Zhen Wang
YOU?
Author Swipe
View article: Force Reversal During Systolic–Diastolic Transition Provides Incremental Prognostic Value over LVEF for Heart Failure After STEMI
Force Reversal During Systolic–Diastolic Transition Provides Incremental Prognostic Value over LVEF for Heart Failure After STEMI Open
Background: Left ventricular hemodynamic forces (LV HDFs) are altered in myocardial dysfunction. While infarct location and size influence post-ST-segment elevation myocardial infarction (STEMI) remodeling, their specific effects on HDFs r…
View article: Antler stem cell-derived exosomes restore periodontal homeostasis in a rat model with diabetic periodontitis through enhancing ROS scavenging and osteogenesis
Antler stem cell-derived exosomes restore periodontal homeostasis in a rat model with diabetic periodontitis through enhancing ROS scavenging and osteogenesis Open
View article: Causal Effect of Blood Cell Perturbation Phenotypes on Multiple Sclerosis via Immune Mediation: A Mendelian Randomization Study
Causal Effect of Blood Cell Perturbation Phenotypes on Multiple Sclerosis via Immune Mediation: A Mendelian Randomization Study Open
Multiple sclerosis (MS) is an inflammatory disease that affects the central nervous system, characterized by myelin damage caused by immune dysfunction and genetic factors. Nevertheless, the role of peripheral blood and immune cells in the…
View article: Alternate day fasting alleviates neuroinflammation in diabetic mice by regulating δ-valerobetaine-carnitine-microglia axis via enrichment of Akkermansia muciniphila
Alternate day fasting alleviates neuroinflammation in diabetic mice by regulating δ-valerobetaine-carnitine-microglia axis via enrichment of Akkermansia muciniphila Open
View article: Recent advances in the diagnosis of celiac disease
Recent advances in the diagnosis of celiac disease Open
Celiac disease (CD) is a prevalent immune-mediated disorder triggered by gluten ingestion in genetically susceptible individuals. Primarily affecting the small intestine, CD can also have adverse systemic health effects. However, the major…
View article: FinDebate: Multi-Agent Collaborative Intelligence for Financial Analysis
FinDebate: Multi-Agent Collaborative Intelligence for Financial Analysis Open
We introduce FinDebate, a multi-agent framework for financial analysis, integrating collaborative debate with domain-specific Retrieval-Augmented Generation (RAG). Five specialized agents, covering earnings, market, sentiment, valuation, a…
View article: Can GRPO Boost Complex Multimodal Table Understanding?
Can GRPO Boost Complex Multimodal Table Understanding? Open
Existing table understanding methods face challenges due to complex table structures and intricate logical reasoning. While supervised finetuning (SFT) dominates existing research, reinforcement learning (RL), such as Group Relative Policy…
View article: Unicentric Castleman disease in the left adrenal region: a case report and literature review
Unicentric Castleman disease in the left adrenal region: a case report and literature review Open
Background Castleman disease (CD) is a rare lymphoproliferative disorder that can present either as unicentric (UCD) or multicentric (MCD), with distinct clinical and pathologic features. Involvement of the adrenal region is extremely unco…
View article: Spatial Modeling and Risk Zoning of Global Extreme Precipitation via Graph Neural Networks and r-Pareto Processes
Spatial Modeling and Risk Zoning of Global Extreme Precipitation via Graph Neural Networks and r-Pareto Processes Open
Extreme precipitation events occurring over large spatial domains pose substantial threats to societies because they can trigger compound flooding, landslides, and infrastructure failures across wide areas. A hybrid framework for spatial e…
View article: Targeting Methylglyoxal Metabolism to Enhance Ferroptosis Sensitivity in Tumor Therapy
Targeting Methylglyoxal Metabolism to Enhance Ferroptosis Sensitivity in Tumor Therapy Open
Ferroptosis, characterized by iron‐dependent lipid peroxidation, is a form of oxidative cell death increasingly recognized for its role in cancer therapy. The susceptibility of cancer cells to ferroptosis varies, highlighting the need to e…
