Explanipedia

Xeligekimab, an Interleukin-17A Antagonist for Active Radiographic Axial Spondyloarthritis in Chinese Patients: 16- and 48-Week Results from a Phase III, Randomized, Double-Blind, Placebo-Controlled Study Open

Dong Xu, Shengyun Liu, Shujie Li, Xiaoxia Wang, Fenghong Yuan , et al. · 2025

ClinicalTrials.gov identifier: NCT05881785 (Date: 21 May 2023).

Disruption of Cell-Type-Specific Molecular Programs of Medium Spiny Neurons in Autism Open

Guohua Yuan, Varun Suresh, Emilie M. Wigdor, Yuhan Hao, Rachel Leonard , et al. · 2025

Autism spectrum disorders (ASD) are highly heritable neurodevelopmental conditions with major contributions from rare genetic variants. Most studies have focused on cortical mechanisms; even growing evidence implicates subcortical circuits…

Juvenile systemic lupus erythematosus complicated with posterior reversible encephalopathy syndrome: a case report and literature review Open

Man Luo, Huan He, Qing Zhou, Long Chen, Changming Xia , et al. · 2025

Background Posterior reversible encephalopathy syndrome (PRES) is an acute or subacute neurological syndrome with clinical manifestations including headache, vision loss, altered mental status, and seizures. Magnetic resonance imaging(MRI)…

A Homozygous Wnt10a Mutation Causes Tooth Agenesis With Open Bite Open

Guohua Yuan, Yan Wang, Ximin Xu, Jintao Guo · 2025

Introduction: Tooth agenesis (TA) is a prevalent inherited oral disorder, which can be classified into syndromic tooth agenesis (STA) and non-syndromic tooth agenesis (NSTA). WNT10A is one of most common causative gene of TA, and its mutat…

Expert consensus on the treatment of oral diseases in pregnant women and infants Open

Jilei Zhang, Chenchen Zhou, Liwei Zheng, Jun Wang, Bin Xia , et al. · 2025

With the growing emphasis on maternal and child oral health, the significance of managing oral health across preconception, pregnancy, and infancy stages has become increasingly apparent. Oral health challenges extend beyond affecting mate…

H3K36me3 modification by SETD2 is essential for Col11a2 and Sema3e transcription to maintain dentinogenesis in mice Open

Jiaxin Niu, Jing Fu, Hao Feng, Jiahao Han, Zhi Chen , et al. · 2025

Dentin is a major mineralized component of teeth generated by odontoblasts. Several types of histone methylation have been reported to play important roles in odontoblast differentiation and dentinogenesis. However, the role of methylation…

March2 suppresses odontoblast differentiation by polyubiquitinating Ptprd Open

Guohua Yuan, Hao Feng, Jiaxin Niu, Guobin Yang, Zhi Chen · 2025

Dentin, the main component of dental hard tissues, is produced by differentiated odontoblasts. How odontoblast differentiation is regulated remains understudied. Here, we screen that the expression of membrane-associated RING finger protei…

Dentin sialoprotein promotes endothelial differentiation of dental pulp stem cells through DSPaa34–50–endoglin–AKT1 axis Open

Ximin Xu, Jing Fu, Guobin Yang, Zhi Chen, Shuo Chen , et al. · 2025

A Novel Variant in Dentin Sialophosphoprotein (DSPP) Gene Causes Dentinogenesis Imperfecta Type III: Case Report Open

Yan Wang, Ximin Xu, Yuzhe Ding, Guohua Yuan · 2025

Background Hereditary dentin defects are a group of autosomal dominant disorders characterized by developmental abnormalities in dentin formation and mineralization. They can be categorized into dentin dysplasia and dentinogenesis imperfec…

Dentin sialoprotein acts as an angiogenic factor through association with the membrane receptor endoglin Open

Ximin Xu, Jing Fu, Guobin Yang, Zhi Chen, Shuo Chen , et al. · 2025

Dentin sialophosphoprotein (DSPP) is highly expressed by odontoblasts, the cell type responsible for dentin formation. DSPP therefore has been extensively studied as a regulator of dentinogenesis. Besides defective dentinogenesis in teeth,…

Selenium Nanozyme-Crosslinked Composite Hydrogel for Promoting Cartilage Regeneration in Osteoarthritis Via an Integrated ‘Outside-In’ and ‘Inside-Out’ Strategy Open

