Guoliang Shao
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View article: Regorafenib for Hepatocellular Carcinoma in Real-World Practice (REFINE): A Prospective, Observational Study
Regorafenib for Hepatocellular Carcinoma in Real-World Practice (REFINE): A Prospective, Observational Study Open
Introduction: In the phase 3 RESORCE trial, regorafenib prolonged overall survival (OS) in patients with unresectable hepatocellular carcinoma (uHCC) whose disease progressed on prior sorafenib. The prospective, observational REFINE study …
View article: Tumor burden with AFP improves survival prediction for TACE-treated patients with HCC: An international observational study☆
Tumor burden with AFP improves survival prediction for TACE-treated patients with HCC: An international observational study☆ Open
In this international multicentre study, we developed and internally and externally validated a novel outcome prediction model for candidates with HCC who would be ideal for TACE. The model, called the 6-and-12 model 2.0, was based on 4,37…
View article: Clinical efficacy of TACE combined with targeted or immune drugs for the treatment of unresectable intrahepatic cholangiocarcinoma
Clinical efficacy of TACE combined with targeted or immune drugs for the treatment of unresectable intrahepatic cholangiocarcinoma Open
Purpose To evaluate the clinical efficacy and safety of transarterial chemoembolization (TACE) combined with targeted or immune drugs for the treatment of unresectable intrahepatic cholangiocarcinoma (ICC). Methods A total of 78 patients w…
View article: Deep learning radiomics based on Ultrasound images for assisted diagnosis of Chronic Kidney Disease
Deep learning radiomics based on Ultrasound images for assisted diagnosis of Chronic Kidney Disease Open
Objective. This study aims to explore and discuss the application value of ultrasound images in chronic kidney disease(CKD) screening by constructing a CKD screening model based on gray-scale ultrasoundgraphs. Methods. According to the dia…
View article: Gold nanorods with iron oxide dual-modal bioprobes in SERS-MRI enable accurate programmed cell death ligand-1 expression detection in triple-negative breast cancer
Gold nanorods with iron oxide dual-modal bioprobes in SERS-MRI enable accurate programmed cell death ligand-1 expression detection in triple-negative breast cancer Open
The efficiency of immunotherapy for triple-negative breast cancer (TNBC) is relatively low due to the difficulty in accurately detecting immune checkpoints. The detection of TNBC-related programmed cell death ligand-1 (PD-L1) expression is…
View article: Data-Driven Assisted Decision Making for Surgical Procedure of Hepatocellular Carcinoma Resection and Prognostic Prediction: Development and Validation of Machine Learning Models
Data-Driven Assisted Decision Making for Surgical Procedure of Hepatocellular Carcinoma Resection and Prognostic Prediction: Development and Validation of Machine Learning Models Open
Background: Currently, surgical decisions for hepatocellular carcinoma (HCC) resection are difficult and not sufficiently personalized. We aimed to develop and validate data driven prediction models to assist surgeons in selecting the opti…
View article: A noninvasive nomogram model based on CT features to predict DNA mismatch repair deficiency in gastric cancer
A noninvasive nomogram model based on CT features to predict DNA mismatch repair deficiency in gastric cancer Open
Objectives DNA mismatch repair deficiency (dMMR) status has served as a positive predictive biomarker for immunotherapy and long-term prognosis in gastric cancer (GC). The aim of the present study was to develop a computed tomography (CT)-…
View article: Using host–guest interactions at the interface of quantum dots to load drug molecules for biocompatible, safe, and effective chemo-photodynamic therapy against cancer
Using host–guest interactions at the interface of quantum dots to load drug molecules for biocompatible, safe, and effective chemo-photodynamic therapy against cancer Open
Host–guest interactions were used to direct the interfacial self-assembly of quantum dots into a nanosystem for synergistic chemo-photodynamic therapy against cancer.
View article: Tislelizumab in Patients with Previously Treated Advanced Hepatocellular Carcinoma (RATIONALE-208): A Multicenter, Non-Randomized, Open-Label, Phase 2 Trial
Tislelizumab in Patients with Previously Treated Advanced Hepatocellular Carcinoma (RATIONALE-208): A Multicenter, Non-Randomized, Open-Label, Phase 2 Trial Open
Introduction: Tislelizumab (anti-programmed cell death protein 1 antibody) showed preliminary antitumor activity and tolerability in patients with advanced solid tumors, including hepatocellular carcinoma (HCC). This study aimed to assess …
View article: A combined predictive model based on radiomics features and clinical factors for disease progression in early-stage non-small cell lung cancer treated with stereotactic ablative radiotherapy
A combined predictive model based on radiomics features and clinical factors for disease progression in early-stage non-small cell lung cancer treated with stereotactic ablative radiotherapy Open
Purpose To accurately assess disease progression after Stereotactic Ablative Radiotherapy (SABR) of early-stage Non-Small Cell Lung Cancer (NSCLC), a combined predictive model based on pre-treatment CT radiomics features and clinical facto…
View article: Application of lipid nanovesicle drug delivery system in cancer immunotherapy
Application of lipid nanovesicle drug delivery system in cancer immunotherapy Open
View article: An N6-methyladenosine-associated lncRNA signature for predicting clinical outcome and therapeutic responses in hepatocellular carcinoma
An N6-methyladenosine-associated lncRNA signature for predicting clinical outcome and therapeutic responses in hepatocellular carcinoma Open
This study identified that a novel 14-m6A-related lncRNA signature could be a promising predictor for patient survival, and it might provide a vista for treatment response assessment of chemotherapy and immunotherapy.
