Guiping Kong
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View article: Dietary-dependent sensitization of neuronal leptin signaling promotes neural repair after injury via cAMP and gene transcription
Dietary-dependent sensitization of neuronal leptin signaling promotes neural repair after injury via cAMP and gene transcription Open
Dietary-dependent shifts, ranging from metabolic dysfunction to health, involve transitions in key signaling pathways. Dietary regimens can influence nervous system repair, but whether conserved, diet-specific mechanisms can enhance neuron…
View article: Multiple aseptic abscesses and pulmonary involvement in a child with Behcet’s disease phenotype: a case report
Multiple aseptic abscesses and pulmonary involvement in a child with Behcet’s disease phenotype: a case report Open
Background Behcet’s disease (BD) is a lifelong multi-systemic vasculitis disorder that can affect almost any organ. The frequency of involvement of each organ varies depending on demographic and geographical factors. The commonly affected …
View article: Clonally expanded, targetable, natural killer-like NKG7 T cells seed the aged spinal cord to disrupt myeloid-dependent wound healing
Clonally expanded, targetable, natural killer-like NKG7 T cells seed the aged spinal cord to disrupt myeloid-dependent wound healing Open
Spinal cord injury (SCI) increasingly affects aged individuals, where functional impairment and mortality are highest. However, the aging-dependent mechanisms underpinning tissue damage remain elusive. Here, we find that natural killer-lik…
View article: Three-dimensional chromatin mapping of sensory neurons reveals that promoter–enhancer looping is required for axonal regeneration
Three-dimensional chromatin mapping of sensory neurons reveals that promoter–enhancer looping is required for axonal regeneration Open
The in vivo three-dimensional genomic architecture of adult mature neurons at homeostasis and after medically relevant perturbations such as axonal injury remains elusive. Here, we address this knowledge gap by mapping the three-dimensiona…
View article: Three-dimensional chromatin mapping of sensory neurons reveals that cohesin-dependent genomic domains are required for axonal regeneration
Three-dimensional chromatin mapping of sensory neurons reveals that cohesin-dependent genomic domains are required for axonal regeneration Open
The in vivo three-dimensional genomic architecture of adult mature neurons at homeostasis and after medically relevant perturbations such as axonal injury remains elusive. Here we address this knowledge gap by mapping the three-dimensional…
View article: Macrophages reside in the muscle spindle to control sensorimotor function at millisecond timescale
Macrophages reside in the muscle spindle to control sensorimotor function at millisecond timescale Open
The stretch reflex is a fundamental component of the motor system that orchestrates the coordinated muscle contractions underlying movement. At the heart of this process lie the muscle spindles (MS), specialized receptors finely attuned to…
View article: The association between Helicobacter pylori infection and inflammatory bowel disease in children: A systematic review with meta-analysis
The association between Helicobacter pylori infection and inflammatory bowel disease in children: A systematic review with meta-analysis Open
Background: Available literature has reported the association of Helicobacter pylori (H pylori ) infection with inflammatory bowel disease (IBD) in adults. However, only a few studies have addressed the disease in children. Aim: To ascerta…
View article: The circadian clock is a pacemaker of the axonal regenerative ability
The circadian clock is a pacemaker of the axonal regenerative ability Open
Summary Peripheral nervous system injuries lead to long-term neurological disability due to limited axonal regenerative ability. Injury-dependent and -independent physiological mechanisms have provided important molecular insight into neur…
View article: Leptin Signalling Promotes Axonal Regeneration in the Peripheral and Central Nervous System
Leptin Signalling Promotes Axonal Regeneration in the Peripheral and Central Nervous System Open
Axonal growth is limited or absent following peripheral or central nervous system injury respectively, inhibiting repair. The identification of novel growth-promoting molecular mechanisms is therefore a priority. In the search for dietary-…
View article: CBP/p300 activation promotes axon growth, sprouting, and synaptic plasticity in chronic experimental spinal cord injury with severe disability
CBP/p300 activation promotes axon growth, sprouting, and synaptic plasticity in chronic experimental spinal cord injury with severe disability Open
The interruption of spinal circuitry following spinal cord injury (SCI) disrupts neural activity and is followed by a failure to mount an effective regenerative response resulting in permanent neurological disability. Functional recovery r…
View article: Reversible CD8 T cell–neuron cross-talk causes aging-dependent neuronal regenerative decline
Reversible CD8 T cell–neuron cross-talk causes aging-dependent neuronal regenerative decline Open
Aging is associated with increased prevalence of axonal injuries characterized by poor regeneration and disability. However, the underlying mechanisms remain unclear. In our experiments, RNA sequencing of sciatic dorsal root ganglia (DRG) …
View article: Combinatorial small molecule-mediated activation of CBP/p300 with environmental enrichment in chronic severe experimental spinal cord injury to enable axon regeneration and sprouting for functional recovery
Combinatorial small molecule-mediated activation of CBP/p300 with environmental enrichment in chronic severe experimental spinal cord injury to enable axon regeneration and sprouting for functional recovery Open
The interruption of spinal circuitry following spinal cord injury disrupts neural activity and is followed by a failure to mount an effective regenerative gene expression response resulting in permanent neurological disability. Functional …
View article: The intermittent fasting-dependent gut microbial metabolite indole-3 propionate promotes nerve regeneration and recovery after injury
The intermittent fasting-dependent gut microbial metabolite indole-3 propionate promotes nerve regeneration and recovery after injury Open
The regenerative potential of mammalian peripheral nervous system (PNS) neurons after injury is critically limited by their slow axonal regenerative rate1. Since a delayed target re-innervation leads to irreversible loss of function of tar…
View article: Cyclin-dependent–like kinase 5 is required for pain signaling in human sensory neurons and mouse models
Cyclin-dependent–like kinase 5 is required for pain signaling in human sensory neurons and mouse models Open
CDKL5 controls nociception in human neurons and murine models of CDKL5 deficiency disorder via CaMKII-dependent mechanisms.
View article: Combinatorial proteomics and transcriptomics identify AMPK in the control of the axonal regeneration programme of DRG sensory neurons after spinal injury
Combinatorial proteomics and transcriptomics identify AMPK in the control of the axonal regeneration programme of DRG sensory neurons after spinal injury Open
SUMMARY Regeneration after injury occurs in axons that lie in the peripheral nervous system but it fails in the central nervous system limiting functional recovery. Despite recent progress, the signalling response to injury of peripheral v…
View article: Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models
Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models Open
Environmental enrichment induces activity-dependent histone acetylation via a druggable mechanism to promote recovery after spinal cord injury.
View article: PP4-dependent HDAC3 dephosphorylation discriminates between axonal regeneration and regenerative failure
PP4-dependent HDAC3 dephosphorylation discriminates between axonal regeneration and regenerative failure Open
The molecular mechanisms discriminating between regenerative failure and success remain elusive. While a regeneration-competent peripheral nerve injury mounts a regenerative gene expression response in bipolar dorsal root ganglia (DRG) sen…
View article: AMPK controls the regenerative programme of DRG sensory neurons after injury
AMPK controls the regenerative programme of DRG sensory neurons after injury Open
Regeneration after injury occurs in axons that lie in the peripheral nervous system but it fails in the central nervous system limiting functional recovery. Despite recent progress, to date we ignore the molecular identity of peripheral ve…