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View article: Pyruvate kinase M2-mediated histone lactylation alters three-dimensional genomic architecture in polycystic ovary syndrome
Pyruvate kinase M2-mediated histone lactylation alters three-dimensional genomic architecture in polycystic ovary syndrome Open
View article: Clinical study of single nucleotide polymorphism-based chromosome microarray analysis in the etiological diagnosis of fetal congenital heart disease
Clinical study of single nucleotide polymorphism-based chromosome microarray analysis in the etiological diagnosis of fetal congenital heart disease Open
View article: Intrauterine hyperglycemia impairs mouse primordial germ cell development and fertility by sex-specific epigenetic reprogramming interference
Intrauterine hyperglycemia impairs mouse primordial germ cell development and fertility by sex-specific epigenetic reprogramming interference Open
Adverse intrauterine environments, such as hyperglycemia, impair sexual reproduction and species continuity, yet the underlying mechanisms remain poorly understood. In this study, we demonstrated that intrauterine hyperglycemia significant…
View article: Androgens drive SLC1A5-dependent metabolic reprogramming in polycystic ovary syndrome
Androgens drive SLC1A5-dependent metabolic reprogramming in polycystic ovary syndrome Open
Polycystic ovary syndrome is the primary cause of female infertility. Growing evidence suggests that dysregulation of amino acid metabolism plays a significant role in the onset and progression. However, the underlying mechanism remains un…
View article: Prenatal liver is resistant to low glucose-induced inhibition of mTORC1
Prenatal liver is resistant to low glucose-induced inhibition of mTORC1 Open
SUMMARY Prenatal development may adopt unique patterns of metabolic responses to different nutrient supplies. AMPK and mTOR are two central metabolic regulators, with AMPK acting to slow down and mTOR to promote anabolism. Typically, low g…
View article: Mechanisms and reversibility of nicotine-induced spermatogenesis impairment and DNA methylation changes
Mechanisms and reversibility of nicotine-induced spermatogenesis impairment and DNA methylation changes Open
View article: Herpes Simplex Infection in Treatment-Refractory Plasma Cell Vulvovaginitis
Herpes Simplex Infection in Treatment-Refractory Plasma Cell Vulvovaginitis Open
View article: Ultrasonographic diagnosis of secondary cardiac position alterations led by fetal thoraco-abdominal anomalies: a report of three cases
Ultrasonographic diagnosis of secondary cardiac position alterations led by fetal thoraco-abdominal anomalies: a report of three cases Open
CDH and severe diaphragmatic eventration involve three systems: respiration, circulation and digestion. When ultrasound finds that the fetal heart is abnormal, further check is needed to see whether there are lesions in the heart, lung, di…
View article: Cerium Oxide Nanozymes Improve Skeletal Muscle Function in Gestational Diabetic Offspring by Attenuating Mitochondrial Oxidative Stress
Cerium Oxide Nanozymes Improve Skeletal Muscle Function in Gestational Diabetic Offspring by Attenuating Mitochondrial Oxidative Stress Open
Gestational diabetes mellitus (GDM) is a significant complication during pregnancy that results in abnormalities in the function of multiple systems in the offspring, which include skeletal muscle dysfunction and reduced systemic metabolic…
View article: <scp>FSH</scp> regulates glucose‐stimulated insulin secretion: A bell‐shaped curve effect
<span>FSH</span> regulates glucose‐stimulated insulin secretion: A bell‐shaped curve effect Open
Follicle-stimulating hormone (FSH), a classical hormone derived from the pituitary, primarily affects the gonads and regulates the reproductive process.1 FSH consists of an α and a β subunit, with the β subunit specifically binding to its …
View article: The stability of lower genital tract (LGT) microbiota correlates with reproductive system function and in vitro fertilization and frozen embryo transfer outcomes in women with polycystic ovarian syndrome
The stability of lower genital tract (LGT) microbiota correlates with reproductive system function and in vitro fertilization and frozen embryo transfer outcomes in women with polycystic ovarian syndrome Open
We previously found that the lower genital tract (LGT) microbiota of polycystic ovarian syndrome (PCOS) women has altered when compared to healthy reproductive-aged women, however whether this alternation will have an impact on the reprodu…
View article: LncRNA SNHG5 adversely governs follicular growth in PCOS via miR-92a-3p/CDKN1C axis
LncRNA SNHG5 adversely governs follicular growth in PCOS via miR-92a-3p/CDKN1C axis Open
Small nucleolar RNA host genes (SNHGs) have been implicated in various biological processes, yet their involvement in polycystic ovary syndrome (PCOS) remains elusive. Specifically, SNHG5, a long non-coding RNA implicated in several human …
View article: Follicle-stimulating hormone orchestrates glucose-stimulated insulin secretion of pancreatic islets
Follicle-stimulating hormone orchestrates glucose-stimulated insulin secretion of pancreatic islets Open
Follicle-stimulating hormone (FSH) is involved in mammalian reproduction via binding to FSH receptor (FSHR). However, several studies have found that FSH and FSHR play important roles in extragonadal tissue. Here, we identified the express…
View article: Sex differences in paternal arsenic-induced intergenerational metabolic effects are mediated by estrogen
Sex differences in paternal arsenic-induced intergenerational metabolic effects are mediated by estrogen Open
View article: Research Progress of Maternal Metabolism on Cardiac Development and Function in Offspring
