Guohong Deng
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View article: Back Cover: D‐Mannose Alleviates Type 2 Diabetes and Rescues Multi‐Organ Deteriorations by Controlling Release of Pathological Extracellular Vesicles (EXP2 5/2025)
Back Cover: D‐Mannose Alleviates Type 2 Diabetes and Rescues Multi‐Organ Deteriorations by Controlling Release of Pathological Extracellular Vesicles (EXP2 5/2025) Open
View article: Development and validation of an early diagnostic model to distinguish bacterial infection in patients with acute-on-chronic liver disease (AoCLD) and systemic inflammatory response syndrome (SIRS): a post-hoc analysis of a prospective multicenter cohort
Development and validation of an early diagnostic model to distinguish bacterial infection in patients with acute-on-chronic liver disease (AoCLD) and systemic inflammatory response syndrome (SIRS): a post-hoc analysis of a prospective multicenter cohort Open
The early diagnostic model developed in this study effectively differentiates between infectious and non-infectious SIRS in AoCLD patients, potentially reducing unnecessary antimicrobial exposure and improving clinical outcomes.
View article: TRP channels in epileptogenesis: calcium dysregulation mechanisms and pharmacological targeting strategies
TRP channels in epileptogenesis: calcium dysregulation mechanisms and pharmacological targeting strategies Open
Epilepsy, a prevalent neurological disorder affecting millions globally, manifests as recurrent synchronous neuronal discharges that disrupt normal cerebral function. Emerging evidence characterizes this condition as a network-level hypere…
View article: Correction: Global trends in the application of nanopore sequencing technology in the detection of infectious disease pathogens: a bibliometric analysis from 2014 to 2024
Correction: Global trends in the application of nanopore sequencing technology in the detection of infectious disease pathogens: a bibliometric analysis from 2014 to 2024 Open
[This corrects the article DOI: 10.3389/fmed.2025.1610063.].
View article: D‐Mannose Alleviates Type 2 Diabetes and Rescues Multi‐Organ Deteriorations by Controlling Release of Pathological Extracellular Vesicles
D‐Mannose Alleviates Type 2 Diabetes and Rescues Multi‐Organ Deteriorations by Controlling Release of Pathological Extracellular Vesicles Open
Type 2 diabetes (T2D) is a prevalent metabolic disease inducing alterations of multiple organ systems with currently no cure. Extracellular vesicles (EVs) have been increasingly noticed as one critical paracrine communicator inducing insul…
View article: Dexamethasone treatment is associated with a higher HBsAg sero-clearance rate in HBeAg-positive patients with hepatitis B flares
Dexamethasone treatment is associated with a higher HBsAg sero-clearance rate in HBeAg-positive patients with hepatitis B flares Open
Our study confirmed the beneficial role of low-dose and short-term dexamethasone treatment in flare patients, particularly in patients with ALT ≥ 30 × ULN and platelet counts ≥ 110 × 109/L.
View article: Global trends in the application of nanopore sequencing technology in the detection of infectious disease pathogens: a bibliometric analysis from 2014 to 2024
Global trends in the application of nanopore sequencing technology in the detection of infectious disease pathogens: a bibliometric analysis from 2014 to 2024 Open
Purpose This study aimed to comprehensively analyze the global landscape, trends, and research focus of nanopore sequencing technology in the field of pathogenic microorganism diagnosis using bibliometric analysis. Methods Literature publi…
View article: Anti-HBc IgM associates with acute flare and HBeAg/HBsAg loss in chronic hepatitis B patients with acute exacerbation
Anti-HBc IgM associates with acute flare and HBeAg/HBsAg loss in chronic hepatitis B patients with acute exacerbation Open
Acute exacerbation (AE) is common for patients with chronic hepatitis B (CHB). The aim of the study is to investigate the values of hepatitis B core antibody (anti-HBc) IgM in CHB-AE. Patients were screened from a prospective sub-cohort, 4…
View article: Human cytomegalovirus reactivation in cirrhosis patients with acute decompensation
Human cytomegalovirus reactivation in cirrhosis patients with acute decompensation Open
Background/Aims: The role of reactivation of human cytomegalovirus (HCMV) in determining outcomes of cirrhotic patients with acute decompensation (AD) is unknown. We aimed to investigate HCMV incidence and potential correlation with hepati…
View article: Serum Creatinine of 1.1 mg/dL Can Indicate Disease Deterioration and 90‐day Mortality in Hospitalized Patients With Cirrhosis in Chinese Population
