Jin‐He Guo
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View article: 125I stent plus combination therapy for HCC and portal vein tumor thrombosis: a nationwide target trial emulation
125I stent plus combination therapy for HCC and portal vein tumor thrombosis: a nationwide target trial emulation Open
Background: Patients with hepatocellular carcinoma (HCC) and Vp4 portal vein tumor thrombosis (PVTT) have a poor prognosis and limited effective treatment options. Purpose: To evaluate the safety and efficacy of irradiation stent placement…
View article: 125I seed brachytherapy synergized with PD-1 inhibitor imparts potent antitumor immune responses in hepatocellular carcinoma
125I seed brachytherapy synergized with PD-1 inhibitor imparts potent antitumor immune responses in hepatocellular carcinoma Open
View article: 626 Real-time multidimensional prognostic model for immuno-chemotherapy in advanced biliary tract cancer: an observational multicohort study
626 Real-time multidimensional prognostic model for immuno-chemotherapy in advanced biliary tract cancer: an observational multicohort study Open
View article: Associations between serum 25– hydroxyvitamin D concentrations and assisted reproductive technology outcomes in women with polycystic ovary syndrome: a cohort study
Associations between serum 25– hydroxyvitamin D concentrations and assisted reproductive technology outcomes in women with polycystic ovary syndrome: a cohort study Open
Background The impact of serum vitamin D levels on the success of assisted reproductive technology (ART) among women with polycystic ovary syndrome (PCOS) has not been fully explored. Methods This cohort study enrolled 111 patients with PC…
View article: P4HA2 interacted with ATAD3A to modulate PINK1/parkin-dependent mitophagy and 125I brachytherapy sensitization in esophageal carcinoma
P4HA2 interacted with ATAD3A to modulate PINK1/parkin-dependent mitophagy and 125I brachytherapy sensitization in esophageal carcinoma Open
Interventional brachytherapy, such as iodine-125( 125 I), has improved the survival of obstructive late-stage esophageal cancer patients. However, most patients experience radioresistance after 125 I brachytherapy. It is key to decipher th…
View article: Daily multi-time monitoring of SLST jointly using FY-3 dawn-dusk and afternoon orbit satellite data with 250 m resolution
Daily multi-time monitoring of SLST jointly using FY-3 dawn-dusk and afternoon orbit satellite data with 250 m resolution Open
Snow/land surface temperature (SLST) has a significant impact on snow melting, metamorphism, and land-atmosphere energy exchange. It is also an important factor that affects outdoor skiing during the Olympic Winter Games (OWG). Currently, …
View article: Combination of hepatic artery infusion chemotherapy and PD1 immune checkpoint inhibitor improve survival in patients with KRAS-mutated unresectable colorectal liver metastases: A propensity score matching study
Combination of hepatic artery infusion chemotherapy and PD1 immune checkpoint inhibitor improve survival in patients with KRAS-mutated unresectable colorectal liver metastases: A propensity score matching study Open
Objective: This study examined the effect of hepatic arterial infusion chemotherapy (HAIC) plus programmed death 1 inhibitors (HAICPs) in patients with unresected colorectal cancer liver metastases (UCRLM) with and without KRAS mutations. …
View article: China Liver Cancer Guidelines for the Diagnosis and Treatment of Hepatocellular Carcinoma (2024 Edition)
China Liver Cancer Guidelines for the Diagnosis and Treatment of Hepatocellular Carcinoma (2024 Edition) Open
Hepatocellular carcinoma (HCC), which accounts for approximately 75–85% of primary liver cancers, ranks 4th in newly diagnosed cases among various types of cancer in China, and is the 2nd leading cause of cancer-related mortality, thereby …
View article: Trends and future directions in chronic rhinosinusitis with nasal polyps: A bibliometric analysis
Trends and future directions in chronic rhinosinusitis with nasal polyps: A bibliometric analysis Open
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View article: Interventional management of pancreatic cancer: Current strategies and future horizons
Interventional management of pancreatic cancer: Current strategies and future horizons Open
Pancreatic cancer is a highly lethal malignancy characterized by rapid progression and increasing global incidence and mortality rates. Although surgery remains the only potentially curative treatment, most patients are ineligible for surg…
View article: Hepatic artery infusion chemotherapy plus an immune checkpoint inhibitor and lenvatinib for the treatment of biliary tract carcinoma
Hepatic artery infusion chemotherapy plus an immune checkpoint inhibitor and lenvatinib for the treatment of biliary tract carcinoma Open
The combination therapy of Gemox-HAIC with ICIs and lenvatinib shows promising efficacy and tolerable safety profiles in BTC patients.
