Explanipedia

HER3 promotes triple-negative breast cancer progression by upregulating PHF8 via miR-34b-5p-dependent mechanism Open

Hui Lyu, Congcong Tan, Yakun Wu, Margaret E. Larsen, Qingzhao Yu , et al. · 2025

Development and validation of a novel nomogram to predict coronary artery calcification: a single center study Open

Xiangnan Shen, Xia Li, Fang He, Honglei Su, Hongtao He , et al. · 2025

Global burden and health inequality of atrial fibrillation/atrial flutter from 1990 to 2021 Open

Xia Li, Zhen Li, Hongtao He, Sizhou Wang, Honglei Su , et al. · 2025

Introduction Atrial fibrillation (AF) and atrial flutter (AFL) are the most prevalent tachyarrhythmias worldwide, leading to severe complications such as stroke and heart failure. Despite advancements in diagnosis and management, the globa…

Proton pump inhibitor in treating a patient with ventricular arrhythmia Open

Qi Ding, Hongtao He, Yujie Xue, Guobin Kang · 2024

Co-infection and co-localization of Kaposi sarcoma-associated herpesvirus and Epstein-Barr virus in HIV-associated Kaposi sarcoma: a case report Open

Peter Julius, Guobin Kang, Stepfanie N. Siyumbwa, Jane Musumali, For Yue Tso , et al. · 2023

Kaposi sarcoma (KS), a multifocal vascular neoplasm frequently observed in HIV-positive individuals, primarily affects the skin, mucous membranes, visceral organs, and lymph nodes. KS is associated primarily with Kaposi sarcoma-associated …

Yes-associated protein-1 overexpression in ocular surface squamous neoplasia; a potential diagnostic marker and therapeutic target Open

Peter Julius, Stepfanie N. Siyumbwa, Fred Maate, Phyllis Moonga, Guobin Kang , et al. · 2023

Yes-associated protein-1 (YAP-1) is a Hippo system transcription factor, which serves as an oncogene in squamous cell carcinoma, and several solid tumors when the Hippo pathway is dysregulated. Yet, the activity of YAP-1 in ocular surface …

Predictive value of gut microbiota in long-term blood pressure control: a cross-sectional study Open

Guobin Kang, Hongtao He, Huawei Miao, Tiejun Zhang, Zongde Meng , et al. · 2023

Objectives To investigate the prediction of long-term blood pressure control using the intestinal flora of patients with hypertension. Methods A total of 125 patients with primary grade-2 hypertension who attended the cardiovascular depart…

Subtype C HIV-1 reservoirs throughout the body in ART-suppressed individuals Open

Zhou Liu, Peter Julius, Guobin Kang, John T. West, Charles Wood · 2022

Subtype B HIV-1 reservoirs have been intensively investigated, but reservoirs in other subtypes and how they respond to antiretroviral therapy (ART) is substantially less established. To characterize subtype C HIV-1 reservoirs, we implemen…

Systematic post-mortem analysis of brain tissue from an HIV-1 subtype C viremic decedent revealed a paucity of infection and pathology Open

Jane Musumali, Peter Julius, Stepfanie N. Siyumbwa, Dicle Yalcin, Guobin Kang , et al. · 2022

Network Pharmacology-Based Combined with Experimental Validation Study to Explore the Underlying Mechanism of Agrimonia pilosa Ledeb. Extract in Treating Acute Myocardial Infarction Open

Muqing Zhang, Jian Chen, Yanwei Wang, Guobin Kang, Yixin Zhang , et al. · 2022

APL extract had a protective effect against Iso-induced AMI. APL extract could ameliorate AMI through antioxidant and anti-apoptosis actions which may be associated with the activation of the PI3K/Akt signaling pathway.

