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View article: Amyloid fibril structures link CHCHD10 and CHCHD2 to neurodegeneration
Amyloid fibril structures link CHCHD10 and CHCHD2 to neurodegeneration Open
Mitochondrial proteins CHCHD10 and CHCHD2 are mutated in rare cases of heritable FTD, ALS and PD and aggregate in tissues affected by these diseases. Here, we show that both proteins form amyloid fibrils and report cryo-EM structures of fi…
View article: Salt gradient-driven adaptation in okra: uncovering mechanisms of tolerance and growth regulation
Salt gradient-driven adaptation in okra: uncovering mechanisms of tolerance and growth regulation Open
Soil salinity is an increasingly critical constraint on crop establishment and yield stability, especially in marginal and irrigated agricultural zones. Despite its nutritional and economic value, the mechanistic basis of salt tolerance in…
View article: Hypoxic Upregulation of IER2 Increases Paracrine GMFG Signaling of Endoplasmic Reticulum Stress‐CAF to Promote Chordoma Progression via Targeting ITGB1
Hypoxic Upregulation of IER2 Increases Paracrine GMFG Signaling of Endoplasmic Reticulum Stress‐CAF to Promote Chordoma Progression via Targeting ITGB1 Open
Currently, the oncogenic mechanism of endoplasmic reticulum stress‐CAF (ERS‐CAF) subpopulation in chordoma remains unknown. Here, single‐cell RNA sequencing, spatial transcriptomics, GeoMx Digital Spatial Profiler, data‐independent acquisi…
View article: Ultrasonic treatment can improve maize seed germination and abiotic stress resistance
Ultrasonic treatment can improve maize seed germination and abiotic stress resistance Open
View article: Comparative analysis of gut microbiota and intestinal transcriptomic profile between fast- and slow-growing American eels (Anguilla rostrata)
Comparative analysis of gut microbiota and intestinal transcriptomic profile between fast- and slow-growing American eels (Anguilla rostrata) Open
During American eel farming (from glass eels to silver eels), significant individual growth differences were commonly observed even under the same farming conditions. However, the underlying mechanism is not clear. In this study, a batch o…
View article: Risk factors of instrumentation failure after laminectomy and posterior cervical fusions (PCF)
Risk factors of instrumentation failure after laminectomy and posterior cervical fusions (PCF) Open
Background For patients with multilevel degenerative cervical myelopathy, laminectomy and posterior cervical fusions (PCF) with instrumentation are widely accepted techniques for symptom relief. However, hardware failure is not rare and re…
View article: Development and validation of nomograms to predict survival and recurrence following hepatectomy for intermediate/advanced (BCLC stage B/C) hepatocellular carcinoma
Development and validation of nomograms to predict survival and recurrence following hepatectomy for intermediate/advanced (BCLC stage B/C) hepatocellular carcinoma Open
View article: Integrating single-cell and spatial transcriptomics reveals endoplasmic reticulum stress-related CAF subpopulations associated with chordoma progression
Integrating single-cell and spatial transcriptomics reveals endoplasmic reticulum stress-related CAF subpopulations associated with chordoma progression Open
Background With cancer-associated fibroblasts (CAFs) as the main cell type, the rich myxoid stromal components in chordoma tissues may likely contribute to its development and progression. Methods Single-cell RNA sequencing (scRNA-seq), sp…
View article: Corrigendum: Gut microbes reveal Pseudomonas medicates ingestion preference via protein utilization and cellular homeostasis under feed domestication in freshwater drum, Aplodinotus grunniens
Corrigendum: Gut microbes reveal Pseudomonas medicates ingestion preference via protein utilization and cellular homeostasis under feed domestication in freshwater drum, Aplodinotus grunniens Open
[This corrects the article DOI: 10.3389/fmicb.2022.861705.].
View article: Table of Contents
Table of Contents Open
View article: Rbm15 mediated m6A RNA modification participates in the regulation of AKAP2 on chondrogenesis
Rbm15 mediated m6A RNA modification participates in the regulation of AKAP2 on chondrogenesis Open
Purpose: To investigate the function of AKAP2 in the pathogenesis of AIS by regulating the growth of chondrocyt e and explore the mechanism involved. Methods: ATDC-5 cells was used as chondrogenic cell model, and the AKAP2 overexpression a…
View article: Corrigendum: Coexpression of HHLA2 and PD-L1 on tumor cells independently predicts the survival of spinal chordoma patients
Corrigendum: Coexpression of HHLA2 and PD-L1 on tumor cells independently predicts the survival of spinal chordoma patients Open
[This corrects the article DOI: 10.3389/fimmu.2021.797407.].
