Gunilla Rask
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View article: Stromal collagen IV expression and risk of breast cancer death in ductal carcinoma in situ
Stromal collagen IV expression and risk of breast cancer death in ductal carcinoma in situ Open
Background Current treatment for ductal carcinoma in situ (DCIS) of the breast is generic, due to lack of risk stratification tools. We investigate the correlation between expression of collagen IV in the breast and risk of dying of breast…
View article: Stromal collagen IV expression and risk of breast cancer death in ductal carcinoma in situ
Stromal collagen IV expression and risk of breast cancer death in ductal carcinoma in situ Open
Background. Current treatment for ductal carcinoma in situ (DCIS) of the breast is generic, due to lack of risk stratification tools. We investigate the correlation between expression of collagen IV in the breast and risk of breast cancer …
View article: Management and risk of upgrade of atypical ductal hyperplasia in the breast: A population-based retrospective cohort study
Management and risk of upgrade of atypical ductal hyperplasia in the breast: A population-based retrospective cohort study Open
Background: International guidelines recommend open surgery for atypical ductal hyperplasia (ADH) in the breast due to risk of underestimating malignant disease. Considering the ongoing randomized trials of active surveillance of low-risk …
View article: Stromal Type I Collagen in Breast Cancer: Correlation to Prognostic Biomarkers and Prediction of Chemotherapy Response
Stromal Type I Collagen in Breast Cancer: Correlation to Prognostic Biomarkers and Prediction of Chemotherapy Response Open
Introduction: Fibrillar collagens accumulate in the breast cancer stroma and appear as poorly defined spiculated masses in mammography imaging. The prognostic value of tissue type I collagen remains elusive in treatment-naïve and chemother…
View article: Immune cell infiltrate in ductal carcinoma <i>in situ</i> and the risk of dying from breast cancer: case–control study
Immune cell infiltrate in ductal carcinoma <i>in situ</i> and the risk of dying from breast cancer: case–control study Open
Background Studies identifying risk factors for death from breast cancer after ductal carcinoma in situ (DCIS) are rare. In this retrospective nested case–control study, clinicopathological factors in women treated for DCIS and who died fr…
View article: Targeting collagen XVIII improves the efficiency of ErbB inhibitors in breast cancer models
Targeting collagen XVIII improves the efficiency of ErbB inhibitors in breast cancer models Open
The tumor extracellular matrix (ECM) critically regulates cancer progression and treatment response. Expression of the basement membrane component collagen XVIII (ColXVIII) is induced in solid tumors, but its involvement in tumorigenesis h…
View article: Type IV Collagen in Human Colorectal Liver Metastases—Cellular Origin and a Circulating Biomarker
Type IV Collagen in Human Colorectal Liver Metastases—Cellular Origin and a Circulating Biomarker Open
Circulating type IV collagen (cCOL IV) is a potential biomarker for patients with colorectal liver metastases (CLM) who present with elevated levels of COL IV in both CLM tissue and circulation. This study aimed to establish the cellular o…
View article: Prognostic Value of Stromal Type IV Collagen Expression in Small Invasive Breast Cancers
Prognostic Value of Stromal Type IV Collagen Expression in Small Invasive Breast Cancers Open
Breast cancer is the most common cause of cancer death among women worldwide. Localized breast cancer can be cured by surgery and adjuvant therapy, but mortality remains high for tumors that metastasize early. Type IV collagen is a basemen…
View article: Collagen XVIII promotes breast cancer through EGFR/ErbB signaling and its ablation improves the efficacy of ErbB-targeting inhibitors
Collagen XVIII promotes breast cancer through EGFR/ErbB signaling and its ablation improves the efficacy of ErbB-targeting inhibitors Open
The tumor extracellular matrix (ECM) is a critical regulator of cancer progression and metastasis, significantly affecting the treatment response. Expression of collagen XVIII (ColXVIII), a ubiquitous component of basement membranes, is in…
View article: Correlation of Tumour Subtype With Long-term Outcome in Small Breast Carcinomas: A Swedish Population-based Retrospective Cohort Study
Correlation of Tumour Subtype With Long-term Outcome in Small Breast Carcinomas: A Swedish Population-based Retrospective Cohort Study Open
Purpose : To investigate if molecular subtype is associated with outcome in stage 1 breast cancer (BC). Method : Tissue samples from 445 women with node-negative BC £15 mm, treated in 1986-2004, were classified into surrogate molecular sub…