Epstein–Barr Virus, But Not Human Papillomavirus, Is Associated With Preinvasive and Invasive Ocular Surface Squamous Neoplasias in Zambian Patients Open

Peter Julius, Stepfanie N. Siyumbwa, Phyllis Moonga, Fred Maate, Trevor Kaile , et al. · 2022

Background The etiopathogenesis of ocular surface squamous neoplasia (OSSN) is not fully understood. We assessed the frequency of oncogenic viruses in OSSN by immunohistochemistry (IHC) and polymerase chain reaction (PCR) for human papillo…

Bone Marrow-Derived SH-SY5Y Neuroblastoma Cells Infected with Kaposi’s Sarcoma-Associated Herpesvirus Display Unique Infection Phenotypes and Growth Properties Open

Xiaohong Kong, Dongmei Li, Amirsalar Mansouri, Guobin Kang, Khalid Sayood , et al. · 2021

Our study has provided evidence that neuronal SH-SY5Y cells displayed unique cellular responses upon KSHV infection. Unlike other infected cells, this neuronal cell line displayed a higher growth rate upon infection and can spontaneously t…

Clinical and Pathologic Presentation of Primary Ocular Surface Tumors among Zambians Open

Peter Julius, Stepfanie N. Siyumbwa, Phyllis Moonga, Fred Maate, Trevor Kaile , et al. · 2021

Aim: This study aimed to characterize the clinical and pathologic presentation of ocular surface tumors (OSTs) and to more precisely differentiate the grades of ocular surface squamous neoplasia (OSSN) and benign lesions amon…

Supplementary Material for: Clinical and Pathologic Presentation of Primary Ocular Surface Tumors among Zambians Open

Peter Julius, S.N. Siymbwa, Phyllis Moonga, Fred Maate, Trevor Kaile , et al. · 2021

Aim: This study aimed to characterize the clinical and pathologic presentation of ocular surface tumors (OSTs) and to more precisely differentiate the grades of ocular surface squamous neoplasia (OSSN) and benign lesions amon…

Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques Open

Shaheed Abdulhaqq, Melween I. Martínez, Guobin Kang, Idia V. Rodríguez, Stephanie M. Nichols , et al. · 2019

Macrophages but not Astrocytes Harbor HIV DNA in the Brains of HIV-1-Infected Aviremic Individuals on Suppressive Antiretroviral Therapy Open

Allen Ko, Guobin Kang, Julian B. Hattler, Hadiza Galadima, Junfeng Zhang , et al. · 2018

Brain is a potential sanctuary for subtype C HIV-1 irrespective of ART treatment outcome Open

For Yue Tso, Guobin Kang, Eun Hee Kwon, Peter Julius, Qingsheng Li , et al. · 2018

Subtype C HIV-1 is responsible for the largest proportion of people living with HIV-1 infection. However, there is limited information about the roles of the brain and its cell types as a potential sanctuary for this subtype and how the sa…

Long-acting parenteral combination antiretroviral loaded nano-drug delivery system to treat chronic HIV-1 infection: A humanized mouse model study Open

Subhra Mandal, Guobin Kang, Pavan Kumar Prathipati, Wenjin Fan, Qingsheng Li , et al. · 2018

SIVcpz closely related to the ancestral HIV-1 is less or non-pathogenic to humans in a hu-BLT mouse model Open

Zhe Yuan, Guobin Kang, Lance Daharsh, Wenjin Fan, Qingsheng Li · 2018

The HIV-1 pandemic is a consequence of the cross-species transmission of simian immunodeficiency virus in wild chimpanzees (SIVcpz) to humans. Our previous study demonstrated SIVcpz strains that are closely related to the ancestral viruses…

Identification of Unequally Represented Founder Viruses Among Tissues in Very Early SIV Rectal Transmission Open

Jian Chen, Yanqin Ren, Lance Daharsh, Lu Liu, Guobin Kang , et al. · 2018

Characterizing the transmitted/founder (T/F) viruses of multi-variant SIV infection may shed new light on the understanding of mucosal transmission. We intrarectally inoculated six Chinese rhesus macaques with a single high dose of SIVmac2…

A DNA Vaccine Expressing Consensus Hemagglutinin-Esterase Fusion Protein Protected Guinea Pigs from Infection by Two Lineages of Influenza D Virus Open

Yanmin Wan, Guobin Kang, Chithra Sreenivasan, Lance Daharsh, Junfeng Zhang , et al. · 2018

