Guoping Sun
YOU?
Author Swipe
View article: Endoplasmic reticulum stress upregulate HYOU1 and mediates lenvatinib resistance in liver cancer through ERK/MAPK pathway
Endoplasmic reticulum stress upregulate HYOU1 and mediates lenvatinib resistance in liver cancer through ERK/MAPK pathway Open
Endoplasmic reticulum stress (ERS) is commonly observed in liver cancer and is associated with drug sensitivity. Consequently, ERS-related genes may serve as targets for enhancing treatment sensitivity. This study analyzed RNA and proteomi…
View article: Targeting endoplasmic reticulum stress-induced CLGN resensitizes hepatocellular carcinoma to apoptosis: paeonol synergistically enhances efficacy by dual inhibition of CLGN and NF-κB
Targeting endoplasmic reticulum stress-induced CLGN resensitizes hepatocellular carcinoma to apoptosis: paeonol synergistically enhances efficacy by dual inhibition of CLGN and NF-κB Open
Purpose Endoplasmic reticulum stress (ERS) drives hepatocellular carcinoma (HCC) progression and therapy resistance. This study identifies Calmegin (CLGN) as a novel ERS-induced pro-survival factor and explores shCLGN combined with Paeonol…
View article: Endoplasmic reticulum stress-related CLIP4 plays a procarcinogenic role in hepatocellular carcinoma: an integrated analysis
Endoplasmic reticulum stress-related CLIP4 plays a procarcinogenic role in hepatocellular carcinoma: an integrated analysis Open
CLIP4 is a potential immune-related oncogenic molecule in HCC. ERS regulates the expression of CLIP4, and CLIP4 promotes the proliferation, migration, and EMT of HCC cells.
View article: Endoplasmic reticulum stress-related super enhancer promotes epithelial-mesenchymal transformation in hepatocellular carcinoma through CREB5 mediated activation of TNC
Endoplasmic reticulum stress-related super enhancer promotes epithelial-mesenchymal transformation in hepatocellular carcinoma through CREB5 mediated activation of TNC Open
Super-enhancers (SEs) are associated with key genes that control cellular state and cell identity. Endoplasmic reticulum stress (ERS) regulates epithelial-mesenchymal transformation (EMT). However, whether SEs are involved in ERS-related a…
View article: Real‐World Efficacy of HLX02‐Based Neoadjuvant Therapy in HER2‐Positive Breast Cancer: Clinical Insights and Future Directions
Real‐World Efficacy of HLX02‐Based Neoadjuvant Therapy in HER2‐Positive Breast Cancer: Clinical Insights and Future Directions Open
Background: The efficacy of HLX02, a trastuzumab biosimilar, in combination with chemotherapy for treating metastatic breast cancer (BC) has been established as equivalent to the reference Herceptin. This study aimed to assess the treatmen…
View article: RNA-binding protein quaking: a multifunctional regulator in tumour progression
RNA-binding protein quaking: a multifunctional regulator in tumour progression Open
QKI play a critical role as tumour suppressor or an oncogene in tumour progression due to the different splicing sites and transcripts with various tumour subtype or tumor micorenvironment. Ongoing research about QKI's functions and mechan…
View article: Metagenome-assembled genome reveals species and functional composition of Jianghan chicken gut microbiota and isolation of Pediococcus acidilactic with probiotic properties
Metagenome-assembled genome reveals species and functional composition of Jianghan chicken gut microbiota and isolation of Pediococcus acidilactic with probiotic properties Open
Background Chickens are one of the most widely farmed animals worldwide and play a crucial role in meat and egg production. Gut microbiota is essential for chickens’ health, disease, growth, and egg production. However, native chickens suc…
View article: A retrospective study on the efficacy and safety of Envafolimab, a PD-L1 inhibitor, in the treatment of advanced malignant solid tumors
A retrospective study on the efficacy and safety of Envafolimab, a PD-L1 inhibitor, in the treatment of advanced malignant solid tumors Open
Envafolimab, a PD-L1 inhibitor, has demonstrated potential in treating advanced malignant solid tumors (AMST). To study its’ efficacy and safety in AMST, our retrospective study recruited 64 patients with various AMST, and treated with Env…
View article: Associations of circulating immunomarkers with the efficacy of immunotherapy for primary hepatic carcinoma
Associations of circulating immunomarkers with the efficacy of immunotherapy for primary hepatic carcinoma Open
Background Peripheral blood immunomarkers are associated with prognosis in patients with solid tumors receiving chemotherapy or immunotherapy. In this study, the associations of circulating neutrophil‐to‐lymphocyte ratio (NLR), monocyte‐to…
View article: Metagenome-assembled genome reveals species and functional composition of Jianghan chicken gut microbiota and isolation of Pediococcus acidilactic with probiotic properties
Metagenome-assembled genome reveals species and functional composition of Jianghan chicken gut microbiota and isolation of Pediococcus acidilactic with probiotic properties Open
Background Chickens are one of the most widely farmed animals in the world, playing a crucial role in meat and egg production. Gut microbiota is essential for chickens' health, disease, growth, and egg production. However, native chickens …
