Guogen Mao
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View article: Increased Incidence of DACH1 Mutation in Appalachian Women with Uterine Cancer and Altered Chemotherapy Sensitivity
Increased Incidence of DACH1 Mutation in Appalachian Women with Uterine Cancer and Altered Chemotherapy Sensitivity Open
Background: DACH1 is a tumor suppressor with increased mutation frequency in uterine cancers in Kentucky. We compared the frequency of DACH1mutations between women with uterine cancer in Appalachian versus non-Appalachian regions in the On…
View article: Rad5 and Its Human Homologs, HLTF and SHPRH, Are Novel Interactors of Mismatch Repair
Rad5 and Its Human Homologs, HLTF and SHPRH, Are Novel Interactors of Mismatch Repair Open
DNA mismatch repair (MMR) repairs replication errors, and MMR defects play a role in both inherited cancer predisposition syndromes and in sporadic cancers. MMR also recognizes mispairs caused by environmental and chemotherapeutic agents; …
View article: Author Correction: Identification of novel genetic variants predisposing to familial oral squamous cell carcinomas
Author Correction: Identification of novel genetic variants predisposing to familial oral squamous cell carcinomas Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Identification of novel genetic variants predisposing to familial oral squamous cell carcinomas
Identification of novel genetic variants predisposing to familial oral squamous cell carcinomas Open
Oral squamous cell carcinoma (OSCC) is a common subtype of head and neck squamous cell carcinoma (HNSCC), but the pathogenesis underlying familial OSCCs is unknown. Here, we analyzed whole-genome sequences of a family with autosomal domina…
View article: Coronary Artery Disease Risk-Associated <i>Plpp3</i> Gene and Its Product Lipid Phosphate Phosphatase 3 Regulate Experimental Atherosclerosis
Coronary Artery Disease Risk-Associated <i>Plpp3</i> Gene and Its Product Lipid Phosphate Phosphatase 3 Regulate Experimental Atherosclerosis Open
Objective: Genome-wide association studies identified novel loci in PLPP3 (phospholipid phosphatase 3) that associate with coronary artery disease risk independently of traditional risk factors. PLPP3 encodes LPP3 (lipid phosphate phosphat…
View article: Regulation of PLPP3 gene expression by NF-κB family transcription factors
Regulation of PLPP3 gene expression by NF-κB family transcription factors Open
Lipid phosphate phosphatase 3 (LPP3), encoded by the PLPP3 gene, is an integral membrane enzyme that dephosphorylates phosphate esters of glycero- and sphingophospholipids. Cell surface LPP3 can terminate the signaling actions of bioactive…
View article: J. Lipid Res.-2019-Kraemer-jlr.M093096.pdf
J. Lipid Res.-2019-Kraemer-jlr.M093096.pdf Open
Lysophosphatidic acids (LPA) are bioactive radyl hydrocarbon-substituted derivatives of glycerol 3-phosphate. LPA metabolism and signaling are implicated in heritable risk of coronary artery disease. Genetic and pharmacological inhibition …
View article: Cancer-driving H3G34V/R/D mutations block H3K36 methylation and H3K36me3–MutSα interaction
Cancer-driving H3G34V/R/D mutations block H3K36 methylation and H3K36me3–MutSα interaction Open
Significance Somatic mutations converting glycine 34 of histone H3 (H3G34) to a large side chain-containing residue (e.g., arginine, valine) cause pediatric gliomas; however, the mechanism of this is unknown. Because H3K36me3 is involved i…