Guolin Tan
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View article: Efficacy and safety of intranasal corticosteroids combined with mucoactive drugs for chronic rhinosinusitis
Efficacy and safety of intranasal corticosteroids combined with mucoactive drugs for chronic rhinosinusitis Open
Intranasal corticosteroid combined with mucoactive drugs therapy (budesonide-256 μg/day combined with ELP enteric capsules-0.8 g/day) has the potential to improve subjective symptoms and promote physiological recovery for adult patients wi…
View article: RETRACTED: Zhou et al. HOXA11-AS1 Promotes PD-L1-Mediated Immune Escape and Metastasis of Hypopharyngeal Carcinoma by Facilitating PTBP1 and FOSL1 Association. Cancers 2022, 14, 3694
RETRACTED: Zhou et al. HOXA11-AS1 Promotes PD-L1-Mediated Immune Escape and Metastasis of Hypopharyngeal Carcinoma by Facilitating PTBP1 and FOSL1 Association. Cancers 2022, 14, 3694 Open
The journal retracts the article “HOXA11-AS1 promotes PD-L1–mediated immune escape and metastasis of hypopharyngeal carcinoma by facilitating PTBP1 and FOSL1 association” [...]
View article: The gene signature linked to lactate metabolism predicts the prognosis and correlates with the immune status of head and neck squamous cell carcinoma
The gene signature linked to lactate metabolism predicts the prognosis and correlates with the immune status of head and neck squamous cell carcinoma Open
Lactate, traditionally viewed as a byproduct of glycolysis, is increasingly recognized as a pivotal regulatory factor in cancer biology. This study addresses the limited understanding of lactate metabolism-related genes in head and neck sq…
View article: Chinese Position Paper on Biologic Therapy for Chronic Rhinosinusitis With Nasal Polyps
Chinese Position Paper on Biologic Therapy for Chronic Rhinosinusitis With Nasal Polyps Open
Emerging biologics that selectively target key cytokines present a promising therapeutic alternative for patients suffering from severe, uncontrollable chronic rhinosinusitis with nasal polyps (CRSwNP). Despite the limited availability of …
View article: Expert consensus on nasal anticholinergics in the treatment of allergic rhinitis
Expert consensus on nasal anticholinergics in the treatment of allergic rhinitis Open
Background: Allergic rhinitis (AR) is a common hyperreactive nasal disease in otolaryngology, mainly manifested as rhinorrhea, nasal obstruction, nasal itching, and sneezing. Despite medication and immunotherapy, a large proportion of pati…
View article: Efficacy and safety of azelastine hydrochloride and fluticasone propionate nasal spray in treating allergic rhinitis: A randomized controlled trial
Efficacy and safety of azelastine hydrochloride and fluticasone propionate nasal spray in treating allergic rhinitis: A randomized controlled trial Open
Background: MP-AzeFlu (Dymista; Meda Pharma GmbH & Co., KG), a formulation combining azelastine hydrochloride and fluticasone propionate in a single spray, is superior to fluticasone propionate alone in relieving symptoms and improving the…
View article: The m6A and immune regulatory gene signature predicts the prognosis and correlates with immune infiltration of head and neck squamous cell carcinoma
The m6A and immune regulatory gene signature predicts the prognosis and correlates with immune infiltration of head and neck squamous cell carcinoma Open
Recent investigations have underscored the epigenetic modulation of the immune response; however, the interplay between RNA N6-methyladenosine (m6A) modification and immunomodulation in head and neck squamous cell carcinoma (HNSC) remains …
View article: Two-sample Mendelian randomization analysis of the causal relationship between blood eosinophils and allergic rhinitis.
Two-sample Mendelian randomization analysis of the causal relationship between blood eosinophils and allergic rhinitis. Open
There is a causal association between increased eosinophil count and a higher risk or worsening of allergic rhinitis.
View article: A 10-year comparative study of factors for allergic asthma and/or rhinitis in two cross-sectional surveys
A 10-year comparative study of factors for allergic asthma and/or rhinitis in two cross-sectional surveys Open
Repeated surveys showed variations in the factors affecting allergic asthma and/or rhinitis. The variable factors included age of 25-44 years, secondhand smoke, farmland, forest, and fish consumption.
