Guillermo Risso
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SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing Open
Pre-mRNA splicing is catalyzed by the spliceosome, a multi-megadalton ribonucleoprotein machine. Previous work from our laboratory revealed the splicing factor SRSF1 as a regulator of the SUMO pathway, leading us to explore a connection be…
The Dengue Virus NS5 Protein Intrudes in the Cellular Spliceosome and Modulates Splicing Open
Dengue virus NS5 protein plays multiple functions in the cytoplasm of infected cells, enabling viral RNA replication and counteracting host antiviral responses. Here, we demonstrate a novel function of NS5 in the nucleus where it interfere…