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View article: Heparin decreases serum sphingosine-1-phosphate levels in patients with vascular diseases
Heparin decreases serum sphingosine-1-phosphate levels in patients with vascular diseases Open
Circulating S1P concentrations in patients with atherosclerosis are associated to different blood components before and after interventions. Reduced postoperative serum S1P levels in patients are most likely attributed to heparin treatment…
View article: Associations of sphingosine-1-phosphate with soluble P-selectin and adverse clinical outcome in patients with cerebral ischemia with and without acetylsalicylic acid treatment
Associations of sphingosine-1-phosphate with soluble P-selectin and adverse clinical outcome in patients with cerebral ischemia with and without acetylsalicylic acid treatment Open
Patients with overt cerebral ischemia are at risk for adverse events after hospital discharge. Sphingosine-1-phosphate is a potent lipid mediator produced and secreted by platelets, which is inhibited via acetylsalicylic acid (ASA). The as…
View article: Dynamics of Vascular Protective and Immune Supportive Sphingosine-1-Phosphate During Cardiac Surgery
Dynamics of Vascular Protective and Immune Supportive Sphingosine-1-Phosphate During Cardiac Surgery Open
Introduction Sphingosine-1-phosphate (S1P) is a signaling lipid and crucial in vascular protection and immune response. S1P mediated processes involve regulation of the endothelial barrier, blood pressure and S1P is the only known inducer …
View article: Increased Sphingosine-1-Phosphate Serum Concentrations in Subjects with Periodontitis: A Matter of Inflammation
Increased Sphingosine-1-Phosphate Serum Concentrations in Subjects with Periodontitis: A Matter of Inflammation Open
We report an intriguingly significant association of various periodontal parameters with serum levels of the inflammatory lipid mediator S1P. Our data point towards a key role of S1P during periodontitis pathology. Modulation of local S1P …
View article: Sphingosine‐1‐Phosphate, Motor Severity, and Progression in Parkinson's Disease (<scp>MARK‐PD</scp>)
Sphingosine‐1‐Phosphate, Motor Severity, and Progression in Parkinson's Disease (<span>MARK‐PD</span>) Open
Background Treatment with sphingosine‐1‐phosphate (S1P) agonists confers neuroprotective effects in animal models of Parkinson's disease (PD). Objectives We assessed the association of serum S1P levels with motor and cognitive symptoms in …
View article: Determinants of Serum- and Plasma Sphingosine-1-Phosphate Concentrations in a Healthy Study Group
Determinants of Serum- and Plasma Sphingosine-1-Phosphate Concentrations in a Healthy Study Group Open
Introduction To correctly interpret plasma- or serum-sphingosine-1-phosphate (S1P) concentrations measured in clinical studies it is critical to understand all major determinants in healthy controls. Methods Serum- and plasma-S1P from 174 …
View article: Analyses of sphingosine‐1‐phosphate in the context of transfusion: how much is in stored blood products and in patient blood?
Analyses of sphingosine‐1‐phosphate in the context of transfusion: how much is in stored blood products and in patient blood? Open
BACKGROUND Sphingosine‐1‐phosphate (S1P) is a bloodborne lipid that regulates vascular tone and endothelial permeability. S1P concentrations are reduced in critically ill patients. As hematopoietic cells produce S1P, this study intends to …
View article: Data on subgroup specific baseline characteristics and serum sphingosine-1-phosphate concentrations in the Study of Health in Pomerania
Data on subgroup specific baseline characteristics and serum sphingosine-1-phosphate concentrations in the Study of Health in Pomerania Open
In this data article, we provide subgroup specific baseline characteristics and serum sphingosine-1-phosphate (S1P) concentrations for healthy individuals within the Study of Health in Pomerania (SHIP)-TREND cohort. After exclusion of subj…