View article: The role of PMI in evaluating the efficacy of PD-1 inhibitors and prognosis of patients treated for advanced esophageal squamous cell carcinoma
The role of PMI in evaluating the efficacy of PD-1 inhibitors and prognosis of patients treated for advanced esophageal squamous cell carcinoma Open
Background Skeletal muscle loss is an indicator of poor prognosis for various malignant tumours, including ESCC. We assessed whether the baseline psoas muscle mass index (PMI) could predict the response of ESCC to sintilimab treatment, wit…
View article: The influence of meteorological factors and total malignant tumor health risk in Wuhu city in the context of climate change
The influence of meteorological factors and total malignant tumor health risk in Wuhu city in the context of climate change Open
With the increasing severity of the malignant tumors situation worldwide, the impacts of climate on them are receiving increasing attention. In this study, for the first time, all-malignant tumors were used as the dependent variable and ab…
View article: KIAA1199 promotes oxaliplatin resistance and epithelial mesenchymal transition of colorectal cancer via protein O-GlcNAcylation
KIAA1199 promotes oxaliplatin resistance and epithelial mesenchymal transition of colorectal cancer via protein O-GlcNAcylation Open
Oxaliplatin is a commonly used platinum drug for colorectal cancer (CRC). However, the treatment of CRC by oxaliplatin usually fails because of drug resistance, which results in a huge challenge in the therapy of CRC. Elucidation of molecu…
View article: Identification of oncogenes and tumor-suppressor genes with hepatocellular carcinoma: A comprehensive analysis based on TCGA and GEO datasets
Identification of oncogenes and tumor-suppressor genes with hepatocellular carcinoma: A comprehensive analysis based on TCGA and GEO datasets Open
Aim: Existing targeted therapies for hepatocellular carcinoma (HCC) are resistant and have limitations. It is crucial to find new HCC-related target genes. Methods: RNA-sequencing data of HCC were gathered from The Cancer Genome Atlas and …
View article: Effect of primary radiotherapy on the survival rate of stage IVB cervical cancer patients and factors related to their survival: a real-world study based on SEER database
Effect of primary radiotherapy on the survival rate of stage IVB cervical cancer patients and factors related to their survival: a real-world study based on SEER database Open
This study aimed to investigate the survival and influence factors of radiation therapy on primary tumors in patients with stage ⅣB cervical cancer. The data of 3129 stage IVB cervical cancer patients diagnosed from 2000 to 2018 in the Sur…
View article: Development and validation of a nomogram to predict overall survival in young non-metastatic rectal cancer patients after curative resection: a population-based analysis
Development and validation of a nomogram to predict overall survival in young non-metastatic rectal cancer patients after curative resection: a population-based analysis Open
Purpose This study aimed to establish and validate a nomogram for predicting overall survival (OS) in young non-metastatic rectal cancer (RC) patients after curative resection. Methods Young RC patients (under 50 years of age) from 2010 to…
View article: A Novel Nomogram Combining Alternative Splicing Events and Clinical Factors for Prognosis Prediction in Head and Neck Squamous Cell Carcinoma
A Novel Nomogram Combining Alternative Splicing Events and Clinical Factors for Prognosis Prediction in Head and Neck Squamous Cell Carcinoma Open
Due to limitations of sensitive biomarkers, the clinical prognosis of patients with head and neck squamous cell carcinoma (HNSCC) remains poor. Alternative splicing (AS) is the basis of both transcriptome and proteome richness, so more and…
View article: CD274 (PD-L1) Methylation is an Independent Predictor for Bladder Cancer Patients’ Survival
CD274 (PD-L1) Methylation is an Independent Predictor for Bladder Cancer Patients’ Survival Open
This study was carried out to demonstrate the prognostic value of CD274 (PD-L1 promoter gene) methylation in bladder cancer patients. UCSC Xena database was searched for relevant information on PD-L1 (CD274) methylation and PD-L1 mRNA expr…
View article: Melatonin Reduces Apoptosis Resistance of Hepatocellular Carcinoma Cells by Inhibiting BMAL1
Melatonin Reduces Apoptosis Resistance of Hepatocellular Carcinoma Cells by Inhibiting BMAL1 Open
Purpose: This study aimed to explore the role and molecular mechanism of brain and muscle ARNT-like protein 1 (BMAL1) in hepatocellular carcinoma (HCC), and the effect of melatonin on BMAL1 expression and apoptosis of HCC cells. Methods: W…
View article: Synthesis and Preclinical Evaluation of [<sup>68</sup>Ga]SP94 for Micro-PET Imaging of GRP78 Expression in Hepatocellular Carcinoma
Synthesis and Preclinical Evaluation of [<sup>68</sup>Ga]SP94 for Micro-PET Imaging of GRP78 Expression in Hepatocellular Carcinoma Open
Glucose-regulated protein 78 (GRP78) is overexpressed in a wide variety of solid tumors, serving as a well-characterized target for tumor imaging or therapy. In this work, we developed a GRP78-responsive radiotracer (DOTA-68Ga)-Gly-Gly-Gly…