View article: Is high IgG level associated with disease activity and organ damage in patients with Sjögren’s syndrome? A 3-year follow-up cohort study
Is high IgG level associated with disease activity and organ damage in patients with Sjögren’s syndrome? A 3-year follow-up cohort study Open
Hypergammaglobulinemia is prevalent in primary Sjögren's syndrome (pSS) and is considered a marker of disease activity. However, limited data exist regarding its association with disease activity and organ damage. We enrolled patients with…
View article: Prognostic impact of surgery on thymic malignancies with concurrent or previous extrathymic malignancies: a retrospective analysis from 1998 to 2021
Prognostic impact of surgery on thymic malignancies with concurrent or previous extrathymic malignancies: a retrospective analysis from 1998 to 2021 Open
In conclusion, this study shows that surgery may significantly improve the survival rate of PMTEMs.
View article: Ferroptosis inhibition: New insights for the treatment of acute lung injury
Ferroptosis inhibition: New insights for the treatment of acute lung injury Open
View article: Nanoscale CaO<sub>2</sub>‐Loaded Surface‐Engineered Iodine‐125 Seed with Sustained Self‐Oxygenation for Sensitized Tumor Brachytherapy
Nanoscale CaO<sub>2</sub>‐Loaded Surface‐Engineered Iodine‐125 Seed with Sustained Self‐Oxygenation for Sensitized Tumor Brachytherapy Open
Iodine‐125 ( 125 I) brachytherapy (BT) is renowned for its precision and effectiveness in delivering localized radiation doses to solid tumors. However, the therapeutic efficacy of traditional 125 I seed is often limited due to the inheren…
View article: Camrelizumab Combined with Chemotherapy and Apatinib as First-Line Therapy for Extensive-Stage Small-Cell Lung Cancer: A Single-Arm, Phase II Study
Camrelizumab Combined with Chemotherapy and Apatinib as First-Line Therapy for Extensive-Stage Small-Cell Lung Cancer: A Single-Arm, Phase II Study Open
View article: The Impact of Economic Status on Cause-Specific Survival in Patients with Esophageal Adenocarcinoma in the United States: A Retrospective Analysis
The Impact of Economic Status on Cause-Specific Survival in Patients with Esophageal Adenocarcinoma in the United States: A Retrospective Analysis Open
Objective This study aims to evaluate the impact of economic status on the cause-specific survival (CSS) of patients with esophageal adenocarcinoma (EAC). Methods Using propensity score matching (PSM), we analyzed data from 4676 patients w…
View article: Radiation-emitting metallic stent for unresectable Bismuth type III or IV perihilar cholangiocarcinoma: a multicenter randomized trial
Radiation-emitting metallic stent for unresectable Bismuth type III or IV perihilar cholangiocarcinoma: a multicenter randomized trial Open
Background and Aims: Self-expandable metallic stents (SEMSs) have been recommended for patients with unresectable malignant biliary obstruction, while radiation-emitting metallic stents (REMSs) loaded with 125 I seeds have recently been ap…
View article: Guidelines for permanent iodine-125 seed interstitial brachytherapy for pancreatic cancer (2023 edition): The Chinese expert consensus workshop report
Guidelines for permanent iodine-125 seed interstitial brachytherapy for pancreatic cancer (2023 edition): The Chinese expert consensus workshop report Open
The incidence of pancreatic cancer is increasing worldwide. Approximately, 60% of patients with pancreatic cancer have distant metastases at the time of diagnosis, of which only 10% can be removed using standard resection. Further, patient…
View article: Clinical features and prognostic factors of patients with inoperable hepatocellular carcinoma treated with chemotherapy: a population-based study
