Guo‐Liang Shen
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View article: SLAMF8 expression and prognostic significance in melanoma: A multi-omics and Mendelian randomization study
SLAMF8 expression and prognostic significance in melanoma: A multi-omics and Mendelian randomization study Open
Background Melanoma represents one of the most aggressive skin cancers, responsible for over 75% of skin cancer-related deaths despite comprising only 5% of cases. Despite therapeutic advances, patient responses remain variable and unpredi…
View article: The value of prealbumin in predicting post hepatectomy liver failure for patients with hepatocellular carcinoma undergoing major hepatectomy
The value of prealbumin in predicting post hepatectomy liver failure for patients with hepatocellular carcinoma undergoing major hepatectomy Open
Post hepatectomy liver failure (PHLF) poses a significant threat to the prognosis of patients with hepatocellular carcinoma (HCC), particularly those undergoing major hepatectomy. The present research endeavors to clarify the influence of …
View article: Prognostic poteintial of polyamine metabolism-related genes in hepatocellular carcinoma
Prognostic poteintial of polyamine metabolism-related genes in hepatocellular carcinoma Open
View article: Radiomics analysis based on dynamic contrast-enhanced MRI for predicting early recurrence after hepatectomy in hepatocellular carcinoma patients
Radiomics analysis based on dynamic contrast-enhanced MRI for predicting early recurrence after hepatectomy in hepatocellular carcinoma patients Open
View article: The Clinical Characteristics, Patterns of Recurrence, and Long-Term Survival Outcomes of Dual-Phenotype Hepatocellular Carcinoma After Curative Liver Resection
The Clinical Characteristics, Patterns of Recurrence, and Long-Term Survival Outcomes of Dual-Phenotype Hepatocellular Carcinoma After Curative Liver Resection Open
DPHCC, an aggressive HCC subtype with poor differentiation and high invasiveness, shows inferior RFS and OS post-liver resection compared to CHCC. Clinicians' recognition and addressing of its unique challenges can improve DPHCC patients' …
View article: Survival benefit of adjuvant TACE for patients with hepatocellular carcinoma and child-pugh B7 or B8 after hepatectomy
Survival benefit of adjuvant TACE for patients with hepatocellular carcinoma and child-pugh B7 or B8 after hepatectomy Open
View article: Comprehensive analysis of aberrantly methylated differentially expressed genes and validation of CDC6 in melanoma
Comprehensive analysis of aberrantly methylated differentially expressed genes and validation of CDC6 in melanoma Open
Background Skin Cutaneous Melanoma (SKCM) is a highly aggressive malignant tumor with a significant increase in mortality upon metastasis. The molecular mechanisms driving melanoma progression remain largely unclear. Recent studies have hi…
View article: Survival benefit from adjuvant TACE combined with lenvatinib for patients with hepatocellular carcinoma and microvascular invasion after curative hepatectomy
Survival benefit from adjuvant TACE combined with lenvatinib for patients with hepatocellular carcinoma and microvascular invasion after curative hepatectomy Open
The combination of TACE and Lenvatinib should be considered for anti-recurrence therapy for patients with HCC and MVI after hepatectomy.
