Guoli Yang
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View article: Optogenetic Engineering of Synthetic and Natural Receptors: Design Principles, Functional Mechanisms, and Biomedical Applications
Optogenetic Engineering of Synthetic and Natural Receptors: Design Principles, Functional Mechanisms, and Biomedical Applications Open
Cellular receptors serve as central hubs that translate external signals into intracellular programs governing cell fate, function, and behavior. Achieving precise and reversible control over receptor activity has long been a major challen…
View article: A programmable pAgo nuclease with high activity and specificity for efficient DNA and RNA manipulation
A programmable pAgo nuclease with high activity and specificity for efficient DNA and RNA manipulation Open
Prokaryotic Argonaute proteins (pAgos) are programmable nucleases with potential for the development of novel nucleic acid manipulation tools. Previous studies have shown that several pAgos exhibit strong preferences for either DNA or RNA …
View article: The molecular basis of μ-opioid receptor signaling plasticity
The molecular basis of μ-opioid receptor signaling plasticity Open
Activation of the μ-opioid receptor (μOR) alleviates pain but also elicits adverse effects through diverse G proteins and β-arrestins. The structural details of μOR complexes with G z and β-arrestins have not been determined, impeding a co…
View article: Cooperative Task Allocation for Unmanned Aerial Vehicle Swarm Using Multi-Objective Multi-Population Self-Adaptive Ant Lion Optimizer
Cooperative Task Allocation for Unmanned Aerial Vehicle Swarm Using Multi-Objective Multi-Population Self-Adaptive Ant Lion Optimizer Open
The rational allocation of tasks is a critical issue in enhancing the mission execution capability of unmanned aerial vehicle (UAV) swarms, which is difficult to solve exactly in polynomial time. Evolutionary-algorithm-based approaches are…
View article: Mechanistic insights into miR-584-5p-mediated Inhibition of PDLSCs osteogenic differentiation through H2AFZ upregulation and RUNX2 suppression
Mechanistic insights into miR-584-5p-mediated Inhibition of PDLSCs osteogenic differentiation through H2AFZ upregulation and RUNX2 suppression Open
Periodontal ligament stem cells (PDLSCs) hold promise for bone regeneration, but their osteogenic differentiation is tightly regulated by various molecular mechanisms. MicroRNAs are key regulators of this process, and miR-584-5p has been i…
View article: Expert consensus on peri-implant keratinized mucosa augmentation at second-stage surgery
Expert consensus on peri-implant keratinized mucosa augmentation at second-stage surgery Open
Peri-implant keratinized mucosa (PIKM) augmentation refers to surgical procedures aimed at increasing the width of PIKM. Consensus reports emphasize the necessity of maintaining a minimum width of PIKM to ensure long-term peri-implant heal…
View article: TransMedSeg: A Transferable Semantic Framework for Semi-Supervised Medical Image Segmentation
TransMedSeg: A Transferable Semantic Framework for Semi-Supervised Medical Image Segmentation Open
Semi-supervised learning (SSL) has achieved significant progress in medical image segmentation (SSMIS) through effective utilization of limited labeled data. While current SSL methods for medical images predominantly rely on consistency re…
View article: Engineered bone-targeting apoptotic vesicles as a minimally invasive nanotherapy for heterotopic ossification
Engineered bone-targeting apoptotic vesicles as a minimally invasive nanotherapy for heterotopic ossification Open
Heterotopic Ossification (HO), refers to pathological extra skeletal bone formation, and there are currently no reliable methods except surgery to reverse these unexpected calcified tissues. Apoptotic vesicles (ApoEVs) are membrane-bound v…
View article: Macrophage response to fibrin structure mediated by Tgm2-dependent mitochondrial mechanosensing
Macrophage response to fibrin structure mediated by Tgm2-dependent mitochondrial mechanosensing Open
Following an injury at the implantation position, blood-material interactions form a fibrin architecture, which serves as the initial activator of foreign body response (FBR). However, there is limited knowledge regarding how the topograph…
View article: SP7 transcription factor ameliorates bone defect healing in low-density lipoprotein receptor-related protein 5 (LRP5)-dependent osteoporosis mice
SP7 transcription factor ameliorates bone defect healing in low-density lipoprotein receptor-related protein 5 (LRP5)-dependent osteoporosis mice Open
Loss-of-function variants of low-density lipoprotein receptor-related protein 5 (LRP5) can lead to reduced bone formation, culminating in diminished bone mass. Our previous study reported transcription factor osterix (SP7)-binding sites o…
View article: Exploring the bidirectional causality between neuroticism and frailty: a Mendelian randomization analysis
Exploring the bidirectional causality between neuroticism and frailty: a Mendelian randomization analysis Open
Background Epidemiological studies have confirmed the relationship between personality trait neuroticism and physical health. However, the relationship between neuroticism and frailty remains unconfirmed. This study employed a bi-direction…
View article: Epithelial differentiation of gingival mesenchymal stem cells enhances re-epithelialization for full-thickness cutaneous wound healing
Epithelial differentiation of gingival mesenchymal stem cells enhances re-epithelialization for full-thickness cutaneous wound healing Open
Collectively, this study uncovers that GMSCs have the ability to differentiate into epithelia and highlights a promising strategy for using Epi-GMSCs to improve cutaneous wound healing.
