Explanipedia

Patient versus physician preferences for lipid‐lowering drug therapy: A discrete choice experiment Open

Lingli Zhang, Jiali Chen, Zhaoliu Cao, Mengdie Zhang, Rui Ma , et al. · 2024

Background The emergence of proprotein convertase subtilisin/kexin type 9 inhibitors offered dyslipidemia patients an alternative to statins for lipid‐lowering treatment. Understanding patient and physician preferences for lipid‐lowering d…

Depression follow-up monitoring with the PHQ-9: an open cluster-randomised controlled trial Open

Tony Kendrick, Christopher Dowrick, Glyn Lewis, Michael Moore, Geraldine Leydon , et al. · 2024

Background Outcome monitoring of depression treatment is recommended but there is a lack of evidence on patient benefit in primary care. Aim To test monitoring depression using the Patient Health Questionnaire (PHQ-9) with patient feedback…

The economic burden of antibiotic resistance: A systematic review and meta-analysis Open

Ak Narayan Poudel, Shihua Zhu, Nicola J. Cooper, Paul Little, Carolyn Tarrant , et al. · 2023

Introduction Antibiotic resistance (ABR) has substantial global public health concerns. This systematic review aimed to synthesise recent evidence estimating the economic burden of ABR, characterised by study perspectives, healthcare setti…

Inpatient antibacterial use trends and patterns, China, 2013–2021 Open

Haishaerjiang Wushouer, Yue Zhou, Wanmeng Zhang, Lin Hu, Kexin Du , et al. · 2023

Antibacterial use in inpatients decreased significantly during the study period. However, the rising proportion of last-resort antibacterials used is concerning, as is the large gap between the proportion of antibacterials used belonging t…

Use of the Patient Health Questionnaire as a Patient-Reported Outcome Measure for Monitoring Depression in Primary Care: The PROMDEP Cluster Randomised Controlled Trial Open

Tony Kendrick, Christopher Dowrick, Glyn Lewis, Micheal Moore, Geraldine Leydon , et al. · 2023

Post-consultation acute respiratory tract infection recovery: a latent class-informed analysis of individual patient data Open

Hilda Hounkpatin, Beth Stuart, Shihua Zhu, Guiqing Yao, Michael Moore , et al. · 2022

Background There is a lack of evidence regarding post-consultation symptom trajectories for patients with respiratory tract infections (RTIs) and whether patient characteristics can be used to predict illness duration. Aim To describe symp…

Parallel randomized controlled feasibility trials of the “Active Brains” digital intervention to protect cognitive health in adults aged 60–85 Open

Rosie Essery, Sebastien Pollet, Katherine Bradbury, Max J. Western, Elisabeth Grey , et al. · 2022

Introduction Multidomain interventions to address modifiable risk factors for dementia are promising, but require more cost-effective, scalable delivery. This study investigated the feasibility of the “Active Brains” digital behavior chang…

Characteristics and impact of Long Covid: Findings from an online survey Open

Nida Ziauddeen, Deepti Gurdasani, Margaret O’Hara, Claire Hastie, Paul Roderick , et al. · 2022

Background Long Covid is a public health concern that needs defining, quantifying, and describing. We aimed to explore the initial and ongoing symptoms of Long Covid following SARS-CoV-2 infection and describe its impact on daily life. Met…

Characteristics and impact of Long Covid: Findings from an online survey Open

Nida Ziauddeen, Deepti Gurdasani, Margaret O’Hara, Claire E. Hastie, Paul Roderick , et al. · 2022

Background Long Covid is a public health concern that needs defining, quantifying, and describing. We aimed to explore the initial and ongoing symptoms of Long Covid following SARS-CoV-2 infection and describe its impact on daily life. Met…

Cluster randomised controlled trial to assess a tailored intervention to reduce antibiotic prescribing in rural China: study protocol Open

Wenjuan Cong, Jing Chai, Linhai Zhao, Christie Cabral, Lucy Yardley , et al. · 2022

