Guofen Yang
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Establishment and validation of a prognostic model based on vasculogenic mimicry-related gene clustering in ovarian cancer Open
Background As a critical prognostic factor in ovarian cancer which is the most lethal gynecologic malignancy, vasculogenic mimicry (VM) has not been systematically incorporated into prognostic evaluation frameworks in ovarian cancer (OC). …
View article: Association between dietary vitamin intake and all-cause mortality in ovarian cancer patients: a prospective cohort study
Association between dietary vitamin intake and all-cause mortality in ovarian cancer patients: a prospective cohort study Open
Background While various lifestyle factors have been implicated in cancer prognosis, the role of dietary vitamins in ovarian cancer survival is not well understood. This study aimed to investigate the association between dietary vitamin in…
View article: Prognostic Model Construction Based on Platinum-Free Interval in Ovarian Cancer and Its Implication for Chemotherapy Resistance
Prognostic Model Construction Based on Platinum-Free Interval in Ovarian Cancer and Its Implication for Chemotherapy Resistance Open
Background While platinum sensitivity and resistance have long been central to treatment decisions in high-grade serous ovarian cancer (HGSOC), these categories are increasingly questioned in real-world clinical settings. This study seeks …
Selective uterine artery embolization is a valid adjuvant treatment of choriocarcinoma: a case report and literature review Open
Background Cervical choriocarcinoma is an extremely rare malignancy that is often misdiagnosed due to its nonspecific symptoms, such as vaginal bleeding. Case report A 39-year-old female presented to the emergency department of the First A…
LNMAC Promotes Cervical Squamous Cell Carcinoma Lymphatic Metastasis via Epigenetic Regulation of FGF2‐Induced Lymphangiogenesis Open
The lymph node is the most common site of distant metastasis of cervical squamous cell carcinoma (CSCC), which elicits dismal prognosis and limited efficiency for treatment. Elucidation of the mechanisms underlying CSCC lymphatic metastasi…
Establishment and validation of a prognostic model based on grouping of vasculogenic mimicry-related genes in ovarian cancer Open
Background Vasculogenic mimicry (VM) is a vascular-like microcirculatory delivery system directly formed by tumor cells. It plays significant roles in tumor invasion and resistance to antiangiogenic drugs. However, there is no model based …
CircMAST1 inhibits cervical cancer progression by hindering the N4-acetylcytidine modification of YAP mRNA Open
Background Cervical cancer (CCa) is the fourth most common cancer among females, with high incidence and mortality rates. Circular RNAs (circRNAs) are key regulators of various biological processes in cancer. However, the biological role o…
Pre-existing cancer cells and induced fibroblasts are key cells for early chemoresistance in ovarian cancer Open
Chemoresistance has long been a significant but unresolved issue in the treatment of various cancers, including the most deadly gynecological cancer, the high-grade serous ovary cancer (HGSOC). In this study, single nuclei transcriptome an…
Necroptosis‐related regulatory pattern and scoring system for predicting therapeutic efficacy and prognosis in ovarian cancer Open
Background Ovarian cancer is difficult to treat and is, therefore, associated with a high fatality rate. Although targeted therapy and immunotherapy have been successfully used clinically to improve the diagnosis and treatment of ovarian c…
The Impact of Laterality on the Incidence and Prognosis of Epithelial Ovarian Cancer Open
Epithelial ovarian cancer (EOC) is the most common type of ovarian cancer, and its mortality rate is the highest among gynecological malignancies. Despite numerous factors being linked to the prognosis of EOC, the impact of ovarian lateral…
Additional file 6 of The adaptive evolution of cancer driver genes Open
Additional file 6.
Additional file 10 of The adaptive evolution of cancer driver genes Open
Additional file 10.
Additional file 7 of The adaptive evolution of cancer driver genes Open
Additional file 7.
Additional file 9 of The adaptive evolution of cancer driver genes Open
Additional file 9.
Additional file 4 of The adaptive evolution of cancer driver genes Open
Additional file 4.
Additional file 8 of The adaptive evolution of cancer driver genes Open
Additional file 8.
A novel necroptosis-related lncRNA signature for predicting prognosis and anti-cancer treatment response in endometrial cancer Open
Background Necroptosis, a form of programmed cell death, underlies tumorigenesis and the progression of cancers. Anti-cancer strategies targeting necroptosis have increasingly been shown to present a potential cancer therapy. However, the …
Protein Panel of Serum-Derived Small Extracellular Vesicles for the Screening and Diagnosis of Epithelial Ovarian Cancer Open
Although ovarian cancer, a gynecological malignancy, has the highest fatality rate, it still lacks highly specific biomarkers, and the differential diagnosis of ovarian masses remains difficult to determine for gynecologists. Our study aim…
Misdiagnosis and Chemotherapy Delaying Reduces the Chemosensitivity of Choriocarcinoma Patient: Analysis of 36 Cases Open
Background: Choriocarcinoma is a curable malignant neoplasm when chemotherapy is properly implemented. However, when chemotherapy resistance occurs, disease can be fatal. Misdiagnosis is common, which may lead to delaying of the first cycl…
Recent selection is a major force driving cancer evolution Open
Cancer is one of the most threatening diseases to humans. Understanding the evolution of cancer genes is helpful for therapy management. However, systematic investigation of the evolution of cancer driver genes is sparse. Using comparative…
Anaplastic carcinoma showing rhabdoid features combined with ovarian mucinous borderline cystadenoma: a case report and literature review Open
Anaplastic carcinoma in an ovarian tumor (ACOT) is rare. There have been a few controversial cases illustrating the clinical characteristics and prognostic factors of ACOT, which are not well known. A 60-year-old Chinese woman presented wi…
View article: A novel diagnostic nomogram based on serological and ultrasound findings for preoperative prediction of malignancy in patients with ovarian masses
A novel diagnostic nomogram based on serological and ultrasound findings for preoperative prediction of malignancy in patients with ovarian masses Open
The cost-effective and easily accessible nomogram model exhibited favorable accuracy for preoperative prediction of malignancy in patients with ovarian masses, even at early stages.
Non-target genetic manipulation induces rhabdomyosarcoma in KrasPten-driven mouse model of ovarian cancer Open
Avoiding accidental exposure of non-target tissues to adenovirus is crucial to successfully establish the ovarian cancer mouse model. Moreover, non-specific genetic manipulations can induce the development of RMS.
View article: SRT2183 impairs ovarian cancer by facilitating autophagy
SRT2183 impairs ovarian cancer by facilitating autophagy Open
The 5-year survival rate of ovarian cancer patients is only 47%, and developing novel drugs for ovarian cancer is needed. Herein, we evaluated if and how SRT2183, a sirtuin-1 activator, impairs the ovarian cancer cells. OVCAR-3 and A2780 c…
CHD1L promotes EOC cell invasiveness and metastasis via the regulation of METAP2 Open
Chromodomain helicase DNA binding protein 1-like (CHD1L) gene has been proposed to play an oncogenic role in human hepatocellular carcinoma. Previously we reported that CHD1L overexpression is significantly associated with the metastasis p…
Expression of TBC1D16 Is Associated with Favorable Prognosis of Epithelial Ovarian Cancer Open
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy with high recurrence and poor prognosis duo to the lack of effective biomarkers. TBC1 domain family member 16 (TBC1D16), a GTPase-activating protein, is involved in …