Serum Creatinine of 1.1 mg/dL Can Indicate Disease Deterioration and 90‐day Mortality in Hospitalized Patients With Cirrhosis in Chinese Population Open
Aims Increased serum creatinine (sCR) is associated with increased mortality in cirrhotic patients, while there remains a lack of evidence‐based sCR cutoffs for indicating disease deterioration and predicting 90‐day liver transplantation (…
View article: Impact of cranioplasty on cerebral blood flow perfusion and neurocognitive function in different types of traumatic brain injury
Impact of cranioplasty on cerebral blood flow perfusion and neurocognitive function in different types of traumatic brain injury Open
Background Cranioplasty represents a surgical intervention meticulously designed to tackle the dangers of increased intracranial pressure caused by traumatic brain injury. At its core, the procedure aims to facilitate skull decompression a…
View article: Case report: Pediatric intraventricular Rosai-Dorfman disease: clinical insights and surgical strategies in a decade-long observational study and literature review
Case report: Pediatric intraventricular Rosai-Dorfman disease: clinical insights and surgical strategies in a decade-long observational study and literature review Open
Background Rosai-Dorfman disease (RDD), or sinus histiocytosis with massive lymphadenopathy (SHML), is a rare benign disorder characterized by the proliferation of histiocytes of uncertain origin. Central nervous system (CNS) involvement, …
View article: Nomograms for predicting short-term mortality in acute-on-chronic liver disease caused by the combination of hepatitis B virus and alcohol
Nomograms for predicting short-term mortality in acute-on-chronic liver disease caused by the combination of hepatitis B virus and alcohol Open
This study aimed to identify predictive factors for the prognosis of acute-on-chronic liver disease (AoCLD) due to both hepatitis B virus (HBV) and alcohol and to develop prognostic models to improve treatment management. AoCLD patients wi…
View article: Evidence-based incorporation of key parameters into MELD score for acute-on-chronic liver failure
Evidence-based incorporation of key parameters into MELD score for acute-on-chronic liver failure Open
Background The model for end-stage liver disease (MELD) score is widely used for the prognostication in end-stage liver disease but has limited performance in acute-on-chronic liver failure (ACLF). In this study, we identified additional p…
View article: The removal of excessive neutrophil extracellular traps is helpful for delaying the occurrence of chronic obstructive pulmonary disease
The removal of excessive neutrophil extracellular traps is helpful for delaying the occurrence of chronic obstructive pulmonary disease Open
Neutrophil extracellular traps (NETs) are elevated in peripheral blood and sputum in patients with COPD, but the effect of NETs on the occurrence of COPD is unknown. There is no effective prevention method for chronic obstructive pulmonary…
View article: Barium isotope evidence for a magmatic fluid-dominated petrogenesis of LCT-type pegmatites
Barium isotope evidence for a magmatic fluid-dominated petrogenesis of LCT-type pegmatites Open
Understanding the petrogenesis of granitic pegmatites associated with Li mineralisation is fundamental in constraining rare metal enrichment mechanisms.However, there is still significant controversy surrounding the central issue of the na…
View article: Expression and clinical significance of interleukin-6 pathway in cholangiocarcinoma
Expression and clinical significance of interleukin-6 pathway in cholangiocarcinoma Open
Background Cholangiocarcinoma (CCA) is a typical inflammation-induced malignancy, and elevated serum interleukin-6 (IL-6) levels have been reported to be linked to the onset and progression of CCA. We aim to investigate the potential progn…
View article: Characterization of acute-on-chronic liver diseases: A multicenter prospective cohort study
Characterization of acute-on-chronic liver diseases: A multicenter prospective cohort study Open
BACKGROUND Acute-on-chronic liver disease (AoCLD) accounts for the majority of patients hospitalized in the Department of Hepatology or Infectious Diseases. AIM To explore the characterization of AoCLD to provide theoretical guidance for t…
View article: Association of AST/ALT ratio with 90-day outcomes in patients with acute exacerbation of chronic liver disease: a prospective multicenter cohort study in China
