Guizhen Du
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View article: PFOS Disrupts Oocyte Maturation and Early Embryonic Development via Ovarian FOXK1 O‐GlcNAcylation in Mice
PFOS Disrupts Oocyte Maturation and Early Embryonic Development via Ovarian FOXK1 O‐GlcNAcylation in Mice Open
Perfluorooctane sulfonate (PFOS) is of great concern due to its accumulation in living organisms and reproductive toxicity. Although prior studies indicate that PFOS exposure causes female reproductive disorders, the underlying mechanism r…
View article: Bisphenol S Exposure and MASLD: A Mechanistic Study in Mice
Bisphenol S Exposure and MASLD: A Mechanistic Study in Mice Open
Our study reveals a novel mechanism, through which BPS upregulates JunB and Atf3 to impair hepatic lipid metabolism, and provides new insights into the hepatotoxicity of BPS. https://doi.org/10.1289/EHP17057.
View article: Multi-omics approach characterizes the role of Bisphenol F in disrupting hepatic lipid metabolism
Multi-omics approach characterizes the role of Bisphenol F in disrupting hepatic lipid metabolism Open
Bisphenol F (BPF), a substitute for bisphenol A (BPA), is ubiquitous existed in various environmental media. Exposure to BPF may promote non-alcoholic fatty liver disease (NAFLD), while the potential mechanism is still unknown. In current …
View article: Maternal BPAF exposure impaired synaptic development and caused behavior abnormality in offspring
Maternal BPAF exposure impaired synaptic development and caused behavior abnormality in offspring Open
Bisphenol A (BPA) has been widely restricted, leading to a significant increase in the production of bisphenol AF (BPAF), one of the most common bisphenol analogs use as a substitute for BPA. However, there is limit evidence on the neuroto…
View article: Long-Term Degradation Evaluation of the Mismatch of Sensitive Capacitance in MEMS Accelerometers
Long-Term Degradation Evaluation of the Mismatch of Sensitive Capacitance in MEMS Accelerometers Open
During long-term use, MEMS accelerometers will experience degradation, such as bias and scale factor changes. Bias of MEMS capacitive accelerometers usually comes from the mismatch of parasitic capacitance and sensitive capacitance. This p…
View article: Reliability Evaluation Based on Mathematical Degradation Model for Vacuum Packaged MEMS Sensor
Reliability Evaluation Based on Mathematical Degradation Model for Vacuum Packaged MEMS Sensor Open
Vacuum packaging is used extensively in MEMS sensors for improving performance. However, the vacuum in the MEMS chamber gradually degenerates over time, which adversely affects the long-term performance of the MEMS sensor. A mathematical m…
View article: Enhancer RNA lnc-CES1-1 inhibits decidual cell migration by interacting with RNA-binding protein FUS and activating PPARγ in URPL
Enhancer RNA lnc-CES1-1 inhibits decidual cell migration by interacting with RNA-binding protein FUS and activating PPARγ in URPL Open
Unexplained recurrent pregnancy loss (URPL) is a significant reproductive health issue, affecting approximately 5% of pregnancies. Enhancer RNAs (eRNAs) have been reported to play important roles during embryo development and may be relate…
View article: Effects of Microbiota on the Treatment of Obesity with the Natural Product Celastrol in Rats
Effects of Microbiota on the Treatment of Obesity with the Natural Product Celastrol in Rats Open
Our study revealed that celastrol decreased the BW of obese rats by enhancing energy expenditure but not by suppressing food intake and that this effect was mediated by the improvement of the gut microbiota and the activation of the hypoth…
View article: Hypomethylation of PRDM1 is associated with recurrent pregnancy loss
Hypomethylation of PRDM1 is associated with recurrent pregnancy loss Open
Recurrent pregnancy loss (RPL) rates have continued to rise during the last few decades, yet the underlying mechanisms remain poorly understood. An emerging area of interest is the mediation of gene expression by DNA methylation during ear…
View article: Correction: Perfluorooctane Sulfonate Disturbs Nanog Expression through miR-490-3p in Mouse Embryonic Stem Cells
Correction: Perfluorooctane Sulfonate Disturbs Nanog Expression through miR-490-3p in Mouse Embryonic Stem Cells Open
[This corrects the article DOI: 10.1371/journal.pone.0074968.].
View article: Transcriptome and DNA Methylome Dynamics during Triclosan-Induced Cardiomyocyte Differentiation Toxicity
Transcriptome and DNA Methylome Dynamics during Triclosan-Induced Cardiomyocyte Differentiation Toxicity Open
Cardiac development is a dynamic process and sensitive to environmental chemicals. Triclosan is widely used as an antibacterial agent and reported to transport across the placenta and affect embryonic development. Here, we used human embry…
View article: Single-cell RNA-seq reveals distinct injury responses in different types of DRG sensory neurons
Single-cell RNA-seq reveals distinct injury responses in different types of DRG sensory neurons Open
Peripheral nerve injury leads to various injury-induced responses in sensory neurons including physiological pain, neuronal cell death and nerve regeneration. In this study, we performed single-cell RNA-sequencing (scRNA-seq) analysis of m…
View article: The 14th Ile residue is essential for Leptin function in regulating energy homeostasis in rat
The 14th Ile residue is essential for Leptin function in regulating energy homeostasis in rat Open
LEPTIN (LEP) is a circulating hormone released primarily from white adipocytes and is crucial for regulating satiety and energy homeostasis in humans and animals. Using the CRISPR technology, we created a set of Lep mutant rats that carry …
View article: Simultaneous profiling of transcriptome and DNA methylome from a single cell
Simultaneous profiling of transcriptome and DNA methylome from a single cell Open
Our method can be used to detect transcriptome, methylome, and single nucleotide polymorphism information within single cells to dissect the mechanisms of epigenetic gene regulation.
View article: Additional file 1: of Simultaneous profiling of transcriptome and DNA methylome from a single cell
Additional file 1: of Simultaneous profiling of transcriptome and DNA methylome from a single cell Open
Contains Supplementary Figures 1â 11 and Supplementary Table 1. (PDF 1536 kb)