrospective study
Seizures following surgery for supratentorial extratemporal low-grade tumors in children: a multicenter retrospective study Open
OBJECTIVE Resection of brain tumors may lead to new-onset seizures but may also reduce seizure rates in patients presenting with seizures. Seizures are seen at presentation in about 24% of patients with brain tumors. For lesional epilepsy …
View article: Combined approach (infratentorial supracerebellar–telovelar transventricular) for a large brainstem tumor
Combined approach (infratentorial supracerebellar–telovelar transventricular) for a large brainstem tumor Open
The safe entry zones into the brainstem provide access to challenging lesions in this region that do not reach the surface. However, in large brainstem tumors there are two issues to bear in mind before deciding the approach. First, the an…
View article: Epilepsy outcome following resection of low-grade brain tumors in children
Epilepsy outcome following resection of low-grade brain tumors in children Open
OBJECTIVE The indication for and timing of surgery for epilepsy associated with low-grade mixed neuronal-glial tumors may be controversial. The purpose of this study was to evaluate the effect of resection and associated variables on epile…
View article: GENE-16. EVALUATING THE UTILITY OF INTEGRATED CLINICAL SEQUENCING FOR CHILDHOOD NEURO-ONCOLOGY PATIENTS: THE TEXAS KIDSCANSEQ STUDY
GENE-16. EVALUATING THE UTILITY OF INTEGRATED CLINICAL SEQUENCING FOR CHILDHOOD NEURO-ONCOLOGY PATIENTS: THE TEXAS KIDSCANSEQ STUDY Open
Genomic sequencing technologies have facilitated the unbiased examination of cancer genomes, allowing rational prioritization of candidate genes and pathways for biological study and clinical application. Clinical experience with these met…
View article: The aberrant splicing of BAF45d links splicing regulation and transcription in glioblastoma
The aberrant splicing of BAF45d links splicing regulation and transcription in glioblastoma Open
Our data indicate that AS is a mechanism that contributes to the malignant phenotype of glioblastoma. Understanding the consequences of this biological process will uncover new therapeutic targets for this devastating disease.
View article: Spinal column shortening for tethered cord syndrome associated with myelomeningocele, lumbosacral lipoma, and lipomyelomeningocele in children and young adults
Spinal column shortening for tethered cord syndrome associated with myelomeningocele, lumbosacral lipoma, and lipomyelomeningocele in children and young adults Open
OBJECTIVE Tethered cord syndrome is the clinical manifestation of an abnormal stretch on the spinal cord, presumably causing mechanical injury, a compromised blood supply, and altered spinal cord metabolism. Tethered cord release is the st…
View article: Assessing residents' operative skills for external ventricular drain placement and shunt surgery in pediatric neurosurgery
Assessing residents' operative skills for external ventricular drain placement and shunt surgery in pediatric neurosurgery Open
OBJECTIVE The authors previously demonstrated the use of a validated Objective Structured Assessment of Technical Skills (OSATS) tool for evaluating residents' operative skills in pediatric neurosurgery. However, no benchmarks have been es…