Guixia Yu
YOU?
Author Swipe
View article: Metagenomic Detection of Divergent Insect- and Bat-Associated Viruses in Plasma from Two African Individuals Enrolled in Blood-Borne Surveillance
Metagenomic Detection of Divergent Insect- and Bat-Associated Viruses in Plasma from Two African Individuals Enrolled in Blood-Borne Surveillance Open
Metagenomic next-generation sequencing (mNGS) has enabled the high-throughput multiplexed identification of sequences from microbes of potential medical relevance. This approach has become indispensable for viral pathogen discovery and bro…
View article: Echinococcus multilocularis Calreticulin Interferes with C1q-Mediated Complement Activation
Echinococcus multilocularis Calreticulin Interferes with C1q-Mediated Complement Activation Open
As a zoonotic disease caused by Echinococcus multilocularis larvae, alveolar echinococcosis (AE) is one of the most severe forms of parasitic infection. Over a long evolutional process E. multilocularis has developed complex strategies to …
View article: Purifying selection decreases the potential for Bangui orthobunyavirus outbreaks in humans
Purifying selection decreases the potential for Bangui orthobunyavirus outbreaks in humans Open
Pathogens carried by insects, such as bunyaviruses, are frequently transmitted into human populations and cause diseases. Knowing which spillover events represent a public health threat remains a challenge. Metagenomic next-generation sequ…
View article: ICE volume 42 issue 10 Cover and Front matter
ICE volume 42 issue 10 Cover and Front matter Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: Introduction, Transmission Dynamics, and Fate of Early Severe Acute Respiratory Syndrome Coronavirus 2 Lineages in Santa Clara County, California
Introduction, Transmission Dynamics, and Fate of Early Severe Acute Respiratory Syndrome Coronavirus 2 Lineages in Santa Clara County, California Open
We combined viral genome sequencing with contact tracing to investigate introduction and evolution of severe acute respiratory syndrome coronavirus 2 lineages in Santa Clara County, California, from 27 January to 21 March 2020. From 558 pe…
View article: Pathologic Findings Associated With a Case of Acute Flaccid Myelitis
Pathologic Findings Associated With a Case of Acute Flaccid Myelitis Open
View article: Timely intervention and control of a novel coronavirus (COVID-19) outbreak at a large skilled nursing facility—San Francisco, California, 2020
Timely intervention and control of a novel coronavirus (COVID-19) outbreak at a large skilled nursing facility—San Francisco, California, 2020 Open
Objective: To describe epidemiologic and genomic characteristics of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak in a large skilled-nursing facility (SNF), and the strategies that controlled transmission. Design,…
View article: Fatal Case of Chronic Jamestown Canyon Virus Encephalitis Diagnosed by Metagenomic Sequencing in Patient Receiving Rituximab
Fatal Case of Chronic Jamestown Canyon Virus Encephalitis Diagnosed by Metagenomic Sequencing in Patient Receiving Rituximab Open
A 56-year-old man receiving rituximab who had months of neurologic symptoms was found to have Jamestown Canyon virus in cerebrospinal fluid by clinical metagenomic sequencing. The patient died, and postmortem examination revealed extensive…
View article: Rapid pathogen detection by metagenomic next-generation sequencing of infected body fluids
Rapid pathogen detection by metagenomic next-generation sequencing of infected body fluids Open
View article: Clinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: A retrospective cohort study of patients with and without COVID-19
Clinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: A retrospective cohort study of patients with and without COVID-19 Open
National Center for Advancing Translational Sciences, National Heart Lung Blood Institute, National Institute of Allergy and Infectious Diseases, Chan Zuckerberg Biohub, Chan Zuckerberg Initiative.
View article: Genomic surveillance reveals multiple introductions of SARS-CoV-2 into Northern California
Genomic surveillance reveals multiple introductions of SARS-CoV-2 into Northern California Open
Epidemic in Northern California Genome sequencing of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks is valuable for tracing the sources and perhaps for drawing lessons about preventing future outbreaks. Genomic anal…
View article: Clinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: a comparison of patients with and without COVID-19
Clinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: a comparison of patients with and without COVID-19 Open
Background Emerging data on the clinical presentation, diagnostics, and outcomes of patients with COVID-19 have largely been presented as case series. Few studies have compared these clinical features and outcomes of COVID-19 to other acut…
View article: CRISPR–Cas12-based detection of SARS-CoV-2
CRISPR–Cas12-based detection of SARS-CoV-2 Open
View article: New Genomes from the Congo Basin Expand History of CRF01_AE Origin and Dissemination
New Genomes from the Congo Basin Expand History of CRF01_AE Origin and Dissemination Open
Although the first HIV circulating recombinant form (CRF01_AE) is the predominant strain in many Asian countries, it is uncommonly found in the Congo Basin from where it first originated. To fill the gap in the evolutionary history of this…
View article: A Genomic Survey of SARS-CoV-2 Reveals Multiple Introductions into Northern California without a Predominant Lineage
A Genomic Survey of SARS-CoV-2 Reveals Multiple Introductions into Northern California without a Predominant Lineage Open
The COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 has spread globally, resulting in >300,000 reported cases worldwide as of March 21st, 2020. Here we investigate the genetic diversity and genomic epidemiology of SARS-CoV-2 i…
View article: Rapid Detection of 2019 Novel Coronavirus SARS-CoV-2 Using a CRISPR-based DETECTR Lateral Flow Assay
Rapid Detection of 2019 Novel Coronavirus SARS-CoV-2 Using a CRISPR-based DETECTR Lateral Flow Assay Open
An outbreak of novel betacoronavirus, SARS-CoV-2 (formerly named 2019-nCoV), began in Wuhan, China in December 2019 and the COVID-19 disease associated with infection has since spread rapidly to multiple countries. Here we report the devel…
View article: Author Correction: Metagenomic sequencing with spiked primer enrichment for viral diagnostics and genomic surveillance
Author Correction: Metagenomic sequencing with spiked primer enrichment for viral diagnostics and genomic surveillance Open
View article: Metagenomic sequencing with spiked primer enrichment for viral diagnostics and genomic surveillance
Metagenomic sequencing with spiked primer enrichment for viral diagnostics and genomic surveillance Open
View article: LB14. Cerebrospinal Fluid Profiling of the Human Host Response Reveals Species-Specific Enterovirus Biosignatures in Acute Flaccid Myelitis Cases
LB14. Cerebrospinal Fluid Profiling of the Human Host Response Reveals Species-Specific Enterovirus Biosignatures in Acute Flaccid Myelitis Cases Open
Background Since 2014 there have been global biennial outbreaks of acute flaccid myelitis (AFM), a rare but severe “polio-like” illness of as yet-unknown etiology primarily affecting children. Enteroviruses (EVs),, especially EV-D68 and EV…
View article: Acute Zika virus infection in an asymptomatic blood donor at the onset of the Puerto Rico epidemic
Acute Zika virus infection in an asymptomatic blood donor at the onset of the Puerto Rico epidemic Open
BACKGROUND Zika virus (ZIKV) spread to Puerto Rico likely originated from southeastern Brazil approximately 8.5 months earlier than blood donation screening for ZIKV was initiated, but the time of ZIKV introduction in the blood donor popul…
View article: Metagenomic Next-Generation Sequencing of the 2014 Ebola Virus Disease Outbreak in the Democratic Republic of the Congo
Metagenomic Next-Generation Sequencing of the 2014 Ebola Virus Disease Outbreak in the Democratic Republic of the Congo Open
We applied metagenomic next-generation sequencing (mNGS) to detect Zaire Ebola virus (EBOV) and other potential pathogens from whole-blood samples from 70 patients with suspected Ebola hemorrhagic fever during a 2014 outbreak in Boende, De…
View article: Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis
Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis Open
Routine microbiologic testing is often insufficient to detect all neuroinvasive pathogens. In this study, metagenomic NGS of CSF obtained from patients with meningitis or encephalitis improved diagnosis of neurologic infections and provide…
View article: 2291. A Real-Time Sequencing Approach for Simultaneous Metagenomic and Transcriptomic-Based Diagnosis of Infectious Diseases
2291. A Real-Time Sequencing Approach for Simultaneous Metagenomic and Transcriptomic-Based Diagnosis of Infectious Diseases Open
BACKGROUND: Recent studies have demonstrated the utility of metagenomic next-generation sequencing (mNGS) and RNA gene expression sequencing (RNA-Seq) for identifying causes of infections. Although these approaches have been largely tested…
View article: Differentiation enhances Zika virus infection of neuronal brain cells
Differentiation enhances Zika virus infection of neuronal brain cells Open
Zika virus (ZIKV) is an emerging, mosquito-borne pathogen associated with a widespread 2015–2016 epidemic in the Western Hemisphere and a proven cause of microcephaly and other fetal brain defects in infants born to infected mothers. ZIKV …
View article: Genomic Epidemiology Reconstructs the Introduction and Spread of Zika Virus in Central America and Mexico
Genomic Epidemiology Reconstructs the Introduction and Spread of Zika Virus in Central America and Mexico Open
View article: A Child With Intermittent Headaches and Eosinophilic Meningitis
A Child With Intermittent Headaches and Eosinophilic Meningitis Open
Eosinophilic pleocytosis of the CSF is always considered abnormal and warrants urgent diagnostic evaluation for an infectious,
View article: Nanopore DNA Sequencing and Genome Assembly on the International Space Station
Nanopore DNA Sequencing and Genome Assembly on the International Space Station Open
View article: Experimental Zika Virus Inoculation in a New World Monkey Model Reproduces Key Features of the Human Infection
Experimental Zika Virus Inoculation in a New World Monkey Model Reproduces Key Features of the Human Infection Open
View article: A mouse model of paralytic myelitis caused by enterovirus D68
A mouse model of paralytic myelitis caused by enterovirus D68 Open
In 2014, the United States experienced an epidemic of acute flaccid myelitis (AFM) cases in children coincident with a nationwide outbreak of enterovirus D68 (EV-D68) respiratory disease. Up to half of the 2014 AFM patients had EV-D68 RNA …
View article: Experimental Zika Virus Infection in a New World Monkey Model Reproduces Key Features of the Human Disease
Experimental Zika Virus Infection in a New World Monkey Model Reproduces Key Features of the Human Disease Open
Human infections by Zika virus (ZIKV), a mosquito-borne flavivirus, are associated with a current widespread outbreak in the Americas, and have been associated with neurological complications and adverse fetal outcomes such as microcephaly…