View article: Prognostic value of platelet distribution width to lymphocyte ratio in patients with hepatocellular carcinoma following hepatectomy
Prognostic value of platelet distribution width to lymphocyte ratio in patients with hepatocellular carcinoma following hepatectomy Open
View article: Prognostic Value of Platelet Distribution Width to Lymphocyte Ratio in Patients with Hepatocellular Carcinoma Following Hepatectomy
Prognostic Value of Platelet Distribution Width to Lymphocyte Ratio in Patients with Hepatocellular Carcinoma Following Hepatectomy Open
Background Platelet distribution width (PDW), but not platelet count, was found to more comprehensively reflect platelet activity. The present study, thus, aimed to evaluate the prognostic value of PDW to lymphocyte ratio (PDWLR)in patient…
View article: Identification of sterile a-motif domain-containing 9-like as a potential biomarker in patients with cutaneous melanoma
Identification of sterile a-motif domain-containing 9-like as a potential biomarker in patients with cutaneous melanoma Open
Skin cutaneous melanoma (SKCM) is one of the most aggressive malignancies, accounting for approximately 75% of skin cancer-related fatalities annually. Sterile a-motif domain-containing 9-like (SAMD9L) has been found to regulate cell proli…
View article: Evaluating the Diagnostic Potentials of Circulating Tumor DNA against Melanoma: A Systematic Review and Meta-Analysis
Evaluating the Diagnostic Potentials of Circulating Tumor DNA against Melanoma: A Systematic Review and Meta-Analysis Open
Background. The accurate detection of circulating tumor (ct) DNA is affected by multiple factors, and several controversies still persists regarding clinical applications. In order to assess the consistency of ctDNA gene mutation detection…
View article: Association of preoperative albumin–bilirubin with surgical textbook outcomes following laparoscopic hepatectomy for hepatocellular carcinoma
Association of preoperative albumin–bilirubin with surgical textbook outcomes following laparoscopic hepatectomy for hepatocellular carcinoma Open
Background and aims Recently, the effectiveness of “textbook outcomes (TO)” in the evaluation of surgical quality has been recognized by more and more scholars. This study tended to examine the association between preoperative albumin–bili…
View article: Identification of aberrantly methylated differentially expressed genes and pro-tumorigenic role of KIF2C in melanoma
Identification of aberrantly methylated differentially expressed genes and pro-tumorigenic role of KIF2C in melanoma Open
Background: Skin Cutaneous Melanoma (SKCM) is known as an aggressive malignant cancer, which could be directly derived from melanocytic nevi. However, the molecular mechanisms underlying the malignant transformation of melanocytes and mela…
View article: Preparation of laser microporous porcine acellular dermal matrix and observation of wound transplantation
Preparation of laser microporous porcine acellular dermal matrix and observation of wound transplantation Open
View article: HIF-1/2α-Activated RNF146 Enhances the Proliferation and Glycolysis of Hepatocellular Carcinoma Cells via the PTEN/AKT/mTOR Pathway
HIF-1/2α-Activated RNF146 Enhances the Proliferation and Glycolysis of Hepatocellular Carcinoma Cells via the PTEN/AKT/mTOR Pathway Open
Hypoxia microenvironment, a critical feature of hepatocellular carcinoma, contributes to hepatocarcinogenesis, tumor progression and therapeutic resistance. Hypoxia-inducible factors (HIFs)-activated target genes are the main effectors in …
View article: Lnc524369 promotes hepatocellular carcinoma progression and predicts poor survival by activating YWHAZ-RAF1 signaling
Lnc524369 promotes hepatocellular carcinoma progression and predicts poor survival by activating YWHAZ-RAF1 signaling Open
Lnc524369 might be a promising target of HCC as it can enhance liver cancer progression and decrease the overall survival time of HCC by activating the YWHAZ/RAF1 pathway.
View article: Downregulation of lncRNA NEAT1 inhibits the proliferation of human cutaneous squamous cell carcinoma in vivo and in vitro
Downregulation of lncRNA NEAT1 inhibits the proliferation of human cutaneous squamous cell carcinoma in vivo and in vitro Open
In CSCC tissues, NEAT1 lncRNA was expressed at high levels and correlated with lymph node metastasis and TNM stage. The knockdown of NEAT1 lncRNA could significantly impede CSCC proliferation, metastasis, and invasion. Additionally, by mea…
View article: Integrative Analysis of Minichromosome Maintenance Proteins and Their Prognostic Significance in Melanoma
Integrative Analysis of Minichromosome Maintenance Proteins and Their Prognostic Significance in Melanoma Open
Background Minichromosome maintenance ( MCM ) is known for participating in cell cycle progression, as well as DNA replication. While the diverse expression patterns and prognostic values of MCM s in melanoma still remained unclear. Method…
View article: Long noncoding RNA LINC01291 promotes the aggressive properties of melanoma by functioning as a competing endogenous RNA for microRNA-625-5p and subsequently increasing IGF-1R expression
Long noncoding RNA LINC01291 promotes the aggressive properties of melanoma by functioning as a competing endogenous RNA for microRNA-625-5p and subsequently increasing IGF-1R expression Open
View article: Transcript levels of keratin 1/5/6/14/15/16/17 as potential prognostic indicators in melanoma patients
Transcript levels of keratin 1/5/6/14/15/16/17 as potential prognostic indicators in melanoma patients Open
Keratins ( KRTs ), the intermediate filament-forming proteins of epithelial cells, are extensively used as diagnostic biomarkers in cancers and associated with tumorigenesis and metastasis in multiple cancers. However, the diverse expressi…
View article: The feasibility of modified pancreatogastrostomy <i>in vivo</i> and its effect on intestinal microecology.