Clinical features and prognostic factors of patients with inoperable hepatocellular carcinoma treated with chemotherapy: a population-based study Open
We preliminarily developed survival models with strong predictive capabilities for estimating survival probabilities in patients with HCC following chemotherapy. These models hold potential for clinical application and warrant further expl…
View article: Exploring immune-related pathogenesis in lung injury: Providing new insights Into ALI/ARDS
Exploring immune-related pathogenesis in lung injury: Providing new insights Into ALI/ARDS Open
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) represent a significant global burden of morbidity and mortality, with lung injury being the primary cause of death in affected patients. The pathogenesis of lung injur…
View article: Kallstatin/Serpina3c improves hyperlipidemia induced by high-fat diet via regulating glycolipid metabolism in adipose tissue
Kallstatin/Serpina3c improves hyperlipidemia induced by high-fat diet via regulating glycolipid metabolism in adipose tissue Open
Background Hyperlipidemia is an independent risk factor for cardiovascular diseases. Studies showed that the plasma Kallstatin (KS) in obese patients was reduced, and the decreased KS in obese patients with type 2 diabetes was increased af…
View article: Endovascular brachytherapy with iodine-125 seed strand for extensive portal vein tumor thrombus in patients with hepatocellular carcinoma
Endovascular brachytherapy with iodine-125 seed strand for extensive portal vein tumor thrombus in patients with hepatocellular carcinoma Open
Objective The aim of this study is to investigate the feasibility and effectiveness of endovascular brachytherapy with iodine-125 (I-125) seed strand for the treatment of extensive portal vein tumor thrombus (PVTT) in hepatocellular carcin…
View article: A Novel Neutrophil-to-Lymphocyte Ratio and Sarcopenia Based TACE-Predict Model of Hepatocellular Carcinoma Patients
A Novel Neutrophil-to-Lymphocyte Ratio and Sarcopenia Based TACE-Predict Model of Hepatocellular Carcinoma Patients Open
A novel nomogram based on NLR and sarcopenia may be useful to predict the prognosis of HCC patients who underwent TACE across BCLC A-C stage patients.
View article: Expert Consensus on the Interventional Treatment of Choledocholithiasis with Integrative Medicine
Expert Consensus on the Interventional Treatment of Choledocholithiasis with Integrative Medicine Open
Percutaneous transhepatic papillary balloon drainage (PTPBD) is a newly emerging interventional treatment modality for choledocholithiasis in China. Compared with other treatments, it has some advantages. Traditional Chinese medicine has b…
View article: HSV: The scout and assault for digestive system tumors
HSV: The scout and assault for digestive system tumors Open
More than 25% of all malignant tumors are digestive system tumors (DSTs), which mostly include esophageal cancer, gastric cancer, pancreatic cancer, liver cancer, gallbladder cancer and cholangiocarcinoma, and colorectal cancer. DSTs have …
View article: AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation
AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation Open
View article: Chinese expert consensus on conversion and perioperative therapy of primary liver cancer (2024 edition)
Chinese expert consensus on conversion and perioperative therapy of primary liver cancer (2024 edition) Open
View article: Establishment and validation of a prediction model for the first recurrence of Budd–Chiari syndrome after endovascular treatment: a large sample size, single-center retrospective study
Establishment and validation of a prediction model for the first recurrence of Budd–Chiari syndrome after endovascular treatment: a large sample size, single-center retrospective study Open