Gunnar Nilsson
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View article: Evaluating Melanoma Risk in Adult Mastocytosis: Potential Impact of Detection Bias – A Registry-based Study (Sweden)
Evaluating Melanoma Risk in Adult Mastocytosis: Potential Impact of Detection Bias – A Registry-based Study (Sweden) Open
There is some evidence that mastocytosis patients are at increased risk of skin cancer. This study aimed to assess the risk of malignant melanoma (MM), melanoma in situ (Mis), and basal cell carcinoma (BCC). A dataset was generated by indi…
View article: IgE-activated human lung mast cells preferentially release prostaglandin D2, thromboxane A2, and cysteinyl-leukotrienes
IgE-activated human lung mast cells preferentially release prostaglandin D2, thromboxane A2, and cysteinyl-leukotrienes Open
There is a high degree of specialization in HLMC with a strong and specific increase in cysteinyl leukotrienes and PGD2 but also the bronchoconstrictor thromboxane A2 after IgE-dependent activation.
View article: Increased risk of skin cancer in mastocytosis: A large-scale retrospective cohort study of over 20,000 patients
Increased risk of skin cancer in mastocytosis: A large-scale retrospective cohort study of over 20,000 patients Open
View article: Allergic airway inflammation amplifies mast cell responses in isolated guinea pig intralobular bronchi
Allergic airway inflammation amplifies mast cell responses in isolated guinea pig intralobular bronchi Open
A protocol to avoid postmortem constriction in isolated intralobular bronchi from guinea pigs was established. A new model makes it possible to investigate bronchial responses in airways with asthmatic features. Increased responses in bron…
View article: Single-cell omics-based characterization of human basophils reveals two transcriptionally distinct populations
Single-cell omics-based characterization of human basophils reveals two transcriptionally distinct populations Open
Background Basophils are implicated in various diseases including allergies, but a comprehensive characterization of human basophils has yet to be performed at the single-cell level. Objective We aimed to generate a single-cell omics-based…
View article: Lack of ST2 aggravates glioma invasiveness, vascular abnormality, and immune suppression
Lack of ST2 aggravates glioma invasiveness, vascular abnormality, and immune suppression Open
Background Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, characterized by aggressive growth and a dismal prognosis. Interleukin-33 (IL-33) and its receptor ST2 have emerged as regulators of glioma growth, b…
View article: Patient-reported outcome measures and satisfaction after laminectomy for cervical spondylotic myelopathy in octogenarians: An observational study from the Swedish national spine registry
Patient-reported outcome measures and satisfaction after laminectomy for cervical spondylotic myelopathy in octogenarians: An observational study from the Swedish national spine registry Open
View article: Safety of anterior cervical corpectomy and fusion (ACCF) for the treatment of subaxial cervical spine injuries, a single center comparative matched analysis
Safety of anterior cervical corpectomy and fusion (ACCF) for the treatment of subaxial cervical spine injuries, a single center comparative matched analysis Open
View article: Plasma Protein Profiling to Discern Indolent from Advanced Systemic Mastocytosis
Plasma Protein Profiling to Discern Indolent from Advanced Systemic Mastocytosis Open
View article: Predictors of early mortality following surgical or nonsurgical treatment of subaxial cervical spine fractures: a retrospective nationwide registry study
Predictors of early mortality following surgical or nonsurgical treatment of subaxial cervical spine fractures: a retrospective nationwide registry study Open
Age and SCI emerged as significant predictors of early mortality in both surgically and nonsurgically treated patients. An intact neurological function served as a protective factor against early mortality in nonsurgically treated patients…
View article: CRISPR/Cas9-mediated gene disruption determines the roles of MITF and CITED2 in human mast cell differentiation
CRISPR/Cas9-mediated gene disruption determines the roles of MITF and CITED2 in human mast cell differentiation Open
A CRISPR/Cas9-based framework allows the identification of genes involved in human mast cell differentiation
View article: An optimized method for IgE-mediated degranulation of human lung mast cells
An optimized method for IgE-mediated degranulation of human lung mast cells Open
Background Mast cells are critically involved in IgE-mediated diseases, e.g., allergies and asthma. Human mast cells are heterogeneous, and mast cells from different anatomical sites have been shown to respond differently to certain stimul…
View article: Long-term outcomes after surgery for subaxial cervical spine injuries in octogenarians, a matched population-based cohort study
Long-term outcomes after surgery for subaxial cervical spine injuries in octogenarians, a matched population-based cohort study Open
