Guoning Zhang
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View article: Novel Oxazolidinone Derivatives Containing Quaternary Ammonium Fragments with Potent Antibacterial Potency
Novel Oxazolidinone Derivatives Containing Quaternary Ammonium Fragments with Potent Antibacterial Potency Open
We reported a series of oxazolidinone derivatives containing quaternary ammonium fragments as potent antibacterial agents. Among them, compound 7a exhibited potent antibacterial activity against a range of pathogens, including MSSE …
View article: Using Bridging Ligands to Regulate Pyrazole Carboxylic Acid Coordination Polymers: Investigating Crystal Structure and Electrochemiluminescence Properties
Using Bridging Ligands to Regulate Pyrazole Carboxylic Acid Coordination Polymers: Investigating Crystal Structure and Electrochemiluminescence Properties Open
View article: Rational Design, Synthesis, and Evaluating Primary Biological Activities of Novel Hiv-1 Protease Inhibitors Containing Heteraryl Acetamides as the P2 Ligands
Rational Design, Synthesis, and Evaluating Primary Biological Activities of Novel Hiv-1 Protease Inhibitors Containing Heteraryl Acetamides as the P2 Ligands Open
View article: A Novel Lightweight Network Vmobilenet for Visual Detection of Workpiece Surface Roughness Based on State Space Model
A Novel Lightweight Network Vmobilenet for Visual Detection of Workpiece Surface Roughness Based on State Space Model Open
View article: Discovery and Rational Optimization of 2, 2'-((1h-Indole-2,3-Diyl) Bis (Thio))Diacetamide as Novel Sars-Cov-2 Rdrp Inhibitors
Discovery and Rational Optimization of 2, 2'-((1h-Indole-2,3-Diyl) Bis (Thio))Diacetamide as Novel Sars-Cov-2 Rdrp Inhibitors Open
View article: Discovery of Novel Oxazolidinone Derivatives Containing Quaternary Ammonium Fragments with Potent Antibacterial Potency and Excellent Safety
Discovery of Novel Oxazolidinone Derivatives Containing Quaternary Ammonium Fragments with Potent Antibacterial Potency and Excellent Safety Open
View article: Effect of a semirigid ankle brace on the in vivo kinematics and muscle activity of patients with functional ankle instability during simulated ankle sprain
Effect of a semirigid ankle brace on the in vivo kinematics and muscle activity of patients with functional ankle instability during simulated ankle sprain Open
Introduction: Ankle braces can effectively decrease the incidence of recurrent ankle sprain; however, whether the brace can decrease the severity of sprain and its related mechanism during sprain remain unknown. Methods: Twenty-two patient…
View article: Effect of a Semi-rigid Ankle Brace on the In Vivo Kinematics and Muscle Activity of Patients with Functional Ankle Instability During Simulated Ankle Sprain
Effect of a Semi-rigid Ankle Brace on the In Vivo Kinematics and Muscle Activity of Patients with Functional Ankle Instability During Simulated Ankle Sprain Open
Background Ankle braces can effectively decrease the incidence of recurrent ankle sprain; however, whether the brace can decrease the severity of sprain and its related mechanism during sprain remain unknown. Methods 22 patients with funct…
View article: Design, synthesis, and biological evaluation of novel HIV-1 protease inhibitors containing pyrrolidine-derived P2 ligands to combat drug-resistant variant
Design, synthesis, and biological evaluation of novel HIV-1 protease inhibitors containing pyrrolidine-derived P2 ligands to combat drug-resistant variant Open
View article: New IMB16-4 Hot-Melt Extrusion Preparation Improved Oral Bioavailability and Enhanced Anti-Cholestatic Effect on Rats
New IMB16-4 Hot-Melt Extrusion Preparation Improved Oral Bioavailability and Enhanced Anti-Cholestatic Effect on Rats Open
The HME preparation significantly increased the oral bioavailability and anti-cholestatic effect of pure IMB16-4, but caused liver injury at high dose, which require a dose balance between the curative effect and safety in the future resea…
View article: Structure based design and evaluation of benzoheterocycle derivatives as potential dual HIV-1 protease and reverse transcriptase inhibitors
Structure based design and evaluation of benzoheterocycle derivatives as potential dual HIV-1 protease and reverse transcriptase inhibitors Open
View article: The mechanism and pharmacodynamics of 2-((1H-indol-3-yl)thio/sulfinyl)-N-pheny acetamide derivative as a novel inhibitor against human respiratory syncytial virus
The mechanism and pharmacodynamics of 2-((1H-indol-3-yl)thio/sulfinyl)-N-pheny acetamide derivative as a novel inhibitor against human respiratory syncytial virus Open
Human respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infection worldwide. Until now, there are no licenced vaccines or effective antiviral drugs against RSV infections. In our previous work, we found 2-((1H…
View article: A kind of HIV-1 protease inhibitors containing phenols with antiviral activity against DRV-resistant variants
A kind of HIV-1 protease inhibitors containing phenols with antiviral activity against DRV-resistant variants Open
View article: Effect of a Semi-rigid Ankle Brace on the In Vivo Kinematics and Muscle Activity of Patients with Functional Ankle Instability Duing Simulated Ankle Sprain
