Gulimiran Alitongbieke
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View article: RXRα modulates hepatic stellate cell activation and liver fibrosis by targeting CaMKKβ–AMPKα axis
RXRα modulates hepatic stellate cell activation and liver fibrosis by targeting CaMKKβ–AMPKα axis Open
Hepatic stellate cells (HSCs) are the primary fibrogenic cells in the liver, and their activation plays a crucial role in the development and progression of hepatic fibrosis. Here, we report that retinoid X receptor-alpha (RXRα), a …
View article: Lentinan inhibits melanoma development by regulating the AKT/Nur77/Bcl-2 signaling axis
Lentinan inhibits melanoma development by regulating the AKT/Nur77/Bcl-2 signaling axis Open
Background: Melanoma is a highly malignant and difficult-to-treat skin cancer. Many researchers are exploring natural products for its treatment. Lentinan (LNT), extracted from Lentinus edodes, exerts strong anti-tumor effect…
View article: β-chitosan attenuates hepatic macrophage-driven inflammation and reverses aging-related cognitive impairment
β-chitosan attenuates hepatic macrophage-driven inflammation and reverses aging-related cognitive impairment Open
View article: Immunoinformatic of novel self-amplifying mRNA vaccine lipid nanoparticle against SARS-CoV-2
Immunoinformatic of novel self-amplifying mRNA vaccine lipid nanoparticle against SARS-CoV-2 Open
We developed innovative self-amplifying mRNA (sa-mRNA) vaccine based on the derivative of S and Nsp3 proteins, which are considered crucial adhering to human host cells. We performed B-cell, Major histocompatibility complex (MHC) I, and II…
View article: Glucan from<i> Oudemansiella raphanipes</i> suppresses breast cancer proliferation and metastasis by regulating macrophage polarization and the WNT/β-catenin signaling pathway
Glucan from<i> Oudemansiella raphanipes</i> suppresses breast cancer proliferation and metastasis by regulating macrophage polarization and the WNT/β-catenin signaling pathway Open
Background: The glucan extract of Oudemansiella raphanipes (Orp) has multiple biological properties, similar to extracts of other natural edible fungi. Drugs traditionally used in cancer treatment are associated with s…
View article: β‐Glucan produced by <i>Lentinus edodes</i> suppresses breast cancer progression via the inhibition of macrophage M2 polarization by integrating autophagy and inflammatory signals
β‐Glucan produced by <i>Lentinus edodes</i> suppresses breast cancer progression via the inhibition of macrophage M2 polarization by integrating autophagy and inflammatory signals Open
Background β‐Glucan from Lentinus edodes (LNT), an edible mushroom, possesses strong anticancer activity. However, the therapeutic effects of LNT during the occurrence and progression of breast cancer and their underlying molecular mechani…
View article: Data from BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway
Data from BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway Open
Nur77 (also called TR3 or NGFI-B), an orphan member of the nuclear receptor superfamily, induces apoptosis by translocating to mitochondria where it interacts with Bcl-2 to convert Bcl-2 from an antiapoptotic to a pro-apoptotic molecule. N…
View article: Supplementary methods and Supplementary Figures S1-S8 from BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway
Supplementary methods and Supplementary Figures S1-S8 from BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway Open
The Supplementary Methods show the Synthesis of DIM-C-pPhCF3+MeSO3- (BI1071); Figure S1 shows BI1071 induces apoptosis in different cancer cell lines; Fig. S2 shows BI1071 induces apoptosis in different breast cancer cell lines; Fig. S3 sh…
View article: Data from BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway
Data from BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway Open
Nur77 (also called TR3 or NGFI-B), an orphan member of the nuclear receptor superfamily, induces apoptosis by translocating to mitochondria where it interacts with Bcl-2 to convert Bcl-2 from an antiapoptotic to a pro-apoptotic molecule. N…
View article: Supplementary methods and Supplementary Figures S1-S8 from BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway
Supplementary methods and Supplementary Figures S1-S8 from BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway Open
The Supplementary Methods show the Synthesis of DIM-C-pPhCF3+MeSO3- (BI1071); Figure S1 shows BI1071 induces apoptosis in different cancer cell lines; Fig. S2 shows BI1071 induces apoptosis in different breast cancer cell lines; Fig. S3 sh…
View article: Supplementary Table S1 from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB
Supplementary Table S1 from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB Open
Supplementary Table S1. Z serial compounds.