Introduction Up to 80% of patients with respiratory tract infections (RTI) attending healthcare facilities in rural areas of China are prescribed antibiotics, many of which are unnecessary. Since 2009, China has implemented several policie…

The feasibility and acceptability of assessing and managing sarcopenia and frailty among older people with upper limb fracture Open

Kinda Ibrahim, Mark Mullee, Natalie Cox, Cynthia K. Russell, Mark Baxter , et al. · 2021

Background sarcopenia and frailty are associated with increased risk of falls and fractures. This study evaluated the feasibility of assessing sarcopenia and frailty among older people attending fracture clinics. Methods patients aged 65+ …

Impact of Covid-19 on health-related quality of life of patients: A structured review Open

Ak Narayan Poudel, Shihua Zhu, Nicola J. Cooper, Paul Roderick, Nisreen A Alwan , et al. · 2021

Introduction Coronavirus disease (Covid-19) has led to a global pandemic since its emergence in December 2019. The majority of research into Covid-19 has focused on transmission, and mortality and morbidity associated with the virus. Howev…

Antibiotics for lower respiratory tract infection in children presenting in primary care in England (ARTIC PC): a double-blind, randomised, placebo-controlled trial Open

Paul Little, Nick Francis, Beth Stuart, Gilly O’Reilly, Natalie Thompson , et al. · 2021

P108 Characteristics of long COVID: findings from a social media survey Open

Nida Ziauddeen, Deepti Gurdasani, Margaret O’Hara, Claire Hastie, Paul Roderick , et al. · 2021

Background: many people are not recovering for months after being infected with COVID-19. Long Covid (LC) is a major public health problem that needs defining, quantifying and describing. We aimed to explore and develop understanding of LC…

Antimicrobial Use in COVID-19 Patients in the First Phase of the SARS-CoV-2 Pandemic: A Scoping Review Open

Wenjuan Cong, Ak Narayan Poudel, Nour Alhusein, Hexing Wang, Guiqing Yao , et al. · 2021

This scoping review provides new evidence on the prevalence and patterns of global antimicrobial use in the treatment of COVID-19 patients; identifies the most commonly used antibiotics and clinical scenarios associated with antibiotic pre…

Delayed antibiotic prescribing for respiratory tract infections: individual patient data meta-analysis Open

Beth Stuart, Hilda Hounkpatin, Taeko Becque, Guiqing Yao, Shihua Zhu , et al. · 2021

Objective To assess the overall effect of delayed antibiotic prescribing on average symptom severity for patients with respiratory tract infections in the community, and to identify any factors modifying this effect. Design Systematic revi…

Characteristics of Long Covid: findings from a social media survey Open

Nida Ziauddeen, Deepti Gurdasani, Margaret O’Hara, Claire Hastie, Paul Roderick , et al. · 2021

Many people are not recovering for months after being infected with SARS-CoV-2. Long Covid has emerged as a major public health concern that needs defining, quantifying, and describing. We aimed to explore the initial and ongoing symptoms …

20 Comparison of Six Frailty Screening Tools in Patients Aged 65+ with An Arm Fragility Fracture Open

Kinda Ibrahim, Tiong K. Lim, Mark Mullee, Guiqing Yao, Shihua Zhu , et al. · 2021

Introduction Frailty is associated with an increased risk of falling and fracture, but not routinely assessed in fracture clinic. Early identification and management of frailty among older people with arm fragility fracture could help avoi…

154 The Feasibility of Assessing Sarcopenia Among Older People with Arm Fracture Using Different Criteria Open

Kinda Ibrahim, Mark Mullee, Guiqing Yao, Shihua Zhu, Mark Baxter , et al. · 2021

Introduction Osteoporosis and sarcopenia often co-exist (osteo-sarcopenia) and both are associated with increased risk of falls and fractures. Early identification and treatment of sarcopenia among older people with fragility arm fractures…

