Gunasekaran Rameshkumar
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View article: Trends in aetiology and antibiotic resistance in bacterial keratitis isolates from South India between 2013-2024
Trends in aetiology and antibiotic resistance in bacterial keratitis isolates from South India between 2013-2024 Open
Aim: To measure aetiology and antibiotic resistance (AMR) trends of bacteria cultured from corneal scrapings from patients with infectious keratitis at a tertiary referral hospital in South India. Methods: In this retrospective study, bact…
View article: Automated Detection of Filamentous Fungal Keratitis on Whole Slide Images of Potassium Hydroxide Smears with Multiple Instance Learning
Automated Detection of Filamentous Fungal Keratitis on Whole Slide Images of Potassium Hydroxide Smears with Multiple Instance Learning Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: Clinical perspective and outcome of culture-negative microbial keratitis: A retrospective study
Clinical perspective and outcome of culture-negative microbial keratitis: A retrospective study Open
Purpose: To study the risk factors, clinical features, and treatment outcomes of patients with culture-negative keratitis (CNK). Methods: A retrospective data review of 933 patients with CNK was performed from January 2018 to December 2020…
View article: Uncommon case of isolated conjunctival histoplasmosis: A rare clinical entity
Uncommon case of isolated conjunctival histoplasmosis: A rare clinical entity Open
We report an unusual case of isolated conjunctival histoplasmosis in a healthy immunocompetent patient. A 62-year-old male presented with a gradually progressing, painless, fleshy mass in both eyes for 2 months. On examination, a diffuse, …
View article: Development and Clinical Evaluation of a CRISPR/Cas12a-Based Nucleic Acid Detection Platform for the Diagnosis of Keratomycoses
Development and Clinical Evaluation of a CRISPR/Cas12a-Based Nucleic Acid Detection Platform for the Diagnosis of Keratomycoses Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: Rapid Point-of-Care Identification of <i>Aspergillus</i> Species in Microbial Keratitis
Rapid Point-of-Care Identification of <i>Aspergillus</i> Species in Microbial Keratitis Open
Importance Microbial keratitis (MK) is a common cause of unilateral visual impairment, blindness, and eye loss in low-income and middle-income countries. There is an urgent need to develop and implement rapid and simple point-of-care diagn…
View article: Clinical perspectives and outcomes of Culture-Negative Microbial keratitis: A Retrospective study
Clinical perspectives and outcomes of Culture-Negative Microbial keratitis: A Retrospective study Open
Objectives: To study the risk factors, clinical features, and treatment outcomes of patients with culture-negative keratitis (CNK). Methods: A total of 2347 patients of microbial keratitis, excluding clinically viral keratitis, were regist…
View article: Deep Convolutional Neural Networks Detect no Morphological Differences Between Culture-Positive and Culture-Negative Infectious Keratitis Images
Deep Convolutional Neural Networks Detect no Morphological Differences Between Culture-Positive and Culture-Negative Infectious Keratitis Images Open
These deep learning models were not able to identify morphological differences between microbiologically positive and negative corneal ulcers. This finding suggests that similar artificial intelligence models trained to identify the causat…
View article: Deep sequencing analysis of clinical samples from patients with acute infectious conjunctivitis during the COVID-19 delta surge in Madurai, India
Deep sequencing analysis of clinical samples from patients with acute infectious conjunctivitis during the COVID-19 delta surge in Madurai, India Open
View article: Outpatient human coronavirus associated conjunctivitis in India
Outpatient human coronavirus associated conjunctivitis in India Open
View article: Prevalence and Molecular Characterization of Metallo β-Lactamase Producing Gram-Negative Pathogens Causing Eye Infections
Prevalence and Molecular Characterization of Metallo β-Lactamase Producing Gram-Negative Pathogens Causing Eye Infections Open
Purpose: Metallo β-lactamases (MβL) production is a worldwide problem, particularly in gram-negative bacteria. As scanty data is available on the prevalence of MBL, the present study is being undertaken to determine the prevalence, antibac…
View article: Seroprevalence of SARS-CoV-2 specific IgG antibodies among eye care workers in South India
Seroprevalence of SARS-CoV-2 specific IgG antibodies among eye care workers in South India Open
View article: The role of fungi in fungal keratitis
The role of fungi in fungal keratitis Open
View article: Periconia species - An unusual fungal pathogen causing mycotic keratitis
Periconia species - An unusual fungal pathogen causing mycotic keratitis Open
This is the first report on Periconia sp causing human corneal ulcer. This study signifies the importance of molecular identification in the diagnosis of rare fungi which will improve our understanding on disease pathology and outcome. Vis…
View article: Clinical and demographic study of non-tuberculous mycobacterial ocular infections in South India
Clinical and demographic study of non-tuberculous mycobacterial ocular infections in South India Open
High degree of clinical suspicion, multidrug antibiotic therapy and timely surgical intervention in patients with NTM infections, are advised for better clinical outcomes. Prior ocular trauma, prior ocular surgery and presence of biomateri…
View article: Evaluation of Metagenomic Deep Sequencing as a Diagnostic Test for Infectious Keratitis
Evaluation of Metagenomic Deep Sequencing as a Diagnostic Test for Infectious Keratitis Open
View article: Exploratory Use of Fluorescent SmartProbes for the Rapid Detection of Microbial Isolates Causing Corneal Ulcer
Exploratory Use of Fluorescent SmartProbes for the Rapid Detection of Microbial Isolates Causing Corneal Ulcer Open
Fluorescent SmartProbes offer a comparative method to Gram stain for delineating gram-positive or gram-negative bacteria or fungi within corneal scrapes. We demonstrate equivalent or higher sensitivity, specificity, PPV and NPVs, and accur…
View article: Acute endophthalmitis caused by Enterococcus faecalis following intravitreal ranibizumab injection
Acute endophthalmitis caused by Enterococcus faecalis following intravitreal ranibizumab injection Open
A 58-year-old immunocompetent male developed acute endophthalmitis after intravitreal ranibizumab injection for choroidal neovascular membrane. The preinjection vision in the left eye (LE) was 6/24. One-day postinjection, he presented with…
View article: A rare case of Myrothecium species causing mycotic keratitis: Diagnosis and management
A rare case of Myrothecium species causing mycotic keratitis: Diagnosis and management Open
We report two cases of keratitis caused by a rare fungus Myrothecium species. Clinical presentation, identification, and management were studied. Both fungi were grown from corneal scraping and identified as M. verrucaria and…
View article: Pythium keratitis in South India: Incidence, clinical profile, management, and treatment recommendation
Pythium keratitis in South India: Incidence, clinical profile, management, and treatment recommendation Open
We report a large series of patients with Pythium keratitis. Promoting early and differential diagnosis, awareness of clinicians and specific treatment options are needed for this devastating corneal disease.
View article: Fungal Keratitis Caused by Podospora austroamericana: A First Case Report
Fungal Keratitis Caused by Podospora austroamericana: A First Case Report Open
We report a case of keratitis caused by a rare fungus Podospora austroamericana. Clinical and microbiological evaluation of the corneal ulcer was done and the treatment outcome was studied. The fungus was grown from the corneal scraping, a…
View article: Prevalence and antibacterial resistance patterns of extended-spectrum beta-lactamase producing Gram-negative bacteria isolated from ocular infections
Prevalence and antibacterial resistance patterns of extended-spectrum beta-lactamase producing Gram-negative bacteria isolated from ocular infections Open
The higher rate of prevalence of ESBLs-encoding genes among ocular Gram-negative bacteria is of great concern, as it causes limitation to therapeutic options. This regional knowledge will help in guiding appropriate antibiotic use which is…