View article: 95P Omission of postoperative radiation therapy in older patients with low-risk breast cancer treated with breast-conserving surgery: Long-term results of the KohoRT study
95P Omission of postoperative radiation therapy in older patients with low-risk breast cancer treated with breast-conserving surgery: Long-term results of the KohoRT study Open
Postoperative radiotherapy after breast-conserving surgery in node-negative breast cancer halves the risk of local recurrence, though the absolute benefit varies depending on baseline risk of recurrence. In some subgroups, the benefit of r…
View article: Predictors of failure after primary anterior cervical discectomy and fusion for subaxial traumatic spine injuries
Predictors of failure after primary anterior cervical discectomy and fusion for subaxial traumatic spine injuries Open
Introduction Traumatic subaxial fractures account for more than half of all cervical spine injuries. The optimal surgical approach is a matter of debate and may include anterior, posterior or a combined anteroposterior (360º) approach. Ana…
View article: Epidemiology of mastocytosis: a population-based study (Sweden)
Epidemiology of mastocytosis: a population-based study (Sweden) Open
Background: Mastocytosis is a disease characterized by accumulation of aberrant mast cells and mediator-related symptoms and is divided into systemic mastocytosis (SM) and cutaneous mastocytosis (CM). The epidemiology of mastocytosis remai…
View article: Dysphagia, health-related quality of life, and return to work after occipitocervical fixation
Dysphagia, health-related quality of life, and return to work after occipitocervical fixation Open
Purpose The purpose of this study was to evaluate patient-reported outcome measures (PROMS) on dysphagia, health-related quality of life (HRQoL) and return to work after occipitocervical fixation (OCF). Postoperative radiographic measureme…
View article: Supplemental Table S3 from Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future
Supplemental Table S3 from Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future Open
Supplemental Table S3
View article: Data from Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future
Data from Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future Open
Mastocytosis is a term used to denote a heterogeneous group of conditions defined by the expansion and accumulation of clonal (neoplastic) tissue mast cells in various organs. The classification of the World Health Organization (WHO) divid…
View article: Supplemental Table S4 from Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future
Supplemental Table S4 from Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future Open
Supplemental Table S4
View article: Data from Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future
Data from Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future Open
Mastocytosis is a term used to denote a heterogeneous group of conditions defined by the expansion and accumulation of clonal (neoplastic) tissue mast cells in various organs. The classification of the World Health Organization (WHO) divid…
View article: Supplemental Table S1 from Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future
Supplemental Table S1 from Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future Open
Supplemental Table S1
View article: Supplemental Table S4 from Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future
Supplemental Table S4 from Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future Open
Supplemental Table S4
View article: Supplemental Table S3 from Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future
Supplemental Table S3 from Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future Open
Supplemental Table S3
View article: Supplemental Table S2 from Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future
Supplemental Table S2 from Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future Open
Supplemental Table S2
View article: Supplemental Table S2 from Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future
Supplemental Table S2 from Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future Open
Supplemental Table S2
View article: Supplemental Table S3 from Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future
Supplemental Table S3 from Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future Open
Supplemental Table S3
View article: Supplemental Table S3 from Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future
Supplemental Table S3 from Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future Open
Supplemental Table S3
View article: Supplemental Table S1 from Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future
Supplemental Table S1 from Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future Open
Supplemental Table S1
View article: Analysis of human lung mast cells by single cell RNA sequencing
Analysis of human lung mast cells by single cell RNA sequencing Open
Mast cells are tissue-resident cells playing major roles in homeostasis and disease conditions. Lung mast cells are particularly important in airway inflammatory diseases such as asthma. Human mast cells are classically divided into the su…