View article: Association of Type 2 Diabetes Mellitus with Spinal Degenerative Disorders: An Observational and Two-Sample Mendelian Randomization Study
Association of Type 2 Diabetes Mellitus with Spinal Degenerative Disorders: An Observational and Two-Sample Mendelian Randomization Study Open
View article: A toxin-deformation dependent inhibition mechanism in the T7SS toxin-antitoxin system of Gram-positive bacteria
A toxin-deformation dependent inhibition mechanism in the T7SS toxin-antitoxin system of Gram-positive bacteria Open
Toxin EsaD secreted by some S. aureus strains through the type VII secretion system (T7SS) specifically kills those strains lacking the antitoxin EsaG. Here we report the structures of EsaG, the nuclease domain of EsaD and their complex, w…
View article: Corrigendum: Risk factors for tuberculous or nontuberculous spondylitis after percutaneous vertebroplasty or kyphoplasty in patients with osteoporotic vertebral compression fracture: A case-control study
Corrigendum: Risk factors for tuberculous or nontuberculous spondylitis after percutaneous vertebroplasty or kyphoplasty in patients with osteoporotic vertebral compression fracture: A case-control study Open
[This corrects the article DOI: 10.3389/fsurg.2022.962425.].
View article: CircPARD3 promotes osteosarcoma proliferation and metastasis through regulating the miRNA-1294/ SKIL Pathway
CircPARD3 promotes osteosarcoma proliferation and metastasis through regulating the miRNA-1294/ SKIL Pathway Open
Background: Osteosarcoma (OS) is the most common malignant bone tumor in the pediatric population. The main goal of this study is to investigate the role of circPARD3 and the underlying signaling pathway involved in OS.Methods: Cell prolif…
View article: Exosomes from dysfunctional chondrocytes affect osteoarthritis in Sprague-Dawley rats through FTO-dependent regulation of PIK3R5 mRNA stability
Exosomes from dysfunctional chondrocytes affect osteoarthritis in Sprague-Dawley rats through FTO-dependent regulation of PIK3R5 mRNA stability Open
Aims Exosomes (exo) are involved in the progression of osteoarthritis (OA). This study aimed to investigate the function of dysfunctional chondrocyte-derived exo (DC-exo) on OA in rats and rat macrophages. Methods Rat-derived chondrocytes …
View article: Long Noncoding RNA LINC00525 Promotes the Aggressive Phenotype of Chordoma Through Acting as a microRNA-505-3p Sponge and Consequently Raising HMGB1 Expression [Retraction]
Long Noncoding RNA LINC00525 Promotes the Aggressive Phenotype of Chordoma Through Acting as a microRNA-505-3p Sponge and Consequently Raising HMGB1 Expression [Retraction] Open
[This retracts the article DOI: 10.2147/OTT.S268678.].
View article: Risk factors for tuberculous or nontuberculous spondylitis after percutaneous vertebroplasty or kyphoplasty in patients with osteoporotic vertebral compression fracture: A case-control study
Risk factors for tuberculous or nontuberculous spondylitis after percutaneous vertebroplasty or kyphoplasty in patients with osteoporotic vertebral compression fracture: A case-control study Open
Objectives The contributing factors for spondylitis after percutaneous vertebroplasty (PVP) or percutaneous kyphoplasty (PKP) remain unclear. Here, we sought to investigate the factors affecting spondylitis occurrence after PVP/PKP. We als…
View article: Molecular and functional interactions of alpha-synuclein with Rab3a
Molecular and functional interactions of alpha-synuclein with Rab3a Open
View article: Effect Analysis of Preoperative Intravenous Tranexamic Acid Combined With Intraoperative Immersion in Reducing Perioperative Blood Loss of One Stage Posterior Thoracolumbar Tuberculosis
Effect Analysis of Preoperative Intravenous Tranexamic Acid Combined With Intraoperative Immersion in Reducing Perioperative Blood Loss of One Stage Posterior Thoracolumbar Tuberculosis Open
Background To investigate the efficacy and safety of preoperative intravenous tranexamic acid (TXA) combined with intraoperative immersion in reducing perioperative blood loss in one-stage posterior thoracolumbar tuberculosis. Methods All …
View article: Gut Microbes Reveal Pseudomonas Medicates Ingestion Preference via Protein Utilization and Cellular Homeostasis Under Feed Domestication in Freshwater Drum, Aplodinotus grunniens
Gut Microbes Reveal Pseudomonas Medicates Ingestion Preference via Protein Utilization and Cellular Homeostasis Under Feed Domestication in Freshwater Drum, Aplodinotus grunniens Open
