Guoping Chen
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View article: Impact of catheter-directed thrombolysis access approach on entire-limb deep vein thrombosis: a focus on inflow patency
Impact of catheter-directed thrombolysis access approach on entire-limb deep vein thrombosis: a focus on inflow patency Open
Objective This retrospective study aimed to evaluate the influence of inflow (femoropopliteal) patency on the efficacy of catheter-directed thrombolysis (CDT) in treating entire-limb deep venous thrombosis (DVT). Methods From January 2018 …
View article: Research Strategies and Methods of Hydrogels for Antitumor Drug Delivery
Research Strategies and Methods of Hydrogels for Antitumor Drug Delivery Open
Tumor treatments have substantially advanced through various approaches, including chemotherapy, radiotherapy, immunotherapy, and gene therapy. However, efficient treatment necessitates overcoming physiological barriers that impede the del…
View article: Advanced Cancer Immunotherapy via SMARCAL1 Blockade Using a Glucose‐Responsive CRISPR Nanovaccine
Advanced Cancer Immunotherapy via SMARCAL1 Blockade Using a Glucose‐Responsive CRISPR Nanovaccine Open
Cancer immunotherapy that activates the stimulator of interferon genes (STING) signaling pathway to resist tumors has recently attracted considerable attention. However, STING activation can induce opposing interferon functions that contri…
View article: Targeting CD16A on NK cells and GPC3 in hepatocellular carcinoma: development and functional validation of a therapeutic bispecific antibody
Targeting CD16A on NK cells and GPC3 in hepatocellular carcinoma: development and functional validation of a therapeutic bispecific antibody Open
Introduction Advanced hepatocellular carcinoma (HCC) poses significant therapeutic challenges due to chemotherapy resistance and limited efficacy of current targeted therapies. To address this unmet need, we developed a bispecific antibody…
View article: Understanding Self‐Perceived and Other‐Perceived Body Image in Adolescents: The Roles of Neuroticism, Mindfulness, and Self‐Compassion
Understanding Self‐Perceived and Other‐Perceived Body Image in Adolescents: The Roles of Neuroticism, Mindfulness, and Self‐Compassion Open
This study explored the intricate dynamics between neuroticism and body image among adolescents, focusing on the mediating roles of mindfulness and self‐compassion. We also differentiate between self‐perceived body image—how individuals vi…
View article: Harnessing delta-like ligand 3: bridging biomarker discovery to next-generation immunotherapies in refractory small cell lung cancer
Harnessing delta-like ligand 3: bridging biomarker discovery to next-generation immunotherapies in refractory small cell lung cancer Open
Small cell lung cancer (SCLC), accounting for 10–20% of lung cancers, remains one of the most aggressive neuroendocrine malignancies, with fewer than 7% of patients surviving beyond five years. While the addition of immune checkpoint inhib…
View article: YEATS2: a novel cancer epigenetic reader and potential therapeutic target
YEATS2: a novel cancer epigenetic reader and potential therapeutic target Open
YEATS2, an evolutionarily conserved reader of histone acylation marks (H3K27ac, H3K27cr, H3K27bz), functions as a central oncogenic driver in diverse cancers, including non-small cell lung cancer (NSCLC), pancreatic ductal adenocarcinoma (…
View article: Morphological Parameters of 29994 sperm in a fertile male population—based on Papanicolaou staining and SSA-II Plus
Morphological Parameters of 29994 sperm in a fertile male population—based on Papanicolaou staining and SSA-II Plus Open
Objective This study aims to provide reference data for sperm morphology in a healthy, fertile male population providing a foundation for future studies on male infertility assessment and sperm selection in assisted reproductive technologi…
View article: Enhancing Photocatalytic Hydrogen Evolution with Oxygen Vacancy-Modified P/Ag/Ag2O/Ag3PO4/TiO2 by Using Optimized NaBH4 Reduction Strategy
Enhancing Photocatalytic Hydrogen Evolution with Oxygen Vacancy-Modified P/Ag/Ag2O/Ag3PO4/TiO2 by Using Optimized NaBH4 Reduction Strategy Open
The introduction of oxygen vacancies (OVs) is a promising strategy to enhance the hydrogen (H2) evolution efficiency of photocatalysts. Sodium borohydride (NaBH4) is widely used as a reducing agent to introduce OVs, particularly in composi…
View article: Endoscopic surgery affects the gut microbiota and its metabolism in breast cancer patients
Endoscopic surgery affects the gut microbiota and its metabolism in breast cancer patients Open
Background Despite the advantages of endoscopic surgery in reducing trauma and enhancing recovery for breast cancer patients, its impact on gut microbiota, which is crucial for health and estrogen metabolism, remains unclear. Further inves…
View article: Differential intracellular influence of cancer cells and normal cells on magnetothermal properties and magnetic hyperthermal effects of magnetic nanoparticles
Differential intracellular influence of cancer cells and normal cells on magnetothermal properties and magnetic hyperthermal effects of magnetic nanoparticles Open
Differential influence of the intracellular microenvironment of cancer cells and normal cells on the magnetothermal properties of internalized MNPs and the magnetic hyperthermia efficiency.
