Guobin Chang
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View article: Multi-Omics Insights into the Relationship Between Intestinal Microbiota and Abdominal Fat Deposition in Meat Ducks
Multi-Omics Insights into the Relationship Between Intestinal Microbiota and Abdominal Fat Deposition in Meat Ducks Open
Abdominal fat deposition is an important economic trait in poultry, as excessive accumulation reduces feed efficiency and carcass yield. The gut microbiota is known to influence host energy metabolism and fat storage, suggesting its potent…
View article: The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding
The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding Open
MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken. By precisely modulating the expression of key immune genes, miRNAs coordinate both innate and ada…
View article: Molecular Characteristics, Circularization Mechanism, and Potential Functions of circRNA-0172
Molecular Characteristics, Circularization Mechanism, and Potential Functions of circRNA-0172 Open
Background/Objectives: Avian leukosis virus subgroup J (ALV-J) harms poultry via tumors and immunosuppression; MDM2-derived circRNA-0172′s role in ALV-J infection is unknown. This study explores its molecular characteristics, circularizati…
View article: Comprehensive Identification of miRNAs and circRNAs in the Regulation of Intramuscular and Subcutaneous Fat Deposition in Meat Ducks
Comprehensive Identification of miRNAs and circRNAs in the Regulation of Intramuscular and Subcutaneous Fat Deposition in Meat Ducks Open
Fat deposition is an important factor that affects meat production and its quality in livestock animals, including poultry. Non−coding RNAs (ncRNAs) play an important role in duck fat deposition. This study aims to systematically identify …
View article: ATG5 negatively regulates grass carp reovirus-induced immune-inflammatory response by degrading RIG-I and MDA5
ATG5 negatively regulates grass carp reovirus-induced immune-inflammatory response by degrading RIG-I and MDA5 Open
Grass carp reovirus (GCRV) is the most virulent aquareovirus, inducing hemorrhagic disease that results in significant economic losses for the grass carp aquaculture industry in China. It has been reported that the cytokine storm, resultin…
View article: Mechanism of circRNA_4083 Circularization and Its Role in Regulating Cell Viability
Mechanism of circRNA_4083 Circularization and Its Role in Regulating Cell Viability Open
Circular RNAs (circRNAs), a class of covalently closed non-coding RNAs, are pivotal regulators of gene expression and contributors to disease pathogenesis. This study elucidated the biogenesis, functional significance, and regulatory netwo…
View article: Analysis of the Transcriptional Control of Bcl11b in Chicken: IRF1 and GATA1 as Negative Regulators
Analysis of the Transcriptional Control of Bcl11b in Chicken: IRF1 and GATA1 as Negative Regulators Open
B-cell lymphoma/leukemia 11B (Bcl11b) plays roles in cell proliferation and apoptosis and holds a pivotal position within the immune system. Our previous studies have demonstrated that Bcl11b can promote cell apoptosis to curb ALV-J infect…
View article: Whole Transcriptome Sequencing Reveals miRNAs and ceRNA Networks in Duck Abdominal Fat Deposition
Whole Transcriptome Sequencing Reveals miRNAs and ceRNA Networks in Duck Abdominal Fat Deposition Open
Excessive deposition of abdominal fat will cause a waste of resources. In order to explore the key miRNAs and circRNA/lncRNA-miRNA-mRNA ceRNA regulatory network involved in regulating abdominal fat deposition, hematoxylin and eosin (H&E) s…
View article: Autophagy-mediated TET2 degradation by ALV-J Env protein suppresses innate immune activation to promote viral replication
Autophagy-mediated TET2 degradation by ALV-J Env protein suppresses innate immune activation to promote viral replication Open
Avian leukosis virus subgroup J (ALV-J) poses a significant threat to the poultry industry; yet, our understanding of its replication and pathogenic mechanisms is limited. The Ten-Eleven Translocation 2 (TET2) is an indispensable regulator…
View article: Genome Sequencing Reveals the Adaptation of Chickens to High Altitudes in Different Regions
Genome Sequencing Reveals the Adaptation of Chickens to High Altitudes in Different Regions Open
Altitudinal adaptation is a key factor in species formation and leads to increased species diversity. Chickens are one of the most widely distributed and important domesticated species, making them ideal models for studying the evolution o…
View article: RNA-Seq Analysis of Glycolysis Regulation of Avian Leukosis Virus Subgroup J Replication
RNA-Seq Analysis of Glycolysis Regulation of Avian Leukosis Virus Subgroup J Replication Open
Avian Leukosis virus (ALV) is a widely spread virus that causes major economic losses to the global poultry industry. This study aims to investigate the effect of glycolysis on the replication of the ALV-J virus and identify the key circul…
View article: Effect of Early Ciprofloxacin Administration on Growth Performance, Meat Quality, Food Safety, and Metabolomic Profiles in Xueshan Chickens
Effect of Early Ciprofloxacin Administration on Growth Performance, Meat Quality, Food Safety, and Metabolomic Profiles in Xueshan Chickens Open