Antimicrobial use in COVID-19 patients in the first phase of the SARS-CoV-2 pandemic: Rapid review and evidence synthesis Open

Wenjuan Cong, Ak Narayan Poudel, Nour Alhusein, Hexing Wang, Guiqing Yao , et al. · 2021

Background As the numbers of people with COVID-19 continue to increase globally, concerns have been raised regarding the widespread use of antibiotics for the treatment of COVID-19 patients and its consequences for antimicrobial resistance…

Pelargonium sidoides root extract for the treatment of acute cough due to lower respiratory tract infection in adults: a feasibility double-blind, placebo-controlled randomised trial Open

Merlin Willcox, Catherine Simpson, Sam Wilding, Beth Stuart, Dia Soilemezi , et al. · 2021

The Prevalence of Diabetes in Autistic Persons: A Systematic Review Open

Samuel Tromans, Guiqing Yao, Regi Alexander, Elizabeta B. Mukaetova‐Ladinska, Reza Kiani , et al. · 2020

Background: It has been proposed that autistic individuals are at an increased risk of type 1 and type 2 diabetes. Improved understanding of diabetes prevalence in autistic persons will help inform resource allocation for diabetes-related …

Treatment burden for patients with multimorbidity: cross-sectional study with exploration of a single-item measure Open

James Morris, Paul Roderick, Scott Harris, Guiqing Yao, Sam Crowe , et al. · 2020

Background Treatment burden is the effort required of patients to look after their health, and the impact this has on their wellbeing. Quantitative data on treatment burden for patients with multimorbidity are sparse, and no single-item tr…

Modelling the health and economic impacts of different testing and tracing strategies for COVID-19 in the UK Open

Tim Colbourn, William Waites, David Manheim, Derek Foster, Simone Sturniolo , et al. · 2020

Background: Coronavirus disease 2019 (COVID-19) is resurgent in the UK and health and economic costs of the epidemic continue to rise. There is a need to understand the health and economic costs of different courses of action. Methods: We…

Is patient blood management cost-effective? Response to Br J Anaesth 2020 https://doi.org/10.1016/j.bja.2020.09.003 Open

Marius Roman, Riccardo Abbasciano, Guiqing Yao, Gavin J. Murphy · 2020

The Active Brains Digital Intervention to Reduce Cognitive Decline in Older Adults: Protocol for a Feasibility Randomized Controlled Trial Open

Kirsten A. Smith, Katherine Bradbury, Rosie Essery, Sebastien Pollet, Fiona Mowbray , et al. · 2020

Background Increasing physical activity, improving diet, and performing brain training exercises are associated with reduced cognitive decline in older adults. Objective In this paper, we describe a feasibility trial of the Active Brains i…

Active Brains: Protocol for a Feasibility Randomised Control Trial of a Digital Intervention to Reduce Cognitive Decline in Older Adults Open

Kirsten A. Smith, Katherine Bradbury, Rosie Essery, Sebastien Pollet, Fiona Mowbray , et al. · 2020

Patient blood management interventions do not lead to important clinical benefits or cost-effectiveness for major surgery: a network meta-analysis Open

Marius Roman, Riccardo Abbasciano, Suraj Pathak, Shwe Oo, Syabira Yusoff , et al. · 2020

In randomised trials, PBM interventions do not have important clinical benefits beyond reducing bleeding and transfusion in people undergoing major surgery.

Investigating time, strength, and duration of measures in controlling the spread of COVID-19 using a networked meta-population model Open

Jiang Zhang, Lei Dong, Yanbo Zhang, Xinyue Chen, Guiqing Yao , et al. · 2020

Patient-reported outcome measures for monitoring primary care patients with depression (PROMDEP): study protocol for a randomised controlled trial Open

Tony Kendrick, Michael Moore, Geraldine Leydon, Beth Stuart, Adam W A Geraghty , et al. · 2020

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