Two lineages of influenza D virus (IDV) have been found to infect cattle and promote bovine respiratory disease complex, one of the most commonly diagnosed causes of morbidity and mortality within the cattle industry. Furthermore, IDV can …

Associations of Simian Immunodeficiency Virus (SIV)-Specific Follicular CD8+ T Cells with Other Follicular T Cells Suggest Complex Contributions to SIV Viremia Control Open

Mohammad Arif Rahman, Katherine McKinnon, Tatiana Karpova, David A. Ball, David Venzon , et al. · 2018

Follicular CD8+ T (fCD8) cells reside within B cell follicles and are thought to be immune-privileged sites of HIV/SIV infection. We have observed comparable levels of fCD8 cells between chronically SIV-infected rhesus macaques with low vi…

Branched chain α‐ketoacid dehydrogenase kinase 111–130, a T cell epitope that induces both autoimmune myocarditis and hepatitis in A/J mice Open

Bharathi Krishnan, Chandirasegaran Massilamany, Rakesh H. Basavalingappa, Arunakumar Gangaplara, Guobin Kang , et al. · 2017

Introduction Organ‐specific autoimmune diseases are believed to result from immune responses generated against self‐antigens specific to each organ. However, when such responses target antigens expressed promiscuously in multiple tissues, …

Controlling Multicycle Replication of Live-Attenuated HIV-1 Using an Unnatural Genetic Switch Open

Zhe Yuan, Nanxi Wang, Guobin Kang, Wei Niu, Qingsheng Li , et al. · 2017

A safe and effective human immunodeficiency virus type 1 (HIV-1) vaccine is urgently needed, but remains elusive. While HIV-1 live-attenuated vaccine can provide potent protection as demonstrated in rhesus macaque-simian immunodeficiency v…

Reactivation of HIV-1 proviruses in immune-compromised mice engrafted with human VOA-negative CD4+ T cells Open

Zhe Yuan, Guobin Kang, Wuxun Lu, Qingsheng Li · 2017

Table of Contents Open

Gwendalyn J. Randolph, Shashi Bala, Jean‐François Rahier, M. Ross Johnson, Peter Wang , et al. · 2016

Identification of an Epitope from Adenine Nucleotide Translocator 1 That Induces Inflammation in Heart in A/J Mice Open

Rakesh H. Basavalingappa, Chandirasegaran Massilamany, Bharathi Krishnan, Arunakumar Gangaplara, Guobin Kang , et al. · 2016

Recapitulating Cross-Species Transmission of Simian Immunodeficiency Virus SIVcpz to Humans by Using Humanized BLT Mice Open

Zhe Yuan, Guobin Kang, Fangrui Ma, Wuxun Lu, Wenjin Fan , et al. · 2016

The origins of human immunodeficiency virus type 1 (HIV-1) have been widely accepted to be the consequences of simian immunodeficiency viruses from wild chimpanzees (SIVcpz) crossing over to humans. However, there has not been any in vivo …

Topical Tenofovir Disoproxil Fumarate Nanoparticles Prevent HIV-1 Vaginal Transmission in a Humanized Mouse Model Open

Christopher J. Destache, Subhra Mandal, Zhe Yuan, Guobin Kang, Abhijit A. Date , et al. · 2016

Preexposure prophylaxis (PrEP) with 1% tenofovir (TFV) vaginal gel has failed in clinical trials. To improve TFV efficacy in vaginal gel, we formulated tenofovir disoproxil fumarate nanoparticles in a thermosensitive (TMS) gel (TDF-NP-TMS …

Vaccine Induction of Lymph Node–Resident Simian Immunodeficiency Virus Env-Specific T Follicular Helper Cells in Rhesus Macaques Open

Diego A. Vargas‐Inchaustegui, Andrew Demers, Julia M. Shaw, Guobin Kang, David A. Ball , et al. · 2016

Measurement of Ag-specific T follicular helper (TFH) cell activity in rhesus macaques has not previously been reported. Given that rhesus macaques are the animal model of choice for evaluating protective efficacy of HIV/SIV vaccine candida…

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