View article: Changes of immune microenvironment in head and neck squamous cell carcinoma in 3D-4-culture compared to 2D-4-culture
Changes of immune microenvironment in head and neck squamous cell carcinoma in 3D-4-culture compared to 2D-4-culture Open
Background The immune system plays a crucial role in initiating, progressing, and disseminating HNSCC. This study aims to investigate the differences in immune microenvironments between 2D-4-culture and 3D-4-culture models of head and neck…
View article: Changes of immune microenvironment in head and neck squamous cell carcinoma in 3D-4-culture compared to 2D-4-culture
Changes of immune microenvironment in head and neck squamous cell carcinoma in 3D-4-culture compared to 2D-4-culture Open
Background The immune system plays a crucial role in initiating, progressing, and disseminating HNSCC. This study aims to investigate the differences in immune microenvironments between 2D-4-culture and 3D-4-culture models of head and neck…
View article: Clustering and machine learning-based integration identify cancer associated fibroblasts genes’ signature in head and neck squamous cell carcinoma
Clustering and machine learning-based integration identify cancer associated fibroblasts genes’ signature in head and neck squamous cell carcinoma Open
Background: A hallmark signature of the tumor microenvironment in head and neck squamous cell carcinoma (HNSCC) is abundantly infiltration of cancer-associated fibroblasts (CAFs), which facilitate HNSCC progression. However, some clinical …
View article: A clinical study to assess the efficacy and safety of MP-AzeFlu (Azelastine Hydrochloride and Fluticasone Propionate) nasal spray in comparison to commercially available nasal sprays in Chinese volunteers with allergic rhinitis
A clinical study to assess the efficacy and safety of MP-AzeFlu (Azelastine Hydrochloride and Fluticasone Propionate) nasal spray in comparison to commercially available nasal sprays in Chinese volunteers with allergic rhinitis Open
Objective: The objective of the present study was to evaluate the efficacy and safety of MP-AzeFlu nasal spray in comparison to commercially available azelastine and fluticasone sprays in Chinese patients with moderate-to-severe allergic r…
View article: LncRNA NR120519 Blocks KRT17 to Promote Cell Proliferation and Migration in Hypopharyngeal Squamous Carcinoma
LncRNA NR120519 Blocks KRT17 to Promote Cell Proliferation and Migration in Hypopharyngeal Squamous Carcinoma Open
Background: Hypopharyngeal carcinoma is the worst type of head and neck squamous cell carcinoma. It is necessary to identify the key molecular targets related to the carcinogenesis and development of hypopharyngeal carcinoma. Methods: Diff…
View article: A novel immune signature predicts immunotherapy responsiveness and reveals the landscape of the tumor immune microenvironment in head and neck squamous cell carcinoma
A novel immune signature predicts immunotherapy responsiveness and reveals the landscape of the tumor immune microenvironment in head and neck squamous cell carcinoma Open
Background: Immune-checkpoint blockade (ICB) has been routinely implemented to treat head and neck squamous cell carcinoma (HNSCC) patients. However, only a few patients benefit from immune checkpoint inhibitor (ICI) therapies. Methods: In…
View article: Increased miR-124-3p alleviates type 2 inflammatory response in allergic rhinitis via IL-4Rα
Increased miR-124-3p alleviates type 2 inflammatory response in allergic rhinitis via IL-4Rα Open
Background and objectives miRNAs play a crucial role in regulating immune responses. However, the effect of miR-124-3p on type 2 inflammation in allergic rhinitis (AR) is unclear. We aimed to study the immune regulation of miR-124-3p in AR…
View article: RETRACTED: HOXA11-AS1 Promotes PD-L1-Mediated Immune Escape and Metastasis of Hypopharyngeal Carcinoma by Facilitating PTBP1 and FOSL1 Association
RETRACTED: HOXA11-AS1 Promotes PD-L1-Mediated Immune Escape and Metastasis of Hypopharyngeal Carcinoma by Facilitating PTBP1 and FOSL1 Association Open
Background: The metastatic characteristics of hypopharyngeal squamous cell carcinoma (HSCC) lead to many diagnostic and therapeutic challenges, while functional long non-coding RNAs (lncRNAs) can provide effective strategies for its diagno…
View article: Identity of <scp><i>MMP1</i></scp> and its effects on tumor progression in head and neck squamous cell carcinoma
Identity of <span><i>MMP1</i></span> and its effects on tumor progression in head and neck squamous cell carcinoma Open
Background Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignant tumor worldwide with high morbidity and mortality. However, the diagnosis and molecular mechanisms of HNSCC remains poor. Methods Robust rank aggre…
View article: Long-Term Exposure to Sulfur Dioxide Before Sensitization Decreased the Production of Specific IgE in HDM-Sensitized Allergic Rhinitis Mice
Long-Term Exposure to Sulfur Dioxide Before Sensitization Decreased the Production of Specific IgE in HDM-Sensitized Allergic Rhinitis Mice Open
SO2 exposure aggravated nasal symptom, serum sIgE level, eosinophil infiltration, and Th1/Th2/Th17 inflammation in AR mice. However, the serum sIgE level could be lowered by long-term SO2 exposure. This inhibitory effect of SO2 on IgE prod…
View article: Environmental and sensitization variations among asthma and/or rhinitis patients between 2008 and 2018 in China
Environmental and sensitization variations among asthma and/or rhinitis patients between 2008 and 2018 in China Open
Background Little is known about the changes in allergen sensitization in China secondary to the environmental variations over the past decade. We aimed at investigating the variations in sensitization among asthma and/or rhinitis patients…
View article: [Clinical analysis of head and neck malignant tumor patients with postoperative venous thromboembolism].
[Clinical analysis of head and neck malignant tumor patients with postoperative venous thromboembolism]. Open
Objective:To investigate the incidence, risk factors, prevention and treatment of venous thromboembolism（VTE） after head and neck malignant tumor surgery. Methods:From February 2014 to February 2020, a total of 889 patients with head and n…
View article: Analysis of ceRNA network of differentially expressed genes in FaDu cell line and a cisplatin-resistant line derived from it
Analysis of ceRNA network of differentially expressed genes in FaDu cell line and a cisplatin-resistant line derived from it Open
Background Hypopharyngeal cancer accounts for 2% in head and neck cancers and has a poor prognosis. Cisplatin is a widely used chemotherapeutic drug in kinds of carcinomas, concluding hypopharyngeal cancer. However, the resistance of cispl…
View article: Ethyl pyruvate ameliorate inflammatory response of sinonasal mucosa by inhibiting HMGB1 in rats with acute rhinosinusitis
Ethyl pyruvate ameliorate inflammatory response of sinonasal mucosa by inhibiting HMGB1 in rats with acute rhinosinusitis Open
High mobility group box 1 (HMGB1) has been known to involve in the pathogenesis of many inflammatory diseases. The aim of this study was to establish animal model of acute rhinosinusitis (ARS), and determine whether ethyl pyruvate (EP) att…