Wenyan Gao, Shaochun Li, Ya Miao, Guohua Yuan, Gaoyang Li , et al. · 2025

CREB3L1 deficiency impairs odontoblastic differentiation and molar dentin deposition partially through the TMEM30B Open

Yuanyuan Li, Yuxiu Lin, Jinqiang Guo, Delan Huang, Huanyan Zuo , et al. · 2024

Odontoblasts are primarily responsible for synthesizing and secreting extracellular matrix proteins, which are crucial for dentinogenesis. Our previous single-cell profile and RNAscope for odontoblast lineage revealed that cyclic adenosine…

Axin1 regulates tooth root development by inhibiting AKT1-mTORC1 activation and Shh translation in Hertwig's epithelial root sheath Open

Xiaoyu Zheng, Hongcan Huang, Zhipeng Zhou, Weihua Guo, Guobin Yang , et al. · 2024

Hertwig's epithelial root sheath (HERS) interacts with dental apical mesenchyme and guides development of the tooth root, which is integral to the function of the whole tooth. However, the key genes in HERS essential for root development a…

Clinical characteristics of systemic lupus erythematosus complicated with thrombocytopenia Open

Yuanhong Peng, Jirong Cheng, Di Ma, Miao He, Xing Li , et al. · 2024

Objective:To explore the clinical characteristics and treatment outcomes of systemic lupus erythematosus (SLE) complicated with thrombocytopenia (TP). Methods:The clinical data of SLE patients with TP were collected. These TP patients were…

CREB3L1 deficiency impairs odontoblastic differentiation and molar dentin deposition partially through the TMEM30B Open

Zhi Chen, Yuanyuan Li, Yuxiu Lin, Jinqiang Guo, Delan Huang , et al. · 2024

Odontoblasts are primarily responsible for synthesizing and secreting extracellular matrix proteins, which are crucial for dentinogenesis. Our previous single-cell profile and RNAscope for odontoblast lineage revealed that cyclic adenosine…

CREB3L1 deficiency impairs odontoblastic differentiation and molar root dentin deposition partially through the TMEM30B Open

Zhi Chen, Yuanyuan Li, Yuxiu Lin, Jinqiang Guo, Delan Huang , et al. · 2023

Odontoblasts are primarily responsible for synthesizing and secreting extracellular matrix proteins, which are crucial for dentinogenesis. Our previous single-cell profile and RNAscope for odontoblast lineage revealed that cyclic adenosine…

Loss of Bmp2 impairs odontogenesis via dysregulating pAkt/pErk/GCN5/Dlx3/Sp7 Open

Shuo Chen, Feng Wang, Guobin Yang, Guohua Yuan, Mengmeng Liu , et al. · 2023

BMP2 signaling plays a pivotal role in odontoblast differentiation and maturation during odontogenesis. Teeth lacking Bmp2 exhibit a morphology reminiscent of dentinogenesis imperfecta (DGI), associated with mutations in dentin matrix prot…

CHIP inhibits odontoblast differentiation through promoting DLX3 polyubiquitylation and degradation Open

Huiwen Zheng, Xiaobo Zhang, Jing Fu, Yifan Xue, Zhi Chen , et al. · 2023

Dentin is the major hard tissue of teeth formed by differentiated odontoblasts. How odontoblast differentiation is regulated remains enigmatic. Here, we report that the E3 ubiquitin ligase CHIP is highly expressed in undifferentiated denta…

Correlation Between Total Bilirubin, Total Bilirubin/Albumin Ratio with Disease Activity in Patients with Rheumatoid Arthritis Open

Hui Zhang, Guizhao Yang, Rongqiong Jiang, Dan Feng, Yuqin Li , et al. · 2023

Bilirubin levels remain associated with a reduction of disease activity, suggesting that bilirubin may be a protective factor for RA aggravation.

