Gunnar Engström
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View article: The circulating dihydrotestosterone/testosterone ratio is increased by gut microbial 5α-reductase activity in females
The circulating dihydrotestosterone/testosterone ratio is increased by gut microbial 5α-reductase activity in females Open
See Acknowledgements.
View article: The metabolic signature of salt intake: a cross-sectional analysis from the SCAPIS-study
The metabolic signature of salt intake: a cross-sectional analysis from the SCAPIS-study Open
Background Untargeted metabolomic analysis provides novel insights into the relationship between sodium intake and cardiometabolic risk. This study examined cross-sectional associations between estimated sodium intake and plasma metabolite…
View article: Identification of Gut Microbiome Signatures and Metabolites Associated With Albuminuria in Type 2 Diabetes
Identification of Gut Microbiome Signatures and Metabolites Associated With Albuminuria in Type 2 Diabetes Open
Context Type 2 diabetes is a growing global concern with serious complications, including kidney damage and cardiovascular morbidity and mortality. Monitoring albuminuria, which is associated with these complications, is crucial in optimal…
View article: Long-term exposure to air pollution and validated cases of Alzheimer's disease and vascular dementia in the Malmö diet and cancer cohort
Long-term exposure to air pollution and validated cases of Alzheimer's disease and vascular dementia in the Malmö diet and cancer cohort Open
Background Dementia is a global public health challenge, with Alzheimer's disease (AD) and vascular dementia (VaD) being the most prevalent subtypes. Air pollution is a potential risk factor for dementia, but few studies separate AD and Va…
View article: Different plasma biomarker patterns associated with coronary atherosclerosis in low- versus high-risk individuals – an observational cross-sectional study
Different plasma biomarker patterns associated with coronary atherosclerosis in low- versus high-risk individuals – an observational cross-sectional study Open
View article: Mosaic loss of chromosome Y and coronary atherosclerosis in men: insights into sex differences in cardiovascular risk from the SCAPIS study
Mosaic loss of chromosome Y and coronary atherosclerosis in men: insights into sex differences in cardiovascular risk from the SCAPIS study Open
Background Atherosclerosis predominantly affects men and is the underlying cause of coronary artery disease (CAD) and myocardial infarction (MI). Recent studies show that mosaic loss of chromosome Y (LOY) in blood is associated with all ma…
View article: Severe-extensive coronary atherosclerosis in low-risk individuals and absence of coronary atherosclerosis in high-risk individuals: the SCAPIS extremes project
Severe-extensive coronary atherosclerosis in low-risk individuals and absence of coronary atherosclerosis in high-risk individuals: the SCAPIS extremes project Open
Aims Factors associated with unexpected absence or presence of coronary atherosclerosis in individuals at high/low estimated cardiovascular (CV) risk are largely unexplored. We assessed two extreme phenotypes: (i) no coronary atheroscleros…
View article: The association between the gut microbiome and 24-h blood pressure measurements in the SCAPIS study
The association between the gut microbiome and 24-h blood pressure measurements in the SCAPIS study Open
View article: Associations between physical activity and CVD-related metabolomic and proteomic biomarkers
Associations between physical activity and CVD-related metabolomic and proteomic biomarkers Open
Aim Habitual physical activity (PA) affects metabolism and homeostasis in various tissues and organs. However, detailed knowledge of associations between PA and cardiovascular disease (CVD) risk markers is limited. We sought to identify as…
View article: Oscillometry findings in altered spirometry patterns and relationship to respiratory symptoms
Oscillometry findings in altered spirometry patterns and relationship to respiratory symptoms Open
Background Preserved ratio impaired spirometry (PRISm) and restrictive spirometry pattern (RSP) are associated with increased morbidity and mortality, but the underlying mechanisms are unclear. Impulse oscillometry (IOS) measures small air…
View article: The ESCAPER study—exploring protective mechanisms against cardiovascular disease in subjects at high risk: rationale, study protocol, and first results
The ESCAPER study—exploring protective mechanisms against cardiovascular disease in subjects at high risk: rationale, study protocol, and first results Open
Introduction. The ESCAPER project explores cardiovascular resilience in individuals who, despite a high-risk factor burden-longstanding Type 1 Diabetes (T1D), obesity, or kidney failure-avoid or delay macrovascular complications. Th…
View article: Plasma proteomic and metabolomic profiling of coronary and carotid atherosclerosis in the SCAPIS study—differences and similarities
Plasma proteomic and metabolomic profiling of coronary and carotid atherosclerosis in the SCAPIS study—differences and similarities Open
Funding Agencies|European Research Council [ERC-STG-2018-801965]; Swedish Research Council [VR 2019-01471, 2019-01236]; Swedish Heart-Lung Foundation [Hjart-Lungfonden] [20190505, 20200173]; Swedish Government [ALFGBG-991828]; Swedish coun…
View article: The relationship between physical activity, orthostatic blood pressure reactions and subclinical atherosclerosis: the Swedish CArdioPulmonary bioImage Study (SCAPIS)
The relationship between physical activity, orthostatic blood pressure reactions and subclinical atherosclerosis: the Swedish CArdioPulmonary bioImage Study (SCAPIS) Open
View article: Reliability of resting heart rate measurements in atrial fibrillation
Reliability of resting heart rate measurements in atrial fibrillation Open
Background Resting heart rate in atrial fibrillation (AF) is a commonly used therapeutic target, but no studies have evaluated whether resting heart rates in AF are reliable over repeated measurements. We aimed to determine the reliability…
View article: IFNγ+ NKT-like cells are associated with increased incidence of atrial fibrillation in elderly women
IFNγ+ NKT-like cells are associated with increased incidence of atrial fibrillation in elderly women Open
Aims T cells are present in atrial tissue from atrial fibrillation (AF) patients. However, prospective studies of T cells and AF development are few. The current aim was to investigate if T-cell subsets are associated with the risk of deve…
View article: Thrombotic risk determined by ABO, F8, and VWF variants in a population-based cohort study
Thrombotic risk determined by ABO, F8, and VWF variants in a population-based cohort study Open
The risk score of 3 common variants in VWF, F8, and AB0 genes is associated with VTE risk similar to FV Leiden.