Research Progress of Maternal Metabolism on Cardiac Development and Function in Offspring Open
The developmental origin of health and disease (DOHaD) hypothesis refers to the adverse effects of suboptimal developmental environments during embryonic and early fetal stages on the long-term health of offspring. Intrauterine metabolic p…
View article: Developmental origins of diabetes mellitus: Environmental epigenomics and emerging patterns
Developmental origins of diabetes mellitus: Environmental epigenomics and emerging patterns Open
Mounting epidemiological evidence indicates that environmental exposures in early life have roles in diabetes susceptibility in later life. Additionally, environmentally induced diabetic susceptibility could be transmitted to subsequent ge…
View article: Spatiotemporal transcriptome atlas of human embryos after gastrulation
Spatiotemporal transcriptome atlas of human embryos after gastrulation Open
The spatial and temporal atlas of gene expression in the human embryo at early gestation is critical in understanding embryo development, organogenesis, and disease origins. We obtained the spatiotemporal transcriptome from 90 sagittal sec…
View article: Compound Heterozygous Mutations in <i>FSIP2</i> Cause Morphological Abnormalities in Sperm Flagella Leading to Male Infertility
Compound Heterozygous Mutations in <i>FSIP2</i> Cause Morphological Abnormalities in Sperm Flagella Leading to Male Infertility Open
Multiple morphological abnormalities of sperm flagella (MMAF) indicate severe teratozoospermia. The fibrous sheath interacting protein 2 (FSIP2) plays an important role in the normal construction of the flagella. In this study, a novel com…
View article: Association of maternal triglyceride responses to thyroid function in early pregnancy with gestational diabetes mellitus
Association of maternal triglyceride responses to thyroid function in early pregnancy with gestational diabetes mellitus Open
Introduction The prevalence of Gestational Diabetes Mellitus (GDM) is increasing globally, and high levels of triglyceride (TG) and low levels of free thyroxine (FT4) in early pregnancy are associated with an increased risk of GDM; however…
View article: Maternal inheritance of glucose intolerance via oocyte TET3 insufficiency
Maternal inheritance of glucose intolerance via oocyte TET3 insufficiency Open
View article: Integrated Multi-Omics Analysis Reveals the Effect of Maternal Gestational Diabetes on Fetal Mouse Hippocampi
Integrated Multi-Omics Analysis Reveals the Effect of Maternal Gestational Diabetes on Fetal Mouse Hippocampi Open
Growing evidence suggests that adverse intrauterine environments could affect the long-term health of offspring. Recent evidence indicates that gestational diabetes mellitus (GDM) is associated with neurocognitive changes in offspring. How…
View article: Anxiety and depression-like behaviours are more frequent in aged male mice conceived by ART compared with natural conception
Anxiety and depression-like behaviours are more frequent in aged male mice conceived by ART compared with natural conception Open
The number of children born after assisted reproductive technology (ART) is accumulating rapidly, and the health problems of the children are extensively concerned. This study aims to evaluate whether ART procedures alter behaviours in mal…
View article: Intrauterine Hyperglycemia Alters the Metabolomic Profile in Fetal Mouse Pancreas in a Gender-Specific Manner
Intrauterine Hyperglycemia Alters the Metabolomic Profile in Fetal Mouse Pancreas in a Gender-Specific Manner Open
Mounting evidence has shown that intrauterine hyperglycemia exposure during critical stages of development may be contributing to the increasing prevalence of diabetes. However, little is known about the mechanisms responsible for offsprin…
View article: Intrauterine hyperglycemia impairs memory across two generations
Intrauterine hyperglycemia impairs memory across two generations Open
View article: Integrative Single-Cell Transcriptomic Analysis of Human Fetal Thymocyte Development
Integrative Single-Cell Transcriptomic Analysis of Human Fetal Thymocyte Development Open
Intrathymic differentiation of T lymphocytes begins as early as intrauterine stage, yet the T cell lineage decisions of human fetal thymocytes at different gestational ages are not currently understood. Here, we performed integrative singl…
View article: Author Correction: REV-ERB in GABAergic neurons controls diurnal hepatic insulin sensitivity
Author Correction: REV-ERB in GABAergic neurons controls diurnal hepatic insulin sensitivity Open
View article: Early-life undernutrition induces enhancer RNA remodeling in mice liver
Early-life undernutrition induces enhancer RNA remodeling in mice liver Open
View article: REV-ERB in GABAergic neurons controls diurnal hepatic insulin sensitivity
REV-ERB in GABAergic neurons controls diurnal hepatic insulin sensitivity Open
View article: Inter‐ and Transgenerational Effects of Paternal Exposure to Inorganic Arsenic
Inter‐ and Transgenerational Effects of Paternal Exposure to Inorganic Arsenic Open
The rise of metabolic disorders in modern times is mainly attributed to the environment. However, heritable effects of environmental chemicals on mammalian offsprings' metabolic health are unclear. Inorganic arsenic (iAs) is the top chemic…
View article: Abnormal Glucose Metabolism in Male Mice Offspring Conceived by in vitro Fertilization and Frozen-Thawed Embryo Transfer
Abnormal Glucose Metabolism in Male Mice Offspring Conceived by in vitro Fertilization and Frozen-Thawed Embryo Transfer Open
Frozen and thawed embryo transfer (FET) is currently widely applied in routine assisted reproductive technology (ART) procedure. It is of great necessity to assess the safety of FET and investigate the long-term effect including glucose me…