Effect of a Semi-rigid Ankle Brace on the In Vivo Kinematics and Muscle Activity of Patients with Functional Ankle Instability Duing Simulated Ankle Sprain Open
Background Ankle braces can effectively decrease the incidence of recurrent ankle sprain; however, whether the brace can decrease the severity of sprain and its related mechanism during sprain remain unknown. Methods 12 patients with funct…
View article: Design, synthesis and biological evaluation of protease inhibitors containing morpholine cores with remarkable potency against both HIV-1 subtypes B and C
Design, synthesis and biological evaluation of protease inhibitors containing morpholine cores with remarkable potency against both HIV-1 subtypes B and C Open
View article: T1AM Attenuates the Hypoxia/Reoxygenation‐Induced Necroptosis of H9C2 Cardiomyocytes via RIPK1/RIPK3 Pathway
T1AM Attenuates the Hypoxia/Reoxygenation‐Induced Necroptosis of H9C2 Cardiomyocytes via RIPK1/RIPK3 Pathway Open
Purpose . To investigate the detailed mechanism of 3‐iodothyronamine (T1AM) in cell apoptosis and programmed necrosis of hypoxia/reoxygenation‐ (H/R‐) induced H9C2 injury. Materials and Methods . Cardiomyocyte H9C2 cells were cultured in v…
View article: Synthesis and Biological Evaluation of Novel N, N′-Diarylurea Derivatives as Potent Antibacterial Agents Against MRSA
Synthesis and Biological Evaluation of Novel N, N′-Diarylurea Derivatives as Potent Antibacterial Agents Against MRSA Open
View article: miR-29cb2 promotes angiogenesis and osteogenesis by inhibiting HIF-3α in bone
miR-29cb2 promotes angiogenesis and osteogenesis by inhibiting HIF-3α in bone Open
Coordination between osteogenesis and angiogenesis is required for bone homeostasis. Here, we show that miR-29cb2 is a bone-specific miRNA and plays critical roles on angiogenesis-osteogenesis coupling during bone remodeling. Mice with del…
View article: 2-((1H-indol-3-yl)thio)-N-phenyl-acetamides: SARS-CoV-2 RNA-dependent RNA polymerase inhibitors
2-((1H-indol-3-yl)thio)-N-phenyl-acetamides: SARS-CoV-2 RNA-dependent RNA polymerase inhibitors Open
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of Coronavirus Disease 2019 (COVID-19) pandemic. Despite intensive and global efforts to discover and develop novel antiviral therapies, only Remdesivir ha…
View article: CCDC 2018115: Experimental Crystal Structure Determination
CCDC 2018115: Experimental Crystal Structure Determination Open
View article: CCDC 2018125: Experimental Crystal Structure Determination
CCDC 2018125: Experimental Crystal Structure Determination Open
View article: CCDC 2048535: Experimental Crystal Structure Determination
CCDC 2048535: Experimental Crystal Structure Determination Open
View article: CCDC 2018127: Experimental Crystal Structure Determination
CCDC 2018127: Experimental Crystal Structure Determination Open
View article: Discovery and optimization of 2-((1H-indol-3-yl)thio)-N-benzyl-acetamides as novel SARS-CoV-2 RdRp inhibitors
Discovery and optimization of 2-((1H-indol-3-yl)thio)-N-benzyl-acetamides as novel SARS-CoV-2 RdRp inhibitors Open
View article: Design and biological evaluation of cinnamic and phenylpropionic amide derivatives as novel dual inhibitors of HIV-1 protease and reverse transcriptase
Design and biological evaluation of cinnamic and phenylpropionic amide derivatives as novel dual inhibitors of HIV-1 protease and reverse transcriptase Open
View article: Design and evaluation of novel piperidine HIV-1 protease inhibitors with potency against DRV-resistant variants
Design and evaluation of novel piperidine HIV-1 protease inhibitors with potency against DRV-resistant variants Open
View article: miR-29cb2 Promotes Angiogenesis and Osteogenesis by Inhibiting HIF-3α in Bone
miR-29cb2 Promotes Angiogenesis and Osteogenesis by Inhibiting HIF-3α in Bone Open
View article: Piperidine scaffold as the novel P2-ligands in cyclopropyl-containing HIV-1 protease inhibitors: Structure-based design, synthesis, biological evaluation and docking study
Piperidine scaffold as the novel P2-ligands in cyclopropyl-containing HIV-1 protease inhibitors: Structure-based design, synthesis, biological evaluation and docking study Open
A series of potent HIV-1 protease inhibitors, containing diverse piperidine analogues as the P2-ligands, 4-substituted phenylsulfonamides as the P2'-ligands and a hydrophobic cyclopropyl group as the P1'-ligand, were designed, synthesized …
View article: Design and biological evaluation of novel HIV-1 protease inhibitors with isopropanol as P1′ ligand to enhance binding with S1′ subsite
Design and biological evaluation of novel HIV-1 protease inhibitors with isopropanol as P1′ ligand to enhance binding with S1′ subsite Open
View article: Novel HIV-1 Protease Inhibitors with Morpholine as the P2 Ligand to Enhance Activity against DRV-Resistant Variants
Novel HIV-1 Protease Inhibitors with Morpholine as the P2 Ligand to Enhance Activity against DRV-Resistant Variants Open
Flexible heterocyclic moieties as the P2 ligands of HIV-1 protease inhibitors may be adapted to the minimally distorted active site of mutations easily and enhance activity against DRV-resistant HIV-1 variants. Herein, the design, synthesi…