View article: A CT-Based Radiomics Nomogram to Predict Complete Ablation of Pulmonary Malignancy: A Multicenter Study
A CT-Based Radiomics Nomogram to Predict Complete Ablation of Pulmonary Malignancy: A Multicenter Study Open
Objective Thermal ablation is a minimally invasive procedure for the treatment of pulmonary malignancy, but the intraoperative measure of complete ablation of the tumor is mainly based on the subjective judgment of clinicians without quant…
View article: Pancreatic Serous Cystic Neoplasms and Mucinous Cystic Neoplasms: Differential Diagnosis by Combining Imaging Features and Enhanced CT Texture Analysis
Pancreatic Serous Cystic Neoplasms and Mucinous Cystic Neoplasms: Differential Diagnosis by Combining Imaging Features and Enhanced CT Texture Analysis Open
Objective To establish a diagnostic model by combining imaging features with enhanced CT texture analysis to differentiate pancreatic serous cystadenomas (SCNs) from pancreatic mucinous cystadenomas (MCNs). Materials and Methods Fifty-seve…
View article: Diagnostic Value of CT- and MRI-Based Texture Analysis and Imaging Findings for Grading Cartilaginous Tumors in Long Bones
Diagnostic Value of CT- and MRI-Based Texture Analysis and Imaging Findings for Grading Cartilaginous Tumors in Long Bones Open
Objective To confirm the diagnostic performance of computed tomography (CT)-based texture analysis (CTTA) and magnetic resonance imaging (MRI)-based texture analysis for grading cartilaginous tumors in long bones and to compare these findi…
View article: Optimized Loading of Idarubicin in CalliSpheres® Drug-Eluting Beads and Characterization of Release Profiles and Morphological Properties
Optimized Loading of Idarubicin in CalliSpheres® Drug-Eluting Beads and Characterization of Release Profiles and Morphological Properties Open
This study aimed to investigate the idarubicin loading method, compatible stability with contrast agent, release profiles, and morphological properties of 50–150, 100–300, and 300–500 μm CalliSpheres®. The amounts of idarubicin added, load…
View article: lncRNA PCAT6 facilitates cell proliferation and invasion via regulating the miR‑326/hnRNPA2B1 axis in liver cancer
lncRNA PCAT6 facilitates cell proliferation and invasion via regulating the miR‑326/hnRNPA2B1 axis in liver cancer Open
Liver cancer is one of the most common malignant human tumors with the highest morbidity and mortality rates of all cancer types in China. Evidence suggests that long non-coding RNA prostate cancer-associated transcript 6 (PCAT6) plays an …
View article: Functional Doxorubicin-Loaded Omega-3 Unsaturated Fatty Acids Nanoparticles in Reversing Hepatocellular Carcinoma Multidrug Resistance
Functional Doxorubicin-Loaded Omega-3 Unsaturated Fatty Acids Nanoparticles in Reversing Hepatocellular Carcinoma Multidrug Resistance Open
BACKGROUND This study investigated a nanoparticle drug delivery system to reverse multidrug resistance (MDR) and assessed its anticancer efficacy in hepatocellular carcinoma (HCC). MATERIAL AND METHODS Docosahexaenoic acid (DHA) was used a…
View article: Atorvastatin potentiates the chemosensitivity of human liver cancer cells to cisplatin via downregulating YAP1
Atorvastatin potentiates the chemosensitivity of human liver cancer cells to cisplatin via downregulating YAP1 Open
Atorvastatin is a competitive inhibitor of β-hydroxy β-methylglutaryl-CoA reductase, which is involved in anticancer effects in numerous types of cancer, including in human liver cancer. However, its functions and underlying mechanisms of …
View article: Cancer patient management strategy in a Cancer Center of Zhejiang, China during the COVID-19 pandemic
Cancer patient management strategy in a Cancer Center of Zhejiang, China during the COVID-19 pandemic Open
View article: Cancer Patient Management Strategy in a Cancer Center of Zhejiang, China During the COVID-19 Pandemic 
Cancer Patient Management Strategy in a Cancer Center of Zhejiang, China During the COVID-19 Pandemic Open
Background: Due to the increased risk of viral infection and the severe shortage of medical resources during the pandemic of COVID-19, most hospitals in the epidemic areas significantly reduced non-emergency admissions and services, if not…
View article: <p>Targeting Yes1 Associated Transcriptional Regulator Inhibits Hepatocellular Carcinoma Progression and Improves Sensitivity to Sorafenib: An in vitro and in vivo Study</p>
Targeting Yes1 Associated Transcriptional Regulator Inhibits Hepatocellular Carcinoma Progression and Improves Sensitivity to Sorafenib: An in vitro and in vivo Study Open
