Jun Guo
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View article: 1-Year Clinical Outcomes and the Impact of Procedural Configurations in Left Atrial Appendage Occlusion Patients
1-Year Clinical Outcomes and the Impact of Procedural Configurations in Left Atrial Appendage Occlusion Patients Open
In Chinese centers, patients undergoing LAAO had low rates of ischemic and bleeding events at 1 year. Combining LAAO with catheter ablation was associated with a lower rate of ischemic events than LAAO only. (Registry to Evaluate Chinese R…
View article: Mendelian randomization study on the causal relationship between chronic hepatitis B/C virus infection and idiopathic pulmonary fibrosis
Mendelian randomization study on the causal relationship between chronic hepatitis B/C virus infection and idiopathic pulmonary fibrosis Open
This study, using the bidirectional MR, provides preliminary evidence that chronic HBV and HCV infections are not causally related to IPF at the genetic level. However, this conclusion requires support from larger sample sizes in genome-wi…
View article: An Explainable Non-local Network for COVID-19 Diagnosis
An Explainable Non-local Network for COVID-19 Diagnosis Open
The CNN has achieved excellent results in the automatic classification of medical images. In this study, we propose a novel deep residual 3D attention non-local network (NL-RAN) to classify CT images included COVID-19, common pneumonia, an…
View article: Multi-expert ensemble ECG diagnostic algorithm using mutually exclusive–symbiotic correlation between 254 hierarchical multiple labels
Multi-expert ensemble ECG diagnostic algorithm using mutually exclusive–symbiotic correlation between 254 hierarchical multiple labels Open
Electrocardiograms (ECGs) are a cheap and convenient means of assessing heart health and provide an important basis for diagnosis and treatment by cardiologists. However, existing intelligent ECG diagnostic approaches can only detect up to…
View article: Normal forms for ordinary differential operators, I
Normal forms for ordinary differential operators, I Open
In this paper we develop the generalised Schur theory offered in the recent paper by the second author in dimension one case, and apply it to obtain a new explicit parametrisation of torsion free rank one sheaves on projective irreducible …
View article: [Selection of postoperative adjuvant therapy for patients with stage IB lung adenocarcinoma: analysis of 653 cases].
[Selection of postoperative adjuvant therapy for patients with stage IB lung adenocarcinoma: analysis of 653 cases]. Open
Adjuvant therapy with TKIs helps improve DFS in patients with stage IB (T3-4cmN0M0) lung adenocarcinoma but not in patients with T2ViscPlN0M0. Adjuvant chemotherapy does not improve DFS or OS in patients with stage IB lung adenocarcinoma.
View article: A rare mutation in THRB gene of resistance to thyroid hormone: a case report of a Chinese pedigree
A rare mutation in THRB gene of resistance to thyroid hormone: a case report of a Chinese pedigree Open
Learning points for cliniciansClinical manifestations of resistance to thyroid hormone syndrome (RTH) exhibit a wide range of variations.Here, we present a Chinese pedigree harboring a thyroid hormone receptor beta (THRB) gene mutation (c.…
View article: Multi-expert ensemble ECG diagnostic algorithm using mutually exclusive-symbiotic correlation between 254 hierarchical multiple labels
Multi-expert ensemble ECG diagnostic algorithm using mutually exclusive-symbiotic correlation between 254 hierarchical multiple labels Open
Electrocardiograms (ECGs) are a cheap and convenient means of assessing heart health, and provide an important basis for diagnosis and treatment by cardiologists. However, existing intelligent ECG diagnostic approaches can only detect up t…
View article: Sex Differences in Clinical Outcomes Associated With Quantitative Flow Ratio-Guided Percutaneous Coronary Intervention
Sex Differences in Clinical Outcomes Associated With Quantitative Flow Ratio-Guided Percutaneous Coronary Intervention Open
BACKGROUND: FAVOR III China (Comparison of Quantitative Flow Ratio Guided and Angiography Guided Percutaneous Intervention in Patients with Coronary Artery Disease) reported improved clinical outcomes in quantitative flow ratio (QFR) relat…
View article: Application of AMR in evaluating microvascular dysfunction after ST‐elevation myocardial infarction
Application of AMR in evaluating microvascular dysfunction after ST‐elevation myocardial infarction Open
Background A guidewire‐free angiography‐derived microcirculatory resistance (AMR) derived from Quantitative flow ratio (QFR) exhibits good diagnostic accuracy for assessing coronary microvascular dysfunction (CMD), but there are no relevan…
View article: Phase II clinical trial of neoadjuvant anti-PD-1 (toripalimab) combined with axitinib in resectable mucosal melanoma
Phase II clinical trial of neoadjuvant anti-PD-1 (toripalimab) combined with axitinib in resectable mucosal melanoma Open
Neoadjuvant toripalimab combined with axitinib in resectable mucosal melanoma demonstrated a promising pathologic response rate with significantly increased infiltrating CD3+ and CD3+CD8+ T cells after therapy.