With strong demand for aquatic products, as well as a rapid decrease in global fishery resources and capture fisheries, domesticating animals to provide more high-quality proteins is meaningful for humans. Freshwater drum ( Aplodinotus gru…
View article: Learning Curve and Initial Outcomes of Full-Endoscopic Posterior Lumbar Interbody Fusion
Learning Curve and Initial Outcomes of Full-Endoscopic Posterior Lumbar Interbody Fusion Open
Study Design This was a retrospective cohort study. Objective We evaluated the feasibility, safety, and accuracy of full-endoscopic posterior lumbar interbody fusion (FE-PLIF) by assessing the learning curve and initial clinical outcomes. …
View article: Incidence and Risk Factors for Cerebrovascular-Specific Mortality in Patients with Colorectal Cancer: A Registry-Based Cohort Study Involving 563,298 Patients
Incidence and Risk Factors for Cerebrovascular-Specific Mortality in Patients with Colorectal Cancer: A Registry-Based Cohort Study Involving 563,298 Patients Open
Background: Colorectal cancer (CRC) is one of the most prevalent diseases and the second leading cause of death worldwide. However, the relationship between CRC and cerebrovascular-specific mortality (CVSM) remains elusive, and less is kno…
View article: Clinicopathological Characteristics and Prognostic Factors in Axial Chondroblastomas: A Retrospective Analysis of 61 Cases and Comparison with Extra-Axial Chondroblastomas
Clinicopathological Characteristics and Prognostic Factors in Axial Chondroblastomas: A Retrospective Analysis of 61 Cases and Comparison with Extra-Axial Chondroblastomas Open
Background : The clinical characteristics and prognostic factors of axial chondroblastoma (ACB) are still poorly understood. Purpose : To characterize clinicopathological characteristics in a large ACB cohort and investigate their correlat…
View article: Coexpression of HHLA2 and PD-L1 on Tumor Cells Independently Predicts the Survival of Spinal Chordoma Patients
Coexpression of HHLA2 and PD-L1 on Tumor Cells Independently Predicts the Survival of Spinal Chordoma Patients Open
Background Immunotherapy only achieves efficacy in some cancer patients, and less is known about other immune checkpoint molecules in chordoma. Here, we aimed to determine the expression of PD-L1, HHLA2, B7H3, IDO-1 and Galectin-9 in spina…
View article: Clinicopathological Characteristics and Prognostic Factors in Axial Chondroblastomas: A Retrospective Analysis of 61 Cases and Comparison with Extra-Axial Chondroblastomas
Clinicopathological Characteristics and Prognostic Factors in Axial Chondroblastomas: A Retrospective Analysis of 61 Cases and Comparison with Extra-Axial Chondroblastomas Open
Background The clinical characteristics and prognostic factors of axial chondroblastoma (ACB) are still poorly understood. Purpose To characterize clinicopathological characteristics in a large ACB cohort and investigate their correlation …
View article: Early-stage structure-based drug discovery for small GTPases by NMR spectroscopy
Early-stage structure-based drug discovery for small GTPases by NMR spectroscopy Open
Small GTPase or Ras superfamily, including Ras, Rho, Rab, Ran and Arf, are fundamental in regulating a wide range of cellular processes such as growth, differentiation, migration and apoptosis. They share structural and functional similari…
View article: Incidence and Risk Factors for Cerebrovascular-Specific Mortality in Patients with Colorectal Cancer: A Registry-Based Cohort Study Involving 563298 Patients
Incidence and Risk Factors for Cerebrovascular-Specific Mortality in Patients with Colorectal Cancer: A Registry-Based Cohort Study Involving 563298 Patients Open
Background: Colorectal cancer (CRC) is one of the most prevalent diseases and the second leading cause of death worldwide. However, the relationship between CRC and cerebrovascular-specific mortality (CVSM) remains elusive and less is know…
View article: RUNX3 derived hsa_circ_0005752 accelerates the osteogenic differentiation of adipose-derived stem cells via the miR-496/MDM2-p53 pathway
RUNX3 derived hsa_circ_0005752 accelerates the osteogenic differentiation of adipose-derived stem cells via the miR-496/MDM2-p53 pathway Open
Our study demonstrated that RUNX3 promoted osteogenic differentiation via regulating the hsa_circ_0005752/miR-496/MDM2 axis and thus provided a new therapeutic strategy for osteoporosis.