The feasibility of modified pancreatogastrostomy <i>in vivo</i> and its effect on intestinal microecology. Open
Anastomosis might be achieved sooner and with less pancreatic leakage using MBPA compared with TPA. Pancreatogastrostomy inhibits Ruminococcaceae activity, leading to increased expressions of pyruvic and lactic acids in the gut.
View article: Data mining of immune-related prognostic genes in metastatic melanoma microenvironment
Data mining of immune-related prognostic genes in metastatic melanoma microenvironment Open
Skin cutaneous melanoma (SKCM) is one of the most deadly malignancies. Although immunotherapies showed the potential to improve the prognosis for metastatic melanoma patients, only a small group of patients can benefit from it. Therefore, …
View article: Screening and identification of potential prognostic biomarkers in metastatic skin cutaneous melanoma by bioinformatics analysis
Screening and identification of potential prognostic biomarkers in metastatic skin cutaneous melanoma by bioinformatics analysis Open
Skin cutaneous melanoma (SKCM) is a multifactorial disease that presents a poor prognosis due to its rapid progression towards metastasis. This study focused on the identification of prognostic differentially expressed genes (DEGs) between…
View article: Identification of immune-related biomarkers associated with tumorigenesis and prognosis in cutaneous melanoma patients
Identification of immune-related biomarkers associated with tumorigenesis and prognosis in cutaneous melanoma patients Open
Background：Skin cutaneous melanoma (SKCM) is one of the most malignant and aggressive cancers, causing about 72% of deaths in skin carcinoma. Although extensive study has explored the mechanism of recurrence and metastasis, the tumorigenes…
View article: Identification of immune-related biomarkers associated with tumorigenesis and prognosis in cutaneous melanoma patients
Identification of immune-related biomarkers associated with tumorigenesis and prognosis in cutaneous melanoma patients Open
View article: Identification of biomarkers and pathways associated with immune infiltration and prognosis in melanoma patients
Identification of biomarkers and pathways associated with immune infiltration and prognosis in melanoma patients Open
Background Skin cutaneous melanoma (SKCM) is one of the most malignancy and aggressive cancers, causing about 72% of deaths in skin carcinoma. Although extensive study has explored the mechanism of recurrence and metastasis, the tumorigene…
View article: The genetic association between type 2 diabetic and hepatocellular carcinomas
The genetic association between type 2 diabetic and hepatocellular carcinomas Open
This study identified a number of genes that may play important roles in the association of T2DM and HCC, including four genes which may be the target of metformin treatment for diabetes and HCC. The specific mechanisms involved remain to …
View article: Identification of aberrantly methylated differentially expressed genes in melanoma
Identification of aberrantly methylated differentially expressed genes in melanoma Open
Background: Skin Cutaneous Melanoma (SKCM) is known as an aggressive malignant cancer, which could be directly derived from melanocytic nevi. However, the molecular mechanisms underlying malignant transformation of melanocytes and melanoma…
View article: Identification of new biomarkers and pathways associated with treatment and prognosis in melanoma patients
Identification of new biomarkers and pathways associated with treatment and prognosis in melanoma patients Open
Background Skin cutaneous melanoma (SKCM) is known as the most malignancy and treatment-resistant in human tumor, causing about 72% of deaths in skin carcinoma. However, the potential mechanism and new effective targets remain to be furthe…