To investigate the effects of early administration of ciprofloxacin (CIP) on Xueshan chickens, in this study Xueshan chickens were measured for growth performance, tested for drug residues, evaluated for meat quality, and muscle metabolism…
View article: Effect of High Dietary Iron on Fat Deposition and Gut Microbiota in Chickens
Effect of High Dietary Iron on Fat Deposition and Gut Microbiota in Chickens Open
To meet the demand of consumers for chicken products, poultry breeders have made improvements to chickens. However, this has led to a new problem in the modern poultry industry, namely excessive fat deposition. This study aims to understan…
View article: Threonine Deficiency Increases Triglyceride Deposition in Primary Duck Hepatocytes by Reducing STAT3 Phosphorylation
Threonine Deficiency Increases Triglyceride Deposition in Primary Duck Hepatocytes by Reducing STAT3 Phosphorylation Open
Liver lipid metabolism disruption significantly contributes to excessive fat buildup in waterfowl. Research suggests that the supplementation of Threonine (Thr) in the diet can improve liver lipid metabolism disorder, while Thr deficiency …
View article: Effects of Sex on Growth Performance, Carcass Traits, Blood Biochemical Parameters, and Meat Quality of XueShan Chickens
Effects of Sex on Growth Performance, Carcass Traits, Blood Biochemical Parameters, and Meat Quality of XueShan Chickens Open
The demand for high-quality chilled chicken has continued to increase in China. Chickens are sexually dimorphic, and to better understand the specific differences in chicken production based on sex, we examined how sex affects growth perfo…
View article: Metagenomic insights into the relationship between intestinal flora and residual feed intake of meat ducks
Metagenomic insights into the relationship between intestinal flora and residual feed intake of meat ducks Open
In this study, we sought to determine the effects of intestinal flora on the feed efficiency of meat ducks by evaluating the correlation between intestinal flora and residual feed intake. The F2 generation of Cherry Valley ducks × Runzhou …
View article: Gut–brain bidirectional determination in regulating the residual feed intake of small-sized meat ducks
Gut–brain bidirectional determination in regulating the residual feed intake of small-sized meat ducks Open
The gut-brain axis is essential in maintaining the homeostasis of neuronal system, endocrine system, and intestinal microbiota in both the afferent and efferent directions. This axis is considered to be a key mechanism that regulates feed …
View article: RNA-Seq Analysis Revealed circRNAs and Genes Associated with Abdominal Fat Deposition in Ducks
RNA-Seq Analysis Revealed circRNAs and Genes Associated with Abdominal Fat Deposition in Ducks Open
Fat deposition is an important factor affecting meat quality and feed conversion efficiency in meat ducks. This study aims to identify key circRNAs and genes affecting abdominal fat deposition. The correlations between abdominal fat and ot…
View article: Study on changing disciplinarian of beak colors in ducks and the regulation network based on transcriptome sequencing
Study on changing disciplinarian of beak colors in ducks and the regulation network based on transcriptome sequencing Open
Beak color in ducks is a primary characteristic of local breeds and genetic resources. Among them, black beaks, a rare packaging trait of high-quality duck products, have attracted much attention. In this study, Runzhou White Created ducks…
View article: Research Note: Transcriptome analysis reveals differentially expressed genes regulated muscle development in Pekin ducks during dietary threonine deficiency
Research Note: Transcriptome analysis reveals differentially expressed genes regulated muscle development in Pekin ducks during dietary threonine deficiency Open
To investigate the underlying molecular mechanism of threonine (Thr) regulation on the development of breast muscle in Pekin ducks, 240 male Pekin ducks at 1 d of age were fed a Thr deficiency diet (Thr-D), Thr sufficiency diet (Thr-S), or…
View article: Transcriptome analysis reveals the genetic basis of crest cushion formation in duck
Transcriptome analysis reveals the genetic basis of crest cushion formation in duck Open
The Chinese crested duck is a unique duck breed having a bulbous feather shape on its duck head. However, the mechanisms involved in its formation and development are unclear. In the present study, RNA sequencing analysis was performed on …
View article: Identification of SNPs in MITF associated with beak color of duck
Identification of SNPs in MITF associated with beak color of duck Open
Introduction: Beak color—a pigment-related trait—is an important feature of duck breeds. Recently, little research has addressed genetic mechanism of the beak colors in poultry, whereas the process and the regulation factors of melanin dep…
View article: Combine with RNA-seq Reveals the Effect of Melatonin in the Synthesis of Melanin in Primary Melanocytes of Silky Fowls Black-Bone Chicken
Combine with RNA-seq Reveals the Effect of Melatonin in the Synthesis of Melanin in Primary Melanocytes of Silky Fowls Black-Bone Chicken Open
(1) Background: It was found that the melanin of black-bone chicken has various effects such as scavenging DPPH free radicals and anti-oxidation, and the synthesis of melanin is affected by various factors including hormones. In addition, …