View article: Impact of diabetes and glycemic status on ventricular–arterial coupling in the general population
Impact of diabetes and glycemic status on ventricular–arterial coupling in the general population Open
Background/aims Ventricular–arterial coupling (VAC) plays a crucial role in cardiovascular physiology, affecting cardiac function and arterial properties for optimal organ perfusion. Considering that diabetes mellitus (DM) is a known risk …
View article: Intermediate Monocytes and High Levels of Chemokine CCL3 Are Associated With Increased Risk of Atrial Fibrillation in the General Population
Intermediate Monocytes and High Levels of Chemokine CCL3 Are Associated With Increased Risk of Atrial Fibrillation in the General Population Open
View article: Exploring the interaction between ambient air pollution and road traffic noise on stroke incidence in ten Nordic cohorts
Exploring the interaction between ambient air pollution and road traffic noise on stroke incidence in ten Nordic cohorts Open
View article: Prevalence and common cardiovascular risk factors in aortic valve calcification in the middle-aged general population
Prevalence and common cardiovascular risk factors in aortic valve calcification in the middle-aged general population Open
Aims Aortic valve calcification (AVC) is an underlying pathophysiological mechanism for aortic stenosis that is common in the elderly, but less is known in younger individuals. The aim was to study the prevalence and associated characteris…
View article: Plasma metabolite profiles of meat intake and their association with cardiovascular disease risk: A population-based study in Swedish cohorts
Plasma metabolite profiles of meat intake and their association with cardiovascular disease risk: A population-based study in Swedish cohorts Open
This study provides comprehensive analysis of self-reported meat intake and plasma metabolites. The findings may enhance our understanding of the relationship between meat intake and CVD, and provide insights into underlying mechanisms.
View article: Aortic valve calcification across stages of dysglycemia in middle-aged individuals from the general population
Aortic valve calcification across stages of dysglycemia in middle-aged individuals from the general population Open
View article: Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes
Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes Open
View article: Exposure to Lead and Coronary Artery Atherosclerosis: A Swedish Cross‐Sectional Population‐Based Study
Exposure to Lead and Coronary Artery Atherosclerosis: A Swedish Cross‐Sectional Population‐Based Study Open
Background Lead is an established causal risk factor for coronary heart disease. Atherosclerosis may be the key mediator for this association, but evidence from studies in humans is limited. Our objective was to test the hypothesis that en…
View article: Estimated sodium intake and premature ventricular complexes: data from the population-based Swedish CArdioPulmonary bioImage Study
Estimated sodium intake and premature ventricular complexes: data from the population-based Swedish CArdioPulmonary bioImage Study Open
Background Premature ventricular complexes (PVCs) predict coronary heart disease, heart failure, atrial fibrillation and death, all of which are also related to sodium intake. We studied estimated sodium intake and PVC frequency in the ran…
View article: Artificial intelligence for direct-to-physician reporting of ambulatory electrocardiography
Artificial intelligence for direct-to-physician reporting of ambulatory electrocardiography Open
View article: Arterial Stiffness and Markers of Atrial Myopathy
Arterial Stiffness and Markers of Atrial Myopathy Open
Background Arterial stiffness, measured using carotid‐femoral pulse wave velocity (c‐f PWV) and heart rate‐corrected augmentation index (Aix75), is associated with cardiovascular disease, and in some studies incident atrial fibrillation (A…
View article: Proteins associated with preserved ratio impaired spirometry
Proteins associated with preserved ratio impaired spirometry Open
Background Preserved ratio impaired spirometry (PRISm) is a spirometry pattern of interest regarding incident airflow obstruction and higher mortality risk. We applied a proteomic approach to gain more insight into the biological mechanism…
View article: Locus of control and breathlessness: a cross-sectional analysis of 28 730 people
Locus of control and breathlessness: a cross-sectional analysis of 28 730 people Open
Background Long-term pathological breathlessness is a life-limiting symptom that risks taking control of the individual's life. We aimed to evaluate how locus of control (LOC), an individual's perceived control of present and past life eve…
View article: Meat intake in relation to composition and function of gut microbiota
Meat intake in relation to composition and function of gut microbiota Open