YAP1 is upregulated in both HCC tumor tissues and cell lines. Moreover, it promotes cell proliferation and invasion and promoted the progression of epithelial-mesenchymal transition in vitro. Furthermore, targeting YAP1 inhibits HCC progre…
View article: The Comprehensive Analysis of Efficacy and Safety of CalliSpheres<sup>®</sup> Drug-Eluting Beads Transarterial Chemoembolization in 367 Liver Cancer Patients: A Multiple-Center, Cohort Study
The Comprehensive Analysis of Efficacy and Safety of CalliSpheres<sup>®</sup> Drug-Eluting Beads Transarterial Chemoembolization in 367 Liver Cancer Patients: A Multiple-Center, Cohort Study Open
This study aimed to investigate the efficacy, safety, and prognostic factors of drug-eluting beads transarterial chemoembolization (DEB-TACE) in treating Chinese patients with liver cancer. A total of 367 liver cancer patients from 24 medi…
View article: <scp>YAP</scp>1 overexpression is associated with poor prognosis of breast cancer patients and induces breast cancer cell growth by inhibiting <scp>PTEN</scp>
<span>YAP</span>1 overexpression is associated with poor prognosis of breast cancer patients and induces breast cancer cell growth by inhibiting <span>PTEN</span> Open
YES ‐associated protein 1 ( YAP 1) plays a key role as a transcriptional coactivator in the Hippo tumor suppressor pathway. YAP 1 is overexpressed in a variety of cancers and is considered to be encoded by a proto‐oncogene. However, the ro…
View article: MicroRNA-339 inhibits human hepatocellular carcinoma proliferation and invasion via targeting ZNF689
MicroRNA-339 inhibits human hepatocellular carcinoma proliferation and invasion via targeting ZNF689 Open
Hui Zeng,1 Jiaping Zheng,1 Song Wen,1 Jun Luo,1 Guoliang Shao,1 Yongjun Zhang2 1Department of Interventional Radiology, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang, P.R. China; 2Department of Integration of Traditional Chinese and …
View article: <p>MicroRNA-339 inhibits human hepatocellular carcinoma proliferation and invasion via targeting ZNF689</p>
MicroRNA-339 inhibits human hepatocellular carcinoma proliferation and invasion via targeting ZNF689 Open
Our study revealed that miR-339 inhibits HCC growth through targeting oncoprotein ZNF689 and restoration of miR-339 might be feasible therapeutic strategy for HCC treatment.
View article: [Diffusion-weighted imaging texture features in differentiation of malignant from benign nonpalpable breast lesions for patients with microcalcifications-only in mammography].
[Diffusion-weighted imaging texture features in differentiation of malignant from benign nonpalpable breast lesions for patients with microcalcifications-only in mammography]. Open
The texture feature analysis of DWI can improve the diagnostic accuracy of differentiating benign and malignant breast nonpalpable lesions with microcalcifications-only in mammography. Histogram features of mean, variance, skewness, entrop…
View article: Evaluation of efficacy of transcatheter arterial chemoembolization combined with computed tomography-guided radiofrequency ablation for hepatocellular carcinoma using magnetic resonance diffusion weighted imaging and computed tomography perfusion imaging
Evaluation of efficacy of transcatheter arterial chemoembolization combined with computed tomography-guided radiofrequency ablation for hepatocellular carcinoma using magnetic resonance diffusion weighted imaging and computed tomography perfusion imaging Open
These findings indicate that MR-DWI and CT-PI can effectively evaluate the efficacy of TACE combined with CT-RFA and postoperative recurrence of HCC.
View article: Association of DW/DCE-MRI Features with Prognostic Factors in Breast Cancer
Association of DW/DCE-MRI Features with Prognostic Factors in Breast Cancer Open
Background Through analyzing apparent diffusion coefficient (ADC) values and morphological evaluations, this research aimed to study how magnetic resonance imaging (MRI)-based breast lesion characteristics can enhance the diagnosis and pro…
View article: Knockdown of TAZ modifies triple-negative breast cancer cell sensitivity to EGFR inhibitors by regulating YAP expression
Knockdown of TAZ modifies triple-negative breast cancer cell sensitivity to EGFR inhibitors by regulating YAP expression Open
Triple-negative breast cancer (TNBC) constitutes ~10-15% of breast cancer patients and represents an aggressive subtype with poor overall prognosis. TNBC is an important clinical challenge because it does not respond well to endocrine ther…