View article: Case report of a child with long <scp>QT</scp> syndrome type 14 caused by <scp>CALM1</scp> gene mutation and literature review
Case report of a child with long <span>QT</span> syndrome type 14 caused by <span>CALM1</span> gene mutation and literature review Open
Objective To analyze the clinical and genetic characteristics of a patient with long QT syndrome type 14 (long QT syndrome‐14, LQT14, OMIM # 616247) caused by a de novo CALM1 mutation. Methods The clinical data of the patient were collecte…
View article: Radiomics Prediction Models of Left Atrial Appendage Hypercoagulability Based on Machine Learning Algorithms: An Exploration about Cardiac Computed Tomography Angiography Imaging
Radiomics Prediction Models of Left Atrial Appendage Hypercoagulability Based on Machine Learning Algorithms: An Exploration about Cardiac Computed Tomography Angiography Imaging Open
Background: Transesophageal echocardiography(TEE) is the standard method for diagnosing left atrial appendage (LAA) hypercoagulability in patients with atrial fibrillation (AF), which means LAA thrombus/sludge, dense spontaneous echo contr…
View article: Efficiency of optimal fluoroscopic projection angle defined by computed tomography angiography for left atrial appendage closure
Efficiency of optimal fluoroscopic projection angle defined by computed tomography angiography for left atrial appendage closure Open
By unfolding the LAA depth and orifice diameter for a better view, OPA demonstrated the potential to optimize LAAC procedural efficiency, although further larger-scale studies are required to confirm this.
View article: Feasibility and safety of the direct current cardioversion at the time of left atrial appendage occlusion for patients with atrial fibrillation
Feasibility and safety of the direct current cardioversion at the time of left atrial appendage occlusion for patients with atrial fibrillation Open
Background With an increasing number of patients undergoing left atrial appendage occlusion (LAAO), more attention is being paid to relieving clinical symptoms and improving the quality of life of these patients. For patients with atrial f…
View article: Practical intelligent diagnostic algorithm for wearable 12-lead ECG via self-supervised learning on large-scale dataset
Practical intelligent diagnostic algorithm for wearable 12-lead ECG via self-supervised learning on large-scale dataset Open
Cardiovascular disease is a major global public health problem, and intelligent diagnostic approaches play an increasingly important role in the analysis of electrocardiograms (ECGs). Convenient wearable ECG devices enable the detection of…
View article: Does the homologous booster with the inactivated coronavirus disease 2019 vaccine work for the omicron variant? Real-world evidence from Jilin, China
Does the homologous booster with the inactivated coronavirus disease 2019 vaccine work for the omicron variant? Real-world evidence from Jilin, China Open
To the Editor: The latest variant of concern, Omicron, has become the dominant global variant immediately after it was first reported in November 2021.[1] It contains >30 mutations in the spike protein, with 17 mutations in the receptor-bi…
View article: Supplemental Table 2 from Mechanisms of Acquired Resistance to Trastuzumab Emtansine in Breast Cancer Cells
Supplemental Table 2 from Mechanisms of Acquired Resistance to Trastuzumab Emtansine in Breast Cancer Cells Open
KPL-4 TR vs. Parental cells, gene expression changes > 5-fold
View article: Supplemental Figures and Legends from Mechanisms of Acquired Resistance to Trastuzumab Emtansine in Breast Cancer Cells
Supplemental Figures and Legends from Mechanisms of Acquired Resistance to Trastuzumab Emtansine in Breast Cancer Cells Open
Supplemental Figure 1. Upregulated BHLHE41 in KPL-4 TR and BT-474M1 TR cells does not confer resistance to T-DM1. Supplemental Figure 2. Flow cytometry analysis of HER2 and MDR1 expression in KPL-4 P and TR cells, and tumor derived KPL-4 T…
View article: Data from Mechanisms of Acquired Resistance to Trastuzumab Emtansine in Breast Cancer Cells
Data from Mechanisms of Acquired Resistance to Trastuzumab Emtansine in Breast Cancer Cells Open
The receptor tyrosine kinase HER2 is overexpressed in approximately 20% of breast cancer, and its amplification is associated with reduced survival. Trastuzumab emtansine (Kadcyla, T-DM1), an antibody–drug conjugate that is comprised of tr…
View article: Supplemental Table 3 from Mechanisms of Acquired Resistance to Trastuzumab Emtansine in Breast Cancer Cells
Supplemental Table 3 from Mechanisms of Acquired Resistance to Trastuzumab Emtansine in Breast Cancer Cells Open
Differentially expressed genes in T-DM1-resistant BT-474M1 cells with respect to the parental cell line (fold change > 2 fold and P < 0.05 of individual probes for a given gene in the microarray)
View article: Data from Mechanisms of Acquired Resistance to Trastuzumab Emtansine in Breast Cancer Cells
Data from Mechanisms of Acquired Resistance to Trastuzumab Emtansine in Breast Cancer Cells Open
The receptor tyrosine kinase HER2 is overexpressed in approximately 20% of breast cancer, and its amplification is associated with reduced survival. Trastuzumab emtansine (Kadcyla, T-DM1), an antibody–drug conjugate that is comprised of tr…
View article: Supplemental Table 2 from Mechanisms of Acquired Resistance to Trastuzumab Emtansine in Breast Cancer Cells
Supplemental Table 2 from Mechanisms of Acquired Resistance to Trastuzumab Emtansine in Breast Cancer Cells Open
KPL-4 TR vs. Parental cells, gene expression changes > 5-fold
View article: Table S1 from Safety, Efficacy, and Biomarker Analysis of Toripalimab in Previously Treated Advanced Melanoma: Results of the POLARIS-01 Multicenter Phase II Trial
Table S1 from Safety, Efficacy, and Biomarker Analysis of Toripalimab in Previously Treated Advanced Melanoma: Results of the POLARIS-01 Multicenter Phase II Trial Open
Grade 3 and above treatment-related adverse events in the study.