View article: Doping functional ions in phase-stabilizing core–shell biphasic granules readily tunes bone regeneration <i>in situ</i>
Doping functional ions in phase-stabilizing core–shell biphasic granules readily tunes bone regeneration <i>in situ</i> Open
Phase-stabilized, core–shell bioceramic granules with selective regional ion doping were fabricated by tailoring their core-to-shell thickness ratios. This design can tune functional ion release and thus remarkably promote bone repair.
View article: Radiographic Assessment of Root/Crown Ratio and Short Root Anomaly: A Retrospective Study in Chinese Population
Radiographic Assessment of Root/Crown Ratio and Short Root Anomaly: A Retrospective Study in Chinese Population Open
Objectives Research suggested that racial and gender differences may exist in tooth root development and the prevalence of short root anomaly (SRA). However, data on Asian and specifically Chinese populations were limited. This retrospecti…
View article: An evolutionary algorithm‐based classification method for high‐dimensional imbalanced mixed data with missing information
An evolutionary algorithm‐based classification method for high‐dimensional imbalanced mixed data with missing information Open
The data scale keeps growing by leaps and the majority of it is high‐dimensional imbalanced data, which is hard to classify. Data missing often happens in software which further aggravates the difficulty of classifying the data. In order t…
View article: Epithelial differentiation of gingival mesenchymal stem cells enhances re-epithelialization for full-thickness cutaneous wound healing
Epithelial differentiation of gingival mesenchymal stem cells enhances re-epithelialization for full-thickness cutaneous wound healing Open
Background A growing body of evidence supports the notion that mesenchymal stem cells (MSCs) are responsible for repairing traumatized tissues primarily through paracrine secretion and differentiation into specific cell types. However, the…
View article: An Engineered Hierarchical Hydrogel with Immune Responsiveness and Targeted Mitochondrial Transfer to Augmented Bone Regeneration
An Engineered Hierarchical Hydrogel with Immune Responsiveness and Targeted Mitochondrial Transfer to Augmented Bone Regeneration Open
Coordinating the immune response and bioenergy metabolism in bone defect environments is essential for promoting bone regeneration. Mitochondria are important organelles that control internal balance and metabolism. Repairing dysfunctional…
View article: Optogenetics in oral and craniofacial research
Optogenetics in oral and craniofacial research Open
Optogenetics combines optics and genetic engineering to control specific gene expression and biological functions and has the advantages of precise spatiotemporal control, noninvasiveness, and high efficiency. Genetically modified photosen…
View article: Radiographic outcomes of lateral sinus floor elevation at sites without perforations and sites with perforations managed with a resorbable membrane: A retrospective study
Radiographic outcomes of lateral sinus floor elevation at sites without perforations and sites with perforations managed with a resorbable membrane: A retrospective study Open
Aim To evaluate the radiographic outcomes of lateral sinus floor elevation with simultaneous implant placement at sites without sinus membrane perforation (SMP) and sites with SMP managed with a resorbable membrane. Materials and Methods O…
View article: Application of silk fibroin coatings for biomaterial surface modification: a silk road for biomedicine
Application of silk fibroin coatings for biomaterial surface modification: a silk road for biomedicine Open
Silk fibroin (SF) as a natural biopolymer has become a popular material for biomedical applications due to its minimal immunogenicity, tunable biodegradability, and high biocompatibility. Nowadays, various techniques have been developed fo…
View article: Biomaterials derived from hard palate mucosa for tissue engineering and regenerative medicine
Biomaterials derived from hard palate mucosa for tissue engineering and regenerative medicine Open
Autologous materials have superior biosafety and are widely used in clinical practice. Due to its excellent trauma-healing ability, the hard palate mucosa (HPM) has become a hot spot for autologous donor area research. Multiple studies hav…
View article: Effect of mitophagy in the formation of osteomorphs derived from osteoclasts
Effect of mitophagy in the formation of osteomorphs derived from osteoclasts Open
Osteoclasts are specialized multinucleated giant cells with unique bone-destroying capacities. A recent study revealed that osteoclasts undergo an alternative cell fate by dividing into daughter cells called osteomorphs. To date, no studie…
View article: The process of contemporary gay identity development in China: The influence of internet use
The process of contemporary gay identity development in China: The influence of internet use Open
Background Adolescence and emerging adulthood are critical periods for an individual's sexual identity development. The internet has become a primary avenue for gay identity exploration. The purpose of this study was to examine the role of…
View article: An Unexpected Single-step Glycosylation Enables the Construction of Antibody-Biomacromolecule Conjugates as Therapeutics
An Unexpected Single-step Glycosylation Enables the Construction of Antibody-Biomacromolecule Conjugates as Therapeutics Open
Glycoengineering has been demonstrated to be a powerful tool to construct site-specific antibody conjugates. However, with most glycoengineering strategies, several hours to days are needed to complete the reaction, and the payloads are li…
View article: Light‐controlled scaffold‐ and serum‐free hard palatal‐derived mesenchymal stem cell aggregates for bone regeneration
Light‐controlled scaffold‐ and serum‐free hard palatal‐derived mesenchymal stem cell aggregates for bone regeneration Open
Cell aggregates that mimic in vivo cell–cell interactions are promising and powerful tools for tissue engineering. This study isolated a new, easily obtained, population of mesenchymal stem cells (MSCs) from rat hard palates named hard pal…