Gunnar Jacobsson
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View article: Narrow-spectrum antibiotics to male patients with acute cystitis – a retrospective longitudinal study
Narrow-spectrum antibiotics to male patients with acute cystitis – a retrospective longitudinal study Open
Narrow-spectrum antibiotics for acute cystitis in male patients resulted in a very small increase in the incidence of pyelonephritis and a moderate increase in treatment failure or relapse/reinfection. In our opinion this does not motivate…
View article: Patients, antibiotics and <i>Clostridioides difficile</i>: when your best friend becomes your worst enemy
Patients, antibiotics and <i>Clostridioides difficile</i>: when your best friend becomes your worst enemy Open
Background and objectives Patients with recurrent Clostridioides difficile infection (rCDI) suffer long after infection. However, knowledge is incomplete regarding their perceptions of in-hospital care, antibiotic treatment and the most co…
View article: The risk of drug-induced liver injury associated with flucloxacillin: a nationwide, entropy-balanced cohort study
The risk of drug-induced liver injury associated with flucloxacillin: a nationwide, entropy-balanced cohort study Open
In this nationwide cohort study, the use of flucloxacillin was associated with a sevenfold increased risk of DILI, predominantly in the first 45 days of exposure.
View article: Beliefs of Peers' Behavior, Clinical Guidelines, and Private Attitudes to Antibiotics as Drivers of Antibiotic Prescribing
Beliefs of Peers' Behavior, Clinical Guidelines, and Private Attitudes to Antibiotics as Drivers of Antibiotic Prescribing Open
This study examines how doctors' personal views and norms on antibiotics affect their choices when prescribing antibiotics in Sweden. We analyze answers from two surveys, one in 2018 with 357 doctors about their own use and attitudes of an…
View article: Surface-Shaving of Staphylococcus aureus Strains and Quantitative Proteomic Analysis Reveal Differences in Protein Abundance of the Surfaceome
Surface-Shaving of Staphylococcus aureus Strains and Quantitative Proteomic Analysis Reveal Differences in Protein Abundance of the Surfaceome Open
Staphylococcus aureus is a pathogen known to cause a wide range of infections. To find new targets for identification and to understand host–pathogen interactions, many studies have focused on surface proteins. We performed bacterial-cell …
View article: Duration from start of antibiotic exposure to onset of <i>Clostridioides difficile</i> infection for different antibiotics in a non-outbreak setting
Duration from start of antibiotic exposure to onset of <i>Clostridioides difficile</i> infection for different antibiotics in a non-outbreak setting Open
The time gap between antibiotic exposure and onset of CDI is markedly different between different antibiotics. Decreased cephalosporin use could delay onset of healthcare facility-associated CDI and limit infections with onset within the h…
View article: <i>Clostridioides difficile</i>transmission: a compartmental model accounting for environmental spore persistence
<i>Clostridioides difficile</i>transmission: a compartmental model accounting for environmental spore persistence Open
Objective To set up a compartmental model, including environmental spore levels, for C. difficile transmission dynamics in a hospital and determine the effect of preventive interventions on infection and colonization rates. Design Interven…
View article: Outcome of community onset severe sepsis, Sepsis-3 sepsis, and bacteremia in Sweden – a prospective population-based study
Outcome of community onset severe sepsis, Sepsis-3 sepsis, and bacteremia in Sweden – a prospective population-based study Open
Background Register-based studies are common in sepsis epidemiology. Chart review is considered gold standard but is time consuming. This is one of few such studies. Methods In a 9-month prospective and consecutive study conducted in 2011-…
View article: ICE volume 44 issue 12 Cover and Front matter
ICE volume 44 issue 12 Cover and Front matter Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: <i>Clostridioides difficile</i> outbreak detection: Evaluation by ribotyping and whole-genome sequencing of a surveillance algorithm based on ward-specific cutoffs
<i>Clostridioides difficile</i> outbreak detection: Evaluation by ribotyping and whole-genome sequencing of a surveillance algorithm based on ward-specific cutoffs Open
Objective: We evaluated the performance of an early-warning algorithm, based on ward-specific incidence cutoffs for detecting Clostridioides difficile transmission in hospitals. We also sought to determine the frequency of intrahospital Cl…
View article: Risk factors for recurrent healthcare-facility associated Clostridioides difficile infection in a Swedish setting
Risk factors for recurrent healthcare-facility associated Clostridioides difficile infection in a Swedish setting Open
Renal insufficiency and metronidazole treatment were independent risk factors for recurrent HCF-CDI in our setting. The relationship between cefotaxime exposure and risk for recurrent HCF-CDI, dose-dependent, could be evaluated further in …
View article: Antibiotic prescription: Knowledge among physicians and nurses in western Sweden
Antibiotic prescription: Knowledge among physicians and nurses in western Sweden Open
Misuse and overuse of antibiotics are common in primary care. Guidelines for prescribing of antibiotics are often not followed We conducted a survey of 120 health centers in western Sweden to investigate to what extent physicians and nurse…
View article: Remote investigation and assessment of vital signs (RIA-VS)—proof of concept for contactless estimation of blood pressure, pulse, respiratory rate, and oxygen saturation in patients with suspicion of COVID-19
Remote investigation and assessment of vital signs (RIA-VS)—proof of concept for contactless estimation of blood pressure, pulse, respiratory rate, and oxygen saturation in patients with suspicion of COVID-19 Open
Universal Trial Number (UTN) U1111-1251-4114 and the ClinicalTrials.gov Identifier NCT04383457.