Large-scale benchmarking of circRNA detection tools reveals large differences in sensitivity but not in precision Open

Marieke Vromman, Jasper Anckaert, Stefania Bortoluzzi, Alessia Buratin, Chia-Ying Chen , et al. · 2022

The detection of circular RNA molecules (circRNAs) is typically based on short-read RNA sequencing data processed by computational detection tools. During the last decade, a plethora of such tools have been developed, but a systematic comp…

Expert consensus on clinical management for early childhood caries. Open

Qiong Zhang, Jun Wang, Bin Xia, Wei Zhao, Xu Chen , et al. · 2022

Early childhood caries (ECC) is the most prevalent chronic oral disease and one of the worldwide public health problems of great urgency for children. ECC can affect children's teeth, dentition, craniomaxillofacial, and general health and …

A WWP2–PTEN–KLF5 signaling axis regulates odontoblast differentiation and dentinogenesis in mice Open

Jing Fu, Xiaobo Zhang, Huiwen Zheng, Guobin Yang, Zhi Chen , et al. · 2022

WW domain-containing E3 Ubiquitin-protein ligase 2 (WWP2) has been found to positively regulate odontoblastic differentiation by monoubiquitinating the transcription factor Kruppel-like factor 5 (KLF5) in a cell culture system. However, th…

Role of the Demethylase AlkB Homolog H5 in the Promotion of Dentinogenesis Open

Cheng Tian, Jihua Chai, Weidong Liu, Xinye Zhang, Yashu Li , et al. · 2022

Dentinogenesis is a key process in tooth formation and is regulated by a series of pre- and post-transcriptional regulations. N6-methyl-adenosine (m 6 A), which is the most prevalent internal chemical modification that can be removed by th…

circKLF4 Upregulates Klf4 and Endoglin to Promote Odontoblastic Differentiation of Mouse Dental Papilla Cells via Sponging miRNA-1895 and miRNA-5046 Open

Yue Zhang, Hao Zhang, Guohua Yuan, Guobin Yang · 2022

circular RNAs (circRNAs) is a broad and diverse endogenous subfamily of non-coding RNAs, regulating the gene expression by acting as a microRNA (miRNA) sponge. However, the biological functions of circRNAs in odontoblast differentiation re…

Changes in paediatric dental clinic after reopening during COVID-19 pandemic in Wuhan: a retrospective study Open

Jinghui Yang, Guobin Yang, Runze Jin, Guangtai Song, Guohua Yuan · 2022

Objectives Affected by COVID-19 pandemic, The Department of Paediatric Dentistry of School and Hospital of Stomatology, Wuhan University was closed in late January 2020, and resumed on 20 April. Our study aimed to explore the effects of CO…

Ginkgolide B attenuates collagen-induced rheumatoid arthritis and regulates fibroblast-like synoviocytes-mediated apoptosis and inflammation Open

Xie Chuanmei, Jing Jiang, Jianping Liu, Guohua Yuan, Zhenyi Zhao · 2020

This study was the first to demonstrate that the anti-RA effect of GB is related to reducing articular cartilage and bone destruction, inducing RA-FLSs apoptosis, and regulating inflammatory cytokine release and the Wnt5a/JNK/NF-κB axis. A…

IPO7 Promotes Odontoblastic Differentiation of Mouse Dental Papilla Cells by Selectively Importing Odontogenic Transcription Factors Open

Yue Zhang, Hao Zhang, Guohua Yuan, Guobin Yang · 2020

Background : An important biological process for dentin formation and mineralization is odontoblast differentiation, which is precisely governed by a series of transcription factors (TFs). Importin 7 (IPO7) is a member of the Karyopherin β…

Gelatinases Cleave Dentin Sialoprotein Intracellularly Open

Xiaohui Gou, Yifan Xue, Huiwen Zheng, Guobin Yang, Shuo Chen , et al. · 2020

Dentin sialoprotein (DSP), the NH2-terminal fragment of dentin sialophosphoprotein (DSPP), is essential for dentin formation and further processed into small fragments inside the odontoblasts. Gelatinases, including matrix metalloproteinas…

Biomineral Precursor Formation Is Initiated by Transporting Calcium and Phosphorus Clusters from the Endoplasmic Reticulum to Mitochondria Open

Cuizhu Tang, Yan Wei, Lin Gu, Qinghua Zhang, Mei Li , et al. · 2020

Mineral granules in the mitochondria of bone‐forming cells are thought to be the origin of biomineral precursors, which are transported to extracellular matrices to initiate cell‐mediated biomineralization. However, no evidence has reveale…

Triptolide suppresses human synoviocyte MH7A cells mobility and maintains redox balance by inhibiting autophagy Open

Chuanmei Xie, Jing Jiang, Jianping Liu, Guohua Yuan, Zhenyi Zhao · 2019

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