Association of AST/ALT ratio with 90-day outcomes in patients with acute exacerbation of chronic liver disease: a prospective multicenter cohort study in China Open
Background and aim A high aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio is associated with liver injury in liver disease; however, no data exist regarding its relationship with 90-day prognosis in patients with acute …
View article: sTREM-1 as promising prognostic biomarker for acute-on-chronic liver failure and mortality in patients with acute decompensation of cirrhosis
sTREM-1 as promising prognostic biomarker for acute-on-chronic liver failure and mortality in patients with acute decompensation of cirrhosis Open
BACKGROUND Acute decompensation (AD) of cirrhosis is associated with high short-term mortality, mainly due to the development of acute-on-chronic liver failure (ACLF). Thus, there is a need for biomarkers for early and accurate identificat…
View article: Path tracking control of automated vehicles based on adaptive MPC in variable scenarios
Path tracking control of automated vehicles based on adaptive MPC in variable scenarios Open
For complex and dynamic high‐speed driving scenarios, an adaptive model predictive control (MPC) controller is designed to ensure effective path tracking for automated vehicles. Firstly, in order to prevent model mismatch in the MPC contro…
View article: Cell-free DNA testing for early hepatocellular carcinoma surveillance
Cell-free DNA testing for early hepatocellular carcinoma surveillance Open
View article: The clinical courses of HBV-related acute-on-chronic liver failure and a multi-state model to predict disease evolution
The clinical courses of HBV-related acute-on-chronic liver failure and a multi-state model to predict disease evolution Open
Background and Aims: Acute-on-chronic liver failure (ACLF) is a highly dynamic syndrome. The objective of this study was to delineate the clinical course of patients with HBV-ACLF and to develop a model to estimate the temporal evolution o…
View article: Investigation on the short‐term outcome and prognostic impact of predisposition, and precipitants in inpatients with chronic liver disease from Chinese AcuTe on CHronic LIver FailurE (CATCH‐LIFE) cohorts
Investigation on the short‐term outcome and prognostic impact of predisposition, and precipitants in inpatients with chronic liver disease from Chinese AcuTe on CHronic LIver FailurE (CATCH‐LIFE) cohorts Open
Aim The study aimed to investigate the short‐term outcomes of hospitalized patients with chronic liver disease (CLDs) and assess the prognostic impact of predisposition and precipitants, which currently remains unclear. Methods The study i…
View article: Severe anemia is associated with increased short-term and long-term mortality in patients hospitalized with cirrhosis
Severe anemia is associated with increased short-term and long-term mortality in patients hospitalized with cirrhosis Open
Anemia is common in patients with cirrhosis admitted for acute events. Severe anemia was associated with poor 90-day and 1-year prognoses in these patients.
View article: Longitudinal and Lateral Control Strategies for Automatic Lane Change to Avoid Collision in Vehicle High-Speed Driving
Longitudinal and Lateral Control Strategies for Automatic Lane Change to Avoid Collision in Vehicle High-Speed Driving Open
The vehicle particle model was built to compare and analyze the effectiveness of three different collision avoidance methods. The results show that during vehicle high-speed emergency collision avoidance, lane change collision avoidance re…
View article: Table S2 from The Landscape of Cell-Free HBV Integrations and Mutations in Cirrhosis and Hepatocellular Carcinoma Patients
Table S2 from The Landscape of Cell-Free HBV Integrations and Mutations in Cirrhosis and Hepatocellular Carcinoma Patients Open
Table S2
View article: Table S1 from The Landscape of Cell-Free HBV Integrations and Mutations in Cirrhosis and Hepatocellular Carcinoma Patients
Table S1 from The Landscape of Cell-Free HBV Integrations and Mutations in Cirrhosis and Hepatocellular Carcinoma Patients Open
Table S1
View article: Table S6 from The Landscape of Cell-Free HBV Integrations and Mutations in Cirrhosis and Hepatocellular Carcinoma Patients
Table S6 from The Landscape of Cell-Free HBV Integrations and Mutations in Cirrhosis and Hepatocellular Carcinoma Patients Open
Table S6
View article: Supplementary Data from The Landscape of Cell-Free HBV Integrations and Mutations in Cirrhosis and Hepatocellular Carcinoma Patients
Supplementary Data from The Landscape of Cell-Free HBV Integrations and Mutations in Cirrhosis and Hepatocellular Carcinoma Patients Open
Supplementary figures