View article: Impact of obesity on outcome of severe bacterial infections
Impact of obesity on outcome of severe bacterial infections Open
Introduction Obesity is a rapidly growing global health concern with considerable negative impact on life-time expectancy. It has yet not been clarified if and how obesity impacts outcomes of severe bacterial infections. The aim of this st…
View article: Peers, policy, and attitudes as drivers of antibiotic prescribing
Peers, policy, and attitudes as drivers of antibiotic prescribing Open
In this study we investigated how treatment norms about antibiotic use affect a doctor´s decision to prescribe antibiotics. We also investigated the attitudes and behavior of the same physicians as private persons. We find that compared wi…
View article: Patient Transfers and Clostridioides Difficile Infections: A Case-Control Study
Patient Transfers and Clostridioides Difficile Infections: A Case-Control Study Open
Background Clostridioides difficile spores are present in the hospital environment. We hypothesized that patient transfers between rooms is an independent risk factor for C. difficile infections (CDI), as this increases the environmental e…
View article: Increasing incidence and antimicrobial resistance in Escherichia coli bloodstream infections: a multinational population-based cohort study
Increasing incidence and antimicrobial resistance in Escherichia coli bloodstream infections: a multinational population-based cohort study Open
Background Escherichia coli is an important pathogen in humans and is the most common cause of bacterial bloodstream infections (BSIs). The objectives of our study were to determine factors associated with E. coli BSI incidence rate and th…
View article: Mortality in Escherichia coli bloodstream infections: a multinational population-based cohort study
Mortality in Escherichia coli bloodstream infections: a multinational population-based cohort study Open
Background Escherichia coli is the most common cause of bloodstream infections (BSIs) and mortality is an important aspect of burden of disease. Using a multinational population-based cohort of E. coli BSIs, our objectives were to evaluate…
View article: Interventions for prudent antibiotic use in primary healthcare: An econometric analysis
Interventions for prudent antibiotic use in primary healthcare: An econometric analysis Open
Background: Rational antibiotic prescribing is crucial to combat antibiotic resistance. Optimal strategies to improve antibiotic use are not known. Strama, the Swedish strategic program against antibiotic resistance, has been successful in…
View article: Interventions for prudent antibiotic use in primary healthcare: An econometric analysis
Interventions for prudent antibiotic use in primary healthcare: An econometric analysis Open
Background Rational antibiotic prescribing is crucial to combat antibiotic resistance. Optimal strategies to improve antibiotic use are not known. Strama, the Swedish strategic program against antibiotic resistance, has been successful in …
View article: Interventions for prudent antibiotic use in primary healthcare: An econometric analysis
Interventions for prudent antibiotic use in primary healthcare: An econometric analysis Open
Background Rational antibiotic prescribing is crucial to combat antibiotic resistance. Optimal strategies to improve antibiotic use are not known. Strama, the Swedish strategic program against antibiotic resistance, has been successful in …
View article: An International Prospective Cohort Study To Validate 2 Prediction Rules for Infections Caused by Third-generation Cephalosporin-resistant Enterobacterales
An International Prospective Cohort Study To Validate 2 Prediction Rules for Infections Caused by Third-generation Cephalosporin-resistant Enterobacterales Open
Background The possibility of bloodstream infections caused by third-generation cephalosporin-resistant Enterobacterales (3GC-R-BSI) leads to a trade-off between empiric inappropriate treatment (IAT) and unnecessary carbapenem use (UCU). A…
View article: Interventions for prudent antibiotic use in primary healthcare: An econometric analysis
Interventions for prudent antibiotic use in primary healthcare: An econometric analysis Open
Background Rational antibiotic prescribing is crucial to combat antibiotic resistance. Optimal strategies to improve antibiotic use are not known. Strama, the Swedish strategic program against antibiotic resistance, has been successful in …
View article: Interventions for prudent antibiotic use in primary healthcare: An econometric analysis
Interventions for prudent antibiotic use in primary healthcare: An econometric analysis Open
Background Rational antibiotic prescribing is crucial to combat antibiotic resistance. Optimal strategies to improve antibiotic use are not known. Strama, the Swedish strategic program against antibiotic resistance, has been successful in …
View article: Incidences of community onset severe sepsis, Sepsis-3 sepsis, and bacteremia in Sweden – A prospective population-based study
Incidences of community onset severe sepsis, Sepsis-3 sepsis, and bacteremia in Sweden – A prospective population-based study Open
We found a high incidence of community onset severe sepsis, albeit lower than that seen in previous Scandinavian studies. The incidence increased markedly with age of the patient. The incidence of community onset sepsis according to the Se…