Explanipedia

Biological roles and potential clinical value of tRNA-derived small RNAs in gastrointestinal malignancies Open

Yongfu Shao, Xuan Yu, Weihong Zhou, Jianing Yan, Haotian Dong , et al. · 2025

tRNA-derived small RNAs (tsRNAs) are small RNA fragments generated from tRNA molecules or their precursors through cleavage by enzymes such as Dicer. As noncoding small RNAs, tsRNAs have important biological functions, including regulating…

m5C RNA modification in colorectal cancer: mechanisms and therapeutic targets Open

Jiawei Wang, Qi Chen, Ran Wang, Yuepeng Cao, Yuping Zhou , et al. · 2025

5-Methylcytosine (m5C), an important RNA modification, has been extensively studied in colorectal cancer (CRC). In recent years, with advances in high-throughput sequencing technology and RNA modification detection tools, the role of m5C m…

Correction to: Identification of tRF-29-79MP9P9NH525 as a biomarker and tumor suppressor of gastric cancer via regulating KIF14/AKT pathway Open

Jiaxin Ge, Ji Dai, H Ji, Jie Guo, Xian Shen , et al. · 2025

Comprehensive analysis of Mendelian randomization and scRNA-seq identify key prognostic genes and relevant functional roles in colorectal cancer Open

Hu Meng, Haotian Dong, Chujia Chen, Chengyuan Ye, Jianing Yan , et al. · 2025

The prognosis of advanced CRC is poor, and identifying key genes related to CRC is vital for improving CRC prognosis. Our research used univariate Cox analysis and Mendelian randomization (MR) analysis to identify key prognostic genes in C…

Identification of tRF-29-79MP9P9NH525 as a biomarker and tumor suppressor of gastric cancer via regulating KIF14/AKT pathway Open

Jiaxin Ge, Ji Dai, H Ji, Jie Guo, Xian Shen , et al. · 2025

Gastric cancer (GC) is one of the most common malignancies with a poor prognosis. The development of novel biomarkers is of utmost importance to screen patients with GC. Molecular mechanism study of GC may provide a research basis for the …

Comprehensive analysis of scRNA-seq and bulk RNA-seq data via machine learning and bioinformatics reveals the role of lysine metabolism-related genes in gastric carcinogenesis Open

Yongfu Shao, Chujia Chen, Xuan Yu, Jianing Yan, Junming Guo , et al. · 2025

The biological role and molecular mechanism of transfer RNA-derived small RNAs in tumor metastasis Open

Haotian Dong, Chengyuan Ye, Xiangyang Ye, Jianing Yan, Guoliang Ye , et al. · 2025

Tumor metastasis is a significant contributor to increased cancer mortality. Transfer RNA-derived small RNAs (tsRNAs), a class of endogenous non-coding RNA molecules, play crucial functional roles in various physiological processes, includ…

Weighted Gene Coexpression Network Analysis Identifies Neutrophil-Related Molecular Subtypes and Their Clinical Significance in Gastric Cancer Open

Chujia Chen, Yongfu Shao, Chengyuan Ye, Xuan Yu, Meng Hu , et al. · 2025

We identified two neutrophil-related molecular GC subtypes with different prognostic outcomes and clinical significance. VIM, RBMS1 and RGS2 were identified as potential prognostic markers and therapeutic targets for GC. These findings pro…

Molecular subtype of gastric cancer based on apoptosis-related genes reveals differential immune microenvironment and intratumoral microorganisms distribution Open

Xuan Yu, Yongfu Shao, Haotian Dong, Jianing Yan, Xinjun Zhang , et al. · 2025

Our study conducted a comprehensive analysis of the molecular characteristics of ARGs in GC, revealed their association with the tumor immune microenvironment and intratumoral microorganisms. These findings provide new ideas for the molecu…

Histone deacetylase in inflammatory bowel disease: novel insights Open

Chunxiao Li, Shaobo Gu, Yihong Zhang, Z Zhang, Junzhuo Wang , et al. · 2025

Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is characterized by chronic nonspecific intestinal inflammation. Despite considerable efforts, IBD remains a heavy burden on society and human health, with…