View article: Advances in cardiac ultrasound speckle tracking technology for assessing left ventricular systolic function after adjuvant radiotherapy following breast-conserving surgery for breast cancer
Advances in cardiac ultrasound speckle tracking technology for assessing left ventricular systolic function after adjuvant radiotherapy following breast-conserving surgery for breast cancer Open
Breast-conserving surgery is a widely used treatment for breast cancer, often followed by adjuvant therapy such as adjuvant paclitaxel and trastuzumab (APT). While APT effectively reduces local recurrence and distant metastasis, it may als…
View article: Self-control as a predictor of peer relationships in adolescents with rumination as a mediator and gender-role orientation as a moderator: An intervention study
Self-control as a predictor of peer relationships in adolescents with rumination as a mediator and gender-role orientation as a moderator: An intervention study Open
Peer relationships are essential for the social development of adolescents and serve as indicators of social health. Previous research indicates that individuals with high self-control tend to engage in behaviors that strengthen peer relat…
View article: Tailoring cell behaviour by surface micropatterning and interconnected porous structure of gelatin/nano-silica/PLGA 3D composite scaffold for bone tissue engineering
Tailoring cell behaviour by surface micropatterning and interconnected porous structure of gelatin/nano-silica/PLGA 3D composite scaffold for bone tissue engineering Open
3D gelatin/nanosilica/PLGA scaffold with micro-patterned surface and interconnected porous construct was made via Aerojet dispenser 3D printer and ice particulates method to guide cell and enhance nutrient transport for bone regeneration.
View article: Integration of metabolomics and transcriptomics analyses reveals the effects of nano-selenium on pak choi
Integration of metabolomics and transcriptomics analyses reveals the effects of nano-selenium on pak choi Open
Selenium is an essential nutrient element for plants, and optimal selenium levels can enhance plant growth and metabolism while improving yield and quality. Suzhouqing serves as a significant source of selenium for human consumption. Howev…
View article: Pentagon‐Rich Caged Carbon Catalyst for the Oxygen Reduction Reaction in Acidic Electrolytes
Pentagon‐Rich Caged Carbon Catalyst for the Oxygen Reduction Reaction in Acidic Electrolytes Open
The interaction between electron spin and oxygen molecules in non‐platinum catalysts, particularly carbon catalysts, significantly influences the catalytic performance of the oxygen reduction reaction (ORR). A promising approach to develop…
View article: Detection of serum SNHG22 and its correlation with prognosis of non-small cell lung cancer
Detection of serum SNHG22 and its correlation with prognosis of non-small cell lung cancer Open
The overexpression of SNHG22 in NSCLC is related to lymph node metastasis, TNM stage and patient survival, which is expected to be a prognostic predictor of NSCLC patients.
View article: Efficacy and safety analysis of AKT inhibitor in triple-negative breast cancer: A meta-analysis and systematic review
Efficacy and safety analysis of AKT inhibitor in triple-negative breast cancer: A meta-analysis and systematic review Open
Objective: To determine the clinical benefit of monotherapy with AKT inhibitors in patients diagnosed with triple-negative breast cancer (TNBC). Methods: A systematic search was conducted in PubMed, Embase, and Cochrane Library for article…
View article: Integrating risk zoning and multifactor analysis: A strategic approach to ecological carbon sink management
Integrating risk zoning and multifactor analysis: A strategic approach to ecological carbon sink management Open
Ecological carbon sinks play a crucial role in global carbon cycling and climate mitigation, making their effective management essential. This study develops a novel risk zoning and multifactor analysis framework for ecological carbon sink…
View article: Coupling and Coordination Relationship of Economic–Social–Natural Composite Ecosystem in Central Yunnan Urban Agglomeration
Coupling and Coordination Relationship of Economic–Social–Natural Composite Ecosystem in Central Yunnan Urban Agglomeration Open
Exploring the spatio-temporal differentiation characteristics and coupling coordination relationship of the composite ecosystem of urban agglomerations is of great significance for promoting the synergistic sustainable development and inte…
View article: Humanistic Health Management and Cancer: Associations of Psychology, Nutrition, and Exercise with Cancer Progression and Pathogenesis
Humanistic Health Management and Cancer: Associations of Psychology, Nutrition, and Exercise with Cancer Progression and Pathogenesis Open
The incidence rate of cancer is increasing year by year due to the aging of the population, unhealthy living, and eating habits. At present, surgery and medication are still the main treatments for cancer, without paying attention to the i…
View article: Effect of Hydrogel Stiffness on Chemoresistance of Breast Cancer Cells in 3D Culture
Effect of Hydrogel Stiffness on Chemoresistance of Breast Cancer Cells in 3D Culture Open
Chemotherapy is one of the most common strategies for cancer treatment, whereas drug resistance reduces the efficiency of chemotherapy and leads to treatment failure. The mechanism of emerging chemoresistance is complex and the effect of e…
View article: Management of complex jugular paragangliomas: surgical resection and outcomes
Management of complex jugular paragangliomas: surgical resection and outcomes Open
Objectives: To review surgical outcomes in patients with complex jugular paragangliomas（CJPs）and to refine the surgical strategies for CJPs. Design: A retrospective study . Setting: A single university hospital. Participants: Twelve patien…
View article: Coupling and Coordination Relationship of Social-Economic-Natural Composite Ecosystem in Central Yunnan Urban Agglomeration
Coupling and Coordination Relationship of Social-Economic-Natural Composite Ecosystem in Central Yunnan Urban Agglomeration Open
Exploring the spatio-temporal differentiation characteristics and coupling coordination relationship of the composite ecosystem of urban agglomerations is of great significance for promoting the synergistic development and integration cons…