View article: Supplementary Table S2 from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB
Supplementary Table S2 from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB Open
Supplementary Table S2. Z compounds and their carboxyl derivatives.
View article: Data from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB
Data from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB Open
Retinoid X receptor alpha (RXRα) and its N-terminally truncated version, tRXRα, are widely implicated in cancer development and represent intriguing targets for cancer prevention and treatment. Successful manipulation of RXRα and tRXRα req…
View article: Supplementary Methods from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB
Supplementary Methods from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB Open
Supplementary Methods. Description of additional methods and procedures used in the study.
View article: Supplementary Figures S1-S6 from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB
Supplementary Figures S1-S6 from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB Open
Supplementary Figures S1-S6. Z compounds selectively activate Gal4-DBD-RXRα-LBD transcriptional activity in a dose-dependent manner (S1); Nitro group is required for Z-10 and Z-12 binding to RXRα-LBD (S2); Z-10 and Z-12 bind RXRα in a uniq…
View article: Data from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB
Data from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB Open
Retinoid X receptor alpha (RXRα) and its N-terminally truncated version, tRXRα, are widely implicated in cancer development and represent intriguing targets for cancer prevention and treatment. Successful manipulation of RXRα and tRXRα req…
View article: Supplementary Figures S1-S6 from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB
Supplementary Figures S1-S6 from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB Open
Supplementary Figures S1-S6. Z compounds selectively activate Gal4-DBD-RXRα-LBD transcriptional activity in a dose-dependent manner (S1); Nitro group is required for Z-10 and Z-12 binding to RXRα-LBD (S2); Z-10 and Z-12 bind RXRα in a uniq…
View article: Supplementary Figure Legend from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB
Supplementary Figure Legend from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB Open
Supplementary Figure Legend. Legends for Supplementary Figures S1-S6.
View article: Supplementary Table S1 from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB
Supplementary Table S1 from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB Open
Supplementary Table S1. Z serial compounds.
View article: Supplementary Methods from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB
Supplementary Methods from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB Open
Supplementary Methods. Description of additional methods and procedures used in the study.
View article: Supplementary Figure Legend from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB
Supplementary Figure Legend from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB Open
Supplementary Figure Legend. Legends for Supplementary Figures S1-S6.
View article: Supplementary Table S3 from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB
Supplementary Table S3 from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB Open
Supplementary Table S3. Z-10 and its derivatives.
View article: Supplementary Table S3 from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB
Supplementary Table S3 from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB Open
Supplementary Table S3. Z-10 and its derivatives.
View article: Supplementary Table S2 from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB
Supplementary Table S2 from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB Open
Supplementary Table S2. Z compounds and their carboxyl derivatives.
View article: β-glucan from <i>Lentinus edodes</i> inhibits breast cancer progression via the Nur77/HIF-1α axis
β-glucan from <i>Lentinus edodes</i> inhibits breast cancer progression via the Nur77/HIF-1α axis Open
Background: β-glucan from Lentinus edodes (LNT) is a plant-derived medicinal fungus possessing significant bioactivities on anti-tumor. Both hypoxia-induced factor-1α (HIF)-1α and Nur77 have been shown to be involved in the development of …
View article: BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway
BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway Open
Nur77 (also called TR3 or NGFI-B), an orphan member of the nuclear receptor superfamily, induces apoptosis by translocating to mitochondria where it interacts with Bcl-2 to convert Bcl-2 from an antiapoptotic to a pro-apoptotic molecule. N…
View article: Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα
Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα Open
View article: Moving nuclear receptor Nur77 to damaged mitochondria for clearance by mitophagy
Moving nuclear receptor Nur77 to damaged mitochondria for clearance by mitophagy Open
Selective clearance of damaged mitochondria can reverse pathological status in chronic inflammatory diseases. We recently identified a critical role of nuclear receptor Nur77 and celastrol in priming inflamed mitochondria for autophagy thr…
View article: Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy
Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy Open
View article: Honokiol sensitizes breast cancer cells to TNF‐α induction of apoptosis by inhibiting Nur77 expression
Honokiol sensitizes breast cancer cells to TNF‐α induction of apoptosis by inhibiting Nur77 expression Open
Background and Purpose The orphan nuclear receptor Nur77 is implicated in the survival and apoptosis of cancer cells. The purpose of this study was to determine whether and how Nur77 serves to mediate the effect of the inflammatory cytokin…