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View article: <i>Lactobacillus rhamnosus</i> LRa05 on glycemic control and gut microbiota in patients with type 2 diabetes
<i>Lactobacillus rhamnosus</i> LRa05 on glycemic control and gut microbiota in patients with type 2 diabetes Open
BACKGROUND Type 2 diabetes mellitus (T2DM) is a metabolic disorder linked to high blood glucose and gut dysbiosis. Probiotics like Lactobacillus rhamnosus LRa05 may improve glycemic control and gut microbiota. AIM To explore the impact of …
View article: Efficacy and safety of JMT103 in patients with unresectable or surgically-challenging giant cell tumor of bone: a multicenter, phase Ib/II study
Efficacy and safety of JMT103 in patients with unresectable or surgically-challenging giant cell tumor of bone: a multicenter, phase Ib/II study Open
This was a multicenter, single-arm, open-label, phase Ib/II study (NCT04255576), aimed to evaluate the efficacy and safety of JMT103 in patients with unresectable or surgically-challenging giant cell tumor of bone (GCTB). JMT103 (2 mg/kg) …
View article: Supplemental Methods S1 from Safety and Efficacy of Anlotinib, a Multikinase Angiogenesis Inhibitor, in Patients with Refractory Metastatic Soft-Tissue Sarcoma
Supplemental Methods S1 from Safety and Efficacy of Anlotinib, a Multikinase Angiogenesis Inhibitor, in Patients with Refractory Metastatic Soft-Tissue Sarcoma Open
Supplemental Methods S1 contained the complete inclusion and exclusion criteria.
View article: Data from Safety and Efficacy of Anlotinib, a Multikinase Angiogenesis Inhibitor, in Patients with Refractory Metastatic Soft-Tissue Sarcoma
Data from Safety and Efficacy of Anlotinib, a Multikinase Angiogenesis Inhibitor, in Patients with Refractory Metastatic Soft-Tissue Sarcoma Open
Purpose: The prognosis for patients with refractory soft-tissue sarcoma (STS) is dismal. Anlotinib has previously shown antitumor activity on STS in preclinical and phase I studies.Patients and Methods: Patients 18 years and older, progres…
View article: Supplemental Methods S1 from Safety and Efficacy of Anlotinib, a Multikinase Angiogenesis Inhibitor, in Patients with Refractory Metastatic Soft-Tissue Sarcoma
Supplemental Methods S1 from Safety and Efficacy of Anlotinib, a Multikinase Angiogenesis Inhibitor, in Patients with Refractory Metastatic Soft-Tissue Sarcoma Open
Supplemental Methods S1 contained the complete inclusion and exclusion criteria.
View article: Supplemental Figure 1 from Safety and Efficacy of Anlotinib, a Multikinase Angiogenesis Inhibitor, in Patients with Refractory Metastatic Soft-Tissue Sarcoma
Supplemental Figure 1 from Safety and Efficacy of Anlotinib, a Multikinase Angiogenesis Inhibitor, in Patients with Refractory Metastatic Soft-Tissue Sarcoma Open
Kaplan-Meier curves for progression-free survival (A) and overall survival (B) of the initial 43 patients and the subsequent 123 patients enrolled.
View article: Supplemental Figure 1 from Safety and Efficacy of Anlotinib, a Multikinase Angiogenesis Inhibitor, in Patients with Refractory Metastatic Soft-Tissue Sarcoma
Supplemental Figure 1 from Safety and Efficacy of Anlotinib, a Multikinase Angiogenesis Inhibitor, in Patients with Refractory Metastatic Soft-Tissue Sarcoma Open
Kaplan-Meier curves for progression-free survival (A) and overall survival (B) of the initial 43 patients and the subsequent 123 patients enrolled.
View article: Data from Safety and Efficacy of Anlotinib, a Multikinase Angiogenesis Inhibitor, in Patients with Refractory Metastatic Soft-Tissue Sarcoma
Data from Safety and Efficacy of Anlotinib, a Multikinase Angiogenesis Inhibitor, in Patients with Refractory Metastatic Soft-Tissue Sarcoma Open
Purpose: The prognosis for patients with refractory soft-tissue sarcoma (STS) is dismal. Anlotinib has previously shown antitumor activity on STS in preclinical and phase I studies.Patients and Methods: Patients 18 years and older, progres…
View article: Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins
Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins Open
Osteosarcoma (OS) is the common primary bone cancer that affects mostly children and young adults. To augment the standard-of-care chemotherapy, we examined the possibility of protein-based therapy using mesenchymal stem cells (MSCs)-deriv…
View article: Author response: Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins
Author response: Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Abstract Osteosarcoma (OS) is the commo…
View article: Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins
Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins Open
Osteosarcoma (OS) is the common primary bone cancer that affects mostly children and young adults. To augment the standard-of-care chemotherapy, we examined the possibility of protein-based therapy using mesenchymal stem cells (MSCs)-deriv…
View article: Efficacy and safety of apatinib in patients with untreated or chemotherapy-refractory soft tissue sarcoma: a multicenter, phase 2 trial
Efficacy and safety of apatinib in patients with untreated or chemotherapy-refractory soft tissue sarcoma: a multicenter, phase 2 trial Open
This study suggested that apatinib might be effective and tolerable in patients with untreated or chemotherapy-refractory STS (NCT03064243).