Biological function and potential application of PANoptosis-related genes in colorectal carcinogenesis Open

Xuan Yu, Yongfu Shao, Haotian Dong, Xinjun Zhang, Guoliang Ye · 2024

PANoptosis induces programmed cell death (PCD) through extensive crosstalk and is associated with development of cancer. However, the functional mechanisms, clinical significance, and potential applications of PANoptosis-related genes (PRG…

Analysis of Helicobacter pylori resistance in patients with different gastric diseases Open

Yongfu Shao, Yi‐Fan Lin, Ziyi Fang, Jianing Yan, Tuo Zheng , et al. · 2024

Acting mechanism and clinical significance of hsa_circ_0005927 in the invasion and metastasis of gastric cancer Open

Yongfu Shao, Xuan Yu, Hu Meng, Jianing Yan, Min Miao , et al. · 2024

Background: An increasing number of studies have demonstrated that differentially expressed circular RNAs (circRNAs) play critical roles in carcinogenesis. However, the biological function and clinical significance of hsa_circ_00059…

Defining the biological functions and clinical significance of AKR1C3 in gastric carcinogenesis through multiomics functional analysis and immune infiltration analysis Open

Yongfu Shao, Xuan Yu, Keshu Shan, Jianing Yan, Guoliang Ye · 2024

Background: Human aldo-keto reductase family 1 member C3 (AKR1C3) is an important molecule that participates in multiple physiological metabolic processes. However, its expression, biological functions and clinical significance in g…

Clinical outcomes and risk factors of non-curative endoscopic submucosal dissection for early gastric cancer: a retrospective multicenter study in Zhejiang, China Open

Chao-qiong Jin, Jing Zhao, Xiaoyun Ding, Liang Yu, Guoliang Ye , et al. · 2023

Background Endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) does not always lead to curative resection. Risk factors of lymph node metastasis (LNM)/local cancer residue after non-curative ESD for EGC have not been full…

Transfer RNA-derived fragments as novel biomarkers of the onset and progression of gastric cancer Open

Yaoyao Xie, Shuangshuang Zhang, Xiuchong Yu, Guoliang Ye, Junming Guo · 2023

Gastric cancer (GC) is a particularly malignant disease; thus, early diagnosis and treatment are especially important. Transfer RNA-derived small RNAs (tsRNAs) have been implicated in the onset and progression of various cancers. Therefore…

Identification of novel prognostic circRNA biomarkers in circRNA-miRNA-mRNA regulatory network in gastric cancer and immune infiltration analysis Open

Jianing Yan, Guoliang Ye, Yanping Jin, Min Miao, Qier Li , et al. · 2023

Absolute quantification of a plasma tRNA-derived fragment for the diagnosis and prognosis of gastric cancer Open

Shuangshuang Zhang, Yaoyao Xie, Xiuchong Yu, Jiaxin Ge, Guoliang Ye , et al. · 2023

Background The transition from a healthy gastric mucosa to gastric cancer is a multi-step process. Early screening can significantly improve the survival rate of gastric cancer patients. A reliable liquid biopsy for gastric cancer predicti…

Antibiotic resistance in <i>Helicobacter pylori</i>: From potential biomolecular mechanisms to clinical practice Open

Yi‐Fan Lin, Yongfu Shao, Jianing Yan, Guoliang Ye · 2023

Increasing rates of Helicobacter pylori resistance are associated with multiple clinical challenges. Bacterial factors linked to H. pylori resistance are mutations, efflux pumps, and biofilms. Gene mutations such as nucleic acid synthesis‐…

CircRNA: A new class of targets for gastric cancer drug resistance therapy Open

Ying Zheng, Zhe Li, Yao Wang, Wanjiao Chen, Yifan Lin , et al. · 2023

Gastric cancer (GC) is one of the most common malignancies worldwide. Patients with advanced GC need palliative care to ensure survival. This includes the use of chemotherapy agents, such as cisplatin, 5-fluorouracil, oxaliplatin, paclitax…

Identification of novel prognostic biomarkers in the TF-enhancer-target regulatory network in hepatocellular carcinoma and immune infiltration analysis Open