View article: Fluorescent Assay for Salmonella Detection Based on Triangle Multivalent Aptamer-Initiated Catalytic Hairpin Assembly
Fluorescent Assay for Salmonella Detection Based on Triangle Multivalent Aptamer-Initiated Catalytic Hairpin Assembly Open
Salmonella poses a severe global threat to food safety and public health, necessitating rapid, sensitive, and reliable detection methods. Conventional techniques often suffer from complexity, time consumption, cost, or limited sensitivity.…
View article: Repopulating Microglia Suppress Peripheral Immune Cell Infiltration to Promote Poststroke Recovery
Repopulating Microglia Suppress Peripheral Immune Cell Infiltration to Promote Poststroke Recovery Open
Aims Sustained neuroinflammation following ischemic stroke impedes post‐injury tissue repairment and neurological functional recovery. Developing innovative therapeutic strategies that simultaneously suppress detrimental inflammatory casca…
View article: Dynamic Optimization of Emergency Infrastructure Layouts Based on Population Influx: A Macao Case Study
Dynamic Optimization of Emergency Infrastructure Layouts Based on Population Influx: A Macao Case Study Open
This study investigates the spatiotemporal optimization of small-scale emergency infrastructure in high-density urban environments, using nucleic acid testing sites in Macao as a case study. The objective is to enhance emergency responsive…
View article: Catheter Ablation vs Drug Therapy in Patients With Atrial Fibrillation and Nonmodifiable Recurrence Risk Factors
Catheter Ablation vs Drug Therapy in Patients With Atrial Fibrillation and Nonmodifiable Recurrence Risk Factors Open
Importance Large-scale randomized studies evaluating the impact of catheter ablation on cardiovascular prognoses across different atrial fibrillation (AF) recurrence risk profiles are lacking. Objective To investigate the benefits of cathe…
View article: KNN-based frequency-adjustable ferroelectric heterojunction and biomedical applications
KNN-based frequency-adjustable ferroelectric heterojunction and biomedical applications Open
View article: Orthostatic Systolic Blood Pressure Elevation and Incident Atrial Fibrillation: Insights From the SPRINT Trial
Orthostatic Systolic Blood Pressure Elevation and Incident Atrial Fibrillation: Insights From the SPRINT Trial Open
Exaggerated orthostatic changes in systolic blood pressure (SBP) were associated with adverse cardiovascular events. We aim to assess the association between orthostatic SBP changes and incident atrial fibrillation (AF). We performed a pos…
View article: Infection dynamics and management in patients undergoing extracorporeal membrane oxygenation: a retrospective analysis
Infection dynamics and management in patients undergoing extracorporeal membrane oxygenation: a retrospective analysis Open
Introduction: The aim of this study was to summarize the infection situation of patients during extracorporeal membrane oxygenation (ECMO) treatment, and analyze the relevant infectious indexes before and after ECMO treatment; so as to pro…
View article: Single-cell multi-omics reveals unique regulatory mechanisms that sustains unprecedented elongation rate of bone structure, the deer antler
Single-cell multi-omics reveals unique regulatory mechanisms that sustains unprecedented elongation rate of bone structure, the deer antler Open
Bone growth and regeneration remain clinically important problems in medicine, and understanding the mechanism of rapid bone growth is a key to new therapeutic approaches. Deer antlers represent the fastest-growing bone structure in mammal…
View article: The Ins and Outs of Manganese: ZIP14 facilitates the efflux of excess manganese from the brain
The Ins and Outs of Manganese: ZIP14 facilitates the efflux of excess manganese from the brain Open
Manganese (Mn) is essential for many enzymatic processes in the brain; however, Mn overload can lead to neurotoxicity and behavioral deficits. The blood-brain barrier (BBB), comprised of polarized endothelial cells, tightly regulates metal…
View article: Harnessing mRNA for heart health: a new era in cardiovascular treatment
Harnessing mRNA for heart health: a new era in cardiovascular treatment Open
mRNA serves as a versatile platform for the expression of paracrine factors, thereby promoting cardioprotection and regeneration. In recent years, mRNA and gene editing technologies have emerged as innovative tools for tackling complex dis…