View article: Glycogen synthase kinase 3β promotes osteosarcoma invasion and migration via regulating PTEN and phosphorylation of focal adhesion kinase
Glycogen synthase kinase 3β promotes osteosarcoma invasion and migration via regulating PTEN and phosphorylation of focal adhesion kinase Open
Aim: Typical features of human osteosarcoma are highly invasive and migratory capacities. Our study aimed to investigate the roles of glycogen synthase kinase 3β (GSK3β) in human osteosarcoma metastasis. Methods: GSK3β expressions in clini…
View article: RETRACTED: Phototherapy together with it triggered immunological response for Anti-HPV treatment of oropharyngeal cancer: Removing tumor and pathogenic virus simultaneously
RETRACTED: Phototherapy together with it triggered immunological response for Anti-HPV treatment of oropharyngeal cancer: Removing tumor and pathogenic virus simultaneously Open
Oropharyngeal squamous cell carcinoma (OPSCC) is one of most common cancers that often brings lots of inconvenience to the patient in swallowing and phonation even after the operation. Moreover, OPSCC is typically as nodal metastases and h…
View article: <p>The Relationship Between Human Papillomavirus, OFD1 and Primary Ciliogenesis in the Progression of Oropharyngeal Cancer: A Retrospective Cohort Study</p>
The Relationship Between Human Papillomavirus, OFD1 and Primary Ciliogenesis in the Progression of Oropharyngeal Cancer: A Retrospective Cohort Study Open
Our study demonstrated that HPV may be related to the progression of OPSCC by regulating OFD1 expression and primary ciliogenesis, making this protein a potential therapeutic target.
View article: <p>Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles</p>
Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles Open
The ultimate goal of phototherapy based on nanoparticles, such as photothermal therapy (PTT) which generates heat and photodynamic therapy (PDT) which not only generates reactive oxygen species (ROS) but also induces a variety of anti-tumo…
View article: Peer Review #5 of "REG γ knockdown suppresses proliferation by inducing apoptosis and cell cycle arrest in osteosarcoma (v0.1)"
Peer Review #5 of "REG γ knockdown suppresses proliferation by inducing apoptosis and cell cycle arrest in osteosarcoma (v0.1)" Open
Background: Osteosarcoma (OS) is the most common malignant bone tumor with high mortality in children and adolescents.REG γ is overexpressed and plays oncogenic roles in various types of human cancers.However, the expression and potential …
View article: REG γ knockdown suppresses proliferation by inducing apoptosis and cell cycle arrest in osteosarcoma
REG γ knockdown suppresses proliferation by inducing apoptosis and cell cycle arrest in osteosarcoma Open
Background Osteosarcoma (OS) is the most common malignant bone tumor with high mortality in children and adolescents. REG γ is overexpressed and plays oncogenic roles in various types of human cancers. However, the expression and potential…
View article: Peer Review #2 of "REG γ knockdown suppresses proliferation by inducing apoptosis and cell cycle arrest in osteosarcoma (v0.1)"
Peer Review #2 of "REG γ knockdown suppresses proliferation by inducing apoptosis and cell cycle arrest in osteosarcoma (v0.1)" Open
Background: Osteosarcoma (OS) is the most common malignant bone tumor with high mortality in children and adolescents.REG γ is overexpressed and plays oncogenic roles in various types of human cancers.However, the expression and potential …
View article: Identification of Biomarkers for Osteosarcoma Based on Integration Strategy
Identification of Biomarkers for Osteosarcoma Based on Integration Strategy Open
BACKGROUND Osteosarcoma (OS) is the most common primary malignant tumor of bone. The identification of novel biomarkers is necessary for the diagnosis and treatment of osteosarcoma. MATERIAL AND METHODS We obtained 11 paired fresh-frozen O…
View article: A Retrospective Clinicopathological Study of Osteosarcoma Patients with Metachronous Metastatic Relapse
A Retrospective Clinicopathological Study of Osteosarcoma Patients with Metachronous Metastatic Relapse Open
Purpose: Although osteosarcoma patients receive a standardized treatment, metachronous metastatic relapse still impairs the overall survival (OS). This study aimed to explore the clinicopathological features and prognostic factors of osteo…
View article: Efficacy of anlotinib in advanced soft tissue sarcoma by prior lines of therapy, age and dose modification
Efficacy of anlotinib in advanced soft tissue sarcoma by prior lines of therapy, age and dose modification Open
Background: ALTER0203 was a randomized phase IIB trial (NCT02449343) that demonstrated single-agent activity of anlotinib in advanced STS (aSTS). The primary endpoint progression-free survival (PFS) was met and presented as an oral present…
View article: Evaluation of hypertension and hand-foot syndrome as markers of anlotinib efficacy in advanced soft tissue sarcoma
Evaluation of hypertension and hand-foot syndrome as markers of anlotinib efficacy in advanced soft tissue sarcoma Open
Background: ALTER0203 was a randomized phase IIB trial (NCT02449343) that demonstrated single-agent activity of anlotinib in advanced STS (aSTS). The primary endpoint progression-free survival (PFS) was met and presented as an oral present…
View article: The overexpression of MDM4: an effective and novel predictor of gastric adenocarcinoma lymph node metastasis
The overexpression of MDM4: an effective and novel predictor of gastric adenocarcinoma lymph node metastasis Open
MDM4 expression may result in LMN of GTAC. High MDM4 expression levels are associated with LMN of GTAC and influence the prognosis of patients with GTAC.