Jianing Yan, Guoliang Ye, Yongfu Shao, Hanxuan Zhou · 2023

Background: Hepatocellular carcinoma (HCC) remains notorious for its high malignancy, poor prognosis and high mortality. The exploration of novel therapeutic agents for HCC has remained challenging due to its complex aetiology. Therefore, …

tRNA derived fragments:A novel player in gene regulation and applications in cancer Open

Shuangshuang Zhang, Xiuchong Yu, Yaoyao Xie, Guoliang Ye, Junming Guo · 2023

The heterogeneous species of tRNA-derived fragments (tRFs) with specific biological functions was recently identified. Distinct roles of tRFs in tumor development and viral infection, mediated through transcriptional and post-transcription…

Screening intention of MTs-DNA test for Colorectal Cancer screening and associated factors among hospital-based populations in southeastern China Open

Xiaoyan Sun, Jinqing Fan, Wang-Fang Zhao, Qiwen Lu, Jundi Gu , et al. · 2022

Background Multi-target stool DNA (MT-sDNA) test can reduce colorectal cancer (CRC) incidence and mortality as a simple, noninvasive screening method. It is crucial to understand people's willingness to accept and willingness to pay for MT…

Clinical significance and potential application of cuproptosis-related genes in gastric cancer Open

Jianing Yan, Yifan Lin, Guoliang Ye, Yongfu Shao · 2022

Worldwide, gastric cancer (GC) is a common lethal solid malignancy with a poor prognosis. Cuproptosis is a novel kind of cell death mediated by protein lipoylation and the relationship between cuprotosis and GC prognosis. We estimated the …

Biological and clinical implications of hsa_circ_0086720 in gastric cancer and its clinical application Open

Yongfu Shao, Changlei Qi, Jianing Yan, Rongdan Lu, Guoliang Ye , et al. · 2022

Background Circular RNAs (circRNAs) are thought to be vital participants in carcinogenesis and have the characteristics of being stable, specific, and well conserved. However, their clinical significance and application value in gastric ca…

Extracellular vesicles-associated tRNA-derived fragments (tRFs): biogenesis, biological functions, and their role as potential biomarkers in human diseases Open

Qiuyan Weng, Yao Wang, Yaoyao Xie, Xiuchong Yu, Shuangshuang Zhang , et al. · 2022

Characteristics and Predictors of Long-Time Survivors in Non-Metastatic Gastric Signet Ring Cell Carcinoma: A Large Population-Based Study Open

Qiuyan Weng, Zhe Li, Yaoyao Xie, Junming Guo, Yong Zhang , et al. · 2022

Qiuyan Weng,1 Zhe Li,2,3 Yaoyao Xie,4 Junming Guo,2– 4 Yong Zhang,5 Guoliang Ye2,3 1Department of Neurology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, Zhejiang, People’s Republic of China; 2Department of Gastroe…

High expression of the ferroptosis‐associated MGST1 gene in relation to poor outcome and maladjusted immune cell infiltration in uterine corpus endometrial carcinoma Open

Jianing Yan, Guoliang Ye, Yongfu Shao · 2022

Background Uterine corpus endometrial carcinoma (UCEC) tightly correlates with dysregulated iron homeostasis. MGST1 (microsomal glutathione S‐transferase 1) involves in the regulation of oxidative stress and plays a key role in inhibiting …

tRNA-derived small RNAs: Mechanisms and potential roles in cancers Open

Yao Wang, Qiuyan Weng, Jiaxin Ge, Xinjun Zhang, Junming Guo , et al. · 2022

Artificial intelligence‐assisted colonoscopy: A prospective, multicenter, randomized controlled trial of polyp detection Open

Lei Xu, Xinjue He, Jianbo Zhou, Jie Zhang, Xin‐Li Mao , et al. · 2021

Background Artificial intelligence (AI) assistance has been considered as a promising way to improve colonoscopic polyp detection, but there are limited prospective studies on real‐time use of AI systems. Methods We conducted a prospective…

Guoliang Ye YOU? Author Swipe