View article: Research on the Digital Design of Cloud Collar from the Perspective of Qualia Theory
Research on the Digital Design of Cloud Collar from the Perspective of Qualia Theory Open
This paper explores a new model for the digital design of intangible cultural heritage (ICH) Cloud Collar within the framework of qualia theory, aiming to address the issues of audience attrition and generational discontinuities caused by …
View article: Engineered Iontophoresis Patch for Epicutaneous Allergen‐specific Immunotherapy
Engineered Iontophoresis Patch for Epicutaneous Allergen‐specific Immunotherapy Open
Epidermal immunotherapy represents an emerging treatment method for allergic diseases. Nevertheless, an unformidable obstacle for epidermal drug delivery is the dense stratum corneum of the skin. Here, iontophoresis technology is utilized …
View article: Research on State of Charge estimation method for an improved lithium-ion gas-liquid dynamics model with temperature parameters
Research on State of Charge estimation method for an improved lithium-ion gas-liquid dynamics model with temperature parameters Open
View article: Single-Cell and Single-Nuclei transcriptomics profiling reveals dynamic cellular features in tumor-related adipose microenvironment of breast cancer patients with high BMI
Single-Cell and Single-Nuclei transcriptomics profiling reveals dynamic cellular features in tumor-related adipose microenvironment of breast cancer patients with high BMI Open
View article: Effects of sarcopenia on postoperative recovery in elderly patients after cardiac surgery with cardiopulmonary bypass
Effects of sarcopenia on postoperative recovery in elderly patients after cardiac surgery with cardiopulmonary bypass Open
Our study identified preoperative sarcopenia, assessed via ESM muscle mass on chest CT, as an independent predictor of postoperative complications and long-term overall mortality in elderly cardiac surgery patients with CPB.
View article: Plasma CCL3 predicts adverse heart failure outcomes in patients with arrhythmogenic cardiomyopathy
Plasma CCL3 predicts adverse heart failure outcomes in patients with arrhythmogenic cardiomyopathy Open
View article: Evaluation of the acute effects of single‐dose TPN171 on semen quality in healthy Chinese male volunteers
Evaluation of the acute effects of single‐dose TPN171 on semen quality in healthy Chinese male volunteers Open
Aims TPN171 is a novel phosphodiesterase type 5 inhibitor for the treatment of erectile dysfunction. This study aimed to assess the immediate impact of a single dose of TPN171 (10 mg) on semen quality in healthy male Chinese volunteers. Ad…
View article: GeoRAG: A Question-Answering Approach from a Geographical Perspective
GeoRAG: A Question-Answering Approach from a Geographical Perspective Open
Geographic Question Answering (GeoQA) addresses natural language queries in geographic domains to fulfill complex user demands and improve information retrieval efficiency. Traditional QA systems, however, suffer from limited comprehension…
View article: Prevalence, genetic variations and clinical outcomes of BRAF-V600 mutated advanced NSCLC in China: a retrospective real-world multi-centre study
Prevalence, genetic variations and clinical outcomes of BRAF-V600 mutated advanced NSCLC in China: a retrospective real-world multi-centre study Open
National Natural Science Foundation of China (82072583); Beijing Municipal Administration of Hospitals Incubating Program (PX2020044); Beijing Hospitals Authority Youth Programme (QML20231113); Science Foundation of Peking University Cance…
View article: The Effects of Polyphenols on Doxorubicin‐Induced Nephrotoxicity by Modulating Inflammatory Cytokines, Apoptosis, Oxidative Stress, and Oxidative <scp>DNA</scp> Damage
The Effects of Polyphenols on Doxorubicin‐Induced Nephrotoxicity by Modulating Inflammatory Cytokines, Apoptosis, Oxidative Stress, and Oxidative <span>DNA</span> Damage Open
Doxorubicin (DOX) is an anthracyclic antibiotic with anti‐neoplastic activity that has been found to be a highly effective and commonly used chemotherapeutic agent in the treatment of a variety of solid and hematologic malignancies. Howeve…